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OPENSEQ.org
YIAD - Inner membrane lipoprotein YiaD
UniProt: P37665 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12271
Length: 219 (213)
Sequences: 608
Seq/Len: 2.85
YIAD
Paralog alert: 0.05 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: PAL YFIB YIAD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
117_D 124_K 4.982 1.00
151_Y 195_N 4.238 1.00
119_S 160_L 4.147 1.00
162_M 166_Q 3.322 1.00
198_A 205_G 3.089 1.00
158_H 193_P 2.902 1.00
132_T 175_A 2.687 1.00
149_I 191_L 2.544 1.00
87_K 140_E 2.462 1.00
123_L 127_G 2.431 1.00
160_L 163_R 2.399 1.00
199_S 205_G 2.391 1.00
160_L 193_P 2.372 1.00
132_T 179_Q 2.255 1.00
155_T 206_K 2.096 1.00
118_S 155_T 2.075 1.00
85_E 89_R 2.047 1.00
163_R 167_Q 2.02 1.00
158_H 194_A 1.863 0.99
202_T 205_G 1.781 0.99
121_A 167_Q 1.775 0.99
166_Q 170_D 1.629 0.97
191_L 195_N 1.618 0.97
76_G 79_Y 1.617 0.97
24_N 31_E 1.6 0.97
163_R 193_P 1.599 0.97
45_V 48_G 1.578 0.97
200_N 205_G 1.57 0.97
200_N 206_K 1.552 0.96
72_A 76_G 1.537 0.96
155_T 193_P 1.532 0.96
148_V 173_A 1.531 0.96
61_K 65_I 1.484 0.95
65_I 68_A 1.475 0.95
197_I 205_G 1.459 0.94
69_A 73_L 1.453 0.94
37_I 41_L 1.407 0.93
162_M 194_A 1.401 0.92
196_P 200_N 1.381 0.92
49_I 53_S 1.377 0.92
84_Q 141_Y 1.361 0.91
70_G 74_G 1.327 0.89
95_T 99_V 1.316 0.89
76_G 80_Y 1.314 0.89
154_S 205_G 1.306 0.88
77_V 81_M 1.301 0.88
71_A 75_G 1.3 0.88
41_L 44_L 1.3 0.88
118_S 203_A 1.298 0.88
154_S 206_K 1.294 0.88
119_S 167_Q 1.28 0.87
118_S 160_L 1.24 0.85
151_Y 194_A 1.237 0.85
196_P 206_K 1.235 0.84
144_T 185_R 1.213 0.83
48_G 51_A 1.212 0.83
84_Q 144_T 1.197 0.82
46_G 66_G 1.184 0.81
154_S 200_N 1.163 0.79
147_N 217_S 1.159 0.79
94_G 132_T 1.131 0.76
81_M 144_T 1.131 0.76
32_A 37_I 1.123 0.76
175_A 179_Q 1.121 0.76
199_S 202_T 1.1 0.74
79_Y 83_V 1.099 0.74
154_S 198_A 1.099 0.74
95_T 108_L 1.094 0.73
149_I 195_N 1.086 0.72
85_E 101_R 1.083 0.72
15_A 44_L 1.082 0.72
41_L 68_A 1.082 0.72
111_P 115_T 1.071 0.71
101_R 108_L 1.063 0.70
45_V 52_L 1.061 0.70
68_A 72_A 1.049 0.68
158_H 163_R 1.048 0.68
51_A 63_A 1.044 0.68
83_V 87_K 1.044 0.68
117_D 120_S 1.04 0.68
202_T 206_K 1.04 0.68
201_S 205_G 1.036 0.67
134_V 138_L 1.036 0.67
112_N 127_G 1.026 0.66
198_A 206_K 1.023 0.66
44_L 48_G 1.023 0.66
100_T 109_N 1.018 0.65
115_T 127_G 1.017 0.65
157_G 160_L 1.012 0.64
85_E 108_L 1.011 0.64
34_K 37_I 1.004 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ldtA10.73521000.398Contact Map0.276
2k1sA10.64381000.486Contact Map0.452
4b62A10.64381000.549Contact Map0.504
3s06A20.63011000.555Contact Map0.416
3s0yA20.73521000.564Contact Map0.452
1r1mA10.55711000.564Contact Map0.386
2hqsH40.5161000.566Contact Map0.588
3khnA20.69861000.568Contact Map0.545
3oonA10.55711000.576Contact Map0.613
3td3A80.55251000.583Contact Map0.647
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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