| UniProt: | P37617 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12215 | ||
| Length: | 732 (683) | ||
| Sequences: | 6295 | ||
| Seq/Len: | 9.22 |
| ATZN
Paralog alert: 0.83 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ATKB ATMA ATZN COPA |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 587_P | 591_A | 5.245 | 1.00 | |
| 469_V | 508_A | 4.276 | 1.00 | |
| 274_K | 316_E | 4.127 | 1.00 | |
| 160_T | 195_L | 4.06 | 1.00 | |
| 280_A | 313_V | 3.98 | 1.00 | |
| 513_E | 548_N | 3.944 | 1.00 | |
| 499_R | 507_E | 3.701 | 1.00 | |
| 547_R | 552_L | 3.544 | 1.00 | |
| 613_A | 616_E | 3.468 | 1.00 | |
| 609_D | 612_K | 3.462 | 1.00 | |
| 583_T | 590_A | 3.448 | 1.00 | |
| 587_P | 604_G | 3.386 | 1.00 | |
| 564_D | 664_H | 3.316 | 1.00 | |
| 431_T | 621_A | 3.22 | 1.00 | |
| 578_K | 600_E | 3.21 | 1.00 | |
| 450_A | 540_Q | 3.089 | 1.00 | |
| 430_V | 624_A | 3.078 | 1.00 | |
| 277_S | 314_T | 3.015 | 1.00 | |
| 280_A | 308_S | 2.999 | 1.00 | |
| 260_V | 314_T | 2.952 | 1.00 | |
| 468_A | 493_P | 2.949 | 1.00 | |
| 462_L | 553_G | 2.949 | 1.00 | |
| 497_S | 509_Q | 2.941 | 1.00 | |
| 260_V | 276_L | 2.86 | 1.00 | |
| 269_L | 282_F | 2.801 | 1.00 | |
| 459_E | 488_A | 2.784 | 1.00 | |
| 594_A | 601_F | 2.782 | 1.00 | |
| 238_T | 249_E | 2.776 | 1.00 | |
| 240_T | 249_E | 2.75 | 1.00 | |
| 241_R | 248_E | 2.742 | 1.00 | |
| 448_V | 555_I | 2.724 | 1.00 | |
| 260_V | 316_E | 2.713 | 1.00 | |
| 624_A | 643_I | 2.707 | 1.00 | |
| 243_R | 248_E | 2.652 | 1.00 | |
| 302_V | 315_L | 2.596 | 1.00 | |
| 271_A | 317_V | 2.585 | 1.00 | |
| 615_T | 638_A | 2.556 | 1.00 | |
| 566_A | 570_S | 2.533 | 1.00 | |
| 275_L | 313_V | 2.531 | 1.00 | |
| 591_A | 595_G | 2.506 | 1.00 | |
| 484_E | 488_A | 2.439 | 1.00 | |
| 602_K | 613_A | 2.438 | 1.00 | |
| 507_E | 514_R | 2.382 | 1.00 | |
| 242_L | 314_T | 2.364 | 1.00 | |
| 441_L | 597_L | 2.344 | 1.00 | |
| 618_N | 638_A | 2.342 | 1.00 | |
| 448_V | 484_E | 2.309 | 1.00 | |
| 443_V | 560_T | 2.308 | 1.00 | |
| 501_L | 522_K | 2.287 | 1.00 | |
| 443_V | 563_A | 2.28 | 1.00 | |
| 515_V | 547_R | 2.227 | 1.00 | |
| 531_L | 534_E | 2.184 | 1.00 | |
| 578_K | 621_A | 2.182 | 1.00 | |
| 458_S | 461_E | 2.177 | 1.00 | |
| 411_A | 674_L | 2.172 | 1.00 | |
| 465_L | 515_V | 2.169 | 1.00 | |
| 240_T | 267_G | 2.131 | 1.00 | |
| 276_L | 316_E | 2.109 | 1.00 | |
| 681_N | 727_R | 2.105 | 1.00 | |
| 523_H | 546_V | 2.103 | 1.00 | |
| 255_L | 271_A | 2.097 | 1.00 | |
| 542_V | 554_V | 2.083 | 1.00 | |
| 513_E | 547_R | 2.072 | 1.00 | |
| 169_R | 173_R | 2.036 | 1.00 | |
| 570_S | 574_A | 2.013 | 1.00 | |
| 434_A | 617_L | 2.001 | 1.00 | |
| 567_T | 666_R | 1.989 | 1.00 | |
| 431_T | 622_P | 1.983 | 1.00 | |
| 434_A | 614_V | 1.976 | 1.00 | |
| 59_C | 62_C | 1.969 | 1.00 | |
| 612_K | 615_T | 1.965 | 1.00 | |
| 241_R | 250_V | 1.963 | 1.00 | |
| 575_L | 673_E | 1.962 | 1.00 | |
| 275_L | 282_F | 1.953 | 1.00 | |
| 517_I | 545_V | 1.95 | 1.00 | |
| 532_I | 544_L | 1.941 | 1.00 | |
| 571_E | 673_E | 1.937 | 1.00 | |
| 616_E | 619_Q | 1.937 | 1.00 | |
| 591_A | 601_F | 1.933 | 1.00 | |
| 582_L | 613_A | 1.919 | 1.00 | |
| 192_I | 196_F | 1.873 | 1.00 | |
| 484_E | 487_V | 1.866 | 1.00 | |
| 273_G | 315_L | 1.86 | 1.00 | |
| 581_I | 590_A | 1.857 | 1.00 | |
| 434_A | 582_L | 1.853 | 1.00 | |
| 297_A | 300_D | 1.847 | 1.00 | |
| 349_R | 353_I | 1.84 | 1.00 | |
| 284_E | 296_R | 1.828 | 1.00 | |
| 467_A | 485_A | 1.81 | 1.00 | |
| 647_S | 663_N | 1.805 | 1.00 | |
| 545_V | 553_G | 1.801 | 1.00 | |
| 573_N | 579_G | 1.788 | 1.00 | |
| 241_R | 259_D | 1.784 | 1.00 | |
| 360_A | 364_L | 1.773 | 1.00 | |
| 255_L | 261_I | 1.757 | 1.00 | |
| 687_T | 691_G | 1.753 | 1.00 | |
| 243_R | 246_E | 1.742 | 1.00 | |
| 283_D | 309_V | 1.732 | 1.00 | |
| 568_A | 669_V | 1.723 | 1.00 | |
| 561_L | 597_L | 1.72 | 1.00 | |
| 432_Q | 580_V | 1.714 | 1.00 | |
| 516_L | 546_V | 1.709 | 1.00 | |
| 449_T | 540_Q | 1.708 | 1.00 | |
| 331_K | 335_E | 1.707 | 1.00 | |
| 543_V | 557_L | 1.705 | 1.00 | |
| 403_A | 725_A | 1.702 | 1.00 | |
| 507_E | 516_L | 1.697 | 1.00 | |
| 139_A | 208_L | 1.696 | 1.00 | |
| 435_F | 441_L | 1.695 | 1.00 | |
| 365_V | 383_K | 1.694 | 1.00 | |
| 55_S | 110_S | 1.691 | 1.00 | |
| 643_I | 668_L | 1.681 | 1.00 | |
| 509_Q | 514_R | 1.674 | 1.00 | |
| 168_A | 192_I | 1.673 | 1.00 | |
| 433_V | 624_A | 1.657 | 1.00 | |
| 317_V | 320_E | 1.655 | 1.00 | |
| 282_F | 313_V | 1.641 | 1.00 | |
| 414_R | 670_Q | 1.639 | 1.00 | |
| 519_A | 522_K | 1.635 | 1.00 | |
| 432_Q | 621_A | 1.631 | 1.00 | |
| 464_T | 511_N | 1.627 | 1.00 | |
| 258_G | 316_E | 1.618 | 1.00 | |
| 63_A | 83_F | 1.615 | 1.00 | |
| 684_Q | 724_N | 1.604 | 1.00 | |
| 566_A | 596_E | 1.599 | 1.00 | |
| 583_T | 603_A | 1.598 | 1.00 | |
| 262_E | 314_T | 1.593 | 1.00 | |
| 534_E | 538_A | 1.592 | 1.00 | |
| 580_V | 600_E | 1.586 | 1.00 | |
| 466_A | 545_V | 1.586 | 1.00 | |
| 569_I | 579_G | 1.581 | 1.00 | |
| 461_E | 464_T | 1.58 | 1.00 | |
| 564_D | 666_R | 1.572 | 1.00 | |
| 481_I | 555_I | 1.565 | 1.00 | |
| 274_K | 318_L | 1.563 | 1.00 | |
| 441_L | 561_L | 1.563 | 1.00 | |
| 243_R | 259_D | 1.554 | 1.00 | |
| 275_L | 278_P | 1.549 | 1.00 | |
| 457_I | 552_L | 1.536 | 1.00 | |
| 263_V | 315_L | 1.532 | 1.00 | |
| 515_V | 552_L | 1.531 | 1.00 | |
| 474_T | 500_A | 1.53 | 1.00 | |
| 261_I | 315_L | 1.527 | 1.00 | |
| 681_N | 725_A | 1.526 | 1.00 | |
| 407_G | 678_T | 1.523 | 1.00 | |
| 410_A | 414_R | 1.522 | 1.00 | |
| 612_K | 616_E | 1.518 | 1.00 | |
| 446_P | 477_L | 1.518 | 1.00 | |
| 70_V | 88_L | 1.517 | 1.00 | |
| 443_V | 447_R | 1.495 | 1.00 | |
| 516_L | 522_K | 1.49 | 1.00 | |
| 168_A | 188_S | 1.486 | 1.00 | |
| 468_A | 492_I | 1.485 | 1.00 | |
| 479_Q | 483_R | 1.482 | 1.00 | |
| 498_Q | 506_I | 1.48 | 1.00 | |
| 724_N | 727_R | 1.478 | 1.00 | |
| 470_E | 478_A | 1.476 | 1.00 | |
| 447_R | 483_R | 1.474 | 1.00 | |
| 611_V | 638_A | 1.471 | 1.00 | |
| 501_L | 507_E | 1.47 | 1.00 | |
| 429_R | 622_P | 1.463 | 1.00 | |
| 561_L | 593_I | 1.453 | 1.00 | |
| 418_I | 658_A | 1.45 | 1.00 | |
| 188_S | 192_I | 1.447 | 1.00 | |
| 403_A | 681_N | 1.447 | 1.00 | |
| 78_Q | 91_D | 1.441 | 1.00 | |
| 321_P | 324_S | 1.44 | 1.00 | |
| 247_R | 262_E | 1.435 | 0.99 | |
| 590_A | 601_F | 1.429 | 0.99 | |
| 274_K | 299_G | 1.422 | 0.99 | |
| 544_L | 551_V | 1.42 | 0.99 | |
| 102_S | 106_K | 1.413 | 0.99 | |
| 279_F | 297_A | 1.41 | 0.99 | |
| 567_T | 571_E | 1.403 | 0.99 | |
| 279_F | 295_E | 1.402 | 0.99 | |
| 281_S | 295_E | 1.381 | 0.99 | |
| 328_R | 608_E | 1.379 | 0.99 | |
| 496_E | 509_Q | 1.379 | 0.99 | |
| 460_S | 488_A | 1.377 | 0.99 | |
| 457_I | 462_L | 1.377 | 0.99 | |
| 444_G | 559_D | 1.368 | 0.99 | |
| 189_V | 359_M | 1.368 | 0.99 | |
| 535_L | 556_A | 1.367 | 0.99 | |
| 575_L | 676_R | 1.362 | 0.99 | |
| 163_G | 168_A | 1.361 | 0.99 | |
| 469_V | 515_V | 1.359 | 0.99 | |
| 662_H | 667_G | 1.356 | 0.99 | |
| 103_A | 107_A | 1.346 | 0.99 | |
| 239_A | 270_P | 1.341 | 0.99 | |
| 301_K | 319_S | 1.341 | 0.99 | |
| 136_V | 208_L | 1.327 | 0.99 | |
| 312_L | 472_G | 1.319 | 0.99 | |
| 602_K | 616_E | 1.316 | 0.99 | |
| 274_K | 301_K | 1.313 | 0.99 | |
| 469_V | 506_I | 1.31 | 0.99 | |
| 466_A | 517_I | 1.31 | 0.99 | |
| 435_F | 579_G | 1.306 | 0.99 | |
| 464_T | 493_P | 1.303 | 0.99 | |
| 469_V | 517_I | 1.301 | 0.99 | |
| 301_K | 318_L | 1.299 | 0.99 | |
| 681_N | 684_Q | 1.299 | 0.99 | |
| 449_T | 558_Q | 1.29 | 0.99 | |
| 242_L | 247_R | 1.289 | 0.99 | |
| 435_F | 668_L | 1.284 | 0.99 | |
| 493_P | 511_N | 1.283 | 0.99 | |
| 265_A | 280_A | 1.276 | 0.99 | |
| 637_K | 655_T | 1.275 | 0.99 | |
| 679_H | 683_R | 1.271 | 0.98 | |
| 510_V | 515_V | 1.263 | 0.98 | |
| 569_I | 573_N | 1.257 | 0.98 | |
| 366_T | 384_G | 1.256 | 0.98 | |
| 448_V | 557_L | 1.248 | 0.98 | |
| 261_I | 317_V | 1.248 | 0.98 | |
| 172_L | 176_K | 1.247 | 0.98 | |
| 287_L | 303_P | 1.246 | 0.98 | |
| 219_W | 223_R | 1.241 | 0.98 | |
| 452_H | 535_L | 1.239 | 0.98 | |
| 582_L | 605_L | 1.236 | 0.98 | |
| 427_L | 671_M | 1.235 | 0.98 | |
| 644_A | 656_A | 1.233 | 0.98 | |
| 71_R | 79_V | 1.232 | 0.98 | |
| 447_R | 560_T | 1.23 | 0.98 | |
| 594_A | 599_L | 1.226 | 0.98 | |
| 501_L | 504_S | 1.219 | 0.98 | |
| 250_V | 254_S | 1.215 | 0.98 | |
| 240_T | 247_R | 1.215 | 0.98 | |
| 361_V | 701_L | 1.214 | 0.98 | |
| 81_V | 88_L | 1.213 | 0.98 | |
| 471_Q | 486_Q | 1.21 | 0.98 | |
| 516_L | 523_H | 1.203 | 0.98 | |
| 242_L | 262_E | 1.196 | 0.97 | |
| 73_L | 103_A | 1.195 | 0.97 | |
| 286_A | 306_A | 1.194 | 0.97 | |
| 450_A | 459_E | 1.191 | 0.97 | |
| 251_A | 254_S | 1.184 | 0.97 | |
| 265_A | 500_A | 1.184 | 0.97 | |
| 540_Q | 556_A | 1.179 | 0.97 | |
| 451_I | 555_I | 1.178 | 0.97 | |
| 618_N | 640_A | 1.177 | 0.97 | |
| 570_S | 573_N | 1.176 | 0.97 | |
| 67_E | 71_R | 1.175 | 0.97 | |
| 431_T | 620_H | 1.175 | 0.97 | |
| 366_T | 369_P | 1.173 | 0.97 | |
| 565_A | 569_I | 1.173 | 0.97 | |
| 464_T | 468_A | 1.172 | 0.97 | |
| 608_E | 612_K | 1.171 | 0.97 | |
| 277_S | 298_T | 1.166 | 0.97 | |
| 435_F | 572_L | 1.163 | 0.97 | |
| 70_V | 79_V | 1.158 | 0.97 | |
| 468_A | 495_A | 1.158 | 0.97 | |
| 466_A | 555_I | 1.156 | 0.97 | |
| 520_A | 544_L | 1.156 | 0.97 | |
| 571_E | 574_A | 1.153 | 0.97 | |
| 137_M | 141_S | 1.151 | 0.97 | |
| 420_G | 657_D | 1.151 | 0.97 | |
| 587_P | 601_F | 1.15 | 0.97 | |
| 131_L | 166_P | 1.149 | 0.97 | |
| 453_P | 462_L | 1.142 | 0.96 | |
| 66_V | 107_A | 1.139 | 0.96 | |
| 483_R | 486_Q | 1.132 | 0.96 | |
| 410_A | 413_R | 1.131 | 0.96 | |
| 474_T | 498_Q | 1.13 | 0.96 | |
| 581_I | 599_L | 1.127 | 0.96 | |
| 76_V | 100_V | 1.127 | 0.96 | |
| 453_P | 553_G | 1.125 | 0.96 | |
| 255_L | 317_V | 1.122 | 0.96 | |
| 587_P | 603_A | 1.122 | 0.96 | |
| 353_I | 357_A | 1.121 | 0.96 | |
| 504_S | 606_L | 1.118 | 0.96 | |
| 495_A | 508_A | 1.118 | 0.96 | |
| 672_I | 676_R | 1.117 | 0.96 | |
| 261_I | 270_P | 1.117 | 0.96 | |
| 575_L | 672_I | 1.111 | 0.96 | |
| 484_E | 490_L | 1.11 | 0.96 | |
| 257_P | 320_E | 1.11 | 0.96 | |
| 535_L | 540_Q | 1.106 | 0.96 | |
| 262_E | 312_L | 1.104 | 0.95 | |
| 275_L | 280_A | 1.1 | 0.95 | |
| 138_M | 141_S | 1.099 | 0.95 | |
| 529_T | 533_N | 1.098 | 0.95 | |
| 564_D | 567_T | 1.098 | 0.95 | |
| 367_L | 371_L | 1.097 | 0.95 | |
| 564_D | 568_A | 1.094 | 0.95 | |
| 191_A | 207_L | 1.09 | 0.95 | |
| 240_T | 264_A | 1.085 | 0.95 | |
| 590_A | 603_A | 1.083 | 0.95 | |
| 496_E | 512_G | 1.08 | 0.95 | |
| 583_T | 601_F | 1.08 | 0.95 | |
| 304_A | 324_S | 1.078 | 0.95 | |
| 390_I | 696_F | 1.077 | 0.95 | |
| 275_L | 300_D | 1.077 | 0.95 | |
| 54_V | 57_M | 1.076 | 0.95 | |
| 645_M | 648_G | 1.076 | 0.95 | |
| 450_A | 535_L | 1.076 | 0.95 | |
| 515_V | 545_V | 1.076 | 0.95 | |
| 265_A | 308_S | 1.075 | 0.95 | |
| 469_V | 545_V | 1.071 | 0.94 | |
| 426_Q | 640_A | 1.071 | 0.94 | |
| 302_V | 313_V | 1.068 | 0.94 | |
| 428_G | 679_H | 1.065 | 0.94 | |
| 291_S | 589_A | 1.064 | 0.94 | |
| 582_L | 602_K | 1.063 | 0.94 | |
| 242_L | 260_V | 1.061 | 0.94 | |
| 303_P | 306_A | 1.059 | 0.94 | |
| 495_A | 510_V | 1.059 | 0.94 | |
| 462_L | 545_V | 1.057 | 0.94 | |
| 518_C | 522_K | 1.056 | 0.94 | |
| 426_Q | 429_R | 1.051 | 0.94 | |
| 571_E | 575_L | 1.051 | 0.94 | |
| 427_L | 641_I | 1.05 | 0.94 | |
| 449_T | 535_L | 1.047 | 0.93 | |
| 206_V | 711_V | 1.044 | 0.93 | |
| 70_V | 100_V | 1.036 | 0.93 | |
| 615_T | 618_N | 1.036 | 0.93 | |
| 447_R | 487_V | 1.031 | 0.93 | |
| 57_M | 62_C | 1.03 | 0.93 | |
| 71_R | 78_Q | 1.029 | 0.93 | |
| 680_A | 684_Q | 1.027 | 0.93 | |
| 51_S | 87_K | 1.027 | 0.93 | |
| 263_V | 269_L | 1.026 | 0.93 | |
| 602_K | 605_L | 1.024 | 0.92 | |
| 265_A | 474_T | 1.021 | 0.92 | |
| 101_E | 105_Q | 1.019 | 0.92 | |
| 364_L | 368_V | 1.018 | 0.92 | |
| 132_I | 136_V | 1.017 | 0.92 | |
| 428_G | 675_A | 1.016 | 0.92 | |
| 714_D | 717_A | 1.015 | 0.92 | |
| 102_S | 105_Q | 1.015 | 0.92 | |
| 156_F | 199_A | 1.014 | 0.92 | |
| 224_A | 409_A | 1.014 | 0.92 | |
| 418_I | 671_M | 1.013 | 0.92 | |
| 711_V | 715_T | 1.013 | 0.92 | |
| 241_R | 261_I | 1.01 | 0.92 | |
| 163_G | 192_I | 1.009 | 0.92 | |
| 345_R | 349_R | 1.008 | 0.92 | |
| 230_A | 413_R | 1.007 | 0.92 | |
| 461_E | 513_E | 1.002 | 0.91 | |
| 483_R | 487_V | 1.001 | 0.91 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3j09A | 2 | 0.929 | 100 | 0.264 | Contact Map | 0.716 |
| 3rfuA | 4 | 0.9262 | 100 | 0.269 | Contact Map | 0.648 |
| 3j08A | 2 | 0.8251 | 100 | 0.333 | Contact Map | 0.674 |
| 3b8cA | 2 | 0.8388 | 100 | 0.505 | Contact Map | 0.525 |
| 1mhsA | 2 | 0.9057 | 100 | 0.51 | Contact Map | 0.511 |
| 3ar4A | 1 | 0.8197 | 100 | 0.541 | Contact Map | 0.696 |
| 2zxeA | 1 | 0.8825 | 100 | 0.543 | Contact Map | 0.664 |
| 3ixzA | 1 | 0.9098 | 100 | 0.545 | Contact Map | 0.078 |
| 3skxA | 1 | 0.3784 | 100 | 0.782 | Contact Map | 0.768 |
| 3a1cA | 2 | 0.3825 | 100 | 0.799 | Contact Map | 0.804 |
Sequence Conservation (Image Generated using WebLogo v3)