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OPENSEQ.org
ATMA - Magnesium-transporting ATPase, P-type 1
UniProt: P0ABB8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12525
Length: 898 (844)
Sequences: 4798
Seq/Len: 5.68
ATMA
Paralog alert: 0.52 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ATKB ATMA ATZN COPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
197_L 253_A 6.978 1.00
66_Q 168_E 5.257 1.00
69_V 73_R 4.851 1.00
368_D 634_H 4.138 1.00
68_E 72_A 3.879 1.00
185_I 197_L 3.807 1.00
601_D 624_R 3.745 1.00
80_K 177_D 3.656 1.00
605_A 631_R 3.599 1.00
185_I 253_A 3.556 1.00
76_H 181_P 3.555 1.00
600_S 603_E 3.542 1.00
580_C 613_L 3.369 1.00
68_E 71_S 3.326 1.00
197_L 240_C 3.224 1.00
402_S 538_E 3.199 1.00
387_N 508_Q 3.016 1.00
205_L 251_A 2.996 1.00
560_A 755_Q 2.983 1.00
563_I 685_V 2.946 1.00
54_W 254_M 2.94 1.00
71_S 75_Q 2.94 1.00
207_V 246_V 2.923 1.00
103_I 107_I 2.909 1.00
181_P 258_T 2.894 1.00
184_I 200_L 2.835 1.00
82_P 260_A 2.826 1.00
73_R 258_T 2.799 1.00
609_Q 632_E 2.766 1.00
239_L 256_I 2.726 1.00
627_T 651_A 2.722 1.00
693_A 756_K 2.716 1.00
479_S 534_D 2.686 1.00
467_C 535_L 2.655 1.00
185_I 194_P 2.574 1.00
483_H 486_E 2.527 1.00
351_Q 683_E 2.52 1.00
88_P 91_V 2.496 1.00
351_Q 686_I 2.492 1.00
73_R 78_E 2.488 1.00
199_I 202_A 2.486 1.00
380_Q 549_E 2.476 1.00
491_D 494_M 2.426 1.00
438_Q 457_A 2.421 1.00
156_T 173_E 2.401 1.00
630_K 651_A 2.345 1.00
236_C 241_F 2.314 1.00
657_S 669_A 2.312 1.00
278_P 286_S 2.259 1.00
160_L 252_Q 2.257 1.00
505_L 542_A 2.239 1.00
885_Q 888_K 2.231 1.00
353_V 680_V 2.228 1.00
240_C 253_A 2.221 1.00
464_Q 519_Y 2.218 1.00
550_T 677_S 2.217 1.00
609_Q 634_H 2.205 1.00
451_R 477_V 2.185 1.00
566_K 629_L 2.181 1.00
556_K 560_A 2.135 1.00
501_V 504_T 2.126 1.00
78_E 177_D 2.119 1.00
605_A 628_L 2.107 1.00
355_V 671_I 2.105 1.00
555_L 585_L 2.105 1.00
498_I 537_L 2.097 1.00
514_A 537_L 2.094 1.00
78_E 178_Q 2.075 1.00
517_T 536_I 2.061 1.00
467_C 474_I 2.06 1.00
197_L 256_I 2.058 1.00
558_L 682_E 2.053 1.00
160_L 184_I 2.053 1.00
773_G 776_S 2.049 1.00
65_N 168_E 2.047 1.00
201_Q 252_Q 2.046 1.00
89_W 93_L 2.043 1.00
87_S 95_V 2.041 1.00
66_Q 172_L 2.034 1.00
180_V 258_T 2.032 1.00
49_P 52_E 2.023 1.00
440_I 463_H 2.007 1.00
70_E 74_E 1.993 1.00
54_W 200_L 1.989 1.00
207_V 240_C 1.981 1.00
160_L 186_K 1.97 1.00
557_A 686_I 1.969 1.00
243_G 264_F 1.943 1.00
70_E 73_R 1.942 1.00
597_E 621_H 1.932 1.00
89_W 136_F 1.932 1.00
307_N 317_A 1.916 1.00
156_T 175_P 1.909 1.00
564_T 612_T 1.904 1.00
187_L 193_I 1.902 1.00
500_R 504_T 1.889 1.00
136_F 140_A 1.875 1.00
53_L 254_M 1.873 1.00
171_W 186_K 1.871 1.00
367_M 637_G 1.852 1.00
480_Q 536_I 1.85 1.00
205_L 246_V 1.831 1.00
97_Y 132_T 1.831 1.00
160_L 171_W 1.827 1.00
496_R 500_R 1.825 1.00
591_V 611_T 1.817 1.00
67_A 71_S 1.814 1.00
453_S 465_L 1.814 1.00
512_V 540_Y 1.807 1.00
179_L 185_I 1.805 1.00
66_Q 70_E 1.805 1.00
98_R 103_I 1.804 1.00
453_S 467_C 1.794 1.00
553_P 557_A 1.793 1.00
857_A 864_A 1.791 1.00
503_D 574_L 1.791 1.00
492_D 495_L 1.791 1.00
552_A 556_K 1.79 1.00
550_T 553_P 1.786 1.00
174_I 179_L 1.782 1.00
158_T 171_W 1.763 1.00
438_Q 456_V 1.744 1.00
318_A 322_L 1.742 1.00
354_I 674_L 1.726 1.00
175_P 178_Q 1.721 1.00
628_L 631_R 1.716 1.00
577_A 581_H 1.714 1.00
547_P 583_V 1.713 1.00
488_V 494_M 1.713 1.00
495_L 499_K 1.713 1.00
850_A 854_S 1.711 1.00
69_V 78_E 1.702 1.00
54_W 184_I 1.697 1.00
263_W 266_Q 1.696 1.00
50_E 200_L 1.695 1.00
65_N 69_V 1.682 1.00
591_V 599_L 1.678 1.00
866_P 869_Y 1.673 1.00
516_A 535_L 1.665 1.00
605_A 632_E 1.665 1.00
71_S 74_E 1.663 1.00
184_I 254_M 1.65 1.00
158_T 188_A 1.647 1.00
57_F 72_A 1.643 1.00
453_S 532_E 1.641 1.00
113_Y 121_A 1.641 1.00
159_V 174_I 1.64 1.00
187_L 240_C 1.638 1.00
457_A 463_H 1.631 0.99
481_V 494_M 1.63 0.99
106_T 110_A 1.63 0.99
52_E 55_K 1.628 0.99
492_D 496_R 1.618 0.99
430_A 434_A 1.617 0.99
193_I 246_V 1.617 0.99
871_P 875_A 1.616 0.99
400_L 424_G 1.611 0.99
109_G 125_A 1.592 0.99
839_I 843_I 1.591 0.99
414_K 417_L 1.589 0.99
48_M 56_T 1.587 0.99
253_A 256_I 1.581 0.99
186_K 252_Q 1.576 0.99
285_I 337_V 1.574 0.99
51_E 55_K 1.568 0.99
494_M 497_K 1.561 0.99
462_H 519_Y 1.551 0.99
592_I 595_D 1.544 0.99
480_Q 489_P 1.541 0.99
402_S 466_V 1.535 0.99
93_L 133_L 1.527 0.99
487_I 536_I 1.524 0.99
573_E 590_V 1.516 0.99
199_I 240_C 1.51 0.99
65_N 68_E 1.497 0.99
352_K 674_L 1.463 0.99
474_I 478_C 1.454 0.99
603_E 606_N 1.454 0.99
510_L 542_A 1.453 0.99
518_K 534_D 1.452 0.99
87_S 91_V 1.449 0.98
199_I 251_A 1.447 0.98
604_L 624_R 1.432 0.98
206_F 248_S 1.431 0.98
606_N 610_R 1.428 0.98
304_L 321_A 1.425 0.98
627_T 631_R 1.423 0.98
808_V 848_G 1.416 0.98
505_L 510_L 1.415 0.98
709_N 737_Y 1.409 0.98
378_L 583_V 1.407 0.98
193_I 207_V 1.398 0.98
136_F 139_E 1.395 0.98
518_K 533_S 1.392 0.98
133_L 137_I 1.384 0.98
478_C 516_A 1.378 0.98
569_T 576_A 1.377 0.98
819_H 841_T 1.376 0.98
93_L 136_F 1.366 0.98
59_T 254_M 1.356 0.97
146_A 149_L 1.354 0.97
449_R 532_E 1.346 0.97
59_T 200_L 1.345 0.97
127_M 131_S 1.343 0.97
83_A 150_K 1.338 0.97
447_F 450_R 1.336 0.97
690_R 749_V 1.334 0.97
352_K 675_E 1.333 0.97
490_L 498_I 1.332 0.97
649_L 665_A 1.327 0.97
54_W 60_H 1.322 0.97
54_W 59_T 1.322 0.97
476_N 495_L 1.32 0.97
371_C 629_L 1.307 0.97
181_P 257_A 1.301 0.96
568_L 625_I 1.301 0.96
73_R 178_Q 1.3 0.96
567_I 613_L 1.295 0.96
67_A 70_E 1.293 0.96
347_K 687_E 1.287 0.96
198_R 254_M 1.287 0.96
553_P 556_K 1.286 0.96
287_R 291_L 1.285 0.96
386_E 582_E 1.285 0.96
189_A 446_D 1.28 0.96
641_D 644_N 1.262 0.96
187_L 246_V 1.262 0.96
683_E 686_I 1.259 0.96
418_D 421_V 1.254 0.95
369_I 566_K 1.252 0.95
558_L 565_V 1.248 0.95
802_F 806_W 1.245 0.95
52_E 56_T 1.245 0.95
174_I 178_Q 1.242 0.95
266_Q 620_M 1.241 0.95
179_L 255_V 1.239 0.95
599_L 607_L 1.238 0.95
385_L 421_V 1.237 0.95
576_A 615_A 1.233 0.95
580_C 585_L 1.224 0.95
499_K 503_D 1.223 0.95
589_E 610_R 1.221 0.94
199_I 253_A 1.218 0.94
73_R 76_H 1.213 0.94
449_R 453_S 1.212 0.94
608_A 632_E 1.21 0.94
199_I 223_A 1.21 0.94
297_L 301_P 1.21 0.94
452_M 468_K 1.203 0.94
455_V 465_L 1.203 0.94
882_T 886_L 1.203 0.94
106_T 128_V 1.2 0.94
59_T 160_L 1.199 0.94
404_W 425_T 1.197 0.94
417_L 543_F 1.192 0.93
209_Q 221_K 1.192 0.93
838_M 842_V 1.188 0.93
515_V 541_I 1.182 0.93
440_I 457_A 1.181 0.93
550_T 679_M 1.18 0.93
144_K 147_D 1.177 0.93
48_M 52_E 1.176 0.93
240_C 246_V 1.173 0.93
207_V 251_A 1.171 0.93
195_A 255_V 1.169 0.93
544_L 582_E 1.167 0.93
385_L 424_G 1.163 0.92
352_K 680_V 1.162 0.92
48_M 53_L 1.161 0.92
765_L 769_M 1.16 0.92
509_G 578_K 1.159 0.92
737_Y 740_S 1.156 0.92
94_W 97_Y 1.156 0.92
687_E 690_R 1.154 0.92
383_I 418_D 1.154 0.92
50_E 54_W 1.149 0.92
95_V 98_R 1.146 0.92
226_R 238_T 1.146 0.92
776_S 779_F 1.146 0.92
122_G 126_L 1.144 0.92
406_N 558_L 1.142 0.91
373_D 377_T 1.142 0.91
478_C 537_L 1.142 0.91
49_P 53_L 1.141 0.91
500_R 503_D 1.14 0.91
867_L 871_P 1.138 0.91
408_H 439_K 1.138 0.91
455_V 520_L 1.138 0.91
304_L 318_A 1.137 0.91
747_D 822_R 1.136 0.91
658_V 676_K 1.133 0.91
69_V 178_Q 1.131 0.91
849_I 853_F 1.131 0.91
517_T 538_E 1.125 0.91
387_N 505_L 1.123 0.91
637_G 656_I 1.122 0.90
483_H 488_V 1.119 0.90
602_D 605_A 1.119 0.90
654_I 671_I 1.117 0.90
131_S 142_S 1.117 0.90
558_L 678_L 1.117 0.90
573_E 592_I 1.116 0.90
161_R 180_V 1.113 0.90
72_A 76_H 1.112 0.90
290_M 294_R 1.111 0.90
138_Q 142_S 1.109 0.90
504_T 508_Q 1.109 0.90
817_I 820_M 1.108 0.90
138_Q 146_A 1.105 0.90
419_T 423_E 1.104 0.90
507_R 574_L 1.104 0.90
503_D 507_R 1.102 0.89
147_D 150_K 1.098 0.89
567_I 580_C 1.098 0.89
402_S 515_V 1.096 0.89
568_L 617_L 1.096 0.89
118_L 122_G 1.095 0.89
407_S 422_L 1.093 0.89
300_A 303_V 1.093 0.89
465_L 535_L 1.087 0.89
277_E 630_K 1.085 0.88
55_K 58_D 1.085 0.88
192_M 667_E 1.083 0.88
554_A 679_M 1.082 0.88
591_V 596_I 1.081 0.88
414_K 418_D 1.08 0.88
414_K 421_V 1.077 0.88
206_F 220_E 1.076 0.88
604_L 628_L 1.075 0.88
472_Q 572_S 1.072 0.88
471_L 502_T 1.071 0.88
573_E 577_A 1.068 0.87
278_P 283_Q 1.067 0.87
140_A 144_K 1.062 0.87
126_L 130_I 1.058 0.87
812_L 877_L 1.058 0.87
326_V 331_E 1.057 0.87
445_F 450_R 1.055 0.86
451_R 532_E 1.054 0.86
706_N 738_D 1.053 0.86
270_R 620_M 1.051 0.86
200_L 254_M 1.051 0.86
602_D 606_N 1.049 0.86
702_T 741_Q 1.048 0.86
176_I 179_L 1.048 0.86
417_L 447_F 1.048 0.86
769_M 773_G 1.048 0.86
875_A 878_A 1.046 0.86
353_V 684_G 1.045 0.86
857_A 862_L 1.043 0.86
801_L 869_Y 1.043 0.86
367_M 654_I 1.043 0.86
226_R 231_S 1.042 0.86
406_N 409_Y 1.041 0.85
69_V 72_A 1.04 0.85
198_R 238_T 1.04 0.85
59_T 184_I 1.038 0.85
131_S 134_L 1.036 0.85
331_E 734_N 1.028 0.84
496_R 499_K 1.027 0.84
87_S 92_H 1.026 0.84
559_K 565_V 1.026 0.84
233_P 236_C 1.025 0.84
878_A 882_T 1.025 0.84
785_C 789_W 1.024 0.84
732_I 848_G 1.023 0.84
816_L 878_A 1.022 0.84
139_E 142_S 1.019 0.84
591_V 607_L 1.019 0.84
93_L 97_Y 1.019 0.84
294_R 298_V 1.018 0.84
474_I 516_A 1.017 0.84
702_T 737_Y 1.014 0.83
747_D 750_D 1.014 0.83
96_C 135_N 1.012 0.83
836_P 839_I 1.011 0.83
884_T 887_V 1.01 0.83
246_V 251_A 1.009 0.83
711_F 715_V 1.004 0.83
754_I 758_Q 1 0.82
127_M 132_T 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2zxeA10.98781000.23Contact Map0.699
3ixzA10.98781000.233Contact Map0.061
3ar4A10.94321000.246Contact Map0.73
1mhsA20.94771000.265Contact Map0.454
3b8cA20.91431000.28Contact Map0.462
3rfuA40.71161000.587Contact Map0.564
3j08A20.68491000.599Contact Map0.649
3j09A20.73051000.603Contact Map0.666
3gwiA10.18931000.861Contact Map0.756
3a1cA20.31961000.866Contact Map0.73
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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