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OPENSEQ.org
PGM - Phosphoglucomutase
UniProt: P36938 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12144
Length: 546 (497)
Sequences: 5126
Seq/Len: 10.31
PGM
Paralog alert: 0.92 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: GLMM MANB PGM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
240_G 307_Y 4.595 1.00
232_G 297_F 4.25 1.00
315_P 430_Q 3.846 1.00
379_G 382_D 3.823 1.00
230_T 254_N 3.527 1.00
525_E 529_K 3.291 1.00
209_Q 213_E 3.094 1.00
246_R 250_Y 2.871 1.00
361_D 439_R 2.85 1.00
102_L 141_I 2.835 1.00
356_D 368_E 2.779 1.00
256_T 295_D 2.573 1.00
129_V 210_P 2.515 1.00
83_V 99_L 2.461 1.00
344_A 365_K 2.456 1.00
81_C 102_L 2.443 1.00
84_G 123_V 2.427 1.00
230_T 256_T 2.423 1.00
216_A 250_Y 2.411 1.00
103_A 202_V 2.37 1.00
303_N 415_C 2.347 1.00
95_F 111_V 2.32 1.00
533_K 537_E 2.311 1.00
367_V 379_G 2.303 1.00
427_K 435_E 2.293 1.00
66_Q 105_N 2.281 1.00
65_A 98_V 2.252 1.00
330_N 362_L 2.244 1.00
288_A 292_A 2.173 1.00
357_R 360_N 2.158 1.00
312_I 418_A 2.155 1.00
85_K 91_S 2.131 1.00
108_D 203_K 2.122 1.00
58_E 93_P 2.116 1.00
529_K 533_K 2.114 1.00
427_K 431_E 2.107 1.00
232_G 293_L 2.103 1.00
172_V 175_D 2.099 1.00
333_F 364_R 2.077 1.00
70_E 176_R 2.071 1.00
501_N 523_L 2.063 1.00
212_V 247_I 2.032 1.00
98_V 141_I 2.025 1.00
80_P 108_D 1.988 1.00
89_A 265_T 1.982 1.00
69_A 102_L 1.974 1.00
290_L 313_V 1.967 1.00
82_Y 132_K 1.955 1.00
519_C 532_E 1.923 1.00
209_Q 246_R 1.905 1.00
315_P 428_N 1.899 1.00
125_N 129_V 1.891 1.00
85_K 95_F 1.885 1.00
230_T 296_K 1.879 1.00
50_S 151_E 1.877 1.00
335_H 424_V 1.825 1.00
328_A 397_F 1.816 1.00
379_G 383_G 1.804 1.00
92_E 96_I 1.78 1.00
327_V 421_I 1.778 1.00
356_D 360_N 1.759 1.00
66_Q 70_E 1.749 1.00
259_N 289_G 1.747 1.00
70_E 105_N 1.738 1.00
477_P 500_D 1.736 1.00
537_E 541_E 1.732 1.00
461_S 465_P 1.719 1.00
527_H 530_Q 1.712 1.00
524_G 527_H 1.702 1.00
359_V 364_R 1.7 1.00
175_D 179_A 1.698 1.00
521_S 528_R 1.695 1.00
68_I 139_D 1.693 1.00
68_I 157_Y 1.678 1.00
257_I 260_D 1.673 1.00
50_S 152_D 1.672 1.00
74_K 176_R 1.668 1.00
249_E 257_I 1.665 1.00
325_L 389_G 1.665 1.00
530_Q 534_E 1.662 1.00
428_N 431_E 1.659 1.00
330_N 435_E 1.658 1.00
299_L 422_T 1.655 1.00
422_T 432_H 1.651 1.00
314_T 430_Q 1.633 1.00
334_Q 425_T 1.616 1.00
47_H 64_I 1.613 1.00
316_A 430_Q 1.613 1.00
176_R 179_A 1.611 1.00
264_Q 267_R 1.603 1.00
376_F 388_G 1.596 1.00
248_G 255_L 1.586 1.00
290_L 302_A 1.559 1.00
418_A 429_P 1.556 1.00
537_E 540_S 1.547 1.00
85_K 92_E 1.517 1.00
330_N 334_Q 1.507 1.00
231_L 299_L 1.487 1.00
69_A 105_N 1.485 1.00
213_E 250_Y 1.481 1.00
108_D 200_G 1.48 1.00
458_A 461_S 1.48 1.00
215_L 416_L 1.478 1.00
209_Q 250_Y 1.476 1.00
330_N 432_H 1.472 1.00
74_K 172_V 1.451 1.00
61_I 155_I 1.448 1.00
62_L 97_S 1.443 1.00
125_N 214_G 1.442 1.00
369_V 379_G 1.438 1.00
215_L 413_I 1.431 1.00
357_R 443_P 1.428 1.00
47_H 157_Y 1.427 1.00
331_Y 335_H 1.414 1.00
99_L 111_V 1.408 1.00
354_M 436_L 1.402 0.99
251_Y 416_L 1.398 0.99
230_T 295_D 1.39 0.99
82_Y 126_A 1.388 0.99
213_E 217_D 1.386 0.99
229_L 298_D 1.381 0.99
62_L 104_A 1.374 0.99
212_V 243_Y 1.362 0.99
347_K 366_L 1.354 0.99
526_E 530_Q 1.353 0.99
43_G 46_G 1.351 0.99
62_L 100_E 1.338 0.99
446_N 529_K 1.333 0.99
245_K 249_E 1.331 0.99
235_P 260_D 1.33 0.99
218_I 417_L 1.328 0.99
61_I 94_A 1.317 0.99
296_K 315_P 1.309 0.99
301_F 415_C 1.309 0.99
387_F 395_A 1.305 0.99
454_S 458_A 1.304 0.99
331_Y 424_V 1.303 0.99
102_L 107_V 1.303 0.99
95_F 99_L 1.302 0.99
351_S 355_I 1.283 0.99
327_V 433_Y 1.278 0.99
419_A 422_T 1.271 0.99
326_A 358_V 1.27 0.99
378_D 382_D 1.27 0.99
99_L 202_V 1.268 0.99
206_D 209_Q 1.263 0.99
532_E 536_V 1.258 0.99
256_T 293_L 1.257 0.99
358_V 362_L 1.255 0.99
301_F 310_H 1.254 0.99
533_K 540_S 1.25 0.99
69_A 107_V 1.249 0.99
237_G 281_C 1.248 0.99
172_V 176_R 1.247 0.99
51_A 90_L 1.245 0.98
119_P 122_A 1.243 0.98
240_G 303_N 1.237 0.98
299_L 419_A 1.237 0.98
472_T 475_G 1.235 0.98
256_T 297_F 1.235 0.98
287_M 318_L 1.233 0.98
83_V 98_V 1.232 0.98
102_L 109_V 1.231 0.98
329_I 345_V 1.231 0.98
99_L 103_A 1.231 0.98
287_M 311_G 1.229 0.98
171_K 175_D 1.228 0.98
344_A 367_V 1.227 0.98
165_A 173_V 1.225 0.98
464_S 483_T 1.221 0.98
289_G 292_A 1.221 0.98
44_T 510_G 1.215 0.98
71_E 169_V 1.212 0.98
166_D 169_V 1.209 0.98
241_I 245_K 1.205 0.98
430_Q 434_N 1.199 0.98
208_V 243_Y 1.199 0.98
290_L 300_A 1.191 0.98
85_K 111_V 1.191 0.98
65_A 102_L 1.189 0.98
127_I 140_G 1.188 0.98
168_N 172_V 1.185 0.98
291_L 318_L 1.184 0.98
233_V 248_G 1.183 0.98
118_T 122_A 1.18 0.98
210_P 213_E 1.176 0.98
301_F 312_I 1.164 0.97
288_A 291_L 1.164 0.97
458_A 462_K 1.163 0.97
380_L 385_F 1.162 0.97
325_L 355_I 1.158 0.97
248_G 415_C 1.155 0.97
71_E 176_R 1.144 0.97
472_T 477_P 1.14 0.97
258_V 293_L 1.138 0.97
259_N 281_C 1.137 0.97
345_V 359_V 1.129 0.97
231_L 419_A 1.129 0.97
536_V 540_S 1.129 0.97
87_T 117_F 1.125 0.97
175_D 178_N 1.124 0.97
427_K 432_H 1.123 0.97
497_V 504_F 1.119 0.96
129_V 214_G 1.116 0.96
208_V 246_R 1.115 0.96
80_P 110_I 1.112 0.96
347_K 351_S 1.11 0.96
323_H 433_Y 1.107 0.96
233_V 240_G 1.103 0.96
248_G 419_A 1.097 0.96
123_V 140_G 1.094 0.96
235_P 257_I 1.087 0.96
291_L 313_V 1.085 0.96
289_G 293_L 1.083 0.96
529_K 532_E 1.075 0.95
448_L 533_K 1.074 0.95
463_L 506_A 1.073 0.95
457_K 461_S 1.073 0.95
531_I 534_E 1.073 0.95
326_A 354_M 1.069 0.95
66_Q 104_A 1.069 0.95
65_A 101_V 1.069 0.95
246_R 249_E 1.062 0.95
326_A 352_S 1.062 0.95
344_A 385_F 1.061 0.95
91_S 153_G 1.061 0.95
75_N 172_V 1.06 0.95
56_F 60_H 1.053 0.95
263_D 279_M 1.051 0.94
229_L 419_A 1.048 0.94
68_I 141_I 1.046 0.94
446_N 532_E 1.046 0.94
100_E 190_R 1.045 0.94
79_G 138_A 1.045 0.94
233_V 303_N 1.038 0.94
501_N 527_H 1.037 0.94
347_K 368_E 1.036 0.94
112_Q 118_T 1.032 0.94
45_S 348_T 1.031 0.94
357_R 523_L 1.029 0.94
60_H 64_I 1.029 0.94
65_A 155_I 1.028 0.94
229_L 422_T 1.023 0.93
64_I 157_Y 1.022 0.93
97_S 101_V 1.022 0.93
527_H 531_I 1.022 0.93
361_D 440_F 1.02 0.93
333_F 362_L 1.02 0.93
450_A 536_V 1.018 0.93
356_D 366_L 1.018 0.93
394_G 409_K 1.012 0.93
375_W 378_D 1.009 0.93
174_E 178_N 1.009 0.93
420_E 424_V 1.009 0.93
96_I 100_E 1.007 0.93
460_L 508_P 1.004 0.93
346_G 379_G 1.003 0.93
232_G 295_D 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3na5A20.9891000.142Contact Map0.642
2z0fA20.95051000.191Contact Map0.647
1wqaA40.8261000.232Contact Map0.776
2f7lA20.82231000.236Contact Map0.749
1tuoA10.82971000.244Contact Map0.646
3uw2A10.85531000.276Contact Map0.715
1p5dX10.83151000.276Contact Map0.755
3pdkA20.8481000.285Contact Map0.776
3i3wA20.79671000.29Contact Map0.74
3pmgA20.89741000.29Contact Map0.517
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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