May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
GLMM - Phosphoglucosamine mutase
UniProt: P31120 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11553
Length: 445 (441)
Sequences: 5417
Seq/Len: 12.28
GLMM
Paralog alert: 0.93 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: GLMM MANB PGM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
186_T 244_G 4.336 1.00
314_K 317_E 4.298 1.00
178_V 234_A 3.928 1.00
228_R 232_E 3.856 1.00
227_A 231_A 3.806 1.00
252_H 360_H 3.451 1.00
176_K 200_N 3.244 1.00
428_E 432_T 3.165 1.00
156_G 160_E 2.958 1.00
228_R 231_A 2.786 1.00
192_N 196_E 2.702 1.00
291_E 303_R 2.649 1.00
66_L 97_I 2.618 1.00
53_I 211_V 2.58 1.00
279_G 300_P 2.389 1.00
90_T 157_R 2.349 1.00
163_K 196_E 2.31 1.00
176_K 202_I 2.306 1.00
202_I 232_E 2.301 1.00
44_K 72_S 2.295 1.00
67_A 148_A 2.288 1.00
59_E 75_F 2.287 1.00
45_I 66_L 2.283 1.00
30_G 62_L 2.257 1.00
31_W 69_A 2.231 1.00
49_K 55_G 2.23 1.00
302_A 314_K 2.211 1.00
240_F 345_G 2.163 1.00
48_G 84_V 2.127 1.00
47_I 63_E 2.107 1.00
46_I 93_A 2.102 1.00
268_R 297_L 2.086 1.00
178_V 228_R 2.071 1.00
436_H 440_D 2.069 1.00
357_M 365_G 2.057 1.00
33_A 95_A 2.052 1.00
432_T 436_H 2.049 1.00
35_K 132_E 2.019 1.00
226_Q 230_L 2.018 1.00
159_I 193_V 1.977 1.00
23_P 57_M 1.971 1.00
405_R 426_E 1.968 1.00
357_M 361_D 1.931 1.00
34_G 66_L 1.923 1.00
203_A 206_C 1.886 1.00
292_L 295_K 1.868 1.00
62_L 97_I 1.86 1.00
252_H 358_S 1.833 1.00
156_G 192_N 1.83 1.00
427_D 430_Q 1.821 1.00
128_A 131_A 1.807 1.00
271_L 299_I 1.796 1.00
229_V 237_G 1.794 1.00
314_K 318_K 1.784 1.00
249_M 348_V 1.78 1.00
352_M 362_L 1.757 1.00
15_R 107_Y 1.739 1.00
72_S 149_S 1.728 1.00
423_V 435_A 1.724 1.00
430_Q 433_E 1.712 1.00
86_Y 90_T 1.699 1.00
31_W 35_K 1.698 1.00
49_K 59_E 1.698 1.00
176_K 233_K 1.67 1.00
272_R 355_N 1.651 1.00
440_D 443_K 1.645 1.00
56_Y 60_S 1.644 1.00
255_N 364_S 1.628 1.00
39_R 132_E 1.627 1.00
33_A 113_F 1.617 1.00
433_E 437_R 1.616 1.00
358_S 361_D 1.612 1.00
15_R 108_D 1.608 1.00
291_E 295_K 1.607 1.00
389_E 393_A 1.606 1.00
236_L 352_M 1.596 1.00
227_A 230_L 1.578 1.00
263_M 324_A 1.578 1.00
35_K 69_A 1.575 1.00
268_R 365_G 1.569 1.00
425_G 431_V 1.567 1.00
266_I 332_L 1.551 1.00
440_D 444_A 1.542 1.00
294_L 299_I 1.532 1.00
194_L 201_V 1.52 1.00
131_A 135_K 1.492 1.00
132_E 135_K 1.49 1.00
191_P 206_C 1.488 1.00
66_L 71_L 1.487 1.00
225_L 250_V 1.471 1.00
162_C 346_L 1.47 1.00
121_L 129_I 1.455 1.00
72_S 146_G 1.453 1.00
348_V 359_L 1.452 1.00
195_R 203_A 1.452 1.00
251_D 255_N 1.45 1.00
27_L 61_A 1.442 1.00
225_L 239_A 1.439 1.00
156_G 196_E 1.432 1.00
49_K 56_Y 1.425 1.00
34_G 69_A 1.424 1.00
429_A 433_E 1.413 1.00
191_P 195_R 1.407 0.99
396_A 399_E 1.406 0.99
63_E 75_F 1.385 0.99
26_V 111_I 1.378 0.99
36_V 125_V 1.376 0.99
251_D 360_H 1.371 0.99
12_I 29_L 1.366 0.99
238_I 345_G 1.358 0.99
86_Y 161_F 1.354 0.99
175_L 235_D 1.348 0.99
269_E 273_Q 1.338 0.99
49_K 75_F 1.337 0.99
176_K 232_E 1.336 0.99
177_I 236_L 1.335 0.99
268_R 362_L 1.332 0.99
401_A 437_R 1.328 0.99
160_E 196_E 1.327 0.99
304_A 314_K 1.325 0.99
435_A 439_A 1.323 0.99
311_V 323_G 1.321 0.99
47_I 62_L 1.313 0.99
27_L 64_A 1.311 0.99
51_T 78_P 1.306 0.99
8_G 11_G 1.305 0.99
12_I 113_F 1.303 0.99
160_E 164_A 1.299 0.99
253_E 360_H 1.297 0.99
282_G 301_F 1.296 0.99
273_Q 354_R 1.275 0.99
44_K 94_E 1.263 0.99
80_P 83_A 1.255 0.99
222_V 256_K 1.254 0.99
16_V 54_S 1.251 0.99
181_C 206_C 1.246 0.98
15_R 18_D 1.238 0.98
159_I 189_I 1.238 0.98
313_E 317_E 1.234 0.98
236_L 349_L 1.23 0.98
209_N 215_A 1.229 0.98
59_E 63_E 1.228 0.98
46_I 87_L 1.219 0.98
40_H 128_A 1.214 0.98
27_L 68_A 1.211 0.98
26_V 58_L 1.21 0.98
75_F 150_R 1.206 0.98
128_A 132_E 1.203 0.98
197_L 346_L 1.201 0.98
162_C 343_V 1.199 0.98
293_A 297_L 1.198 0.98
279_G 302_A 1.196 0.98
34_G 71_L 1.195 0.98
205_G 224_A 1.193 0.98
125_V 128_A 1.192 0.98
61_A 65_G 1.181 0.98
94_E 116_I 1.181 0.98
268_R 272_R 1.181 0.98
153_D 156_G 1.179 0.98
192_N 195_R 1.177 0.98
66_L 73_A 1.176 0.98
436_H 443_K 1.175 0.98
202_I 228_R 1.171 0.98
186_T 240_F 1.166 0.97
223_R 227_A 1.166 0.97
292_L 369_F 1.165 0.97
264_Y 293_A 1.157 0.97
360_H 364_S 1.157 0.97
357_M 362_L 1.157 0.97
183_N 217_V 1.153 0.97
88_T 96_G 1.148 0.97
238_I 247_V 1.148 0.97
63_E 67_A 1.145 0.97
53_I 210_G 1.143 0.97
225_L 237_G 1.133 0.97
45_I 95_A 1.13 0.97
165_T 347_Q 1.129 0.97
39_R 128_A 1.128 0.97
286_S 290_L 1.122 0.97
222_V 248_I 1.12 0.96
280_A 294_L 1.118 0.96
315_M 320_W 1.118 0.96
310_Y 313_E 1.117 0.96
439_A 443_K 1.113 0.96
63_E 148_A 1.112 0.96
30_G 65_G 1.111 0.96
79_M 83_A 1.109 0.96
194_L 345_G 1.106 0.96
393_A 396_A 1.093 0.96
229_V 250_V 1.087 0.96
25_F 29_L 1.081 0.95
322_I 330_V 1.079 0.95
265_I 363_C 1.076 0.95
187_Y 191_P 1.076 0.95
381_G 385_P 1.075 0.95
361_D 364_S 1.072 0.95
155_A 192_N 1.071 0.95
202_I 234_A 1.067 0.95
175_L 349_L 1.06 0.95
30_G 111_I 1.06 0.95
204_I 228_R 1.059 0.95
155_A 189_I 1.055 0.95
230_L 233_K 1.054 0.95
397_E 400_A 1.053 0.95
269_E 354_R 1.051 0.94
90_T 161_F 1.051 0.94
261_Q 363_C 1.047 0.94
349_L 352_M 1.046 0.94
263_M 290_L 1.046 0.94
374_V 436_H 1.045 0.94
30_G 66_L 1.043 0.94
372_I 432_T 1.04 0.94
394_V 397_E 1.039 0.94
44_K 74_L 1.039 0.94
282_G 286_S 1.038 0.94
127_E 131_A 1.038 0.94
267_A 280_A 1.031 0.94
230_L 253_E 1.029 0.94
179_V 194_L 1.027 0.94
179_V 240_F 1.022 0.93
122_P 125_V 1.018 0.93
84_V 96_G 1.015 0.93
179_V 186_T 1.01 0.93
31_W 68_A 1.006 0.93
238_I 249_M 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pdkA20.9911000.043Contact Map0.788
3i3wA20.98881000.053Contact Map0.759
1wqaA40.9821000.062Contact Map0.794
2f7lA20.97981000.062Contact Map0.777
1tuoA10.97081000.087Contact Map0.625
3uw2A10.96631000.104Contact Map0.734
1p5dX10.96631000.112Contact Map0.766
3na5A20.9911000.128Contact Map0.632
2z0fA20.98431000.133Contact Map0.65
4hjhA20.95511000.164Contact Map0.624
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0272 seconds.