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OPENSEQ.org
HOFC - Protein transport protein HofC homolog
UniProt: P36646 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11798
Length: 400 (392)
Sequences: 2117
Seq/Len: 5.40
HOFC
Paralog alert: 0.38 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GSPF HOFC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
11_G 40_V 5.142 1.00
64_I 125_Y 4.678 1.00
23_L 31_L 4.049 1.00
201_A 205_G 3.98 1.00
25_A 31_L 3.287 1.00
103_D 116_P 3.203 1.00
237_R 240_W 3.203 1.00
110_F 114_L 2.967 1.00
31_L 45_L 2.829 1.00
202_L 380_T 2.722 1.00
303_I 317_L 2.581 1.00
81_L 104_L 2.538 1.00
339_S 342_L 2.481 1.00
288_R 301_T 2.436 1.00
242_I 298_Q 2.396 1.00
268_T 352_R 2.202 1.00
234_L 237_R 2.19 1.00
63_V 97_L 2.178 1.00
154_Q 353_E 2.167 1.00
201_A 204_Q 2.143 1.00
67_L 80_G 2.097 1.00
189_A 211_D 2.089 1.00
13_T 17_N 2.051 1.00
79_E 336_A 2.048 1.00
178_V 182_H 2.045 1.00
271_A 345_D 1.997 1.00
68_A 146_A 1.984 1.00
85_A 98_Q 1.967 1.00
42_P 45_L 1.963 1.00
386_Y 390_F 1.936 1.00
9_W 21_G 1.928 1.00
10_H 20_D 1.921 1.00
99_S 117_W 1.886 1.00
198_P 204_Q 1.877 1.00
28_R 32_L 1.87 1.00
202_L 387_L 1.86 1.00
13_T 19_Q 1.842 1.00
81_L 97_L 1.838 1.00
206_I 384_A 1.813 1.00
268_T 348_A 1.799 1.00
260_G 354_N 1.792 1.00
204_Q 208_T 1.787 1.00
67_L 142_C 1.774 1.00
391_H 394_D 1.769 1.00
179_A 183_F 1.754 1.00
125_Y 145_L 1.748 1.00
284_V 300_L 1.741 1.00
125_Y 149_Q 1.738 1.00
158_K 360_D 1.732 1.00
151_A 356_M 1.73 1.00
285_E 304_Q 1.698 1.00
171_A 175_M 1.647 0.99
34_A 38_Q 1.624 0.99
27_S 30_L 1.618 0.99
72_K 143_F 1.618 0.99
7_W 28_R 1.59 0.99
114_L 129_I 1.588 0.99
219_L 223_F 1.588 0.99
188_F 390_F 1.578 0.99
234_L 240_W 1.574 0.99
72_K 346_N 1.568 0.99
268_T 349_H 1.545 0.99
59_K 90_S 1.533 0.99
111_S 133_E 1.526 0.99
306_D 316_A 1.524 0.99
99_S 103_D 1.517 0.99
245_Q 294_P 1.505 0.99
65_H 150_K 1.486 0.99
115_L 130_R 1.481 0.99
156_T 160_K 1.462 0.98
175_M 179_A 1.461 0.98
266_I 300_L 1.459 0.98
218_W 222_L 1.45 0.98
10_H 18_A 1.443 0.98
31_L 42_P 1.442 0.98
10_H 44_S 1.44 0.98
64_I 145_L 1.438 0.98
200_P 203_T 1.428 0.98
170_L 174_I 1.427 0.98
103_D 108_I 1.423 0.98
280_F 313_I 1.417 0.98
376_G 380_T 1.409 0.98
258_M 262_K 1.399 0.98
177_V 377_I 1.399 0.98
131_T 135_T 1.381 0.98
169_I 378_I 1.372 0.97
245_Q 293_C 1.362 0.97
264_T 352_R 1.352 0.97
103_D 113_A 1.339 0.97
158_K 356_M 1.339 0.97
30_L 34_A 1.336 0.97
101_A 105_E 1.333 0.97
134_L 282_Q 1.328 0.97
275_S 341_D 1.318 0.96
88_H 93_W 1.317 0.96
225_F 229_I 1.31 0.96
161_S 360_D 1.301 0.96
67_L 77_L 1.3 0.96
122_P 125_Y 1.291 0.96
263_L 327_C 1.291 0.96
21_G 35_L 1.288 0.96
270_L 283_G 1.286 0.96
11_G 21_G 1.285 0.96
212_F 220_L 1.282 0.96
242_I 295_Y 1.282 0.96
169_I 374_T 1.279 0.96
65_H 146_A 1.272 0.95
85_A 101_A 1.268 0.95
202_L 205_G 1.267 0.95
379_G 383_V 1.257 0.95
327_C 347_L 1.255 0.95
26_E 30_L 1.249 0.95
82_A 101_A 1.248 0.95
9_W 35_L 1.247 0.95
306_D 311_Q 1.24 0.95
235_M 244_R 1.235 0.94
260_G 358_L 1.23 0.94
40_V 43_L 1.228 0.94
187_E 190_A 1.228 0.94
72_K 139_D 1.227 0.94
224_G 228_A 1.226 0.94
217_S 221_V 1.216 0.94
270_L 344_L 1.212 0.94
167_I 171_A 1.207 0.93
188_F 386_Y 1.204 0.93
300_L 303_I 1.201 0.93
12_I 18_A 1.196 0.93
199_L 203_T 1.188 0.93
294_P 297_V 1.186 0.93
228_A 232_K 1.184 0.93
304_Q 308_S 1.181 0.92
330_L 347_L 1.176 0.92
181_L 209_L 1.172 0.92
243_V 247_L 1.168 0.92
386_Y 393_G 1.165 0.92
256_S 260_G 1.162 0.92
241_L 245_Q 1.161 0.92
273_T 283_G 1.153 0.91
103_D 117_W 1.152 0.91
147_R 151_A 1.15 0.91
288_R 304_Q 1.14 0.91
181_L 185_L 1.126 0.90
282_Q 285_E 1.123 0.90
181_L 213_S 1.117 0.89
164_R 168_I 1.116 0.89
230_A 233_L 1.112 0.89
243_V 246_K 1.11 0.89
318_K 321_G 1.089 0.88
245_Q 248_L 1.083 0.87
157_D 353_E 1.08 0.87
69_T 337_S 1.075 0.87
173_A 390_F 1.075 0.87
177_V 381_L 1.071 0.87
122_P 149_Q 1.069 0.86
306_D 319_N 1.067 0.86
148_Q 152_Q 1.065 0.86
206_I 380_T 1.061 0.86
151_A 352_R 1.056 0.86
389_I 393_G 1.053 0.85
311_Q 315_L 1.047 0.85
203_T 384_A 1.046 0.85
173_A 381_L 1.044 0.85
260_G 355_T 1.041 0.84
74_G 277_G 1.04 0.84
239_T 243_V 1.036 0.84
247_L 251_I 1.028 0.83
388_P 391_H 1.025 0.83
296_W 322_E 1.024 0.83
270_L 280_F 1.019 0.83
233_L 236_R 1.018 0.83
367_E 371_L 1.015 0.82
299_L 320_T 1.014 0.82
153_R 157_D 1.013 0.82
63_V 93_W 1.01 0.82
18_A 43_L 1.008 0.82
220_L 223_F 1.008 0.82
8_R 20_D 1.006 0.82
154_Q 356_M 1.006 0.82
77_L 110_F 1.005 0.81
212_F 216_W 1.003 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c1qA20.307599.90.74Contact Map0.842
4hhxA10.292599.90.745Contact Map0.73
2whnA20.2999.90.762Contact Map0.904
4ev6A50.4831.40.965Contact Map0.259
4i0uA100.492523.40.967Contact Map0.303
3tweA20.067520.30.968Contact Map0.693
3hd7B20.245200.968Contact Map0.302
2m8rA10.245200.968Contact Map0.112
4g3bA20.06518.40.968Contact Map0.597
3hd7A20.22258.30.973Contact Map0.106
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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