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OPENSEQ.org
G3P3 - Putative glyceraldehyde-3-phosphate dehydrogenase C
UniProt: P33898 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12103
Length: 333 (328)
Sequences: 3037
Seq/Len: 9.26
G3P3
Paralog alert: 0.49 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: E4PD G3P1 G3P3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
163_H 221_E 4.481 1.00
77_E 82_N 4.227 1.00
169_E 248_G 3.8 1.00
160_K 164_D 3.457 1.00
271_G 287_F 3.446 1.00
107_Q 111_D 3.381 1.00
79_E 82_N 3.337 1.00
165_S 262_Q 3.123 1.00
250_K 303_D 2.899 1.00
135_D 329_K 2.892 1.00
203_N 280_S 2.751 1.00
145_V 330_F 2.735 1.00
166_F 259_A 2.638 1.00
179_Y 201_A 2.565 1.00
105_K 108_A 2.564 1.00
3_K 28_D 2.537 1.00
289_S 311_A 2.517 1.00
260_L 291_F 2.474 1.00
288_G 322_Q 2.421 1.00
56_W 68_D 2.305 1.00
178_A 235_V 2.3 1.00
276_E 294_T 2.262 1.00
237_T 283_I 2.226 1.00
250_K 302_G 2.136 1.00
28_D 70_K 2.113 1.00
258_N 262_Q 2.104 1.00
204_I 231_Q 2.091 1.00
159_A 222_L 2.083 1.00
80_A 100_Y 2.078 1.00
170_V 246_I 2.063 1.00
131_Y 135_D 2.06 1.00
103_A 107_Q 2.038 1.00
81_K 111_D 2.017 1.00
256_V 307_V 2.014 1.00
51_Y 237_T 1.995 1.00
216_G 223_S 1.95 1.00
231_Q 240_V 1.908 1.00
238_G 282_I 1.901 1.00
102_S 105_K 1.887 1.00
64_S 71_S 1.88 1.00
40_I 194_L 1.88 1.00
17_L 45_L 1.863 1.00
21_L 54_F 1.853 1.00
322_Q 325_R 1.823 1.00
261_K 274_D 1.821 1.00
84_P 87_A 1.815 1.00
20_L 29_V 1.81 1.00
46_K 275_E 1.781 1.00
249_K 255_E 1.781 1.00
17_L 29_V 1.772 1.00
61_T 71_S 1.753 1.00
101_T 119_I 1.748 1.00
49_S 280_S 1.739 1.00
137_T 221_E 1.729 1.00
261_K 265_T 1.729 1.00
49_S 202_E 1.719 1.00
285_S 290_V 1.716 1.00
271_G 285_S 1.703 1.00
3_K 89_G 1.697 1.00
169_E 246_I 1.68 1.00
161_A 270_F 1.653 1.00
247_L 307_V 1.649 1.00
120_S 323_L 1.642 1.00
277_I 282_I 1.621 1.00
73_A 87_A 1.587 1.00
61_T 64_S 1.586 1.00
162_L 260_L 1.584 1.00
118_L 327_L 1.565 1.00
96_C 120_S 1.563 1.00
252_T 255_E 1.562 1.00
43_Y 197_S 1.55 1.00
19_R 321_T 1.55 1.00
199_A 202_E 1.549 1.00
272_Y 293_A 1.547 1.00
253_A 296_T 1.541 1.00
227_K 297_E 1.535 1.00
196_A 207_H 1.534 1.00
9_F 45_L 1.502 1.00
17_L 67_V 1.501 1.00
169_E 303_D 1.497 1.00
116_K 143_T 1.491 1.00
22_E 55_P 1.471 1.00
171_G 226_L 1.457 1.00
107_Q 110_L 1.453 1.00
94_V 327_L 1.445 1.00
75_Y 88_K 1.445 1.00
79_E 108_A 1.434 0.99
166_F 247_L 1.425 0.99
165_S 259_A 1.402 0.99
81_K 108_A 1.394 0.99
273_T 282_I 1.383 0.99
159_A 168_I 1.382 0.99
118_L 145_V 1.382 0.99
43_Y 194_L 1.372 0.99
274_D 293_A 1.361 0.99
217_L 223_S 1.361 0.99
287_F 290_V 1.35 0.99
273_T 277_I 1.327 0.99
193_D 196_A 1.326 0.99
102_S 124_G 1.325 0.99
54_F 68_D 1.321 0.99
286_H 321_T 1.299 0.99
92_I 327_L 1.294 0.99
158_M 309_T 1.279 0.99
286_H 317_Y 1.278 0.99
247_L 251_V 1.277 0.99
257_N 296_T 1.276 0.99
185_L 200_A 1.273 0.99
298_I 302_G 1.271 0.98
64_S 73_A 1.269 0.98
127_K 137_T 1.266 0.98
158_M 289_S 1.228 0.98
158_M 311_A 1.225 0.98
162_L 309_T 1.225 0.98
31_A 75_Y 1.212 0.98
202_E 236_K 1.211 0.98
83_I 88_K 1.203 0.98
280_S 283_I 1.199 0.98
17_L 72_I 1.197 0.98
106_S 119_I 1.197 0.98
53_P 285_S 1.197 0.98
261_K 272_Y 1.193 0.97
96_C 323_L 1.19 0.97
158_M 260_L 1.17 0.97
163_H 219_I 1.167 0.97
129_I 142_D 1.166 0.97
251_V 298_I 1.166 0.97
94_V 323_L 1.163 0.97
127_K 142_D 1.16 0.97
83_I 112_A 1.159 0.97
92_I 118_L 1.154 0.97
288_G 325_R 1.154 0.97
182_T 190_R 1.153 0.97
317_Y 321_T 1.152 0.97
126_M 142_D 1.152 0.97
262_Q 266_N 1.148 0.97
181_G 186_V 1.145 0.97
259_A 262_Q 1.136 0.96
123_A 128_T 1.135 0.96
104_E 107_Q 1.135 0.96
165_S 169_E 1.129 0.96
246_I 303_D 1.125 0.96
167_G 247_L 1.123 0.96
5_G 83_I 1.12 0.96
63_D 73_A 1.117 0.96
5_G 112_A 1.104 0.95
170_V 300_A 1.101 0.95
16_V 323_L 1.101 0.95
38_P 74_V 1.1 0.95
163_H 248_G 1.076 0.95
255_E 258_N 1.075 0.95
128_T 217_L 1.074 0.95
195_R 292_D 1.072 0.94
139_D 142_D 1.068 0.94
199_A 236_K 1.057 0.94
181_G 188_G 1.05 0.94
258_N 261_K 1.046 0.93
251_V 255_E 1.041 0.93
15_L 51_Y 1.04 0.93
184_S 188_G 1.037 0.93
182_T 196_A 1.037 0.93
166_F 251_V 1.034 0.93
251_V 256_V 1.024 0.93
201_A 236_K 1.023 0.92
61_T 66_I 1.022 0.92
41_L 74_V 1.006 0.92
295_Q 310_V 1.003 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3idsC40.9911000.214Contact Map0.757
1rm4O30.9851000.214Contact Map0.786
3docA40.9881000.218Contact Map0.854
4lsmA20.9851000.22Contact Map0.755
2x5jO40.9851000.223Contact Map0.815
1obfO20.9821000.225Contact Map0.745
1u8fO40.9881000.227Contact Map0.788
3pymA20.9881000.228Contact Map0.745
3cpsA20.9881000.231Contact Map0.699
3b1jA20.9881000.232Contact Map0.741
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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