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OPENSEQ.org
G3P1 - Glyceraldehyde-3-phosphate dehydrogenase A
UniProt: P0A9B2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10367
Length: 331 (331)
Sequences: 3040
Seq/Len: 9.18
G3P1
Paralog alert: 0.49 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: E4PD G3P1 G3P3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
163_N 221_E 4.504 1.00
77_E 82_N 4.244 1.00
169_I 248_E 3.716 1.00
160_K 164_D 3.453 1.00
107_R 111_T 3.45 1.00
273_G 289_C 3.432 1.00
79_D 82_N 3.357 1.00
165_N 262_A 3.129 1.00
136_F 328_H 2.889 1.00
250_A 304_N 2.824 1.00
203_N 282_T 2.731 1.00
145_V 329_I 2.719 1.00
166_F 259_A 2.66 1.00
105_T 108_K 2.595 1.00
179_T 201_S 2.581 1.00
4_K 28_E 2.537 1.00
260_V 293_F 2.512 1.00
291_S 310_S 2.496 1.00
290_T 321_K 2.438 1.00
56_G 68_N 2.341 1.00
178_A 235_T 2.304 1.00
237_N 285_N 2.294 1.00
278_D 296_K 2.193 1.00
80_P 100_F 2.123 1.00
204_I 231_F 2.093 1.00
170_E 246_R 2.088 1.00
258_A 262_A 2.073 1.00
28_E 70_K 2.071 1.00
159_A 222_L 2.064 1.00
256_I 306_V 2.051 1.00
132_K 136_F 2.051 1.00
250_A 303_D 2.049 1.00
51_H 237_N 1.999 1.00
103_D 107_R 1.999 1.00
81_A 111_T 1.94 1.00
238_V 284_F 1.928 1.00
216_G 223_N 1.923 1.00
40_Y 194_W 1.897 1.00
261_K 276_E 1.884 1.00
22_Q 54_F 1.875 1.00
231_F 240_V 1.874 1.00
64_H 71_K 1.866 1.00
102_T 105_T 1.863 1.00
321_K 324_D 1.857 1.00
18_F 45_L 1.847 1.00
249_K 255_Q 1.834 1.00
21_A 29_I 1.788 1.00
84_K 87_E 1.786 1.00
101_L 119_M 1.785 1.00
18_F 29_I 1.773 1.00
138_K 221_E 1.753 1.00
287_E 292_V 1.748 1.00
49_S 202_Q 1.741 1.00
261_K 265_E 1.737 1.00
49_S 282_T 1.731 1.00
247_L 306_V 1.72 1.00
273_G 287_E 1.706 1.00
46_K 277_D 1.688 1.00
61_K 71_K 1.683 1.00
169_I 246_R 1.658 1.00
120_T 322_V 1.655 1.00
96_A 120_T 1.621 1.00
43_Y 197_G 1.612 1.00
279_V 284_F 1.609 1.00
162_I 260_V 1.605 1.00
274_Y 295_A 1.588 1.00
199_G 202_Q 1.587 1.00
61_K 64_H 1.58 1.00
4_K 89_G 1.579 1.00
161_V 272_L 1.569 1.00
196_G 207_S 1.566 1.00
227_T 299_I 1.551 1.00
73_R 87_E 1.542 1.00
253_Y 298_G 1.535 1.00
118_V 326_I 1.535 1.00
169_I 304_N 1.533 1.00
20_A 320_N 1.526 1.00
10_F 45_L 1.509 1.00
18_F 67_V 1.508 1.00
252_T 255_Q 1.508 1.00
116_K 143_D 1.507 1.00
171_G 226_L 1.459 1.00
166_F 247_L 1.452 1.00
159_A 168_I 1.45 1.00
275_T 284_F 1.444 1.00
165_N 259_A 1.442 1.00
75_T 88_V 1.44 0.99
94_A 326_I 1.438 0.99
107_R 110_I 1.433 0.99
79_D 108_K 1.431 0.99
43_Y 194_W 1.42 0.99
23_K 55_D 1.396 0.99
217_K 223_N 1.377 0.99
118_V 145_V 1.375 0.99
289_C 292_V 1.366 0.99
275_T 279_V 1.364 0.99
81_A 108_K 1.36 0.99
193_D 196_G 1.353 0.99
54_F 68_N 1.343 0.99
247_L 251_A 1.342 0.99
276_E 295_A 1.336 0.99
182_T 190_S 1.307 0.99
128_P 138_K 1.292 0.99
288_V 316_T 1.288 0.99
102_T 124_K 1.28 0.99
185_T 200_A 1.277 0.99
288_V 320_N 1.277 0.99
158_L 308_L 1.275 0.98
158_L 310_S 1.272 0.98
83_L 88_V 1.268 0.98
162_I 308_L 1.268 0.98
158_L 291_S 1.253 0.98
264_A 267_E 1.252 0.98
92_V 326_I 1.242 0.98
64_H 73_R 1.236 0.98
18_F 72_I 1.226 0.98
96_A 322_V 1.225 0.98
202_Q 236_P 1.215 0.98
83_L 112_A 1.214 0.98
31_A 75_T 1.208 0.98
251_A 300_A 1.206 0.98
300_A 303_D 1.201 0.98
53_R 287_E 1.201 0.98
261_K 274_Y 1.199 0.98
257_K 298_G 1.19 0.97
167_G 247_L 1.189 0.97
163_N 219_L 1.188 0.97
259_A 262_A 1.186 0.97
106_A 119_M 1.185 0.97
6_G 112_A 1.179 0.97
158_L 260_V 1.17 0.97
94_A 322_V 1.169 0.97
290_T 324_D 1.16 0.97
181_A 186_V 1.16 0.97
92_V 118_V 1.157 0.97
282_T 285_N 1.152 0.97
268_M 272_L 1.144 0.96
316_T 320_N 1.138 0.96
246_R 304_N 1.124 0.96
165_N 169_I 1.122 0.96
6_G 83_L 1.119 0.96
104_E 107_R 1.111 0.96
17_V 322_V 1.111 0.96
38_A 74_V 1.098 0.95
251_A 256_I 1.09 0.95
63_G 73_R 1.082 0.95
170_E 302_N 1.081 0.95
102_T 125_D 1.08 0.95
123_S 129_M 1.076 0.95
166_F 251_A 1.075 0.94
199_G 236_P 1.073 0.94
129_M 217_K 1.063 0.94
184_K 188_G 1.059 0.94
16_I 51_H 1.054 0.94
181_A 188_G 1.049 0.93
163_N 248_E 1.049 0.93
257_K 295_A 1.048 0.93
258_A 261_K 1.048 0.93
195_R 294_D 1.048 0.93
255_Q 258_A 1.043 0.93
201_S 236_P 1.038 0.93
262_A 267_E 1.035 0.93
182_T 196_G 1.033 0.93
318_Y 322_V 1.025 0.92
31_A 88_V 1.021 0.92
176_V 231_F 1.016 0.92
57_T 68_N 1.013 0.92
107_R 144_I 1.01 0.92
262_A 266_G 1.009 0.92
251_A 255_Q 1.001 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3idsC411000.193Contact Map0.753
4lsmA211000.2Contact Map0.751
3docA40.9971000.2Contact Map0.848
1rm4O30.9941000.205Contact Map0.784
2x5jO40.9971000.206Contact Map0.813
1obfO20.99091000.212Contact Map0.743
2ep7A20.9941000.212Contact Map0.752
3cpsA211000.215Contact Map0.699
3hjaA40.9941000.217Contact Map0.794
3b1jA20.9971000.217Contact Map0.74
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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