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OPENSEQ.org
NUOL - NADH-quinone oxidoreductase subunit L
UniProt: P33607 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12092
Length: 613 (601)
Sequences: 3767
Seq/Len: 6.27
NUOL
Paralog alert: 0.33 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: HYCC HYFB HYFD HYFF NUOL NUOM NUON
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
223_L 279_V 3.7 1.00
307_V 362_I 3.408 1.00
136_L 269_T 3.289 1.00
196_N 199_E 3.284 1.00
287_G 324_G 3.095 1.00
89_L 132_L 2.878 1.00
308_L 349_S 2.869 1.00
89_L 128_V 2.803 1.00
376_Y 438_H 2.74 1.00
453_H 465_T 2.638 1.00
530_L 535_W 2.574 1.00
160_D 244_A 2.568 1.00
194_T 199_E 2.549 1.00
321_L 418_G 2.522 1.00
136_L 200_M 2.478 1.00
353_I 360_Q 2.476 1.00
453_H 456_P 2.425 1.00
359_E 364_K 2.351 1.00
39_G 97_F 2.317 1.00
383_G 429_T 2.303 1.00
384_A 389_L 2.298 1.00
173_V 237_T 2.257 1.00
169_K 241_D 2.233 1.00
82_D 268_R 2.187 1.00
129_V 142_G 2.181 1.00
194_T 200_M 2.108 1.00
163_N 244_A 2.097 1.00
369_R 376_Y 2.067 1.00
456_P 460_L 2.038 1.00
133_A 138_L 2.024 1.00
389_L 392_V 1.988 1.00
302_T 363_F 1.984 1.00
160_D 163_N 1.98 1.00
380_L 433_I 1.968 1.00
362_I 436_V 1.952 1.00
323_L 331_A 1.934 1.00
420_V 424_M 1.904 1.00
300_V 531_L 1.869 1.00
233_L 289_V 1.855 1.00
416_V 420_V 1.833 1.00
18_L 34_G 1.816 1.00
491_L 495_I 1.811 1.00
168_M 172_V 1.775 1.00
403_L 422_A 1.772 1.00
368_L 372_I 1.764 1.00
42_A 46_A 1.764 1.00
183_F 218_A 1.763 1.00
583_L 587_E 1.752 1.00
42_A 94_G 1.747 1.00
155_G 167_A 1.742 1.00
337_T 394_A 1.74 1.00
504_G 508_A 1.739 1.00
344_L 382_G 1.739 1.00
351_S 448_V 1.737 1.00
112_G 115_R 1.736 1.00
91_V 336_M 1.735 1.00
146_V 258_M 1.724 1.00
228_G 235_L 1.699 1.00
289_V 413_N 1.686 1.00
430_F 509_A 1.685 1.00
362_I 435_I 1.68 1.00
375_V 447_A 1.679 1.00
68_M 75_I 1.672 1.00
267_A 332_I 1.671 1.00
85_S 264_Y 1.648 1.00
142_G 145_G 1.627 1.00
283_V 324_G 1.62 1.00
403_L 418_G 1.62 1.00
456_P 465_T 1.612 1.00
184_A 225_G 1.611 1.00
49_G 90_S 1.61 1.00
110_E 157_Y 1.607 1.00
87_T 336_M 1.604 1.00
372_I 375_V 1.599 1.00
220_L 282_L 1.592 0.99
292_L 421_G 1.59 0.99
227_V 286_V 1.582 0.99
266_I 273_F 1.564 0.99
573_A 577_R 1.563 0.99
497_S 501_A 1.56 0.99
589_G 594_Y 1.558 0.99
191_E 218_A 1.542 0.99
162_K 244_A 1.538 0.99
35_V 101_M 1.531 0.99
333_F 398_S 1.53 0.99
502_V 506_L 1.514 0.99
296_F 535_W 1.512 0.99
14_G 37_S 1.509 0.99
383_G 433_I 1.508 0.99
465_T 468_G 1.506 0.99
219_T 273_F 1.49 0.99
12_L 125_A 1.471 0.99
91_V 339_A 1.467 0.99
267_A 323_L 1.465 0.99
453_H 460_L 1.464 0.99
296_F 424_M 1.461 0.99
503_V 507_L 1.457 0.99
266_I 323_L 1.433 0.99
223_L 283_V 1.43 0.99
184_A 188_L 1.423 0.99
96_G 124_I 1.419 0.99
453_H 458_I 1.407 0.98
35_V 97_F 1.406 0.98
87_T 332_I 1.402 0.98
180_F 224_G 1.391 0.98
430_F 434_F 1.39 0.98
379_F 432_M 1.381 0.98
120_T 249_V 1.378 0.98
105_W 452_T 1.364 0.98
92_V 131_V 1.359 0.98
288_A 414_L 1.359 0.98
58_Q 62_Q 1.358 0.98
371_S 445_A 1.355 0.98
181_L 265_L 1.353 0.98
528_G 532_G 1.351 0.98
299_L 427_L 1.331 0.98
356_C 365_M 1.327 0.98
187_I 218_A 1.316 0.97
354_L 358_H 1.311 0.97
566_N 570_N 1.3 0.97
263_V 283_V 1.299 0.97
334_H 398_S 1.298 0.97
40_L 44_V 1.295 0.97
43_L 47_F 1.294 0.97
46_A 94_G 1.294 0.97
564_P 568_M 1.285 0.97
287_G 317_G 1.284 0.97
429_T 432_M 1.281 0.97
136_L 188_L 1.277 0.97
544_L 548_V 1.272 0.97
422_A 500_V 1.269 0.97
348_A 378_C 1.267 0.96
201_V 271_G 1.266 0.96
451_V 455_L 1.254 0.96
220_L 224_G 1.253 0.96
450_G 453_H 1.247 0.96
354_L 446_H 1.247 0.96
533_T 536_Y 1.244 0.96
161_P 165_A 1.243 0.96
355_A 372_I 1.243 0.96
386_L 429_T 1.24 0.96
368_L 573_A 1.233 0.96
455_L 459_V 1.229 0.96
219_T 279_V 1.225 0.95
41_A 44_V 1.219 0.95
424_M 427_L 1.211 0.95
266_I 320_F 1.209 0.95
263_V 320_F 1.209 0.95
109_G 358_H 1.206 0.95
126_S 145_G 1.204 0.95
46_A 50_V 1.202 0.95
103_A 116_F 1.195 0.95
546_D 550_V 1.195 0.95
499_V 503_V 1.194 0.95
581_K 584_L 1.194 0.95
574_V 578_F 1.194 0.95
276_T 279_V 1.193 0.95
427_L 507_L 1.193 0.95
380_L 438_H 1.191 0.95
315_Q 425_T 1.188 0.94
66_T 74_N 1.187 0.94
315_Q 334_H 1.184 0.94
354_L 400_D 1.181 0.94
97_F 101_M 1.177 0.94
188_L 200_M 1.176 0.94
506_L 510_W 1.172 0.94
176_V 545_Y 1.172 0.94
426_S 501_A 1.171 0.94
454_S 465_T 1.171 0.94
216_M 278_E 1.169 0.94
376_Y 433_I 1.166 0.94
283_V 323_L 1.165 0.94
555_G 559_L 1.163 0.94
460_L 465_T 1.162 0.94
104_S 450_G 1.16 0.93
570_N 573_A 1.156 0.93
223_L 282_L 1.155 0.93
99_I 347_L 1.155 0.93
453_H 468_G 1.154 0.93
295_G 421_G 1.152 0.93
403_L 419_L 1.151 0.93
183_F 221_M 1.151 0.93
381_V 465_T 1.15 0.93
221_M 282_L 1.147 0.93
94_G 98_L 1.146 0.93
551_K 555_G 1.146 0.93
17_L 33_V 1.142 0.93
511_L 517_T 1.14 0.93
458_I 465_T 1.134 0.92
99_I 121_N 1.134 0.92
188_L 218_A 1.132 0.92
426_S 505_I 1.129 0.92
378_C 458_I 1.129 0.92
459_V 463_L 1.127 0.92
273_F 283_V 1.126 0.92
303_D 360_Q 1.126 0.92
295_G 314_S 1.124 0.92
98_L 343_A 1.122 0.92
355_A 358_H 1.122 0.92
334_H 341_F 1.12 0.92
529_R 536_Y 1.118 0.92
78_N 134_D 1.117 0.92
377_L 381_V 1.115 0.92
181_L 222_L 1.114 0.92
529_R 533_T 1.112 0.91
458_I 461_L 1.109 0.91
585_L 588_N 1.108 0.91
230_S 257_T 1.108 0.91
263_V 323_L 1.097 0.91
203_L 206_A 1.097 0.91
577_R 581_K 1.094 0.91
137_L 195_L 1.092 0.90
420_V 507_L 1.089 0.90
355_A 448_V 1.089 0.90
352_V 379_F 1.088 0.90
104_S 113_Y 1.085 0.90
509_A 513_L 1.084 0.90
200_M 269_T 1.084 0.90
311_S 428_Y 1.084 0.90
174_T 360_Q 1.083 0.90
419_L 496_T 1.083 0.90
40_L 43_L 1.077 0.90
415_M 493_L 1.075 0.89
343_A 426_S 1.075 0.89
220_L 279_V 1.074 0.89
197_F 200_M 1.071 0.89
400_D 404_A 1.07 0.89
78_N 196_N 1.068 0.89
367_G 441_E 1.066 0.89
5_A 8_I 1.065 0.89
282_L 286_V 1.065 0.89
113_Y 117_F 1.065 0.89
341_F 395_G 1.065 0.89
374_L 451_V 1.064 0.89
522_I 525_S 1.062 0.89
215_L 276_T 1.06 0.89
541_F 545_Y 1.059 0.89
392_V 397_F 1.055 0.88
304_I 365_M 1.053 0.88
583_L 586_S 1.051 0.88
219_T 272_L 1.051 0.88
240_A 310_Y 1.048 0.88
85_S 89_L 1.048 0.88
415_M 496_T 1.047 0.88
454_S 458_I 1.045 0.88
433_I 438_H 1.045 0.88
236_Q 541_F 1.045 0.88
81_L 86_L 1.044 0.88
322_A 394_A 1.044 0.88
383_G 387_S 1.043 0.88
217_W 221_M 1.041 0.87
549_F 553_F 1.04 0.87
278_E 282_L 1.039 0.87
528_G 534_W 1.036 0.87
194_T 197_F 1.035 0.87
340_F 464_S 1.035 0.87
572_P 575_L 1.034 0.87
36_G 40_L 1.033 0.87
344_L 457_L 1.033 0.87
389_L 501_A 1.031 0.87
509_A 514_G 1.03 0.87
61_S 134_D 1.03 0.87
586_S 600_I 1.028 0.86
325_V 406_A 1.024 0.86
81_L 85_S 1.022 0.86
7_T 44_V 1.022 0.86
5_A 9_I 1.022 0.86
495_I 499_V 1.02 0.86
429_T 433_I 1.019 0.86
533_T 543_W 1.019 0.86
588_N 593_W 1.016 0.86
191_E 214_M 1.015 0.86
127_M 257_T 1.013 0.85
337_T 398_S 1.012 0.85
308_L 429_T 1.012 0.85
89_L 131_V 1.01 0.85
291_L 421_G 1.009 0.85
531_L 535_W 1.009 0.85
510_W 514_G 1.009 0.85
401_E 405_G 1.007 0.85
84_L 332_I 1.004 0.85
376_Y 437_F 1 0.84
362_I 365_M 1 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rkoL20.99181000.244Contact Map0.638
4he8L20.95761000.285Contact Map0.636
3rkoM20.78631000.478Contact Map0.624
4he8M20.7521000.481Contact Map0.584
3rkoN20.75371000.524Contact Map0.499
4he8N20.69331000.574Contact Map0.532
4he8K20.151743.30.979Contact Map0.658
3rkoK20.158223.60.981Contact Map0.458
3bz1X10.079940.987Contact Map0.288
2kv5A10.04733.50.987Contact Map0.51
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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