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OPENSEQ.org
NUOM - NADH-quinone oxidoreductase subunit M
UniProt: P0AFE8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11773
Length: 509 (484)
Sequences: 8149
Seq/Len: 16.84
NUOM
Paralog alert: 0.74 [within 20: 0.56] - ratio of genomes with paralogs
Cluster includes: HYCC HYFB HYFD HYFF NUOL NUOM NUON
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
84_D 273_R 4.426 1.00
13_G 35_T 4.081 1.00
129_G 142_F 3.952 1.00
354_G 391_F 3.504 1.00
347_A 402_G 3.4 1.00
173_K 246_D 3.181 1.00
91_V 132_L 2.993 1.00
298_I 428_G 2.829 1.00
310_D 369_R 2.822 1.00
37_G 99_V 2.694 1.00
98_G 124_L 2.536 1.00
389_L 440_L 2.532 1.00
344_Q 406_G 2.444 1.00
94_T 131_F 2.429 1.00
91_V 128_I 2.394 1.00
11_F 125_G 2.393 1.00
368_T 373_M 2.388 1.00
155_A 171_A 2.344 1.00
314_L 371_M 2.322 1.00
126_G 145_M 2.319 1.00
204_T 207_Y 2.308 1.00
248_H 264_L 2.29 1.00
309_T 372_R 2.256 1.00
40_L 96_L 2.19 1.00
328_I 425_S 2.172 1.00
136_M 274_F 2.156 1.00
237_V 327_L 2.124 1.00
188_A 226_G 2.11 1.00
40_L 95_G 2.077 1.00
302_A 321_S 2.024 1.00
378_W 385_P 2.016 1.00
392_A 436_S 2.004 1.00
315_I 359_C 1.974 1.00
87_S 269_Y 1.949 1.00
294_G 331_Y 1.939 1.00
202_V 207_Y 1.937 1.00
461_S 464_E 1.925 1.00
133_A 138_L 1.925 1.00
272_L 338_Y 1.917 1.00
77_I 137_F 1.913 1.00
248_H 256_S 1.904 1.00
370_D 373_M 1.884 1.00
318_T 435_Y 1.87 1.00
385_P 445_F 1.868 1.00
438_A 442_R 1.862 1.00
105_S 116_F 1.827 1.00
93_L 349_G 1.783 1.00
43_S 95_G 1.776 1.00
411_L 425_S 1.776 1.00
136_M 210_L 1.76 1.00
272_L 330_I 1.756 1.00
371_M 443_A 1.738 1.00
350_L 474_L 1.734 1.00
385_P 440_L 1.731 1.00
330_I 341_A 1.72 1.00
393_V 398_M 1.713 1.00
390_F 472_V 1.71 1.00
306_F 434_V 1.679 1.00
160_K 250_Q 1.676 1.00
228_F 290_A 1.662 1.00
238_V 296_I 1.636 1.00
340_G 413_G 1.618 1.00
236_P 244_L 1.615 1.00
41_A 45_Q 1.596 1.00
381_M 384_L 1.595 1.00
40_L 44_L 1.589 1.00
423_V 427_F 1.581 1.00
34_I 38_L 1.577 1.00
332_T 337_A 1.57 1.00
329_A 337_A 1.55 1.00
363_Y 369_R 1.548 1.00
311_I 439_M 1.546 1.00
264_L 319_S 1.545 1.00
473_V 477_L 1.527 1.00
309_T 370_D 1.524 1.00
481_Y 484_P 1.504 1.00
343_I 406_G 1.503 1.00
89_L 346_I 1.484 1.00
332_T 414_S 1.476 1.00
44_L 48_L 1.473 1.00
188_A 230_A 1.47 1.00
299_F 428_G 1.432 1.00
467_M 470_L 1.427 1.00
388_S 444_Y 1.427 1.00
384_L 459_G 1.419 1.00
9_I 35_T 1.415 1.00
47_W 92_V 1.41 1.00
83_I 132_L 1.407 0.99
9_I 38_L 1.405 0.99
82_A 134_I 1.401 0.99
271_L 330_I 1.398 0.99
97_L 353_A 1.388 0.99
95_G 128_I 1.388 0.99
153_L 255_G 1.38 0.99
177_Y 242_G 1.377 0.99
383_W 469_L 1.377 0.99
256_S 259_L 1.376 0.99
302_A 431_F 1.363 0.99
288_P 292_W 1.361 0.99
219_V 223_L 1.356 0.99
233_V 240_L 1.346 0.99
329_A 410_I 1.341 0.99
6_L 42_L 1.34 0.99
388_S 392_A 1.335 0.99
135_D 204_T 1.333 0.99
32_A 117_H 1.328 0.99
228_F 232_A 1.321 0.99
477_L 481_Y 1.321 0.99
362_L 377_L 1.312 0.99
38_L 42_L 1.309 0.99
81_L 132_L 1.301 0.99
232_A 293_L 1.299 0.99
7_I 125_G 1.296 0.99
170_A 250_Q 1.289 0.99
97_L 349_G 1.287 0.99
414_S 422_T 1.285 0.99
237_V 293_L 1.271 0.99
392_A 440_L 1.27 0.99
119_N 152_F 1.268 0.99
228_F 286_F 1.267 0.99
322_H 435_Y 1.265 0.99
300_Y 304_M 1.263 0.99
37_G 41_A 1.259 0.99
84_D 87_S 1.257 0.99
245_P 308_Q 1.257 0.99
33_L 103_L 1.246 0.98
167_R 250_Q 1.236 0.98
102_V 117_H 1.235 0.98
292_W 296_I 1.222 0.98
462_L 466_F 1.221 0.98
105_S 108_E 1.219 0.98
469_L 473_V 1.216 0.98
490_H 494_G 1.216 0.98
223_L 227_F 1.215 0.98
140_F 186_L 1.215 0.98
139_F 270_G 1.214 0.98
231_F 270_G 1.213 0.98
169_T 173_K 1.205 0.98
291_M 331_Y 1.204 0.98
146_M 263_L 1.202 0.98
80_H 134_I 1.202 0.98
272_L 341_A 1.202 0.98
483_Q 487_D 1.197 0.98
86_L 272_L 1.193 0.98
244_L 248_H 1.19 0.98
321_S 432_A 1.187 0.98
308_Q 313_R 1.184 0.98
130_V 266_T 1.177 0.98
246_D 313_R 1.175 0.98
291_M 328_I 1.174 0.98
82_A 85_G 1.17 0.97
68_D 78_S 1.169 0.97
265_K 269_Y 1.167 0.97
388_S 439_M 1.166 0.97
202_V 205_F 1.154 0.97
96_L 100_L 1.153 0.97
232_A 237_V 1.151 0.97
166_T 250_Q 1.15 0.97
4_P 67_F 1.149 0.97
411_L 429_L 1.149 0.97
478_L 485_I 1.145 0.97
339_Q 490_H 1.143 0.97
253_T 312_K 1.143 0.97
223_L 226_G 1.14 0.97
440_L 445_F 1.139 0.97
24_G 27_V 1.137 0.97
474_L 478_L 1.135 0.97
123_I 127_V 1.122 0.97
264_L 268_A 1.121 0.97
83_I 88_L 1.117 0.96
375_G 449_K 1.115 0.96
395_T 436_S 1.113 0.96
135_D 203_W 1.112 0.96
337_A 413_G 1.111 0.96
89_L 342_V 1.109 0.96
347_A 406_G 1.106 0.96
390_F 476_V 1.101 0.96
136_M 189_I 1.098 0.96
302_A 428_G 1.097 0.96
346_I 485_I 1.096 0.96
257_V 357_I 1.095 0.96
377_L 381_M 1.094 0.96
264_L 269_Y 1.092 0.96
245_P 317_Y 1.088 0.96
97_L 261_G 1.086 0.96
371_M 442_R 1.085 0.96
290_A 331_Y 1.082 0.96
326_V 341_A 1.079 0.95
487_D 490_H 1.078 0.95
70_P 73_P 1.078 0.95
376_G 448_A 1.076 0.95
351_S 394_A 1.07 0.95
42_L 46_L 1.07 0.95
206_N 209_E 1.068 0.95
139_F 205_F 1.063 0.95
244_L 247_A 1.058 0.95
351_S 403_N 1.058 0.95
14_G 18_W 1.051 0.94
127_V 263_L 1.05 0.94
409_M 413_G 1.049 0.94
222_L 226_G 1.045 0.94
31_I 35_T 1.044 0.94
387_L 468_I 1.042 0.94
470_L 474_L 1.041 0.94
294_G 328_I 1.041 0.94
328_I 414_S 1.037 0.94
137_F 203_W 1.036 0.94
319_S 348_H 1.034 0.94
104_C 108_E 1.029 0.94
33_L 99_V 1.028 0.94
100_L 470_L 1.025 0.93
33_L 106_W 1.024 0.93
48_L 52_Y 1.023 0.93
391_F 475_L 1.02 0.93
385_P 389_L 1.017 0.93
197_Y 203_W 1.017 0.93
32_A 102_V 1.017 0.93
30_W 34_I 1.011 0.93
104_C 360_G 1.01 0.93
45_Q 48_L 1.008 0.93
321_S 435_Y 1.002 0.92
191_A 219_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rkoM211000.15Contact Map0.737
4he8M20.92141000.204Contact Map0.692
4he8L20.93121000.239Contact Map0.762
3rkoL20.94891000.258Contact Map0.742
3rkoN20.90771000.27Contact Map0.649
4he8N20.8351000.35Contact Map0.69
4he8K20.186635.10.97Contact Map0.885
3rkoK20.196529.80.971Contact Map0.544
3arcX20.07473.50.981Contact Map0.421
2l0nA10.05892.40.983Contact Map0.094
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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