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OPENSEQ.org
NUPX - Nucleoside permease NupX
UniProt: P33021 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12029
Length: 416 (414)
Sequences: 782
Seq/Len: 1.89
NUPX
Paralog alert: 0.56 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: NUPC NUPX PSUT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
315_D 349_D 3.296 1.00
313_W 316_A 2.923 1.00
383_R 386_E 2.712 1.00
105_I 262_V 2.695 1.00
337_N 340_P 2.611 1.00
69_Y 278_G 2.396 1.00
170_R 389_Q 2.313 1.00
23_N 26_K 2.211 1.00
12_V 308_V 2.184 0.99
20_L 396_A 2.156 0.99
319_A 356_I 2.145 0.99
175_T 214_I 2.135 0.99
277_N 295_E 2.129 0.99
161_V 168_L 2.05 0.99
57_E 61_F 1.97 0.99
392_L 396_A 1.921 0.98
78_F 98_G 1.919 0.98
252_A 268_A 1.917 0.98
22_V 393_R 1.917 0.98
295_E 337_N 1.9 0.98
17_A 219_L 1.836 0.98
8_L 307_W 1.823 0.97
157_I 179_S 1.805 0.97
319_A 352_T 1.795 0.97
212_G 401_S 1.79 0.97
77_I 267_M 1.784 0.97
72_A 75_A 1.781 0.97
114_I 244_I 1.76 0.97
253_M 261_G 1.723 0.96
284_G 292_A 1.694 0.96
15_T 19_L 1.678 0.95
18_F 24_K 1.654 0.95
118_I 244_I 1.627 0.94
7_V 411_F 1.625 0.94
123_I 127_I 1.597 0.93
284_G 293_S 1.576 0.93
248_A 272_I 1.554 0.92
256_L 260_A 1.545 0.92
154_Q 372_V 1.536 0.92
309_M 403_L 1.527 0.91
275_L 279_I 1.524 0.91
303_A 317_N 1.517 0.91
258_I 261_G 1.512 0.91
170_R 386_E 1.497 0.90
325_Q 337_N 1.488 0.90
138_I 143_S 1.485 0.90
117_Y 241_P 1.481 0.89
129_G 140_K 1.479 0.89
17_A 216_F 1.476 0.89
119_G 122_G 1.476 0.89
166_D 382_H 1.473 0.89
27_I 219_L 1.471 0.89
5_R 307_W 1.467 0.89
165_I 380_A 1.464 0.89
189_M 378_A 1.459 0.89
364_A 402_N 1.444 0.88
276_I 294_L 1.443 0.88
1_M 117_Y 1.438 0.88
55_V 58_K 1.422 0.87
155_N 261_G 1.422 0.87
294_L 298_L 1.416 0.86
71_D 100_R 1.402 0.86
145_V 157_I 1.392 0.85
51_P 55_V 1.389 0.85
55_V 59_V 1.381 0.85
392_L 395_L 1.378 0.84
155_N 258_I 1.378 0.84
209_A 212_G 1.376 0.84
65_K 68_A 1.373 0.84
209_A 405_S 1.366 0.84
45_I 49_L 1.363 0.84
309_M 407_T 1.363 0.84
66_V 111_L 1.355 0.83
169_N 223_A 1.352 0.83
366_F 392_L 1.348 0.83
257_K 260_A 1.336 0.82
23_N 224_T 1.33 0.81
327_L 399_T 1.328 0.81
7_V 11_V 1.326 0.81
305_L 308_V 1.309 0.80
220_L 396_A 1.308 0.80
303_A 320_G 1.283 0.78
104_A 187_S 1.282 0.78
88_T 93_A 1.281 0.78
41_V 45_I 1.275 0.77
127_I 130_G 1.274 0.77
104_A 190_I 1.258 0.76
169_N 172_E 1.25 0.75
190_I 258_I 1.246 0.75
204_A 270_V 1.244 0.75
338_F 351_K 1.243 0.75
209_A 402_N 1.243 0.75
247_A 251_G 1.242 0.75
273_I 329_I 1.239 0.75
313_W 320_G 1.239 0.75
311_V 352_T 1.238 0.75
401_S 405_S 1.238 0.75
154_Q 187_S 1.236 0.74
402_N 405_S 1.236 0.74
296_S 300_Y 1.229 0.74
201_Y 358_F 1.228 0.74
303_A 313_W 1.226 0.73
198_P 342_L 1.226 0.73
22_V 170_R 1.224 0.73
187_S 258_I 1.22 0.73
131_I 135_A 1.218 0.73
259_A 263_A 1.215 0.73
299_G 321_S 1.212 0.72
17_A 400_L 1.211 0.72
44_G 412_F 1.209 0.72
261_G 265_V 1.204 0.72
14_L 219_L 1.204 0.72
148_T 152_L 1.197 0.71
338_F 356_I 1.195 0.71
306_A 323_I 1.194 0.71
311_V 319_A 1.188 0.70
358_F 405_S 1.185 0.70
358_F 402_N 1.18 0.69
154_Q 327_L 1.179 0.69
14_L 32_V 1.179 0.69
171_N 223_A 1.177 0.69
220_L 397_A 1.174 0.69
33_G 37_V 1.168 0.68
159_A 258_I 1.165 0.68
82_V 99_F 1.164 0.68
110_A 329_I 1.164 0.68
22_V 221_S 1.164 0.68
113_S 117_Y 1.163 0.68
283_V 286_W 1.159 0.67
106_I 255_G 1.159 0.67
364_A 399_T 1.151 0.67
97_F 367_G 1.151 0.67
148_T 160_I 1.149 0.66
191_G 195_L 1.148 0.66
127_I 131_I 1.145 0.66
369_I 387_I 1.144 0.66
149_T 183_S 1.144 0.66
30_R 34_A 1.144 0.66
184_I 339_S 1.139 0.65
172_E 294_L 1.137 0.65
2_D 351_K 1.136 0.65
174_F 397_A 1.136 0.65
199_V 203_L 1.134 0.65
259_A 262_V 1.133 0.65
300_Y 317_N 1.133 0.65
271_A 367_G 1.128 0.64
138_I 214_I 1.128 0.64
67_M 338_F 1.125 0.64
114_I 272_I 1.124 0.64
409_A 412_F 1.121 0.64
295_E 340_P 1.116 0.63
280_I 293_S 1.112 0.63
43_G 200_E 1.111 0.63
65_K 69_Y 1.11 0.62
15_T 301_L 1.104 0.62
295_E 325_Q 1.102 0.62
109_T 376_F 1.1 0.61
113_S 357_S 1.098 0.61
74_S 99_F 1.091 0.60
20_L 220_L 1.089 0.60
142_E 218_R 1.088 0.60
366_F 399_T 1.086 0.60
149_T 210_I 1.079 0.59
321_S 325_Q 1.078 0.59
326_K 332_F 1.077 0.59
184_I 188_T 1.077 0.59
161_V 176_A 1.074 0.59
255_G 259_A 1.073 0.59
285_G 291_H 1.069 0.58
54_W 57_E 1.065 0.58
8_L 124_L 1.058 0.57
188_T 265_V 1.055 0.57
327_L 364_A 1.053 0.56
117_Y 189_M 1.048 0.56
116_Y 121_M 1.048 0.56
40_V 408_I 1.047 0.56
114_I 248_A 1.047 0.56
200_E 357_S 1.046 0.56
285_G 401_S 1.043 0.55
39_Q 212_G 1.041 0.55
209_A 358_F 1.036 0.55
80_S 91_D 1.034 0.54
28_S 136_L 1.033 0.54
77_I 266_V 1.033 0.54
235_S 293_S 1.032 0.54
105_I 307_W 1.032 0.54
28_S 137_N 1.031 0.54
145_V 179_S 1.027 0.54
354_A 413_I 1.022 0.53
292_A 297_I 1.022 0.53
188_T 380_A 1.021 0.53
155_N 375_A 1.021 0.53
109_T 149_T 1.021 0.53
105_I 115_L 1.018 0.53
112_V 150_I 1.017 0.52
212_G 405_S 1.016 0.52
297_I 320_G 1.01 0.52
6_S 410_G 1.007 0.51
188_T 367_G 1.006 0.51
38_L 45_I 1.006 0.51
60_A 270_V 1.005 0.51
158_P 180_G 1.002 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tijA10.99761000.101Contact Map0.523
1q90G10.062540.986Contact Map0.539
2ks1B10.07213.80.986Contact Map0.26
2l2tA20.07453.80.986Contact Map0.263
4h44G10.06253.50.986Contact Map0.226
4ikvA10.413530.987Contact Map0.134
2jwaA20.06972.30.987Contact Map0.319
2k1kA20.060120.988Contact Map0.021
2lotA10.07451.70.988Contact Map0.193
4b19A10.06011.70.988Contact Map0.551
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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