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OPENSEQ.org
NUPC - Nucleoside permease NupC
UniProt: P0AFF2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11971
Length: 400 (399)
Sequences: 774
Seq/Len: 1.94
NUPC
Paralog alert: 0.56 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: NUPC NUPX PSUT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
305_E 336_S 3.115 1.00
303_S 306_A 2.952 1.00
98_I 253_V 2.68 1.00
370_Q 373_V 2.566 1.00
327_D 330_K 2.503 1.00
70_F 269_A 2.362 1.00
163_R 376_R 2.346 1.00
13_V 298_V 2.295 1.00
268_N 285_Q 2.17 0.99
309_V 343_I 2.149 0.99
168_T 206_F 2.133 0.99
21_V 383_Y 2.105 0.99
24_D 27_K 2.052 0.99
154_Y 161_I 2.027 0.99
285_Q 327_D 1.94 0.99
58_K 62_E 1.938 0.99
243_I 259_G 1.905 0.98
204_S 388_V 1.895 0.98
23_S 380_K 1.87 0.98
79_F 91_F 1.865 0.98
78_V 258_I 1.863 0.98
150_N 172_T 1.847 0.98
9_L 297_W 1.819 0.98
107_I 235_F 1.799 0.97
309_V 339_A 1.775 0.97
73_E 76_N 1.766 0.97
18_A 211_L 1.757 0.97
244_L 252_I 1.74 0.97
379_L 383_Y 1.731 0.96
275_T 282_I 1.7 0.96
111_I 235_F 1.68 0.96
6_H 297_W 1.643 0.95
2_D 110_H 1.615 0.94
16_I 20_L 1.608 0.94
239_L 263_L 1.599 0.94
19_L 25_R 1.581 0.93
247_F 251_I 1.581 0.93
299_M 390_V 1.578 0.93
163_R 373_V 1.567 0.93
315_T 327_D 1.534 0.92
147_Q 359_I 1.532 0.92
293_Y 307_L 1.53 0.92
116_V 120_A 1.513 0.91
28_I 211_L 1.493 0.90
249_V 252_I 1.479 0.90
131_M 136_S 1.474 0.90
72_N 93_K 1.47 0.89
112_R 115_P 1.467 0.89
266_A 270_L 1.452 0.89
284_F 288_L 1.439 0.88
18_A 208_V 1.436 0.88
67_L 104_L 1.433 0.88
353_F 379_L 1.428 0.88
317_L 386_T 1.424 0.87
148_S 252_I 1.419 0.87
182_V 365_G 1.41 0.87
8_V 12_A 1.406 0.86
201_N 392_S 1.396 0.86
201_N 204_S 1.382 0.85
351_A 389_S 1.377 0.85
56_F 59_G 1.373 0.85
295_I 298_V 1.363 0.84
138_N 150_N 1.356 0.84
66_K 69_G 1.344 0.83
52_V 56_F 1.342 0.83
158_L 367_N 1.338 0.83
148_S 249_V 1.332 0.82
159_G 369_E 1.329 0.82
212_I 383_Y 1.323 0.82
299_M 394_S 1.32 0.81
56_F 60_F 1.317 0.81
120_A 123_F 1.314 0.81
122_G 133_K 1.309 0.81
293_Y 310_G 1.307 0.80
301_V 309_V 1.301 0.80
97_P 180_S 1.296 0.80
34_I 38_V 1.292 0.79
46_F 50_S 1.289 0.79
275_T 283_S 1.28 0.79
286_G 290_Y 1.272 0.78
193_Y 345_V 1.268 0.78
248_K 251_I 1.264 0.77
274_V 278_F 1.254 0.77
271_F 283_S 1.253 0.76
23_S 163_R 1.251 0.76
238_M 242_Y 1.247 0.76
388_V 392_S 1.243 0.76
267_L 284_F 1.243 0.76
293_Y 303_S 1.24 0.75
141_S 145_L 1.234 0.75
264_I 319_S 1.233 0.75
289_G 311_S 1.233 0.75
106_G 110_H 1.232 0.75
97_P 183_G 1.232 0.75
379_L 382_V 1.23 0.75
183_G 249_V 1.226 0.74
212_I 384_G 1.222 0.74
389_S 392_S 1.222 0.74
303_S 310_G 1.221 0.74
262_A 354_S 1.22 0.74
250_A 254_A 1.218 0.74
201_N 389_S 1.213 0.73
165_R 284_F 1.208 0.73
328_L 343_I 1.203 0.72
328_L 338_R 1.2 0.72
103_A 319_S 1.198 0.72
99_V 246_G 1.192 0.71
162_S 165_R 1.192 0.71
345_V 389_S 1.188 0.71
396_A 399_V 1.187 0.71
147_Q 317_L 1.187 0.71
15_A 211_L 1.186 0.71
296_A 313_M 1.186 0.71
68_L 328_L 1.182 0.70
18_A 387_L 1.179 0.70
351_A 386_T 1.178 0.70
274_V 277_W 1.173 0.69
45_W 399_V 1.171 0.69
180_S 249_V 1.167 0.69
147_Q 180_S 1.166 0.69
191_P 195_V 1.166 0.69
8_V 398_L 1.162 0.68
290_Y 307_L 1.16 0.68
141_S 153_A 1.159 0.68
41_V 395_I 1.158 0.68
196_A 261_I 1.151 0.67
152_I 249_V 1.151 0.67
120_A 124_L 1.149 0.67
162_S 215_Y 1.149 0.67
252_I 256_M 1.145 0.67
75_T 92_L 1.138 0.66
345_V 392_S 1.135 0.66
131_M 206_F 1.133 0.66
129_N 215_Y 1.128 0.65
142_S 176_T 1.125 0.65
273_T 277_W 1.122 0.64
177_V 329_Q 1.122 0.64
44_A 192_K 1.118 0.64
107_I 263_L 1.117 0.64
135_E 210_S 1.117 0.64
15_A 33_V 1.116 0.64
184_A 188_M 1.116 0.64
177_V 181_I 1.115 0.64
102_S 363_V 1.114 0.64
246_G 250_A 1.113 0.64
181_I 367_N 1.112 0.63
31_R 35_Q 1.112 0.63
23_S 213_N 1.104 0.63
285_Q 315_T 1.1 0.62
167_Y 384_G 1.099 0.62
106_G 344_S 1.098 0.62
124_L 128_V 1.097 0.62
90_F 354_S 1.094 0.62
83_N 92_L 1.087 0.61
65_E 69_G 1.086 0.61
356_I 374_V 1.084 0.61
43_L 83_N 1.083 0.60
316_K 322_F 1.08 0.60
202_M 215_Y 1.079 0.60
164_N 215_Y 1.073 0.59
66_K 70_F 1.068 0.59
55_G 58_K 1.065 0.59
110_H 182_V 1.064 0.58
36_L 207_I 1.064 0.58
14_V 390_V 1.063 0.58
158_L 370_Q 1.062 0.58
287_I 310_G 1.061 0.58
142_S 202_M 1.057 0.58
189_L 348_V 1.056 0.58
353_F 386_T 1.051 0.57
42_L 46_F 1.048 0.57
301_V 339_A 1.048 0.57
102_S 142_S 1.048 0.57
341_G 400_L 1.047 0.57
181_I 256_M 1.044 0.56
16_I 291_I 1.042 0.56
24_D 216_R 1.042 0.56
201_N 345_V 1.038 0.56
3_R 338_R 1.035 0.55
107_I 239_L 1.033 0.55
40_E 204_S 1.022 0.54
250_A 253_V 1.021 0.54
192_K 344_S 1.017 0.53
154_Y 166_M 1.01 0.52
311_S 315_T 1.009 0.52
384_G 391_L 1.008 0.52
57_V 122_G 1.006 0.52
247_F 255_A 1.005 0.52
154_Y 397_A 1.003 0.52
101_I 145_L 1.003 0.52
148_S 362_A 1.003 0.52
204_S 392_S 1.001 0.52
271_F 385_S 1 0.51
7_F 397_A 1 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tijA111000.094Contact Map0.54
1q90G10.05753.90.985Contact Map0.506
2ks1B10.07753.60.986Contact Map0.25
2l2tA20.083.50.986Contact Map0.308
4h44G10.05753.30.986Contact Map0.204
2jwaA20.0752.40.987Contact Map0.383
2k1kA20.0652.10.987Contact Map0.024
3b9wA10.232520.987Contact Map0.354
3b4rA20.2751.40.988Contact Map0.426
4ikvA10.4251.40.988Contact Map0.167
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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