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OPENSEQ.org
MOBA - Molybdenum cofactor guanylyltransferase
UniProt: P32173 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11829
Length: 194 (187)
Sequences: 2544
Seq/Len: 13.60
MOBA
Paralog alert: 0.43 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: MOBA MOCA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_K 41_D 5.338 1.00
20_M 28_L 3.502 1.00
34_P 37_Q 2.868 1.00
26_G 100_C 2.599 1.00
10_V 86_V 2.597 1.00
104_Y 190_W 2.459 1.00
8_T 92_G 2.271 1.00
28_L 187_L 2.229 1.00
10_V 95_F 2.165 1.00
9_G 47_L 2.025 1.00
49_H 67_K 2.025 1.00
33_K 38_H 1.988 1.00
13_A 52_V 1.96 1.00
33_K 37_Q 1.921 1.00
96_L 110_A 1.897 1.00
9_G 43_L 1.843 1.00
83_M 97_F 1.802 1.00
88_Q 147_L 1.786 1.00
43_L 98_C 1.772 1.00
11_V 40_A 1.707 1.00
122_V 164_A 1.675 1.00
71_D 81_A 1.66 1.00
87_M 95_F 1.653 1.00
98_C 105_I 1.628 1.00
53_N 86_V 1.608 1.00
8_T 90_E 1.605 1.00
149_Y 160_F 1.59 1.00
90_E 95_F 1.576 1.00
20_M 184_P 1.552 1.00
156_R 159_V 1.54 1.00
8_T 49_H 1.516 1.00
145_L 163_L 1.499 1.00
94_W 137_L 1.484 1.00
37_Q 41_D 1.469 1.00
52_V 66_L 1.464 1.00
94_W 139_N 1.456 1.00
84_L 88_Q 1.455 1.00
106_P 109_L 1.446 1.00
105_I 135_I 1.422 1.00
11_V 43_L 1.419 1.00
99_P 102_T 1.417 1.00
126_H 170_D 1.407 0.99
107_P 111_A 1.391 0.99
140_R 143_E 1.341 0.99
126_H 168_A 1.319 0.99
30_L 35_L 1.311 0.99
122_V 161_M 1.304 0.99
145_L 164_A 1.3 0.99
15_G 19_R 1.294 0.99
29_E 32_G 1.283 0.99
113_L 137_L 1.283 0.99
138_V 146_L 1.241 0.98
145_L 160_F 1.24 0.98
83_M 99_P 1.23 0.98
11_V 39_V 1.223 0.98
23_V 28_L 1.216 0.98
20_M 187_L 1.207 0.98
160_F 164_A 1.203 0.98
183_T 186_E 1.181 0.98
51_V 69_I 1.165 0.97
23_V 184_P 1.165 0.97
121_P 165_G 1.159 0.97
17_A 26_G 1.154 0.97
80_L 84_L 1.153 0.97
71_D 85_S 1.146 0.97
47_L 96_L 1.143 0.97
77_P 81_A 1.135 0.97
34_P 38_H 1.121 0.97
55_N 74_A 1.118 0.96
8_T 51_V 1.117 0.96
24_D 56_R 1.104 0.96
29_E 34_P 1.097 0.96
102_T 135_I 1.084 0.96
104_Y 179_V 1.075 0.95
179_V 190_W 1.071 0.95
17_A 187_L 1.07 0.95
45_T 107_P 1.067 0.95
83_M 157_V 1.061 0.95
69_I 85_S 1.061 0.95
186_E 189_R 1.052 0.95
121_P 141_A 1.049 0.94
28_L 184_P 1.038 0.94
109_L 177_A 1.036 0.94
142_I 145_L 1.034 0.94
29_E 33_K 1.033 0.94
36_W 64_S 1.031 0.94
20_M 23_V 1.027 0.94
31_N 38_H 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1e5kA111000.191Contact Map0.773
2e8bA10.96391000.293Contact Map0.594
2weeA20.95361000.311Contact Map0.769
3ngwA10.9331000.319Contact Map0.694
2wawA10.95361000.322Contact Map0.675
3d5nA80.9331000.343Contact Map0.749
2i5eA20.922799.90.476Contact Map0.448
2px7A20.938199.90.48Contact Map0.786
2xmeA120.974299.90.486Contact Map0.768
3rsbA40.881499.90.491Contact Map0.747
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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