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OPENSEQ.org
TYPA - GTP-binding protein TypA/BipA
UniProt: P32132 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11837
Length: 607 (600)
Sequences: 2799
Seq/Len: 4.67
TYPA
Paralog alert: 0.87 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: EFG LEPA RF3 TYPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
268_A 274_V 5.188 1.00
102_F 132_R 3.296 1.00
523_I 587_I 3.045 1.00
226_I 268_A 2.985 1.00
409_E 437_V 2.889 1.00
232_K 267_L 2.808 1.00
322_E 584_S 2.807 1.00
392_I 397_Q 2.797 1.00
455_F 463_G 2.683 1.00
527_H 531_N 2.68 1.00
226_I 274_V 2.532 1.00
548_A 551_T 2.531 1.00
496_A 512_L 2.528 1.00
527_H 533_L 2.482 1.00
418_A 451_F 2.432 1.00
520_E 593_T 2.359 1.00
572_I 578_V 2.344 1.00
400_Y 473_D 2.325 1.00
418_A 458_M 2.312 1.00
524_I 537_C 2.299 1.00
304_E 346_R 2.298 1.00
501_L 510_L 2.248 1.00
578_V 585_I 2.247 1.00
419_L 424_G 2.238 1.00
459_T 463_G 2.197 1.00
345_L 358_V 2.178 1.00
73_V 92_V 2.155 1.00
43_M 61_T 2.129 1.00
495_K 517_E 2.123 1.00
230_K 267_L 2.112 1.00
496_A 516_A 2.108 1.00
408_E 462_T 2.055 1.00
228_R 295_E 2.045 1.00
513_G 516_A 2.031 1.00
136_R 139_W 2.024 1.00
469_F 472_Y 2.018 1.00
513_G 562_R 1.992 1.00
4_K 68_Y 1.978 1.00
209_I 222_G 1.977 1.00
100_D 103_D 1.96 1.00
509_K 561_I 1.926 1.00
402_N 440_D 1.922 1.00
256_G 265_T 1.912 1.00
402_N 468_T 1.908 1.00
200_D 203_G 1.901 1.00
253_K 264_E 1.897 1.00
442_V 471_H 1.891 1.00
94_S 194_V 1.886 1.00
402_N 470_S 1.886 1.00
141_V 162_I 1.886 1.00
203_G 228_R 1.88 1.00
99_V 109_T 1.872 1.00
407_V 415_V 1.842 1.00
407_V 463_G 1.83 1.00
496_A 513_G 1.814 1.00
205_F 237_V 1.806 1.00
418_A 454_E 1.779 1.00
32_F 35_R 1.772 1.00
11_I 97_L 1.762 1.00
321_K 517_E 1.752 1.00
7_N 71_N 1.734 1.00
406_D 438_R 1.725 0.99
424_G 443_I 1.72 0.99
546_M 549_S 1.708 0.99
308_S 359_S 1.705 0.99
345_L 369_L 1.704 0.99
370_I 580_V 1.701 0.99
442_V 470_S 1.694 0.99
534_T 594_E 1.692 0.99
489_I 534_T 1.667 0.99
58_A 73_V 1.663 0.99
220_V 340_V 1.663 0.99
140_V 143_Q 1.662 0.99
237_V 251_V 1.64 0.99
374_R 379_E 1.633 0.99
425_D 473_D 1.623 0.99
249_A 279_L 1.61 0.99
127_I 141_V 1.609 0.99
130_V 171_I 1.607 0.99
334_R 373_M 1.593 0.99
64_K 67_D 1.579 0.99
332_L 336_N 1.571 0.99
591_H 596_D 1.564 0.99
592_L 597_R 1.544 0.99
279_L 282_L 1.541 0.99
332_L 349_E 1.534 0.99
173_G 179_M 1.533 0.99
393_D 474_D 1.526 0.98
505_Q 558_V 1.525 0.98
500_A 504_L 1.524 0.98
526_I 561_I 1.521 0.98
12_A 16_H 1.515 0.98
451_F 458_M 1.513 0.98
48_L 368_V 1.508 0.98
68_Y 191_V 1.501 0.98
403_V 448_L 1.496 0.98
549_S 554_A 1.493 0.98
25_L 183_M 1.489 0.98
188_Q 192_D 1.484 0.98
222_G 282_L 1.478 0.98
43_M 55_T 1.477 0.98
163_V 189_A 1.476 0.98
21_L 98_V 1.468 0.98
345_L 365_H 1.467 0.98
499_F 546_M 1.467 0.98
428_N 440_D 1.462 0.98
405_L 419_L 1.46 0.98
125_V 144_V 1.455 0.98
371_E 375_R 1.451 0.98
322_E 583_T 1.447 0.98
415_V 459_T 1.445 0.98
101_A 130_V 1.438 0.98
126_V 165_A 1.436 0.98
339_L 345_L 1.434 0.97
348_E 357_R 1.433 0.97
308_S 357_R 1.432 0.97
206_Q 228_R 1.428 0.97
6_R 197_P 1.428 0.97
512_L 516_A 1.425 0.97
46_N 57_L 1.421 0.97
542_K 546_M 1.409 0.97
145_F 149_V 1.409 0.97
4_K 67_D 1.407 0.97
43_M 59_K 1.394 0.97
314_N 379_E 1.391 0.97
395_R 474_D 1.388 0.97
139_W 143_Q 1.385 0.97
173_G 176_H 1.385 0.97
9_A 92_V 1.383 0.97
12_A 15_D 1.381 0.97
403_V 467_S 1.379 0.97
334_R 338_E 1.356 0.96
24_K 27_Q 1.355 0.96
526_I 571_F 1.354 0.96
325_F 330_Q 1.349 0.96
221_I 275_A 1.349 0.96
350_T 353_A 1.348 0.96
142_D 146_D 1.343 0.96
520_E 594_E 1.336 0.96
25_L 29_S 1.334 0.96
358_V 369_L 1.334 0.96
136_R 140_V 1.33 0.96
498_A 555_V 1.326 0.95
431_P 437_V 1.325 0.95
100_D 143_Q 1.324 0.95
403_V 465_L 1.32 0.95
393_D 397_Q 1.314 0.95
94_S 195_P 1.313 0.95
286_D 299_A 1.309 0.95
451_F 463_G 1.308 0.95
32_F 36_A 1.306 0.95
348_E 359_S 1.298 0.95
204_P 290_D 1.291 0.95
336_N 349_E 1.291 0.95
389_F 396_K 1.285 0.94
102_F 134_G 1.28 0.94
510_L 513_G 1.28 0.94
591_H 600_A 1.28 0.94
173_G 180_A 1.277 0.94
32_F 38_T 1.276 0.94
240_I 289_C 1.275 0.94
255_L 264_E 1.274 0.94
510_L 537_C 1.274 0.94
593_T 596_D 1.273 0.94
487_V 523_I 1.271 0.94
51_E 375_R 1.267 0.94
207_M 224_G 1.265 0.94
416_M 420_G 1.263 0.94
100_D 132_R 1.26 0.94
451_F 455_F 1.257 0.94
254_V 276_I 1.255 0.93
403_V 443_I 1.25 0.93
233_P 254_V 1.248 0.93
238_T 246_T 1.246 0.93
75_T 85_V 1.243 0.93
100_D 140_V 1.241 0.93
505_Q 555_V 1.239 0.93
146_D 149_V 1.235 0.93
404_T 440_D 1.231 0.93
492_G 538_L 1.229 0.92
370_I 382_V 1.227 0.92
386_K 590_R 1.222 0.92
241_D 245_K 1.214 0.92
572_I 585_I 1.209 0.92
236_Q 250_K 1.205 0.92
312_C 381_A 1.203 0.91
342_N 365_H 1.2 0.91
205_F 230_K 1.2 0.91
502_F 556_V 1.199 0.91
417_Q 420_G 1.198 0.91
99_V 125_V 1.193 0.91
338_E 373_M 1.19 0.91
66_N 188_Q 1.188 0.91
403_V 419_L 1.188 0.91
48_L 372_N 1.185 0.91
502_F 553_E 1.183 0.90
109_T 125_V 1.181 0.90
553_E 556_V 1.18 0.90
551_T 554_A 1.176 0.90
504_L 510_L 1.174 0.90
201_L 230_K 1.172 0.90
491_N 504_L 1.171 0.90
236_Q 248_N 1.166 0.90
97_L 112_V 1.166 0.90
412_Q 437_V 1.159 0.89
233_P 266_D 1.157 0.89
506_D 510_L 1.154 0.89
540_G 549_S 1.14 0.88
237_V 288_V 1.138 0.88
97_L 125_V 1.131 0.88
567_Q 571_F 1.13 0.88
595_N 598_R 1.128 0.87
8_I 70_I 1.128 0.87
513_G 560_P 1.123 0.87
502_F 555_V 1.121 0.87
15_D 54_I 1.119 0.87
89_M 119_Y 1.118 0.87
400_Y 476_R 1.116 0.87
33_D 38_T 1.114 0.87
409_E 412_Q 1.113 0.87
57_L 61_T 1.113 0.87
490_S 537_C 1.111 0.86
509_K 527_H 1.11 0.86
26_L 42_V 1.109 0.86
392_I 395_R 1.096 0.85
184_T 188_Q 1.095 0.85
318_F 493_Q 1.095 0.85
577_L 590_R 1.09 0.85
497_V 517_E 1.089 0.85
54_I 129_K 1.088 0.85
568_A 585_I 1.085 0.85
554_A 558_V 1.085 0.85
78_H 87_R 1.085 0.85
316_S 381_A 1.085 0.85
389_F 475_V 1.084 0.85
401_E 445_S 1.084 0.85
21_L 186_L 1.083 0.84
502_F 554_A 1.082 0.84
110_R 462_T 1.081 0.84
83_G 344_A 1.08 0.84
213_D 223_I 1.077 0.84
10_I 22_V 1.075 0.84
12_A 55_T 1.074 0.84
497_V 540_G 1.074 0.84
201_L 270_A 1.071 0.84
523_I 573_D 1.07 0.83
563_M 567_Q 1.07 0.83
26_L 61_T 1.066 0.83
36_A 261_E 1.065 0.83
506_D 528_S 1.065 0.83
501_L 537_C 1.063 0.83
66_N 184_T 1.062 0.83
594_E 598_R 1.061 0.83
569_L 578_V 1.059 0.83
189_A 193_H 1.058 0.83
29_S 63_I 1.057 0.82
61_T 258_L 1.056 0.82
11_I 95_V 1.056 0.82
230_K 269_E 1.054 0.82
224_G 274_V 1.054 0.82
69_R 256_G 1.053 0.82
401_E 467_S 1.052 0.82
550_G 554_A 1.052 0.82
205_F 231_V 1.051 0.82
512_L 537_C 1.046 0.82
79_A 111_F 1.043 0.81
389_F 446_R 1.043 0.81
454_E 458_M 1.042 0.81
64_K 258_L 1.042 0.81
502_F 505_Q 1.041 0.81
542_K 548_A 1.039 0.81
531_N 538_L 1.034 0.81
238_T 294_V 1.033 0.80
310_F 355_A 1.033 0.80
15_D 55_T 1.024 0.80
505_Q 528_S 1.016 0.79
491_N 540_G 1.014 0.79
96_L 126_V 1.014 0.79
8_I 190_I 1.013 0.79
63_I 72_I 1.013 0.79
224_G 276_I 1.013 0.79
173_G 178_D 1.012 0.79
23_D 41_R 1.012 0.79
503_G 539_T 1.012 0.79
96_L 163_V 1.011 0.78
543_L 598_R 1.009 0.78
163_V 174_L 1.008 0.78
174_L 189_A 1.006 0.78
138_D 142_D 1.005 0.78
199_V 270_A 1.003 0.78
491_N 538_L 1.003 0.78
22_V 72_I 1.001 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3j25A10.77591000.493Contact Map0.139
4kiyV10.76281000.495Contact Map0.741
1darA10.77591000.497Contact Map0.756
4fn5A10.76111000.499Contact Map0.752
2xexA20.78091000.5Contact Map0.727
3e3xA10.54531000.501Contact Map0.746
3j3az10.8271000.518Contact Map0.638
2dy1A10.76611000.521Contact Map0.685
2yweA10.87641000.522Contact Map0.715
1n0uA10.82211000.525Contact Map0.719
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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