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OPENSEQ.org
LOIP - Metalloprotease LoiP
UniProt: P25894 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11291
Length: 252 (233)
Sequences: 1605
Seq/Len: 6.89
LOIP
Paralog alert: 0.70 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: LOIP YCAL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
227_S 237_E 3.571 1.00
72_R 121_D 3.26 1.00
111_V 124_V 3.116 1.00
123_E 216_K 2.95 1.00
123_E 212_T 2.587 1.00
80_L 132_M 2.575 1.00
111_V 128_I 2.337 1.00
77_A 81_G 2.277 1.00
215_E 243_R 2.274 1.00
103_A 135_V 2.148 1.00
120_T 123_E 2.099 1.00
45_V 138_G 2.075 1.00
212_T 215_E 2.066 1.00
73_L 111_V 1.942 1.00
126_A 210_L 1.934 1.00
45_V 49_S 1.9 1.00
211_A 242_I 1.857 1.00
198_D 202_Q 1.801 1.00
136_A 199_L 1.741 1.00
137_L 195_Y 1.736 1.00
190_A 237_E 1.726 1.00
119_M 213_S 1.725 1.00
194_D 241_H 1.724 1.00
187_R 190_A 1.724 1.00
190_A 241_H 1.715 1.00
53_C 110_R 1.689 1.00
120_T 209_G 1.663 1.00
218_A 236_A 1.648 1.00
69_Y 72_R 1.647 1.00
122_N 205_I 1.628 1.00
122_N 209_G 1.595 1.00
102_F 110_R 1.54 0.99
211_A 246_M 1.533 0.99
242_I 246_M 1.513 0.99
211_A 243_R 1.502 0.99
96_A 112_Y 1.495 0.99
49_S 104_M 1.492 0.99
77_A 91_Y 1.492 0.99
95_M 113_S 1.477 0.99
195_Y 199_L 1.465 0.99
94_Y 110_R 1.445 0.99
41_S 44_Q 1.43 0.99
123_E 209_G 1.428 0.99
119_M 124_V 1.411 0.99
98_D 112_Y 1.407 0.99
34_A 142_K 1.404 0.99
208_A 246_M 1.387 0.99
115_L 123_E 1.374 0.98
126_A 209_G 1.36 0.98
125_E 205_I 1.347 0.98
143_G 188_Q 1.335 0.98
175_L 178_K 1.309 0.98
149_G 153_V 1.302 0.98
182_S 185_S 1.293 0.97
139_H 191_E 1.292 0.97
212_T 216_K 1.285 0.97
74_T 78_N 1.264 0.97
109_I 128_I 1.264 0.97
46_K 50_D 1.26 0.97
115_L 127_V 1.248 0.97
55_E 59_K 1.235 0.96
157_A 161_G 1.235 0.96
56_M 94_Y 1.232 0.96
70_A 76_I 1.223 0.96
241_H 245_R 1.219 0.96
66_N 69_Y 1.212 0.96
91_Y 109_I 1.201 0.96
226_S 229_F 1.201 0.96
61_T 95_M 1.198 0.96
138_G 141_K 1.197 0.96
53_C 92_K 1.196 0.96
173_G 176_G 1.196 0.96
12_V 15_V 1.186 0.95
240_Q 243_R 1.185 0.95
77_A 109_I 1.173 0.95
183_Q 186_Q 1.16 0.94
105_A 140_V 1.157 0.94
13_A 17_T 1.155 0.94
117_D 123_E 1.145 0.94
47_T 51_Q 1.142 0.94
140_V 143_G 1.13 0.93
72_R 76_I 1.118 0.93
121_D 205_I 1.115 0.93
67_S 71_K 1.113 0.93
182_S 231_D 1.1 0.92
142_K 188_Q 1.099 0.92
119_M 216_K 1.098 0.92
73_L 124_V 1.093 0.92
50_D 108_C 1.092 0.92
90_N 108_C 1.091 0.92
209_G 212_T 1.091 0.92
99_V 112_Y 1.091 0.92
194_D 245_R 1.088 0.92
91_Y 94_Y 1.083 0.91
213_S 235_S 1.081 0.91
133_G 137_L 1.078 0.91
11_S 14_T 1.076 0.91
208_A 243_R 1.073 0.91
53_C 57_D 1.072 0.91
133_G 195_Y 1.069 0.91
14_T 18_G 1.068 0.91
133_G 136_A 1.067 0.91
69_Y 93_V 1.064 0.90
203_R 207_P 1.063 0.90
14_T 17_T 1.062 0.90
230_D 234_A 1.061 0.90
194_D 198_D 1.061 0.90
129_G 196_S 1.059 0.90
66_N 70_A 1.049 0.90
235_S 239_A 1.045 0.89
197_Y 242_I 1.044 0.89
185_S 188_Q 1.042 0.89
52_A 55_E 1.039 0.89
197_Y 246_M 1.028 0.88
53_C 108_C 1.025 0.88
191_E 195_Y 1.025 0.88
63_A 113_S 1.022 0.88
76_I 124_V 1.017 0.88
80_L 199_L 1.002 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c37A20.8811000.343Contact Map0.688
4il3A20.92461000.599Contact Map0.638
4aw6A40.93651000.599Contact Map0.603
3cqbA20.408799.60.764Contact Map0.601
4jixA20.424686.20.929Contact Map0.624
3dteA10.714377.90.935Contact Map0.422
4jiuA10.384955.90.944Contact Map0.631
3zbiC140.190545.60.947Contact Map0
4iuwA10.9246370.95Contact Map0.251
1c7kA10.49629.30.953Contact Map0.263
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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