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FMT - Methionyl-tRNA formyltransferase
UniProt: P23882 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11268
Length: 315 (309)
Sequences: 2546
Seq/Len: 8.24
FMT
Paralog alert: 0.28 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: FMT PUR3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
134_E 156_S 4.528 1.00
97_K 144_V 4.194 1.00
198_D 201_L 3.963 1.00
97_K 101_E 3.96 1.00
215_I 224_L 3.577 1.00
138_T 151_M 3.127 1.00
296_S 299_D 3.02 1.00
143_D 148_T 2.99 1.00
219_L 223_Q 2.934 1.00
155_L 182_T 2.803 1.00
145_G 148_T 2.744 1.00
163_D 171_K 2.734 1.00
163_D 167_T 2.706 1.00
24_L 59_K 2.554 1.00
225_E 251_A 2.485 1.00
85_V 184_L 2.406 1.00
228_I 251_A 2.337 1.00
76_Q 80_E 2.32 1.00
139_I 183_T 2.293 1.00
32_G 81_L 2.26 1.00
118_W 130_A 2.224 1.00
129_W 230_A 2.214 1.00
215_I 248_V 2.183 1.00
118_W 132_D 2.172 1.00
250_K 286_S 2.169 1.00
252_S 283_N 2.16 1.00
186_Q 191_T 2.125 1.00
117_R 132_D 2.115 1.00
21_D 25_S 2.069 1.00
21_D 55_L 2.065 1.00
125_Q 165_S 2.036 1.00
224_L 282_L 2.02 1.00
286_S 294_A 1.994 1.00
244_Q 290_A 1.908 1.00
299_D 302_N 1.881 1.00
6_R 29_N 1.855 1.00
284_L 287_L 1.839 1.00
219_L 227_C 1.837 1.00
126_R 212_E 1.833 1.00
220_S 223_Q 1.826 1.00
55_L 59_K 1.815 1.00
250_K 285_L 1.797 1.00
134_E 158_P 1.782 1.00
217_W 239_L 1.771 1.00
157_C 175_L 1.769 1.00
19_H 110_V 1.767 1.00
157_C 171_K 1.764 1.00
252_S 285_L 1.757 1.00
150_D 196_V 1.75 1.00
151_M 154_K 1.745 1.00
166_G 233_P 1.737 1.00
54_V 57_E 1.732 1.00
83_A 102_M 1.715 1.00
216_D 219_L 1.674 1.00
83_A 86_M 1.663 1.00
249_W 294_A 1.658 1.00
199_E 202_V 1.649 1.00
38_D 53_K 1.634 1.00
298_Q 302_N 1.628 1.00
8_I 83_A 1.599 1.00
114_L 136_G 1.586 1.00
62_P 77_L 1.559 1.00
150_D 194_P 1.553 1.00
160_T 163_D 1.55 1.00
274_Q 281_I 1.533 1.00
53_K 65_Q 1.531 1.00
274_Q 283_N 1.527 1.00
239_L 248_V 1.521 1.00
251_A 282_L 1.488 1.00
24_L 55_L 1.481 0.99
131_G 226_R 1.456 0.99
155_L 178_Q 1.446 0.99
143_D 150_D 1.442 0.99
54_V 58_E 1.411 0.99
53_K 57_E 1.399 0.99
129_W 231_F 1.398 0.99
138_T 154_K 1.381 0.99
261_A 264_T 1.365 0.99
110_V 180_L 1.358 0.99
141_Q 152_L 1.358 0.99
6_R 31_V 1.354 0.99
17_A 55_L 1.35 0.99
289_P 295_M 1.338 0.99
225_E 253_V 1.336 0.99
24_L 30_V 1.335 0.99
222_A 226_R 1.333 0.99
266_L 281_I 1.333 0.99
154_K 195_E 1.319 0.99
275_V 284_L 1.311 0.98
21_D 58_E 1.306 0.98
141_Q 194_P 1.303 0.98
214_R 240_E 1.292 0.98
160_T 171_K 1.29 0.98
152_L 187_L 1.282 0.98
32_G 64_F 1.281 0.98
248_V 284_L 1.276 0.98
286_S 296_S 1.272 0.98
26_S 181_I 1.264 0.98
7_I 85_V 1.263 0.98
34_F 74_N 1.253 0.98
126_R 129_W 1.25 0.98
28_H 185_K 1.24 0.98
135_T 159_I 1.235 0.98
108_I 152_L 1.228 0.97
272_G 283_N 1.227 0.97
128_L 168_L 1.226 0.97
153_Y 183_T 1.217 0.97
86_M 107_C 1.2 0.97
167_T 171_K 1.199 0.97
153_Y 186_Q 1.198 0.97
155_L 175_L 1.193 0.97
287_L 300_L 1.187 0.97
242_E 312_N 1.186 0.97
19_H 180_L 1.185 0.97
55_L 58_E 1.183 0.97
100_L 142_M 1.173 0.96
22_A 178_Q 1.167 0.96
121_A 207_K 1.167 0.96
94_I 146_L 1.164 0.96
164_T 232_N 1.161 0.96
75_Q 98_A 1.155 0.96
13_P 90_A 1.149 0.96
19_H 89_V 1.149 0.96
33_V 61_L 1.137 0.95
122_A 205_A 1.131 0.95
126_R 130_A 1.129 0.95
182_T 186_Q 1.126 0.95
273_I 297_A 1.124 0.95
49_P 57_E 1.114 0.95
129_W 227_C 1.112 0.95
41_A 44_G 1.094 0.94
12_T 50_S 1.093 0.94
70_R 96_P 1.092 0.94
214_R 238_W 1.082 0.94
110_V 139_I 1.08 0.94
84_D 104_R 1.08 0.94
159_I 163_D 1.077 0.93
221_A 277_T 1.077 0.93
36_Q 39_R 1.075 0.93
264_T 276_A 1.07 0.93
126_R 205_A 1.066 0.93
152_L 194_P 1.066 0.93
246_V 287_L 1.065 0.93
273_I 284_L 1.065 0.93
221_A 279_D 1.06 0.93
122_A 126_R 1.058 0.93
153_Y 182_T 1.056 0.92
22_A 181_I 1.055 0.92
77_L 80_E 1.05 0.92
10_A 34_F 1.049 0.92
8_I 32_G 1.044 0.92
162_E 225_E 1.035 0.91
69_L 74_N 1.031 0.91
153_Y 179_G 1.025 0.91
292_K 295_M 1.024 0.91
224_L 277_T 1.024 0.91
114_L 154_K 1.021 0.91
248_V 251_A 1.015 0.90
239_L 246_V 1.009 0.90
260_A 264_T 1.008 0.90
152_L 192_A 1.002 0.90
161_A 222_A 1.002 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3q0iA111000.06Contact Map0.825
1fmtA20.99681000.063Contact Map0.883
3tqqA10.99371000.072Contact Map0.843
4iqfA40.99051000.078Contact Map0.861
2blnA20.96511000.117Contact Map0.805
2bw0A10.93021000.145Contact Map0.784
1z7eA60.96511000.159Contact Map0.765
4lxqA20.85711000.285Contact Map0.67
1zghA10.7271000.367Contact Map0.658
3kcqA40.65081000.478Contact Map0.694
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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