| UniProt: | P22255 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10043 | ||
| Length: | 246 (242) | ||
| Sequences: | 4790 | ||
| Seq/Len: | 19.79 |
| CYSQ
Paralog alert: 0.66 [within 20: 0.03] - ratio of genomes with paralogs Cluster includes: CYSQ SUHB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 213_A | 218_A | 4.751 | 1.00 | |
| 116_Y | 123_M | 3.656 | 1.00 | |
| 78_R | 106_D | 3.099 | 1.00 | |
| 117_A | 120_M | 3.002 | 1.00 | |
| 210_H | 214_A | 2.846 | 1.00 | |
| 11_N | 51_G | 2.702 | 1.00 | |
| 77_Q | 107_H | 2.602 | 1.00 | |
| 153_V | 192_A | 2.532 | 1.00 | |
| 8_L | 51_G | 2.514 | 1.00 | |
| 222_D | 226_K | 2.375 | 1.00 | |
| 13_G | 116_Y | 2.283 | 1.00 | |
| 15_A | 47_V | 2.247 | 1.00 | |
| 29_V | 42_I | 2.232 | 1.00 | |
| 56_T | 59_V | 2.224 | 1.00 | |
| 39_A | 43_A | 2.195 | 1.00 | |
| 81_L | 105_I | 2.132 | 1.00 | |
| 109_K | 128_E | 2.088 | 1.00 | |
| 9_A | 102_I | 2.043 | 1.00 | |
| 211_A | 215_A | 2.036 | 1.00 | |
| 130_K | 215_A | 2.01 | 1.00 | |
| 46_T | 50_D | 2.007 | 1.00 | |
| 106_D | 111_I | 1.971 | 1.00 | |
| 113_G | 211_A | 1.941 | 1.00 | |
| 115_V | 185_C | 1.936 | 1.00 | |
| 98_F | 119_V | 1.9 | 1.00 | |
| 124_Y | 189_E | 1.893 | 1.00 | |
| 126_A | 215_A | 1.891 | 1.00 | |
| 79_Y | 105_I | 1.887 | 1.00 | |
| 49_M | 61_V | 1.881 | 1.00 | |
| 51_G | 54_T | 1.859 | 1.00 | |
| 105_I | 110_P | 1.815 | 1.00 | |
| 16_I | 85_L | 1.813 | 1.00 | |
| 122_V | 191_Q | 1.802 | 1.00 | |
| 45_H | 63_S | 1.801 | 1.00 | |
| 82_V | 102_I | 1.788 | 1.00 | |
| 47_V | 51_G | 1.777 | 1.00 | |
| 185_C | 212_V | 1.737 | 1.00 | |
| 49_M | 53_R | 1.729 | 1.00 | |
| 19_V | 40_A | 1.729 | 1.00 | |
| 103_A | 207_A | 1.724 | 1.00 | |
| 78_R | 104_L | 1.684 | 1.00 | |
| 129_G | 215_A | 1.659 | 1.00 | |
| 38_T | 92_I | 1.656 | 1.00 | |
| 109_K | 214_A | 1.65 | 1.00 | |
| 125_S | 132_W | 1.645 | 1.00 | |
| 5_V | 80_W | 1.645 | 1.00 | |
| 59_V | 78_R | 1.626 | 1.00 | |
| 117_A | 182_L | 1.624 | 1.00 | |
| 133_K | 189_E | 1.6 | 1.00 | |
| 16_I | 44_A | 1.581 | 1.00 | |
| 20_Y | 98_F | 1.581 | 1.00 | |
| 9_A | 114_V | 1.581 | 1.00 | |
| 17_M | 119_V | 1.564 | 1.00 | |
| 28_V | 31_K | 1.53 | 1.00 | |
| 52_L | 59_V | 1.516 | 1.00 | |
| 4_Q | 8_L | 1.466 | 1.00 | |
| 48_I | 82_V | 1.462 | 1.00 | |
| 116_Y | 121_N | 1.455 | 1.00 | |
| 126_A | 211_A | 1.424 | 1.00 | |
| 48_I | 102_I | 1.406 | 0.99 | |
| 213_A | 243_V | 1.394 | 0.99 | |
| 6_C | 125_S | 1.378 | 0.99 | |
| 80_W | 104_L | 1.376 | 0.99 | |
| 128_E | 214_A | 1.372 | 0.99 | |
| 128_E | 215_A | 1.353 | 0.99 | |
| 36_P | 89_K | 1.352 | 0.99 | |
| 36_P | 92_I | 1.316 | 0.99 | |
| 59_V | 80_W | 1.304 | 0.99 | |
| 152_V | 194_L | 1.292 | 0.99 | |
| 44_A | 85_L | 1.28 | 0.99 | |
| 122_V | 189_E | 1.271 | 0.99 | |
| 77_Q | 106_D | 1.27 | 0.99 | |
| 4_Q | 56_T | 1.262 | 0.99 | |
| 7_Q | 55_L | 1.257 | 0.99 | |
| 10_R | 123_M | 1.25 | 0.99 | |
| 81_L | 207_A | 1.238 | 0.98 | |
| 95_N | 178_I | 1.232 | 0.98 | |
| 122_V | 133_K | 1.216 | 0.98 | |
| 16_I | 91_F | 1.21 | 0.98 | |
| 50_D | 54_T | 1.202 | 0.98 | |
| 111_I | 128_E | 1.201 | 0.98 | |
| 49_M | 63_S | 1.191 | 0.98 | |
| 44_A | 48_I | 1.191 | 0.98 | |
| 42_I | 46_T | 1.169 | 0.97 | |
| 103_A | 211_A | 1.168 | 0.97 | |
| 132_W | 139_R | 1.165 | 0.97 | |
| 104_L | 112_L | 1.159 | 0.97 | |
| 186_L | 191_Q | 1.156 | 0.97 | |
| 184_F | 209_G | 1.15 | 0.97 | |
| 4_Q | 55_L | 1.146 | 0.97 | |
| 17_M | 98_F | 1.141 | 0.97 | |
| 6_C | 10_R | 1.135 | 0.97 | |
| 112_L | 127_A | 1.134 | 0.97 | |
| 150_P | 193_Q | 1.134 | 0.97 | |
| 110_P | 210_H | 1.133 | 0.97 | |
| 41_D | 65_E | 1.132 | 0.97 | |
| 176_T | 179_G | 1.117 | 0.96 | |
| 164_K | 168_Q | 1.112 | 0.96 | |
| 65_E | 88_T | 1.109 | 0.96 | |
| 103_A | 110_P | 1.107 | 0.96 | |
| 11_N | 47_V | 1.106 | 0.96 | |
| 184_F | 213_A | 1.089 | 0.96 | |
| 49_M | 66_D | 1.085 | 0.96 | |
| 4_Q | 52_L | 1.082 | 0.96 | |
| 52_L | 56_T | 1.08 | 0.95 | |
| 115_V | 212_V | 1.079 | 0.95 | |
| 43_A | 46_T | 1.076 | 0.95 | |
| 17_M | 121_N | 1.073 | 0.95 | |
| 131_A | 215_A | 1.07 | 0.95 | |
| 222_D | 225_G | 1.062 | 0.95 | |
| 16_I | 98_F | 1.056 | 0.95 | |
| 5_V | 9_A | 1.043 | 0.94 | |
| 5_V | 114_V | 1.04 | 0.94 | |
| 110_P | 211_A | 1.038 | 0.94 | |
| 62_L | 81_L | 1.029 | 0.94 | |
| 12_A | 100_V | 1.026 | 0.94 | |
| 51_G | 55_L | 1.025 | 0.93 | |
| 11_N | 14_D | 1.013 | 0.93 | |
| 6_C | 123_M | 1.008 | 0.93 | |
| 45_H | 66_D | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3b8bA | 1 | 0.9756 | 100 | 0.105 | Contact Map | 0.779 |
| 3t0jA | 4 | 0.9756 | 100 | 0.105 | Contact Map | 0.806 |
| 2fvzA | 4 | 0.9797 | 100 | 0.113 | Contact Map | 0.86 |
| 3lv0A | 2 | 0.9797 | 100 | 0.113 | Contact Map | 0.857 |
| 2p3nA | 4 | 0.9512 | 100 | 0.114 | Contact Map | 0.882 |
| 2qflA | 1 | 0.9797 | 100 | 0.115 | Contact Map | 0.799 |
| 4i3yA | 2 | 0.9593 | 100 | 0.117 | Contact Map | 0.769 |
| 2pcrA | 4 | 0.9634 | 100 | 0.118 | Contact Map | 0.816 |
| 4g62A | 2 | 0.9593 | 100 | 0.12 | Contact Map | 0.771 |
| 2bjiA | 2 | 0.9797 | 100 | 0.127 | Contact Map | 0.756 |
Sequence Conservation (Image Generated using WebLogo v3)