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OPENSEQ.org
PEPQ - Xaa-Pro dipeptidase
UniProt: P21165 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10698
Length: 443 (418)
Sequences: 3236
Seq/Len: 7.74
PEPQ
Paralog alert: 0.62 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: AMPP MAP1 PEPQ YPDF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
171_R 434_E 7.04 1.00
377_P 430_E 6.268 1.00
288_M 428_I 5.086 1.00
167_L 427_V 4.657 1.00
172_E 175_K 3.273 1.00
275_K 279_D 3.001 1.00
273_L 420_I 2.808 1.00
282_L 286_A 2.801 1.00
161_F 376_Q 2.73 1.00
293_S 296_D 2.516 1.00
305_I 387_I 2.358 1.00
170_M 380_V 2.274 1.00
81_W 118_L 2.155 1.00
283_A 286_A 2.129 1.00
177_A 258_L 2.119 1.00
171_R 175_K 2.106 1.00
200_A 203_T 2.062 1.00
427_V 436_M 2.04 1.00
28_L 127_G 2.034 1.00
307_K 311_K 2.005 1.00
125_N 147_N 1.975 1.00
341_L 425_N 1.91 1.00
284_L 297_Y 1.909 1.00
269_D 417_F 1.901 1.00
269_D 272_Q 1.893 1.00
43_L 70_L 1.89 1.00
197_I 243_F 1.879 1.00
246_D 257_D 1.878 1.00
284_L 301_F 1.865 1.00
257_D 423_E 1.84 1.00
287_T 300_Q 1.839 1.00
22_A 25_R 1.822 1.00
239_E 265_K 1.821 1.00
19_T 42_F 1.82 1.00
295_V 372_T 1.811 1.00
114_G 117_S 1.807 1.00
429_H 432_N 1.794 1.00
178_V 440_L 1.775 1.00
170_M 174_Q 1.77 1.00
19_T 72_V 1.769 1.00
246_D 423_E 1.768 1.00
21_D 25_R 1.767 1.00
310_R 320_E 1.746 1.00
213_P 255_A 1.746 1.00
383_I 426_V 1.744 1.00
185_E 262_W 1.735 1.00
183_A 204_A 1.717 1.00
183_A 186_E 1.713 1.00
273_L 418_G 1.686 1.00
382_T 425_N 1.686 1.00
182_R 186_E 1.666 1.00
298_H 302_H 1.654 1.00
319_S 322_A 1.645 1.00
281_Q 285_I 1.628 1.00
169_C 252_N 1.623 1.00
198_N 202_L 1.607 1.00
37_E 344_Q 1.603 1.00
280_E 304_R 1.602 1.00
24_A 74_G 1.59 1.00
426_V 435_N 1.586 1.00
375_L 428_I 1.567 1.00
273_L 389_F 1.567 1.00
276_D 308_L 1.562 1.00
237_P 264_A 1.559 1.00
242_S 261_T 1.553 1.00
250_E 255_A 1.525 1.00
410_K 413_A 1.515 1.00
220_L 237_P 1.512 1.00
164_E 168_A 1.507 0.99
301_F 337_I 1.495 0.99
293_S 374_I 1.484 0.99
290_A 433_V 1.481 0.99
285_I 435_N 1.48 0.99
279_D 283_A 1.464 0.99
271_A 275_K 1.455 0.99
403_S 408_W 1.448 0.99
277_V 420_I 1.438 0.99
289_K 292_V 1.434 0.99
202_L 206_G 1.431 0.99
238_E 241_R 1.427 0.99
60_V 70_L 1.408 0.99
177_A 256_A 1.401 0.99
183_A 207_H 1.396 0.99
17_E 21_D 1.395 0.99
190_S 239_E 1.392 0.99
303_Q 321_E 1.387 0.99
429_H 434_E 1.38 0.99
168_A 172_E 1.379 0.99
242_S 263_S 1.379 0.99
278_N 282_L 1.379 0.99
228_H 346_H 1.377 0.99
310_R 323_M 1.376 0.99
299_I 303_Q 1.355 0.99
222_E 235_Q 1.345 0.99
51_K 54_P 1.345 0.99
73_D 78_P 1.344 0.99
306_A 323_M 1.343 0.99
341_L 380_V 1.336 0.99
283_A 300_Q 1.335 0.99
193_S 196_D 1.329 0.98
73_D 76_N 1.322 0.98
380_V 427_V 1.317 0.98
375_L 381_L 1.312 0.98
227_L 335_H 1.312 0.98
174_Q 178_V 1.312 0.98
188_F 262_W 1.306 0.98
380_V 436_M 1.3 0.98
279_D 311_K 1.294 0.98
193_S 236_A 1.291 0.98
274_V 422_I 1.289 0.98
249_A 256_A 1.286 0.98
288_M 383_I 1.286 0.98
281_Q 424_D 1.284 0.98
157_Y 376_Q 1.281 0.98
290_A 429_H 1.267 0.98
278_N 422_I 1.265 0.98
246_D 259_T 1.26 0.98
218_V 243_F 1.26 0.98
22_A 26_F 1.249 0.97
199_I 203_T 1.244 0.97
197_I 237_P 1.243 0.97
307_K 320_E 1.243 0.97
171_R 427_V 1.235 0.97
292_V 297_Y 1.234 0.97
28_L 149_K 1.231 0.97
221_N 241_R 1.227 0.97
23_L 30_A 1.225 0.97
168_A 175_K 1.221 0.97
167_L 171_R 1.221 0.97
197_I 218_V 1.218 0.97
168_A 171_R 1.215 0.97
283_A 304_R 1.215 0.97
19_T 31_L 1.214 0.97
242_S 270_Y 1.212 0.97
21_D 24_A 1.21 0.97
55_Q 156_H 1.205 0.97
19_T 22_A 1.204 0.97
288_M 297_Y 1.189 0.96
274_V 278_N 1.188 0.96
118_L 121_A 1.187 0.96
203_T 207_H 1.185 0.96
276_D 279_D 1.18 0.96
263_S 267_D 1.178 0.96
427_V 434_E 1.175 0.96
183_A 187_A 1.166 0.96
340_P 347_D 1.165 0.96
290_A 377_P 1.164 0.96
388_Y 419_G 1.16 0.96
376_Q 379_M 1.16 0.96
219_A 224_A 1.154 0.95
284_L 287_T 1.152 0.95
297_Y 300_Q 1.149 0.95
18_R 158_Y 1.145 0.95
292_V 300_Q 1.134 0.95
16_Q 20_R 1.132 0.95
219_A 229_Y 1.13 0.95
296_D 299_I 1.129 0.95
20_R 23_L 1.128 0.95
29_D 125_N 1.127 0.95
426_V 433_V 1.124 0.94
289_K 433_V 1.124 0.94
292_V 296_D 1.123 0.94
157_Y 373_R 1.123 0.94
373_R 376_Q 1.121 0.94
179_N 208_R 1.109 0.94
434_E 438_R 1.107 0.94
374_I 377_P 1.107 0.94
204_A 207_H 1.103 0.94
164_E 429_H 1.101 0.94
38_L 50_F 1.101 0.94
223_H 229_Y 1.1 0.94
14_T 17_E 1.094 0.93
386_G 421_R 1.093 0.93
187_A 200_A 1.09 0.93
175_K 179_N 1.089 0.93
339_H 384_E 1.089 0.93
298_H 337_I 1.088 0.93
167_L 380_V 1.088 0.93
289_K 431_N 1.086 0.93
188_F 197_I 1.085 0.93
246_D 384_E 1.081 0.93
160_S 379_M 1.079 0.93
70_L 79_K 1.073 0.92
240_M 266_S 1.072 0.92
18_R 21_D 1.067 0.92
287_T 292_V 1.067 0.92
29_D 124_G 1.067 0.92
212_V 216_N 1.062 0.92
340_P 349_A 1.062 0.92
388_Y 421_R 1.059 0.92
255_A 345_V 1.054 0.92
301_F 333_M 1.053 0.92
30_A 73_D 1.051 0.91
228_H 421_R 1.049 0.91
181_H 262_W 1.048 0.91
259_T 423_E 1.048 0.91
272_Q 326_N 1.047 0.91
177_A 180_G 1.042 0.91
346_H 421_R 1.038 0.91
406_F 411_I 1.037 0.91
327_D 330_G 1.037 0.91
335_H 388_Y 1.036 0.91
161_F 379_M 1.035 0.91
266_S 271_A 1.034 0.91
290_A 428_I 1.033 0.90
20_R 74_G 1.03 0.90
257_D 384_E 1.021 0.90
389_F 418_G 1.02 0.90
176_M 253_G 1.015 0.89
259_T 346_H 1.009 0.89
195_F 199_I 1.008 0.89
192_M 196_D 1.004 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l24A30.99321000.194Contact Map0.73
3rvaA10.99321000.203Contact Map0.696
2iw2A20.97971000.258Contact Map0.753
2v3zA10.89841000.304Contact Map0.752
3ig4A60.85331000.344Contact Map0.746
1wn1A20.78781000.354Contact Map0.811
3q6dA40.7811000.357Contact Map0.798
4egeA10.81491000.36Contact Map0.704
2zsgA20.77881000.363Contact Map0.847
1wy2A20.7811000.366Contact Map0.812
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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