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OPENSEQ.org
AGP - Glucose-1-phosphatase
UniProt: P19926 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10033
Length: 413 (387)
Sequences: 1060
Seq/Len: 2.74
AGP
Paralog alert: 0.65 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: AGP PPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
391_C 399_C 5.106 1.00
79_E 120_T 4.563 1.00
109_A 125_I 3.38 1.00
296_V 405_D 2.941 1.00
32_Q 348_H 2.752 1.00
319_L 342_I 2.552 1.00
86_M 343_V 2.435 1.00
42_L 78_L 2.351 1.00
31_L 347_W 2.298 1.00
37_M 318_L 2.271 1.00
42_L 338_I 2.136 1.00
112_N 117_T 2.118 1.00
90_L 345_Q 2.103 1.00
110_Y 290_Y 1.89 0.99
42_L 241_E 1.889 0.99
38_S 82_M 1.874 0.99
97_K 106_T 1.868 0.99
404_F 408_L 1.832 0.99
116_R 311_H 1.8 0.99
290_Y 294_A 1.795 0.99
87_R 130_P 1.74 0.98
36_M 86_M 1.733 0.98
291_I 344_F 1.718 0.98
400_P 403_K 1.709 0.98
291_I 318_L 1.695 0.98
29_Y 349_D 1.651 0.97
86_M 124_F 1.651 0.97
87_R 128_A 1.643 0.97
79_E 124_F 1.63 0.97
79_E 339_G 1.626 0.97
315_I 342_I 1.626 0.97
83_G 87_R 1.611 0.97
287_L 291_I 1.608 0.97
34_V 305_I 1.598 0.97
346_R 357_M 1.567 0.96
255_S 258_Q 1.564 0.96
119_A 122_Q 1.555 0.96
295_L 346_R 1.548 0.96
76_G 123_F 1.541 0.96
318_L 344_F 1.51 0.95
233_D 274_F 1.487 0.95
41_N 339_G 1.483 0.94
39_R 43_R 1.475 0.94
80_V 126_T 1.473 0.94
120_T 309_V 1.469 0.94
357_M 401_M 1.449 0.93
403_K 406_S 1.443 0.93
181_Y 185_E 1.438 0.93
311_H 322_L 1.428 0.93
344_F 359_I 1.425 0.93
116_R 391_C 1.418 0.93
73_T 76_G 1.418 0.93
39_R 116_R 1.399 0.92
340_G 361_Y 1.398 0.92
31_L 34_V 1.37 0.91
106_T 304_K 1.356 0.90
40_H 43_R 1.345 0.90
116_R 399_C 1.345 0.90
235_F 238_Q 1.343 0.90
31_L 35_L 1.336 0.89
32_Q 346_R 1.329 0.89
82_M 341_K 1.326 0.89
28_G 350_S 1.314 0.88
46_L 69_G 1.309 0.88
69_G 116_R 1.307 0.88
292_D 405_D 1.306 0.88
117_T 311_H 1.304 0.88
78_L 82_M 1.301 0.88
43_R 312_D 1.295 0.87
83_G 345_Q 1.295 0.87
94_G 121_A 1.284 0.87
108_Y 137_H 1.279 0.86
405_D 409_N 1.278 0.86
203_S 207_G 1.275 0.86
234_A 238_Q 1.275 0.86
312_D 345_Q 1.274 0.86
39_R 311_H 1.266 0.86
237_L 240_Y 1.247 0.84
129_F 342_I 1.24 0.84
172_L 175_L 1.236 0.84
354_R 400_P 1.233 0.83
109_A 121_A 1.229 0.83
109_A 307_V 1.225 0.83
32_Q 355_D 1.224 0.83
78_L 309_V 1.223 0.83
101_C 340_G 1.221 0.83
315_I 319_L 1.219 0.82
38_S 124_F 1.216 0.82
348_H 353_N 1.212 0.82
347_W 358_K 1.205 0.81
44_A 72_T 1.188 0.80
69_G 310_G 1.188 0.80
41_N 79_E 1.186 0.80
124_F 307_V 1.186 0.80
149_F 153_I 1.181 0.80
342_I 361_Y 1.18 0.80
22_A 25_V 1.178 0.79
310_G 314_N 1.172 0.79
257_Q 261_V 1.169 0.79
69_G 312_D 1.168 0.79
233_D 241_E 1.164 0.78
287_L 318_L 1.159 0.78
235_F 251_G 1.157 0.78
38_S 307_V 1.156 0.78
91_A 129_F 1.153 0.77
203_S 206_D 1.152 0.77
180_S 183_L 1.149 0.77
296_V 409_N 1.138 0.76
318_L 322_L 1.134 0.76
116_R 312_D 1.132 0.75
44_A 66_V 1.13 0.75
112_N 311_H 1.129 0.75
46_L 310_G 1.123 0.75
116_R 337_P 1.123 0.75
319_L 324_F 1.12 0.74
136_V 220_G 1.119 0.74
312_D 315_I 1.118 0.74
156_D 299_R 1.117 0.74
345_Q 358_K 1.116 0.74
201_Q 205_V 1.11 0.73
52_V 238_Q 1.11 0.73
115_Q 119_A 1.106 0.73
31_L 345_Q 1.103 0.73
149_F 157_S 1.102 0.73
109_A 260_K 1.098 0.72
32_Q 120_T 1.088 0.71
348_H 355_D 1.085 0.71
78_L 87_R 1.085 0.71
146_D 160_F 1.085 0.71
292_D 408_L 1.081 0.71
200_Q 203_S 1.08 0.71
85_Y 381_A 1.075 0.70
36_M 343_V 1.075 0.70
118_V 281_R 1.072 0.70
271_D 276_S 1.071 0.70
233_D 238_Q 1.065 0.69
44_A 68_G 1.065 0.69
299_R 401_M 1.062 0.69
106_T 111_A 1.057 0.68
82_M 309_V 1.057 0.68
349_D 398_F 1.053 0.68
43_R 311_H 1.048 0.67
89_W 325_K 1.048 0.67
40_H 116_R 1.047 0.67
42_L 90_L 1.046 0.67
294_A 306_T 1.044 0.67
49_N 68_G 1.041 0.66
274_F 317_S 1.04 0.66
76_G 82_M 1.037 0.66
83_G 127_G 1.037 0.66
248_V 254_K 1.034 0.66
52_V 56_S 1.033 0.66
380_P 409_N 1.032 0.65
287_L 314_N 1.032 0.65
291_I 295_L 1.032 0.65
318_L 321_A 1.032 0.65
30_Q 350_S 1.031 0.65
113_S 118_V 1.026 0.65
376_T 379_A 1.019 0.64
128_A 332_Q 1.016 0.64
64_W 337_P 1.016 0.64
320_T 330_H 1.016 0.64
69_G 114_L 1.012 0.63
78_L 241_E 1.011 0.63
182_Q 186_K 1.011 0.63
231_L 235_F 1.01 0.63
159_A 162_E 1.01 0.63
124_F 309_V 1.008 0.63
97_K 392_P 1.006 0.63
29_Y 398_F 1.003 0.62
235_F 275_T 1 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zhcA20.98061000.226Contact Map0.647
3ntlA20.9371000.23Contact Map0.658
4arvA20.98311000.233Contact Map0.628
1dkqA10.93221000.236Contact Map0.618
4aruA10.92981000.245Contact Map0.608
2wnhA20.92741000.273Contact Map0.63
1nd6A40.76271000.358Contact Map0.698
3it3A20.7531000.363Contact Map0.678
4jobA10.80151000.372Contact Map0.699
2gfiA20.84261000.4Contact Map0.612
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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