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OPENSEQ.org
PPA - Periplasmic AppA protein
UniProt: P07102 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10049
Length: 432 (407)
Sequences: 552
Seq/Len: 1.36
PPA
Paralog alert: 0.63 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: AGP PPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
404_C 413_C 4.315 1.00
30_L 360_W 2.581 1.00
107_I 123_A 2.43 1.00
297_I 357_F 2.321 0.99
36_V 332_L 2.306 0.99
41_V 76_L 2.171 0.99
85_R 128_P 1.934 0.97
88_L 358_E 1.933 0.97
28_L 362_R 1.921 0.97
106_A 135_H 1.914 0.97
77_I 118_T 1.896 0.96
241_E 280_Q 1.759 0.94
77_I 352_G 1.733 0.93
418_F 422_V 1.684 0.92
84_Q 356_V 1.649 0.91
39_H 42_R 1.647 0.91
294_L 297_I 1.637 0.90
31_E 361_R 1.633 0.90
110_D 115_T 1.63 0.90
329_L 355_L 1.616 0.89
27_E 363_L 1.615 0.89
302_T 419_T 1.614 0.89
243_F 257_G 1.583 0.88
211_S 214_Q 1.583 0.88
41_V 351_P 1.579 0.88
353_G 374_L 1.562 0.87
326_D 358_E 1.562 0.87
200_C 210_C 1.539 0.86
38_R 42_R 1.514 0.85
114_R 325_H 1.5 0.84
401_L 415_L 1.499 0.84
333_G 355_L 1.486 0.83
263_H 267_T 1.478 0.83
117_K 120_E 1.472 0.83
293_L 332_L 1.459 0.82
388_L 394_P 1.447 0.81
35_I 84_Q 1.442 0.81
207_D 214_Q 1.434 0.80
208_E 223_S 1.376 0.76
314_T 318_S 1.376 0.76
31_E 368_Q 1.374 0.76
198_N 207_D 1.362 0.75
40_G 77_I 1.358 0.75
99_C 130_C 1.341 0.74
33_V 326_D 1.337 0.73
265_W 411_G 1.33 0.73
110_D 326_D 1.326 0.72
38_R 114_R 1.323 0.72
290_A 372_V 1.318 0.72
116_R 287_R 1.318 0.72
293_L 335_A 1.317 0.72
128_P 241_E 1.31 0.71
45_T 67_G 1.307 0.71
67_G 114_R 1.304 0.71
389_S 392_T 1.303 0.71
277_Y 282_T 1.298 0.70
257_G 350_P 1.296 0.70
114_R 413_C 1.277 0.68
243_F 254_P 1.275 0.68
296_L 300_A 1.274 0.68
36_V 294_L 1.265 0.67
381_Q 388_L 1.263 0.67
254_P 257_G 1.259 0.67
109_A 245_L 1.251 0.66
206_Q 214_Q 1.249 0.66
110_D 147_F 1.245 0.66
114_R 404_C 1.244 0.65
40_G 352_G 1.243 0.65
69_L 118_T 1.239 0.65
107_I 321_F 1.237 0.65
30_L 33_V 1.236 0.65
42_R 114_R 1.236 0.65
114_R 350_P 1.229 0.64
55_T 342_L 1.223 0.63
30_L 124_A 1.214 0.63
104_Q 109_A 1.206 0.62
38_R 325_H 1.206 0.62
81_G 85_R 1.204 0.62
29_K 363_L 1.202 0.62
62_W 149_P 1.202 0.62
122_F 323_A 1.199 0.61
104_Q 318_S 1.196 0.61
332_L 335_A 1.192 0.61
71_P 74_G 1.191 0.60
75_E 156_Q 1.191 0.60
114_R 118_T 1.19 0.60
287_R 301_L 1.189 0.60
198_N 206_Q 1.186 0.60
30_L 34_V 1.186 0.60
68_W 332_L 1.177 0.59
250_G 404_C 1.176 0.59
112_D 351_P 1.174 0.59
246_Q 256_W 1.173 0.59
50_L 54_V 1.172 0.59
118_T 328_N 1.171 0.59
156_Q 352_G 1.171 0.59
30_L 122_F 1.165 0.58
99_C 353_G 1.165 0.58
78_A 124_A 1.164 0.58
83_Y 394_P 1.164 0.58
206_Q 211_S 1.161 0.58
85_R 126_L 1.15 0.56
61_T 230_T 1.139 0.55
65_K 113_E 1.138 0.55
111_V 356_V 1.138 0.55
349_T 374_L 1.137 0.55
70_T 85_R 1.133 0.55
18_Q 22_A 1.13 0.54
80_L 329_L 1.128 0.54
386_T 392_T 1.127 0.54
42_R 69_L 1.125 0.54
205_K 208_E 1.125 0.54
70_T 353_G 1.125 0.54
206_Q 212_L 1.125 0.54
414_S 417_G 1.123 0.54
20_A 23_Q 1.123 0.54
22_A 25_E 1.118 0.53
75_E 79_Y 1.115 0.53
19_S 22_A 1.107 0.52
44_P 246_Q 1.106 0.52
65_K 88_L 1.106 0.52
43_A 70_T 1.106 0.52
184_A 370_I 1.105 0.52
388_L 393_P 1.1 0.51
96_K 102_S 1.1 0.51
77_I 351_P 1.098 0.51
81_G 358_E 1.098 0.51
343_P 350_P 1.098 0.51
114_R 326_D 1.095 0.51
111_V 323_A 1.092 0.51
67_G 80_L 1.089 0.50
22_A 215_A 1.086 0.50
196_Q 213_T 1.084 0.50
127_A 355_L 1.083 0.50
64_V 67_G 1.079 0.49
199_L 211_S 1.077 0.49
349_T 359_R 1.064 0.48
54_V 118_T 1.064 0.48
157_L 284_E 1.062 0.48
195_P 208_E 1.061 0.48
333_G 340_W 1.061 0.48
299_T 337_E 1.06 0.47
291_T 358_E 1.059 0.47
121_A 268_L 1.058 0.47
119_G 324_G 1.057 0.47
221_K 224_A 1.056 0.47
55_T 309_Q 1.053 0.47
304_H 352_G 1.051 0.47
60_P 268_L 1.051 0.47
276_F 319_V 1.05 0.46
357_F 372_V 1.047 0.46
37_S 109_A 1.046 0.46
88_L 371_Q 1.045 0.46
41_V 249_Q 1.044 0.46
378_T 395_G 1.043 0.46
108_I 296_L 1.041 0.46
297_I 425_A 1.038 0.45
59_W 67_G 1.037 0.45
110_D 116_R 1.035 0.45
360_W 371_Q 1.035 0.45
107_I 425_A 1.034 0.45
313_V 368_Q 1.031 0.45
207_D 212_L 1.03 0.44
254_P 260_T 1.03 0.44
59_W 135_H 1.027 0.44
249_Q 328_N 1.026 0.44
195_P 198_N 1.026 0.44
88_L 188_L 1.023 0.44
354_E 358_E 1.021 0.44
206_Q 209_S 1.021 0.44
77_I 110_D 1.018 0.43
30_L 412_M 1.017 0.43
208_E 214_Q 1.016 0.43
19_S 206_Q 1.016 0.43
205_K 209_S 1.012 0.43
26_P 163_T 1.012 0.43
398_K 401_L 1.01 0.42
194_F 198_N 1.01 0.42
256_W 289_R 1.008 0.42
334_G 339_N 1.006 0.42
402_A 421_I 1.006 0.42
40_G 76_L 1.004 0.42
361_R 366_N 1.004 0.42
313_V 397_V 1.004 0.42
205_K 211_S 1.003 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zhcA20.99311000.21Contact Map0.446
1dkqA10.94911000.221Contact Map0.418
4arvA20.99311000.232Contact Map0.435
4aruA10.94911000.235Contact Map0.444
3ntlA20.90051000.281Contact Map0.454
2wnhA20.90511000.308Contact Map0.443
3it3A20.73381000.389Contact Map0.505
1nd6A40.74541000.39Contact Map0.512
4jobA10.7871000.41Contact Map0.519
1qwoA10.82641000.446Contact Map0.479
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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