| UniProt: | P16690 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10723 | ||
| Length: | 185 (174) | ||
| Sequences: | 2642 | ||
| Seq/Len: | 15.18 |
| PHNN
Paralog alert: 0.30 [within 20: 0.01] - ratio of genomes with paralogs Cluster includes: KGUA PHNN |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 124_I | 127_Q | 4.135 | 1.00 | |
| 126_R | 130_E | 3.863 | 1.00 | |
| 130_E | 137_A | 2.772 | 1.00 | |
| 37_Y | 80_G | 2.734 | 1.00 | |
| 56_E | 59_T | 2.722 | 1.00 | |
| 54_E | 58_F | 2.69 | 1.00 | |
| 59_T | 63_Q | 2.576 | 1.00 | |
| 158_L | 167_S | 2.498 | 1.00 | |
| 71_H | 74_G | 2.365 | 1.00 | |
| 60_R | 65_L | 2.338 | 1.00 | |
| 19_L | 171_L | 2.272 | 1.00 | |
| 58_F | 76_Y | 2.262 | 1.00 | |
| 26_R | 172_L | 2.158 | 1.00 | |
| 166_Q | 170_T | 2.109 | 1.00 | |
| 73_N | 146_R | 2.096 | 1.00 | |
| 54_E | 76_Y | 2.095 | 1.00 | |
| 53_S | 56_E | 2.077 | 1.00 | |
| 37_Y | 52_L | 2.068 | 1.00 | |
| 61_A | 69_S | 2.001 | 1.00 | |
| 72_A | 98_S | 1.959 | 1.00 | |
| 137_A | 141_N | 1.95 | 1.00 | |
| 54_E | 71_H | 1.941 | 1.00 | |
| 18_S | 164_L | 1.938 | 1.00 | |
| 9_M | 153_Q | 1.903 | 1.00 | |
| 81_V | 84_D | 1.884 | 1.00 | |
| 84_D | 88_H | 1.863 | 1.00 | |
| 126_R | 141_N | 1.861 | 1.00 | |
| 45_G | 50_I | 1.847 | 1.00 | |
| 71_H | 76_Y | 1.812 | 1.00 | |
| 58_F | 62_G | 1.809 | 1.00 | |
| 22_E | 168_V | 1.796 | 1.00 | |
| 106_R | 154_D | 1.766 | 1.00 | |
| 70_W | 100_A | 1.739 | 1.00 | |
| 85_L | 89_A | 1.729 | 1.00 | |
| 163_S | 166_Q | 1.721 | 1.00 | |
| 32_L | 91_F | 1.705 | 1.00 | |
| 52_L | 60_R | 1.633 | 1.00 | |
| 136_N | 139_E | 1.554 | 1.00 | |
| 10_G | 14_S | 1.526 | 1.00 | |
| 158_L | 171_L | 1.516 | 1.00 | |
| 54_E | 75_L | 1.478 | 1.00 | |
| 22_E | 25_L | 1.459 | 1.00 | |
| 58_F | 61_A | 1.388 | 0.99 | |
| 155_C | 174_L | 1.332 | 0.99 | |
| 22_E | 26_R | 1.324 | 0.99 | |
| 17_D | 96_N | 1.321 | 0.99 | |
| 141_N | 145_A | 1.318 | 0.99 | |
| 19_L | 117_C | 1.302 | 0.99 | |
| 61_A | 76_Y | 1.275 | 0.99 | |
| 27_E | 172_L | 1.272 | 0.99 | |
| 116_V | 121_S | 1.271 | 0.99 | |
| 20_L | 96_N | 1.256 | 0.99 | |
| 82_E | 85_L | 1.245 | 0.98 | |
| 82_E | 86_W | 1.2 | 0.98 | |
| 19_L | 168_V | 1.198 | 0.98 | |
| 50_I | 82_E | 1.196 | 0.98 | |
| 135_E | 140_I | 1.194 | 0.98 | |
| 21_A | 25_L | 1.194 | 0.98 | |
| 116_V | 119_Q | 1.187 | 0.98 | |
| 127_Q | 131_N | 1.185 | 0.98 | |
| 8_L | 20_L | 1.185 | 0.98 | |
| 32_L | 86_W | 1.183 | 0.98 | |
| 10_G | 17_D | 1.172 | 0.98 | |
| 56_E | 60_R | 1.171 | 0.98 | |
| 97_G | 105_A | 1.161 | 0.97 | |
| 73_N | 98_S | 1.149 | 0.97 | |
| 164_L | 168_V | 1.129 | 0.97 | |
| 20_L | 94_L | 1.121 | 0.97 | |
| 86_W | 91_F | 1.119 | 0.96 | |
| 170_T | 176_H | 1.117 | 0.96 | |
| 59_T | 62_G | 1.115 | 0.96 | |
| 6_I | 175_I | 1.103 | 0.96 | |
| 21_A | 48_N | 1.093 | 0.96 | |
| 86_W | 89_A | 1.092 | 0.96 | |
| 27_E | 30_Q | 1.083 | 0.96 | |
| 52_L | 56_E | 1.08 | 0.95 | |
| 146_R | 149_R | 1.075 | 0.95 | |
| 95_V | 105_A | 1.074 | 0.95 | |
| 117_C | 121_S | 1.074 | 0.95 | |
| 84_D | 109_Y | 1.074 | 0.95 | |
| 161_D | 166_Q | 1.063 | 0.95 | |
| 45_G | 56_E | 1.06 | 0.95 | |
| 52_L | 80_G | 1.043 | 0.94 | |
| 8_L | 171_L | 1.039 | 0.94 | |
| 64_N | 108_R | 1.031 | 0.94 | |
| 33_V | 96_N | 1.028 | 0.94 | |
| 17_D | 20_L | 1.01 | 0.93 | |
| 22_E | 165_R | 1.01 | 0.93 | |
| 37_Y | 60_R | 1.007 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2xkxA | 2 | 0.9568 | 100 | 0.194 | Contact Map | 0.323 |
| 1kjwA | 1 | 0.9568 | 100 | 0.211 | Contact Map | 0.65 |
| 3tvtA | 1 | 0.9568 | 100 | 0.229 | Contact Map | 0.718 |
| 4deyA | 1 | 0.9568 | 100 | 0.277 | Contact Map | 0.441 |
| 1s96A | 2 | 0.9838 | 100 | 0.368 | Contact Map | 0.728 |
| 3tszA | 1 | 0.8 | 100 | 0.464 | Contact Map | 0.538 |
| 3kfvA | 1 | 0.7946 | 100 | 0.478 | Contact Map | 0.536 |
| 1lvgA | 1 | 0.9892 | 100 | 0.479 | Contact Map | 0.715 |
| 1z6gA | 1 | 0.9892 | 100 | 0.481 | Contact Map | 0.575 |
| 3shwA | 1 | 0.7892 | 100 | 0.503 | Contact Map | 0.516 |
Sequence Conservation (Image Generated using WebLogo v3)