| UniProt: | P15770 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10077 | ||
| Length: | 272 (265) | ||
| Sequences: | 2888 | ||
| Seq/Len: | 10.90 |
| AROE
Paralog alert: 0.33 [within 20: 0.02] - ratio of genomes with paralogs Cluster includes: AROE YDIB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 219_K | 227_E | 4.74 | 1.00 | |
| 9_N | 37_L | 4.054 | 1.00 | |
| 85_V | 98_G | 3.29 | 1.00 | |
| 76_T | 99_D | 3.284 | 1.00 | |
| 210_C | 222_F | 2.87 | 1.00 | |
| 250_L | 256_L | 2.803 | 1.00 | |
| 74_E | 95_R | 2.747 | 1.00 | |
| 74_E | 97_L | 2.614 | 1.00 | |
| 66_E | 132_R | 2.597 | 1.00 | |
| 19_I | 245_A | 2.437 | 1.00 | |
| 104_V | 247_H | 2.378 | 1.00 | |
| 123_L | 181_F | 2.323 | 1.00 | |
| 72_A | 98_G | 2.294 | 1.00 | |
| 247_H | 250_L | 2.255 | 1.00 | |
| 72_A | 88_L | 2.228 | 1.00 | |
| 68_A | 88_L | 2.215 | 1.00 | |
| 221_P | 225_W | 2.152 | 1.00 | |
| 134_V | 213_M | 2.139 | 1.00 | |
| 91_L | 96_L | 2.114 | 1.00 | |
| 124_L | 135_L | 2.102 | 1.00 | |
| 8_G | 61_T | 2.093 | 1.00 | |
| 121_R | 144_A | 2.083 | 1.00 | |
| 79_A | 85_V | 2.079 | 1.00 | |
| 219_K | 224_A | 2.066 | 1.00 | |
| 106_L | 211_Y | 2.035 | 1.00 | |
| 156_E | 160_K | 2.002 | 1.00 | |
| 67_E | 70_A | 1.983 | 1.00 | |
| 59_N | 248_A | 1.976 | 1.00 | |
| 58_A | 88_L | 1.925 | 1.00 | |
| 68_A | 72_A | 1.922 | 1.00 | |
| 72_A | 85_V | 1.901 | 1.00 | |
| 69_F | 75_L | 1.887 | 1.00 | |
| 89_M | 251_L | 1.865 | 1.00 | |
| 4_Y | 24_A | 1.828 | 1.00 | |
| 106_L | 134_V | 1.824 | 1.00 | |
| 9_N | 40_I | 1.805 | 1.00 | |
| 223_L | 234_N | 1.796 | 1.00 | |
| 152_V | 156_E | 1.785 | 1.00 | |
| 127_A | 149_N | 1.748 | 1.00 | |
| 10_P | 13_H | 1.746 | 1.00 | |
| 210_C | 226_C | 1.717 | 1.00 | |
| 7_F | 58_A | 1.693 | 1.00 | |
| 87_T | 101_T | 1.649 | 1.00 | |
| 9_N | 64_F | 1.599 | 1.00 | |
| 109_D | 239_G | 1.583 | 1.00 | |
| 109_D | 211_Y | 1.581 | 1.00 | |
| 77_E | 80_A | 1.58 | 1.00 | |
| 130_A | 213_M | 1.575 | 1.00 | |
| 3_T | 34_G | 1.551 | 1.00 | |
| 108_S | 111_E | 1.55 | 1.00 | |
| 75_L | 98_G | 1.534 | 1.00 | |
| 149_N | 189_S | 1.533 | 1.00 | |
| 191_G | 214_F | 1.523 | 1.00 | |
| 64_F | 67_E | 1.506 | 1.00 | |
| 49_A | 52_S | 1.501 | 1.00 | |
| 249_F | 253_H | 1.493 | 1.00 | |
| 76_T | 97_L | 1.492 | 1.00 | |
| 123_L | 148_T | 1.482 | 1.00 | |
| 6_V | 11_I | 1.473 | 1.00 | |
| 9_N | 39_P | 1.472 | 1.00 | |
| 24_A | 31_H | 1.461 | 1.00 | |
| 73_D | 95_R | 1.449 | 1.00 | |
| 108_S | 243_A | 1.448 | 1.00 | |
| 106_L | 185_I | 1.445 | 1.00 | |
| 88_L | 96_L | 1.438 | 1.00 | |
| 5_A | 36_V | 1.421 | 1.00 | |
| 205_H | 208_I | 1.414 | 1.00 | |
| 82_A | 103_G | 1.407 | 0.99 | |
| 132_R | 161_L | 1.398 | 0.99 | |
| 151_T | 154_R | 1.393 | 0.99 | |
| 78_R | 99_D | 1.389 | 0.99 | |
| 42_D | 45_N | 1.384 | 0.99 | |
| 144_A | 169_Q | 1.368 | 0.99 | |
| 224_A | 228_Q | 1.338 | 0.99 | |
| 75_L | 85_V | 1.334 | 0.99 | |
| 121_R | 182_D | 1.333 | 0.99 | |
| 142_D | 145_V | 1.325 | 0.99 | |
| 99_D | 251_L | 1.323 | 0.99 | |
| 6_V | 35_R | 1.319 | 0.99 | |
| 121_R | 146_T | 1.313 | 0.99 | |
| 78_R | 140_S | 1.307 | 0.99 | |
| 122_I | 142_D | 1.306 | 0.99 | |
| 4_Y | 56_K | 1.296 | 0.99 | |
| 29_I | 253_H | 1.291 | 0.99 | |
| 38_A | 46_T | 1.271 | 0.99 | |
| 103_G | 137_P | 1.27 | 0.99 | |
| 4_Y | 31_H | 1.265 | 0.99 | |
| 45_N | 48_N | 1.257 | 0.99 | |
| 44_I | 48_N | 1.257 | 0.99 | |
| 50_F | 58_A | 1.255 | 0.99 | |
| 188_T | 191_G | 1.254 | 0.99 | |
| 243_A | 259_V | 1.246 | 0.98 | |
| 75_L | 80_A | 1.238 | 0.98 | |
| 8_G | 11_I | 1.205 | 0.98 | |
| 62_V | 189_S | 1.193 | 0.98 | |
| 138_L | 185_I | 1.191 | 0.98 | |
| 122_I | 138_L | 1.18 | 0.98 | |
| 69_F | 72_A | 1.18 | 0.98 | |
| 89_M | 92_E | 1.173 | 0.98 | |
| 11_I | 37_L | 1.17 | 0.97 | |
| 225_W | 229_R | 1.168 | 0.97 | |
| 22_Q | 26_Q | 1.162 | 0.97 | |
| 131_S | 187_A | 1.16 | 0.97 | |
| 208_I | 232_K | 1.159 | 0.97 | |
| 92_E | 97_L | 1.157 | 0.97 | |
| 18_F | 22_Q | 1.146 | 0.97 | |
| 72_A | 75_L | 1.141 | 0.97 | |
| 33_Y | 59_N | 1.134 | 0.97 | |
| 43_F | 68_A | 1.13 | 0.97 | |
| 5_A | 58_A | 1.129 | 0.97 | |
| 92_E | 95_R | 1.127 | 0.97 | |
| 136_L | 140_S | 1.125 | 0.97 | |
| 113_L | 235_A | 1.108 | 0.96 | |
| 66_E | 154_R | 1.106 | 0.96 | |
| 12_A | 37_L | 1.094 | 0.96 | |
| 81_L | 136_L | 1.093 | 0.96 | |
| 155_A | 159_A | 1.089 | 0.96 | |
| 227_E | 234_N | 1.087 | 0.96 | |
| 89_M | 99_D | 1.081 | 0.95 | |
| 5_A | 35_R | 1.078 | 0.95 | |
| 39_P | 42_D | 1.073 | 0.95 | |
| 20_H | 245_A | 1.07 | 0.95 | |
| 3_T | 32_P | 1.056 | 0.95 | |
| 50_F | 55_G | 1.052 | 0.95 | |
| 135_L | 162_F | 1.049 | 0.94 | |
| 11_I | 14_S | 1.049 | 0.94 | |
| 123_L | 184_I | 1.047 | 0.94 | |
| 21_Q | 32_P | 1.034 | 0.94 | |
| 7_F | 60_V | 1.032 | 0.94 | |
| 242_V | 246_A | 1.028 | 0.94 | |
| 75_L | 79_A | 1.021 | 0.93 | |
| 38_A | 64_F | 1.018 | 0.93 | |
| 129_G | 133_G | 1.013 | 0.93 | |
| 146_T | 181_F | 1.011 | 0.93 | |
| 149_N | 155_A | 1.01 | 0.93 | |
| 46_T | 49_A | 1.008 | 0.93 | |
| 187_A | 213_M | 1.005 | 0.93 | |
| 20_H | 87_T | 1.002 | 0.92 | |
| 36_V | 55_G | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1npyA | 4 | 0.9485 | 100 | 0.18 | Contact Map | 0.778 |
| 3t4eA | 2 | 0.9779 | 100 | 0.198 | Contact Map | 0.785 |
| 3phhA | 1 | 0.9338 | 100 | 0.221 | Contact Map | 0.772 |
| 3tnlA | 4 | 0.9669 | 100 | 0.231 | Contact Map | 0.821 |
| 2o7sA | 1 | 0.9743 | 100 | 0.239 | Contact Map | 0.772 |
| 3pwzA | 1 | 0.9816 | 100 | 0.24 | Contact Map | 0.764 |
| 3fbtA | 4 | 0.9669 | 100 | 0.252 | Contact Map | 0.835 |
| 3jyoA | 1 | 0.9743 | 100 | 0.257 | Contact Map | 0.778 |
| 2d5cA | 2 | 0.9559 | 100 | 0.261 | Contact Map | 0.767 |
| 3donA | 1 | 0.9669 | 100 | 0.274 | Contact Map | 0.762 |
Sequence Conservation (Image Generated using WebLogo v3)