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OPENSEQ.org

YDIB - Quinate/shikimate dehydrogenase
UniProt: P0A6D5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11234
Length: 288 (281)
Sequences: 2910
Seq/Len: 10.36

YDIB
Paralog alert: 0.33 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: AROE YDIB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
238_M 246_Q 5.018 1.00
15_Y 43_E 4.149 1.00
91_I 103_G 3.529 1.00
82_T 104_Y 3.439 1.00
229_V 241_L 3.004 1.00
268_T 274_D 2.919 1.00
80_E 100_Y 2.881 1.00
72_Q 137_T 2.663 1.00
80_E 102_R 2.652 1.00
25_M 263_G 2.587 1.00
4_T 36_P 2.485 1.00
265_E 268_T 2.471 1.00
78_V 103_G 2.463 1.00
109_T 265_E 2.443 1.00
96_N 101_L 2.388 1.00
74_A 94_I 2.374 1.00
78_V 94_I 2.366 1.00
128_V 197_A 2.364 1.00
126_T 150_E 2.164 1.00
14_A 67_S 2.162 1.00
240_K 244_Q 2.159 1.00
85_A 91_I 2.144 1.00
238_M 243_Q 2.138 1.00
165_L 169_Q 2.132 1.00
129_L 140_G 2.123 1.00
65_G 266_Q 2.098 1.00
74_A 78_V 2.059 1.00
73_L 76_E 2.05 1.00
111_H 230_T 2.044 1.00
75_C 81_L 1.998 1.00
242_L 252_T 1.997 1.00
64_T 94_I 1.971 1.00
95_V 269_L 1.969 1.00
139_I 232_C 1.948 1.00
78_V 91_I 1.942 1.00
15_Y 46_N 1.902 1.00
16_P 19_H 1.822 1.00
111_H 139_I 1.804 1.00
10_I 30_L 1.798 1.00
12_L 17_I 1.796 1.00
229_V 245_A 1.795 1.00
132_A 155_N 1.765 1.00
13_M 64_T 1.747 1.00
93_T 106_T 1.731 1.00
114_A 257_G 1.69 1.00
155_N 205_K 1.667 1.00
15_Y 70_N 1.637 1.00
81_L 103_G 1.619 1.00
83_P 86_K 1.594 1.00
114_A 230_T 1.578 1.00
137_T 170_R 1.571 1.00
82_T 102_R 1.566 1.00
113_R 261_W 1.564 1.00
55_G 58_A 1.56 1.00
128_V 154_F 1.558 1.00
267_F 271_T 1.558 1.00
135_A 232_C 1.557 1.00
88_V 108_G 1.556 1.00
127_M 148_L 1.556 1.00
70_N 73_L 1.555 1.00
15_Y 45_D 1.526 1.00
48_S 51_G 1.526 1.00
30_L 37_F 1.518 1.00
79_D 100_Y 1.516 1.00
11_G 42_F 1.507 1.00
94_I 101_L 1.493 1.00
207_G 233_V 1.489 1.00
111_H 201_T 1.478 1.00
84_A 104_Y 1.477 1.00
224_H 227_L 1.471 1.00
113_R 116_K 1.46 1.00
35_L 271_T 1.452 1.00
81_L 91_I 1.423 1.00
126_T 198_D 1.382 0.99
275_F 280_V 1.37 0.99
9_L 40_M 1.37 0.99
44_V 52_A 1.366 0.99
81_L 86_K 1.362 0.99
8_E 62_R 1.358 0.99
10_I 37_F 1.349 0.99
243_Q 247_Q 1.34 0.99
148_L 151_I 1.331 0.99
104_Y 269_L 1.323 0.99
126_T 152_K 1.301 0.99
56_L 64_T 1.278 0.99
72_Q 163_K 1.278 0.99
49_F 74_A 1.274 0.99
28_K 32_K 1.268 0.99
246_Q 252_T 1.26 0.99
75_C 78_V 1.252 0.99
204_T 207_G 1.244 0.98
261_W 277_L 1.241 0.98
14_A 17_I 1.232 0.98
50_P 54_E 1.227 0.98
45_D 48_S 1.222 0.98
162_D 166_A 1.22 0.98
78_V 81_L 1.208 0.98
51_G 54_E 1.204 0.98
128_V 200_L 1.191 0.98
17_I 43_E 1.186 0.98
24_E 28_K 1.184 0.98
97_D 102_R 1.183 0.98
39_Y 65_G 1.166 0.97
87_L 141_A 1.151 0.97
164_A 168_A 1.15 0.97
127_M 143_G 1.15 0.97
136_S 203_G 1.149 0.97
244_Q 248_A 1.142 0.97
97_D 100_Y 1.134 0.97
157_R 162_D 1.13 0.97
26_Q 263_G 1.127 0.97
18_R 43_E 1.117 0.96
11_G 64_T 1.114 0.96
17_I 20_S 1.11 0.96
228_L 253_I 1.107 0.96
10_I 62_R 1.104 0.96
203_G 232_C 1.103 0.96
68_M 205_K 1.1 0.96
134_G 138_A 1.1 0.96
260_L 264_A 1.096 0.96
95_V 104_Y 1.092 0.96
162_D 165_L 1.074 0.95
12_L 41_A 1.072 0.95
13_M 66_V 1.071 0.95
44_V 70_N 1.069 0.95
26_Q 93_T 1.064 0.95
56_L 61_M 1.057 0.95
52_A 55_G 1.057 0.95
108_G 142_Q 1.052 0.95
11_G 41_A 1.044 0.94
57_K 79_D 1.039 0.94
50_P 77_Y 1.038 0.94
223_L 229_V 1.034 0.94
81_L 85_A 1.019 0.93
94_I 103_G 1.012 0.93
9_L 59_L 1.011 0.93
152_K 197_A 1.008 0.93
27_N 38_T 1.005 0.93
9_L 38_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3t4eA211000.19Contact Map0.784
1npyA40.92011000.212Contact Map0.78
3tnlA40.98961000.226Contact Map0.818
2o7sA10.94441000.263Contact Map0.756
3phhA10.88541000.273Contact Map0.778
3fbtA40.9341000.281Contact Map0.831
3pwzA10.9341000.293Contact Map0.774
3jyoA10.95831000.293Contact Map0.769
2d5cA20.90621000.306Contact Map0.77
3donA10.92011000.318Contact Map0.768

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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