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GLPD - Aerobic glycerol-3-phosphate dehydrogenase
UniProt: P13035 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10394
Length: 501 (488)
Sequences: 1825
Seq/Len: 3.74
GLPD
Paralog alert: 0.40 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GLPA GLPD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
7_I 184_V 5.294 1.00
159_V 164_G 3.781 1.00
187_E 194_K 3.379 1.00
32_L 186_A 3.337 1.00
34_A 171_R 3.178 1.00
122_G 138_G 3.173 1.00
11_G 31_M 3.146 1.00
4_K 30_L 3.008 1.00
186_A 197_W 2.975 1.00
236_V 268_I 2.881 1.00
7_I 197_W 2.733 1.00
17_G 358_Y 2.731 1.00
37_L 168_T 2.703 1.00
290_N 294_N 2.681 1.00
7_I 32_L 2.61 1.00
16_A 156_A 2.608 1.00
7_I 199_A 2.602 1.00
9_I 213_F 2.515 1.00
185_E 194_K 2.51 1.00
171_R 189_I 2.495 1.00
171_R 187_E 2.494 1.00
203_V 369_L 2.45 1.00
460_V 466_A 2.45 1.00
32_L 172_A 2.427 1.00
19_A 29_V 2.34 1.00
7_I 30_L 2.318 1.00
286_E 306_R 2.31 1.00
190_D 461_R 2.281 1.00
4_K 165_E 2.213 1.00
35_Q 39_C 2.13 1.00
185_E 196_S 2.128 1.00
286_E 290_N 2.106 1.00
170_T 186_A 2.054 1.00
232_S 292_L 2.053 1.00
11_G 33_E 2.013 1.00
173_T 187_E 1.997 1.00
181_L 202_L 1.971 1.00
290_N 306_R 1.958 1.00
455_V 489_L 1.945 1.00
156_A 166_V 1.914 1.00
448_E 452_K 1.91 1.00
297_N 304_L 1.885 1.00
188_D 191_T 1.836 1.00
32_L 184_V 1.823 0.99
451_L 485_V 1.767 0.99
427_L 457_H 1.754 0.99
20_A 158_M 1.745 0.99
8_V 18_I 1.735 0.99
160_V 166_V 1.726 0.99
176_R 183_I 1.722 0.99
227_R 274_E 1.722 0.99
452_K 488_W 1.715 0.99
174_S 185_E 1.697 0.99
350_V 365_A 1.686 0.99
206_T 213_F 1.683 0.99
454_L 466_A 1.682 0.99
21_D 25_R 1.662 0.99
19_A 159_V 1.655 0.99
451_L 466_A 1.651 0.99
21_D 381_T 1.631 0.99
368_K 371_P 1.627 0.99
448_E 484_R 1.624 0.99
5_D 200_R 1.619 0.98
3_T 200_R 1.613 0.98
13_I 155_N 1.613 0.98
440_E 448_E 1.601 0.98
18_I 366_L 1.589 0.98
14_N 350_V 1.585 0.98
122_G 135_I 1.584 0.98
175_A 202_L 1.582 0.98
16_A 152_V 1.582 0.98
289_I 306_R 1.58 0.98
119_G 123_L 1.573 0.98
157_Q 424_N 1.566 0.98
173_T 185_E 1.564 0.98
32_L 197_W 1.56 0.98
6_L 201_G 1.56 0.98
245_A 248_L 1.557 0.98
19_A 164_G 1.554 0.98
18_I 203_V 1.524 0.98
466_A 489_L 1.509 0.97
86_R 142_S 1.505 0.97
381_T 388_G 1.504 0.97
424_N 453_Y 1.482 0.97
121_T 124_R 1.472 0.97
410_T 413_L 1.466 0.97
175_A 218_M 1.466 0.97
201_G 369_L 1.449 0.96
231_G 317_R 1.439 0.96
176_R 182_W 1.428 0.96
232_S 273_V 1.424 0.96
42_S 152_V 1.419 0.96
208_P 316_V 1.407 0.95
37_L 156_A 1.404 0.95
167_L 170_T 1.403 0.95
38_A 149_A 1.401 0.95
30_L 167_L 1.382 0.95
51_G 141_Y 1.381 0.95
124_R 127_A 1.377 0.95
293_L 306_R 1.376 0.95
219_H 340_D 1.376 0.95
34_A 280_K 1.375 0.95
156_A 160_V 1.366 0.94
18_I 205_A 1.364 0.94
463_A 486_S 1.358 0.94
467_L 482_Q 1.355 0.94
448_E 488_W 1.349 0.94
20_A 155_N 1.346 0.94
199_A 202_L 1.343 0.94
123_L 133_P 1.334 0.94
170_T 195_Y 1.328 0.93
24_G 162_K 1.328 0.93
244_Q 248_L 1.326 0.93
38_A 152_V 1.318 0.93
158_M 162_K 1.307 0.93
92_R 135_I 1.299 0.92
336_L 364_H 1.298 0.92
319_L 354_K 1.298 0.92
289_I 312_T 1.295 0.92
293_L 304_L 1.284 0.92
30_L 197_W 1.282 0.92
468_W 474_G 1.28 0.92
161_R 424_N 1.277 0.91
230_K 273_V 1.271 0.91
115_T 121_T 1.27 0.91
395_R 399_A 1.27 0.91
24_G 380_W 1.265 0.91
465_D 469_R 1.265 0.91
4_K 28_S 1.246 0.90
187_E 192_G 1.246 0.90
176_R 196_S 1.244 0.90
172_A 184_V 1.235 0.90
230_K 275_Y 1.23 0.89
230_K 285_E 1.227 0.89
62_R 66_E 1.226 0.89
478_N 481_Q 1.223 0.89
173_T 194_K 1.217 0.89
483_S 487_Q 1.217 0.89
319_L 332_R 1.216 0.89
284_I 312_T 1.215 0.88
14_N 361_L 1.212 0.88
293_L 297_N 1.2 0.88
83_F 419_R 1.198 0.88
118_P 121_T 1.196 0.87
284_I 289_I 1.195 0.87
123_L 131_L 1.194 0.87
271_T 317_R 1.192 0.87
420_T 471_T 1.192 0.87
41_T 208_P 1.191 0.87
440_E 484_R 1.179 0.86
48_L 145_W 1.178 0.86
22_A 366_L 1.177 0.86
40_A 44_A 1.173 0.86
336_L 365_A 1.158 0.85
21_D 363_E 1.156 0.85
454_L 460_V 1.156 0.85
170_T 197_W 1.155 0.85
332_R 354_K 1.152 0.85
64_V 68_L 1.151 0.85
21_D 379_A 1.148 0.84
74_L 151_L 1.147 0.84
155_N 358_Y 1.135 0.83
296_Y 302_K 1.132 0.83
235_V 311_W 1.131 0.83
297_N 303_Q 1.13 0.83
28_S 165_E 1.121 0.82
258_V 266_S 1.119 0.82
54_R 354_K 1.118 0.82
3_T 198_Q 1.11 0.82
117_L 122_G 1.107 0.81
12_G 15_G 1.101 0.81
6_L 22_A 1.098 0.81
367_E 379_A 1.098 0.81
74_L 82_A 1.093 0.80
6_L 29_V 1.092 0.80
214_F 349_S 1.091 0.80
156_A 168_T 1.09 0.80
390_A 423_S 1.087 0.80
45_S 148_D 1.082 0.79
446_F 471_T 1.079 0.79
19_A 156_A 1.066 0.78
252_D 270_T 1.064 0.78
367_E 371_P 1.06 0.77
237_P 265_F 1.057 0.77
233_H 272_D 1.054 0.77
431_N 434_T 1.053 0.77
147_D 420_T 1.052 0.76
55_Y 354_K 1.049 0.76
210_V 226_I 1.042 0.76
175_A 213_F 1.04 0.75
416_H 446_F 1.04 0.75
32_L 170_T 1.037 0.75
46_S 257_F 1.037 0.75
178_E 183_I 1.036 0.75
5_D 28_S 1.033 0.75
396_D 399_A 1.03 0.74
348_L 369_L 1.03 0.74
271_T 354_K 1.029 0.74
441_D 447_Y 1.027 0.74
66_E 70_E 1.027 0.74
420_T 450_E 1.026 0.74
231_G 271_T 1.022 0.74
235_V 267_I 1.02 0.73
4_K 197_W 1.019 0.73
35_Q 169_R 1.018 0.73
10_G 15_G 1.016 0.73
51_G 55_Y 1.015 0.73
486_S 490_V 1.013 0.73
23_A 164_G 1.011 0.72
334_Y 364_H 1.011 0.72
397_D 403_R 1.01 0.72
151_L 355_L 1.009 0.72
203_V 348_L 1.007 0.72
436_S 448_E 1.007 0.72
82_A 144_C 1.006 0.72
9_I 172_A 1.006 0.72
417_Y 428_L 1.006 0.72
205_A 350_V 1.003 0.72
58_H 329_A 1.003 0.72
348_L 365_A 1.001 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2qcuA20.9841000.348Contact Map0.781
2rghA10.97411000.368Contact Map0.796
3da1A10.981000.387Contact Map0.748
3dmeA20.69461000.717Contact Map0.693
3nycA10.71461000.731Contact Map0.701
3axbA10.73051000.751Contact Map0.7
1ryiA40.70461000.752Contact Map0.763
1y56B10.71861000.752Contact Map0.722
2gagB10.72061000.757Contact Map0.731
3znnA20.65271000.758Contact Map0.658
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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