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OPENSEQ.org
GLPA - Anaerobic glycerol-3-phosphate dehydrogenase subunit A
UniProt: P0A9C0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10391
Length: 542 (496)
Sequences: 1838
Seq/Len: 3.71
GLPA
Paralog alert: 0.40 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GLPA GLPD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
12_I 187_V 5.019 1.00
126_A 140_A 3.807 1.00
161_A 166_A 3.758 1.00
37_V 189_V 3.549 1.00
190_R 197_T 3.406 1.00
16_G 36_L 3.021 1.00
9_S 35_I 3.001 1.00
39_R 173_E 2.958 1.00
236_M 266_I 2.912 1.00
189_V 200_L 2.902 1.00
42_I 170_T 2.756 1.00
12_I 200_L 2.728 1.00
22_G 358_Y 2.643 1.00
289_D 293_R 2.636 1.00
37_V 174_V 2.627 1.00
449_E 486_F 2.617 1.00
12_I 202_A 2.575 1.00
12_I 37_V 2.563 1.00
14_I 216_I 2.553 1.00
493_Q 497_Q 2.417 1.00
173_E 190_R 2.407 1.00
188_R 197_T 2.378 1.00
206_V 369_V 2.309 1.00
173_E 192_H 2.302 1.00
12_I 35_I 2.282 1.00
232_S 291_L 2.279 1.00
24_A 34_V 2.277 1.00
21_A 158_M 2.266 1.00
193_L 454_N 2.244 1.00
9_S 167_V 2.209 1.00
285_A 304_K 2.208 1.00
40_H 44_T 2.188 1.00
285_A 289_D 2.169 1.00
448_V 483_L 2.096 1.00
123_P 127_R 2.068 1.00
172_H 189_V 2.058 1.00
188_R 199_A 1.993 1.00
490_T 493_Q 1.99 1.00
441_A 445_Q 1.954 1.00
16_G 38_E 1.948 1.00
158_M 168_I 1.94 1.00
184_V 205_V 1.934 1.00
175_T 190_R 1.932 1.00
13_I 23_I 1.915 1.00
445_Q 482_L 1.835 1.00
25_R 160_D 1.812 0.99
73_S 363_E 1.789 0.99
162_K 168_I 1.783 0.99
444_V 479_A 1.78 0.99
289_D 304_K 1.769 0.99
191_N 194_T 1.745 0.99
227_F 272_R 1.734 0.99
421_A 450_N 1.73 0.99
368_A 371_R 1.708 0.99
26_D 381_T 1.706 0.99
8_S 203_P 1.703 0.99
37_V 187_V 1.685 0.99
350_I 365_A 1.675 0.99
24_A 161_A 1.641 0.99
11_V 204_V 1.641 0.99
209_A 216_I 1.628 0.99
418_R 446_Y 1.628 0.99
37_V 200_L 1.623 0.98
178_I 186_G 1.612 0.98
26_D 30_R 1.58 0.98
10_D 203_P 1.574 0.98
21_A 154_T 1.556 0.98
172_H 198_Q 1.537 0.98
24_A 166_A 1.536 0.98
177_L 205_V 1.534 0.98
43_A 151_F 1.529 0.98
176_G 188_R 1.52 0.97
23_I 206_V 1.509 0.97
18_A 157_N 1.508 0.97
441_A 482_L 1.494 0.97
204_V 369_V 1.493 0.97
404_P 407_L 1.492 0.97
159_L 418_R 1.487 0.97
431_S 441_A 1.481 0.97
435_E 478_R 1.48 0.97
126_A 137_L 1.467 0.97
231_G 315_R 1.466 0.97
441_A 478_R 1.464 0.97
292_L 304_K 1.458 0.96
23_I 366_T 1.449 0.96
125_Q 128_I 1.423 0.96
160_D 164_H 1.414 0.96
178_I 185_C 1.412 0.96
232_S 271_L 1.408 0.95
435_E 441_A 1.405 0.95
211_I 314_V 1.399 0.95
127_R 135_P 1.392 0.95
19_T 350_I 1.391 0.95
296_E 302_M 1.388 0.95
414_R 463_T 1.375 0.95
39_R 279_D 1.371 0.95
35_I 169_L 1.367 0.94
56_S 143_V 1.364 0.94
288_V 304_K 1.361 0.94
174_V 187_V 1.352 0.94
455_S 497_Q 1.348 0.94
42_I 158_M 1.347 0.94
169_L 172_H 1.347 0.94
177_L 219_Y 1.346 0.94
47_T 154_T 1.326 0.93
127_R 133_V 1.325 0.93
190_R 195_G 1.325 0.93
25_R 157_N 1.323 0.93
230_K 273_I 1.319 0.93
257_L 264_S 1.311 0.93
35_I 200_L 1.307 0.92
106_T 109_R 1.305 0.92
292_L 302_M 1.305 0.92
230_K 271_L 1.303 0.92
460_R 466_G 1.296 0.92
43_A 154_T 1.294 0.92
29_L 380_T 1.281 0.91
29_L 164_H 1.28 0.91
414_R 443_E 1.279 0.91
335_L 364_W 1.275 0.91
122_D 125_Q 1.266 0.91
453_V 459_L 1.266 0.91
84_H 388_G 1.258 0.90
317_L 354_K 1.256 0.90
492_A 496_E 1.255 0.90
158_M 162_K 1.252 0.90
288_V 310_A 1.249 0.90
175_T 197_T 1.241 0.90
456_L 480_A 1.232 0.89
230_K 284_T 1.227 0.89
175_T 188_R 1.219 0.89
23_I 208_A 1.218 0.89
283_V 310_A 1.218 0.89
269_T 315_R 1.204 0.88
445_Q 485_R 1.196 0.87
121_I 126_A 1.196 0.87
283_V 288_V 1.195 0.87
102_S 106_T 1.195 0.87
202_A 205_V 1.193 0.87
8_S 201_H 1.185 0.87
9_S 33_R 1.183 0.87
92_L 140_A 1.181 0.86
180_E 201_H 1.179 0.86
26_D 379_C 1.178 0.86
447_A 453_V 1.171 0.86
70_E 364_W 1.171 0.86
477_C 481_G 1.169 0.86
119_E 125_Q 1.167 0.85
470_C 473_E 1.166 0.85
27_C 366_T 1.165 0.85
235_I 309_R 1.162 0.85
59_R 354_K 1.156 0.85
123_P 183_T 1.156 0.85
335_L 365_A 1.154 0.85
491_S 495_I 1.152 0.84
87_E 413_Y 1.148 0.84
26_D 363_E 1.144 0.84
45_G 49_R 1.144 0.84
213_G 226_M 1.144 0.84
208_A 350_I 1.142 0.84
46_A 211_I 1.138 0.83
411_A 440_T 1.134 0.83
410_S 439_V 1.127 0.83
86_V 146_G 1.122 0.82
157_N 358_Y 1.122 0.82
17_G 20_G 1.118 0.82
174_V 219_Y 1.117 0.82
19_T 361_M 1.116 0.82
169_L 198_Q 1.108 0.81
429_H 445_Q 1.106 0.81
78_L 153_L 1.104 0.81
124_Q 128_I 1.103 0.81
103_F 106_T 1.103 0.81
220_A 338_H 1.102 0.81
11_V 34_V 1.099 0.80
163_E 418_R 1.093 0.80
29_L 384_L 1.09 0.80
67_S 71_C 1.089 0.80
149_D 414_R 1.088 0.80
273_I 276_N 1.086 0.79
33_R 167_V 1.084 0.79
489_T 497_Q 1.084 0.79
11_V 27_C 1.083 0.79
499_S 502_L 1.081 0.79
91_G 94_I 1.079 0.79
390_Q 417_D 1.076 0.78
37_V 169_L 1.075 0.78
68_A 317_L 1.072 0.78
178_I 199_A 1.07 0.78
233_L 270_S 1.07 0.78
426_G 429_H 1.065 0.77
68_A 72_I 1.061 0.77
348_I 369_V 1.061 0.77
14_I 174_V 1.059 0.77
315_R 331_R 1.056 0.77
172_H 200_L 1.052 0.76
60_Y 354_K 1.051 0.76
25_R 387_P 1.048 0.76
240_I 257_L 1.046 0.76
106_T 255_D 1.045 0.76
90_N 94_I 1.044 0.76
204_V 373_L 1.041 0.75
102_S 105_A 1.04 0.75
381_T 388_G 1.04 0.75
481_G 494_S 1.04 0.75
111_C 118_A 1.039 0.75
15_G 20_G 1.034 0.75
153_L 355_L 1.034 0.75
411_A 422_W 1.032 0.74
106_T 110_A 1.029 0.74
217_A 349_T 1.025 0.74
273_I 314_V 1.025 0.74
50_N 150_P 1.022 0.73
348_I 365_A 1.022 0.73
37_V 172_H 1.021 0.73
231_G 269_T 1.02 0.73
429_H 432_L 1.016 0.73
238_H 262_T 1.014 0.72
158_M 170_T 1.012 0.72
331_R 354_K 1.01 0.72
40_H 171_A 1.009 0.72
369_V 373_L 1.008 0.72
439_V 463_T 1.006 0.72
18_A 47_T 1.004 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rghA10.93731000.421Contact Map0.796
3da1A10.95761000.437Contact Map0.73
2qcuA20.87641000.462Contact Map0.774
3dmeA20.64941000.735Contact Map0.694
3nycA10.67341000.742Contact Map0.701
1y56B10.68081000.763Contact Map0.732
1pj5A10.91511000.765Contact Map0.702
3axbA10.69191000.766Contact Map0.675
1ryiA40.66241000.766Contact Map0.757
2gagB10.68821000.768Contact Map0.722
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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