May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
TDCD - Propionate kinase
UniProt: P11868 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11172
Length: 402 (391)
Sequences: 1937
Seq/Len: 4.95
TDCD
Paralog alert: 0.42 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ACKA TDCD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
109_R 127_E 4.572 1.00
348_E 369_N 3.693 1.00
336_R 351_T 3.226 1.00
100_I 140_A 3.217 1.00
185_R 188_S 3.194 1.00
353_M 368_E 3.018 1.00
211_C 218_S 2.991 1.00
255_S 258_D 2.91 1.00
304_I 338_V 2.861 1.00
305_A 341_H 2.808 1.00
302_H 314_S 2.787 1.00
283_E 331_S 2.763 1.00
300_F 327_I 2.744 1.00
272_I 299_T 2.659 1.00
158_G 232_M 2.647 1.00
232_M 299_T 2.536 1.00
237_S 263_V 2.516 1.00
17_I 63_A 2.512 1.00
198_G 317_R 2.421 1.00
162_K 166_E 2.32 1.00
161_W 292_R 2.288 1.00
348_E 367_S 2.286 1.00
147_H 218_S 2.28 1.00
180_R 388_D 2.276 1.00
286_W 297_I 2.256 1.00
294_Q 298_K 2.245 1.00
261_R 266_E 2.245 1.00
229_E 239_D 2.237 1.00
102_D 130_Q 2.204 1.00
87_I 126_I 2.201 1.00
154_A 302_H 2.192 1.00
250_S 257_G 2.13 1.00
245_M 259_L 2.129 1.00
301_V 334_I 2.045 1.00
153_E 298_K 2.038 1.00
65_K 69_F 2.034 1.00
105_I 123_L 2.002 1.00
206_N 234_G 1.964 1.00
163_Y 262_V 1.957 1.00
162_K 266_E 1.957 1.00
93_I 107_N 1.904 1.00
105_I 130_Q 1.884 1.00
179_H 201_V 1.875 1.00
186_A 375_A 1.869 1.00
166_E 252_T 1.863 1.00
347_L 374_C 1.832 1.00
336_R 340_E 1.831 1.00
61_E 131_Q 1.795 1.00
284_K 288_E 1.795 1.00
321_I 347_L 1.788 1.00
275_L 290_H 1.768 1.00
87_I 140_A 1.765 1.00
283_E 333_L 1.745 1.00
97_S 388_D 1.729 1.00
84_G 385_I 1.724 1.00
367_S 370_A 1.72 1.00
99_I 137_T 1.702 1.00
249_A 259_L 1.674 0.99
364_I 373_I 1.668 0.99
364_I 375_A 1.663 0.99
89_H 174_F 1.654 0.99
228_L 263_V 1.649 0.99
232_M 272_I 1.641 0.99
185_R 362_E 1.641 0.99
285_A 293_A 1.632 0.99
159_L 237_S 1.627 0.99
88_A 115_A 1.615 0.99
192_L 197_S 1.613 0.99
222_S 311_H 1.607 0.99
337_L 340_E 1.594 0.99
193_A 196_D 1.585 0.99
106_D 109_R 1.582 0.99
108_I 140_A 1.571 0.99
99_I 392_L 1.57 0.99
27_C 387_L 1.563 0.99
96_E 391_H 1.559 0.99
201_V 213_V 1.547 0.99
201_V 211_C 1.546 0.99
261_R 265_K 1.54 0.99
312_A 344_V 1.539 0.99
248_V 252_T 1.534 0.99
152_P 291_E 1.532 0.99
186_A 322_I 1.515 0.99
87_I 122_N 1.496 0.98
98_A 104_V 1.472 0.98
285_A 290_H 1.468 0.98
160_P 271_G 1.462 0.98
380_N 383_K 1.462 0.98
201_V 322_I 1.46 0.98
273_S 276_S 1.458 0.98
59_S 62_G 1.455 0.98
297_I 337_L 1.449 0.98
266_E 270_L 1.447 0.98
106_D 110_R 1.443 0.98
40_S 277_S 1.434 0.98
384_M 388_D 1.431 0.98
107_N 110_R 1.429 0.98
199_L 320_G 1.429 0.98
279_L 297_I 1.426 0.98
192_L 196_D 1.41 0.97
204_L 327_I 1.41 0.97
200_V 318_L 1.404 0.97
208_A 300_F 1.402 0.97
190_L 320_G 1.4 0.97
250_S 260_E 1.398 0.97
269_L 279_L 1.388 0.97
198_G 214_R 1.387 0.97
318_L 321_I 1.376 0.97
186_A 190_L 1.365 0.97
190_L 375_A 1.363 0.97
156_L 299_T 1.356 0.97
286_W 294_Q 1.352 0.97
19_F 47_V 1.338 0.96
317_R 344_V 1.33 0.96
108_I 123_L 1.324 0.96
129_A 133_F 1.321 0.96
210_I 222_S 1.315 0.96
93_I 110_R 1.314 0.96
309_A 313_A 1.303 0.95
123_L 127_E 1.302 0.95
105_I 127_E 1.3 0.95
339_M 347_L 1.294 0.95
122_N 125_G 1.29 0.95
187_H 197_S 1.283 0.95
339_M 374_C 1.274 0.95
220_D 306_R 1.27 0.95
161_W 295_L 1.256 0.94
202_A 210_I 1.243 0.94
156_L 161_W 1.237 0.93
19_F 33_G 1.232 0.93
100_I 126_I 1.232 0.93
339_M 349_I 1.231 0.93
182_V 324_T 1.231 0.93
234_G 277_S 1.231 0.93
133_F 136_V 1.225 0.93
209_S 224_G 1.223 0.93
154_A 314_S 1.22 0.93
20_S 32_S 1.215 0.93
180_R 384_M 1.209 0.92
239_D 307_H 1.206 0.92
301_V 337_L 1.205 0.92
113_P 251_Q 1.205 0.92
153_E 302_H 1.201 0.92
202_A 321_I 1.193 0.92
163_Y 252_T 1.193 0.92
159_L 263_V 1.19 0.92
108_I 126_I 1.185 0.91
208_A 231_L 1.183 0.91
291_E 294_Q 1.182 0.91
196_D 215_N 1.173 0.91
366_S 374_C 1.168 0.91
161_W 165_E 1.164 0.90
186_A 377_I 1.154 0.90
275_L 282_L 1.146 0.90
154_A 219_V 1.143 0.89
305_A 313_A 1.139 0.89
35_A 67_I 1.136 0.89
181_Y 185_R 1.133 0.89
179_H 211_C 1.124 0.88
156_L 295_L 1.124 0.88
320_G 373_I 1.123 0.88
82_L 389_A 1.121 0.88
174_F 218_S 1.117 0.88
274_G 292_R 1.11 0.87
189_L 375_A 1.101 0.87
222_S 307_H 1.1 0.87
316_R 341_H 1.093 0.86
306_R 314_S 1.088 0.86
183_S 213_V 1.087 0.86
333_L 337_L 1.085 0.86
383_K 387_L 1.085 0.86
58_H 62_G 1.084 0.86
155_Y 164_Y 1.083 0.86
159_L 163_Y 1.078 0.85
240_V 244_A 1.078 0.85
312_A 318_L 1.074 0.85
35_A 57_H 1.067 0.85
249_A 256_L 1.057 0.84
283_E 334_I 1.057 0.84
126_I 140_A 1.056 0.84
87_I 108_I 1.056 0.84
200_V 308_I 1.046 0.83
12_C 17_I 1.045 0.83
210_I 308_I 1.037 0.82
348_E 371_R 1.032 0.82
83_I 138_Q 1.029 0.81
204_L 304_I 1.028 0.81
152_P 156_L 1.028 0.81
272_I 295_L 1.028 0.81
180_R 184_Q 1.022 0.81
285_A 289_G 1.021 0.81
178_S 379_T 1.008 0.80
92_S 164_Y 1.006 0.79
155_Y 170_R 1.004 0.79
185_R 189_L 1.002 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2e1zA111000.018Contact Map0.727
2iirA100.98011000.026Contact Map0.861
3sk3A20.97511000.035Contact Map0.659
1g99A20.98011000.038Contact Map0.829
4h0oA20.95771000.053Contact Map0.764
4h0pA20.991000.067Contact Map0.706
3khyA20.95021000.19Contact Map0.779
3r9pA20.94781000.329Contact Map0.645
4ijnA20.93531000.457Contact Map0.777
1sazA10.85321000.528Contact Map0.507
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0848 seconds.