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OPENSEQ.org
ACKA - Acetate kinase
UniProt: P0A6A3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10027
Length: 400 (394)
Sequences: 1923
Seq/Len: 4.88
ACKA
Paralog alert: 0.42 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ACKA TDCD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
114_K 132_E 4.575 1.00
355_E 376_G 3.742 1.00
192_E 195_K 3.244 1.00
343_E 358_H 3.228 1.00
105_I 147_A 3.175 1.00
360_R 375_E 2.993 1.00
218_S 225_C 2.971 1.00
310_L 345_S 2.915 1.00
262_S 265_A 2.905 1.00
311_A 348_K 2.822 1.00
290_E 338_A 2.805 1.00
308_H 320_L 2.774 1.00
306_Y 334_I 2.723 1.00
279_L 305_V 2.69 1.00
165_A 239_V 2.689 1.00
244_S 270_L 2.576 1.00
239_V 305_V 2.557 1.00
16_L 66_A 2.53 1.00
169_N 173_E 2.428 1.00
205_N 323_G 2.405 1.00
187_F 394_D 2.379 1.00
168_Y 298_D 2.31 1.00
355_E 374_K 2.298 1.00
154_H 225_C 2.266 1.00
92_I 131_I 2.232 1.00
268_K 273_E 2.23 1.00
300_K 304_D 2.228 1.00
293_Y 303_M 2.217 1.00
236_E 246_D 2.171 1.00
252_I 266_I 2.16 1.00
161_S 308_H 2.149 1.00
107_E 135_L 2.148 1.00
257_D 264_D 2.131 1.00
68_N 72_N 2.095 1.00
307_C 341_V 2.09 1.00
160_E 304_D 2.041 1.00
291_D 295_T 1.989 1.00
169_N 273_E 1.988 1.00
173_E 259_L 1.969 1.00
343_E 347_G 1.965 1.00
110_I 128_L 1.962 1.00
213_N 241_G 1.961 1.00
110_I 135_L 1.929 1.00
98_K 112_G 1.919 1.00
170_L 269_L 1.91 1.00
186_H 208_T 1.9 1.00
354_F 380_A 1.842 1.00
374_K 377_T 1.83 1.00
102_S 394_D 1.791 1.00
328_V 354_F 1.787 1.00
371_F 381_V 1.777 1.00
64_S 136_K 1.77 1.00
104_V 144_K 1.769 1.00
290_E 340_M 1.767 1.00
92_I 147_A 1.751 1.00
89_G 391_I 1.74 1.00
199_K 204_L 1.73 1.00
256_H 266_I 1.706 1.00
192_E 369_S 1.699 0.99
371_F 379_P 1.698 0.99
141_L 144_K 1.692 0.99
239_V 279_L 1.672 0.99
113_I 147_A 1.66 0.99
193_A 381_V 1.656 0.99
292_N 299_A 1.655 0.99
104_V 398_L 1.648 0.99
344_L 347_G 1.642 0.99
235_L 270_L 1.64 0.99
26_G 393_Q 1.633 0.99
93_V 120_A 1.632 0.99
166_L 244_S 1.629 0.99
229_S 317_Y 1.62 0.99
94_H 181_A 1.614 0.99
318_T 351_V 1.608 0.99
18_F 46_W 1.598 0.99
101_S 397_R 1.592 0.99
208_T 220_I 1.591 0.99
111_Q 114_K 1.582 0.99
193_A 329_V 1.54 0.99
193_A 197_L 1.534 0.99
159_E 297_E 1.531 0.99
92_I 127_H 1.53 0.99
197_L 327_A 1.53 0.99
207_I 325_L 1.526 0.99
268_K 272_K 1.526 0.99
199_K 203_E 1.521 0.99
390_V 394_D 1.52 0.99
255_L 259_L 1.5 0.98
62_A 65_E 1.498 0.98
167_P 278_G 1.493 0.98
200_P 203_E 1.481 0.98
208_T 218_S 1.48 0.98
280_T 283_T 1.477 0.98
208_T 329_V 1.463 0.98
197_L 381_V 1.46 0.98
112_G 115_D 1.456 0.98
303_M 344_L 1.45 0.98
215_G 306_Y 1.446 0.98
39_L 284_S 1.442 0.98
325_L 328_V 1.437 0.98
286_C 303_M 1.428 0.98
273_E 277_L 1.428 0.98
103_V 109_V 1.425 0.98
206_I 327_A 1.421 0.98
211_L 334_I 1.395 0.97
276_L 286_C 1.395 0.97
205_N 221_R 1.388 0.97
163_L 305_V 1.384 0.97
386_N 389_L 1.383 0.97
111_Q 115_D 1.37 0.97
257_D 267_N 1.367 0.97
315_G 319_A 1.364 0.97
323_G 351_V 1.348 0.96
34_A 70_I 1.338 0.96
98_K 115_D 1.33 0.96
127_H 130_G 1.329 0.96
128_L 132_E 1.325 0.96
217_V 229_S 1.317 0.96
134_A 138_F 1.313 0.96
110_I 132_E 1.309 0.95
113_I 128_L 1.304 0.95
346_L 380_A 1.297 0.95
346_L 354_F 1.291 0.95
187_F 390_V 1.274 0.95
346_L 356_V 1.271 0.94
105_I 131_I 1.261 0.94
227_D 312_K 1.255 0.94
168_Y 301_R 1.254 0.94
194_A 204_L 1.254 0.94
241_G 284_S 1.246 0.94
138_F 141_L 1.243 0.94
189_V 331_T 1.241 0.93
161_S 320_L 1.239 0.93
160_E 308_H 1.236 0.93
163_L 168_Y 1.236 0.93
216_S 231_G 1.225 0.93
373_N 380_A 1.222 0.93
215_G 238_L 1.221 0.93
209_C 217_V 1.219 0.93
203_E 222_N 1.219 0.93
307_C 344_L 1.218 0.93
166_L 270_L 1.214 0.92
293_Y 300_K 1.212 0.92
87_A 395_A 1.211 0.92
246_D 313_Y 1.206 0.92
168_Y 172_K 1.201 0.92
19_A 31_S 1.194 0.92
170_L 259_L 1.188 0.91
118_S 258_T 1.188 0.91
18_F 32_G 1.182 0.91
113_I 131_I 1.171 0.91
311_A 319_A 1.158 0.90
209_C 328_V 1.152 0.90
161_S 226_V 1.15 0.90
181_A 225_C 1.139 0.89
282_V 289_V 1.132 0.89
188_Y 192_E 1.128 0.88
61_A 65_E 1.126 0.88
229_S 313_Y 1.123 0.88
322_D 348_K 1.122 0.88
193_A 383_I 1.115 0.88
340_M 344_L 1.114 0.87
186_H 218_S 1.111 0.87
318_T 325_L 1.111 0.87
312_K 320_L 1.109 0.87
163_L 301_R 1.105 0.87
28_E 386_N 1.104 0.87
166_L 170_L 1.099 0.86
281_E 298_D 1.097 0.86
34_A 60_G 1.097 0.86
247_I 251_I 1.096 0.86
279_L 301_R 1.092 0.86
297_E 300_K 1.088 0.86
162_Y 171_Y 1.086 0.86
211_L 310_L 1.073 0.85
192_E 196_M 1.071 0.85
196_M 381_V 1.062 0.84
131_I 147_A 1.06 0.84
159_E 163_L 1.056 0.83
256_H 263_V 1.052 0.83
327_A 379_P 1.05 0.83
207_I 314_I 1.048 0.83
205_N 351_V 1.047 0.83
217_V 314_I 1.041 0.82
92_I 113_I 1.039 0.82
290_E 341_V 1.034 0.82
185_S 385_T 1.029 0.81
341_V 345_S 1.024 0.81
389_L 393_Q 1.023 0.81
355_E 378_R 1.022 0.81
11_C 16_L 1.019 0.80
162_Y 177_R 1.016 0.80
292_N 296_K 1.013 0.80
187_F 191_Q 1.011 0.80
178_R 236_E 1.004 0.79
105_I 109_V 1.002 0.79
134_A 145_N 1.001 0.79
16_L 70_I 1 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2iirA100.98251000.008Contact Map0.861
3sk3A20.99251000.009Contact Map0.652
2e1zA10.9751000.014Contact Map0.723
1g99A20.97751000.02Contact Map0.821
4h0oA20.961000.047Contact Map0.766
4h0pA20.98251000.048Contact Map0.708
3khyA20.95751000.186Contact Map0.779
3r9pA20.941000.331Contact Map0.64
4ijnA20.9351000.459Contact Map0.774
1sazA10.841000.534Contact Map0.492
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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