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OPENSEQ.org
INSH6 - Transposase InsH for insertion sequence element IS5H
UniProt: P0CE53 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG60032
Length: 338 (318)
Sequences: 1110
Seq/Len: 3.49
INSH6
Paralog alert: 0.48 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: INH10 INH11 INSH1 INSH2 INSH3 INSH4 INSH5 INSH6 INSH7 INSH8 INSH9
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
263_L 272_T 3.872 1.00
195_V 287_V 2.979 1.00
266_H 272_T 2.883 1.00
205_L 316_A 2.718 1.00
92_A 96_I 2.656 1.00
87_G 114_R 2.644 1.00
192_H 208_T 2.587 1.00
75_I 93_L 2.528 1.00
263_L 266_H 2.488 1.00
202_T 319_F 2.258 1.00
242_E 246_E 2.227 1.00
70_E 74_R 2.159 1.00
79_Q 89_M 2.122 1.00
244_L 249_V 2.031 1.00
52_V 132_Q 2.031 1.00
115_T 118_M 1.971 1.00
93_L 103_A 1.921 1.00
58_P 62_N 1.911 1.00
136_T 139_R 1.879 1.00
95_E 98_S 1.855 0.99
307_G 310_K 1.823 0.99
305_Y 310_K 1.822 0.99
208_T 217_Q 1.776 0.99
16_Q 19_F 1.767 0.99
195_V 290_P 1.727 0.99
179_T 190_K 1.714 0.99
191_A 315_L 1.696 0.99
294_I 318_L 1.605 0.98
157_T 295_K 1.592 0.98
201_L 326_R 1.582 0.98
152_T 194_G 1.568 0.98
86_D 121_R 1.568 0.98
115_T 119_N 1.535 0.97
205_L 319_F 1.531 0.97
88_A 92_A 1.502 0.97
204_S 224_G 1.496 0.97
189_M 308_L 1.496 0.97
17_L 20_A 1.479 0.96
131_R 135_K 1.474 0.96
160_E 302_K 1.462 0.96
75_I 117_I 1.45 0.96
244_L 253_I 1.446 0.96
176_M 189_M 1.424 0.95
231_A 253_I 1.418 0.95
72_M 120_F 1.397 0.95
156_A 190_K 1.389 0.94
322_A 326_R 1.381 0.94
281_A 284_R 1.376 0.94
194_G 204_S 1.357 0.93
280_K 284_R 1.357 0.93
272_T 275_N 1.353 0.93
218_L 240_Q 1.342 0.93
50_V 70_E 1.329 0.93
263_L 273_A 1.302 0.91
277_E 280_K 1.302 0.91
105_L 109_S 1.297 0.91
237_G 240_Q 1.293 0.91
291_F 295_K 1.283 0.91
90_E 117_I 1.273 0.90
296_R 301_V 1.271 0.90
102_F 187_F 1.266 0.90
152_T 203_H 1.262 0.90
179_T 210_A 1.261 0.90
269_K 272_T 1.248 0.89
41_E 74_R 1.247 0.89
100_R 111_L 1.247 0.89
160_E 186_H 1.246 0.89
183_N 186_H 1.237 0.88
78_M 82_Y 1.232 0.88
228_F 252_L 1.228 0.88
193_I 291_F 1.221 0.88
134_F 319_F 1.218 0.87
139_R 143_E 1.214 0.87
50_V 68_P 1.209 0.87
18_T 21_D 1.209 0.87
80_H 314_Q 1.205 0.87
219_G 243_E 1.205 0.87
31_T 38_S 1.203 0.87
263_L 269_K 1.203 0.87
137_I 141_L 1.202 0.86
133_L 320_T 1.196 0.86
74_R 103_A 1.185 0.85
193_I 290_P 1.183 0.85
259_K 263_L 1.173 0.85
305_Y 311_N 1.171 0.84
303_A 311_N 1.17 0.84
207_T 312_D 1.168 0.84
196_D 199_S 1.168 0.84
79_Q 92_A 1.166 0.84
192_H 221_L 1.166 0.84
212_E 217_Q 1.166 0.84
114_R 118_M 1.161 0.84
201_L 327_A 1.16 0.84
76_H 121_R 1.16 0.84
49_M 53_I 1.143 0.82
20_A 25_S 1.142 0.82
303_A 314_Q 1.13 0.81
154_V 194_G 1.129 0.81
192_H 235_Y 1.126 0.81
75_I 112_P 1.122 0.81
204_S 221_L 1.122 0.81
57_Y 123_L 1.114 0.80
266_H 269_K 1.107 0.80
35_I 38_S 1.104 0.79
141_L 327_A 1.103 0.79
223_H 243_E 1.102 0.79
86_D 120_F 1.1 0.79
54_E 59_K 1.099 0.79
90_E 113_D 1.097 0.79
78_M 99_M 1.097 0.79
22_S 26_S 1.091 0.78
24_F 27_K 1.09 0.78
156_A 192_H 1.085 0.78
19_F 26_S 1.08 0.77
158_I 179_T 1.077 0.77
321_L 325_F 1.07 0.76
234_G 237_G 1.068 0.76
300_F 318_L 1.068 0.76
72_M 116_T 1.064 0.76
286_K 289_H 1.064 0.76
298_F 325_F 1.064 0.76
113_D 121_R 1.062 0.76
36_F 40_M 1.058 0.75
75_I 89_M 1.057 0.75
223_H 226_E 1.054 0.75
154_V 218_L 1.049 0.74
202_T 205_L 1.047 0.74
326_R 329_Q 1.047 0.74
71_T 105_L 1.04 0.73
163_S 172_R 1.038 0.73
323_N 326_R 1.038 0.73
165_T 182_G 1.03 0.72
305_Y 314_Q 1.029 0.72
86_D 118_M 1.024 0.72
153_L 286_K 1.024 0.72
19_F 27_K 1.022 0.72
19_F 22_S 1.021 0.71
190_K 214_D 1.021 0.71
213_H 216_N 1.017 0.71
67_Y 109_S 1.016 0.71
153_L 197_A 1.015 0.71
38_S 101_L 1.015 0.71
92_A 99_M 1.01 0.70
156_A 179_T 1.01 0.70
223_H 247_V 1.01 0.70
35_I 95_E 1.009 0.70
206_V 312_D 1.007 0.70
47_Q 50_V 1.007 0.70
41_E 104_R 1.005 0.70
293_I 322_A 1.004 0.70
192_H 217_Q 1 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1musA10.78796.90.922Contact Map0.546
3hotA20.798847.40.961Contact Map0.616
2ql9A20.171640.20.963Contact Map0.034
3kksA20.399436.50.964Contact Map0.618
1bcoA10.49733.60.964Contact Map0.428
2dkoA10.1746310.965Contact Map0.053
1c6vA40.4201300.965Contact Map0.645
4jb8A10.177529.20.966Contact Map0.04
4fw1A20.43229.10.966Contact Map0.562
4dyqA20.390524.20.967Contact Map0.455
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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