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OPENSEQ.org
DEGP - Periplasmic serine endoprotease DegP
UniProt: P0C0V0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10463
Length: 474 (433)
Sequences: 1574
Seq/Len: 3.64
DEGP
Paralog alert: 0.52 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: DEGP DEGQ DEGS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
242_N 246_E 6.006 1.00
46_E 185_R 5.396 1.00
367_L 376_V 4.489 1.00
396_G 399_G 4.211 1.00
139_I 153_M 4.013 1.00
338_S 366_G 3.825 1.00
180_D 183_A 3.712 1.00
413_V 427_L 3.414 1.00
164_L 281_V 3.399 1.00
120_D 123_K 3.313 1.00
184_L 248_I 3.304 1.00
231_I 265_G 3.27 1.00
149_F 167_I 3.145 1.00
208_V 225_I 2.913 1.00
177_K 246_E 2.894 1.00
431_D 464_R 2.862 1.00
130_N 156_K 2.827 1.00
322_N 326_A 2.813 1.00
182_D 271_N 2.747 1.00
316_V 330_I 2.673 1.00
443_N 446_E 2.623 1.00
51_S 175_A 2.599 1.00
180_D 271_N 2.553 1.00
366_G 373_Q 2.544 1.00
118_I 143_L 2.543 1.00
316_V 336_I 2.486 1.00
364_T 375_N 2.461 1.00
127_V 273_V 2.433 1.00
125_Y 154_V 2.401 1.00
436_A 447_L 2.388 1.00
395_N 399_G 2.382 1.00
152_K 168_Q 2.369 1.00
340_N 357_M 2.357 1.00
330_I 365_L 2.31 1.00
127_V 277_T 2.309 1.00
42_A 185_R 2.28 1.00
40_S 188_D 2.276 1.00
117_V 247_L 2.272 1.00
330_I 367_L 2.203 1.00
339_L 354_V 2.163 1.00
126_V 167_I 2.093 1.00
339_L 357_M 2.075 1.00
48_V 176_I 2.059 1.00
119_I 277_T 2.057 1.00
43_P 185_R 2.055 1.00
42_A 188_D 2.016 1.00
117_V 239_A 2.005 1.00
362_K 377_N 2 1.00
337_T 368_L 1.996 1.00
125_Y 164_L 1.975 1.00
239_A 247_L 1.934 1.00
184_L 208_V 1.886 1.00
463_Q 466_D 1.862 1.00
176_I 241_V 1.83 0.99
51_S 176_I 1.819 0.99
367_L 374_V 1.791 0.99
278_S 282_E 1.791 0.99
138_V 150_D 1.777 0.99
399_G 403_S 1.769 0.99
362_K 379_E 1.764 0.99
291_L 378_L 1.713 0.99
364_T 377_N 1.692 0.99
256_A 259_G 1.687 0.99
250_I 273_V 1.68 0.99
151_A 165_I 1.678 0.99
291_L 323_S 1.674 0.99
208_V 248_I 1.661 0.99
302_L 306_M 1.614 0.98
58_E 138_V 1.604 0.98
125_Y 281_V 1.584 0.98
140_K 148_K 1.581 0.98
366_G 375_N 1.578 0.98
338_S 343_P 1.544 0.98
41_L 189_Y 1.535 0.98
464_R 469_I 1.534 0.98
48_V 193_I 1.531 0.97
396_G 400_A 1.525 0.97
321_P 326_A 1.523 0.97
442_K 446_E 1.497 0.97
229_A 265_G 1.493 0.97
118_I 173_L 1.485 0.97
44_M 191_V 1.474 0.97
330_I 376_V 1.474 0.97
396_G 401_E 1.46 0.96
233_R 257_P 1.459 0.96
338_S 341_G 1.445 0.96
189_Y 205_S 1.444 0.96
45_L 203_V 1.442 0.96
152_K 166_Q 1.424 0.96
57_V 113_L 1.423 0.96
145_D 149_F 1.4 0.95
337_T 366_G 1.392 0.95
117_V 241_V 1.382 0.95
297_E 347_F 1.374 0.94
162_I 250_I 1.372 0.94
73_Q 77_G 1.368 0.94
227_T 240_L 1.367 0.94
439_Q 450_V 1.362 0.94
54_S 112_A 1.359 0.94
181_S 271_N 1.352 0.94
337_T 373_Q 1.35 0.94
396_G 403_S 1.349 0.94
178_M 270_S 1.342 0.93
257_P 262_I 1.328 0.93
134_D 158_P 1.318 0.93
312_R 343_P 1.314 0.93
74_Q 78_D 1.302 0.92
127_V 270_S 1.289 0.92
446_E 449_K 1.285 0.91
176_I 247_L 1.285 0.91
125_Y 166_Q 1.277 0.91
123_K 166_Q 1.268 0.91
323_S 326_A 1.267 0.91
195_N 253_A 1.263 0.90
328_A 378_L 1.263 0.90
298_L 311_Q 1.244 0.90
441_V 446_E 1.243 0.89
283_Y 287_K 1.236 0.89
357_M 380_L 1.229 0.89
287_K 382_Q 1.229 0.89
287_K 380_L 1.228 0.89
219_E 222_E 1.227 0.89
441_V 450_V 1.225 0.89
273_V 277_T 1.223 0.88
178_M 273_V 1.211 0.88
48_V 241_V 1.207 0.88
331_K 374_V 1.203 0.87
296_T 317_S 1.203 0.87
298_L 308_V 1.201 0.87
199_L 202_T 1.194 0.87
55_I 139_I 1.193 0.87
203_V 207_I 1.188 0.86
74_Q 77_G 1.188 0.86
331_K 370_D 1.177 0.86
184_L 225_I 1.174 0.86
339_L 365_L 1.17 0.85
327_K 381_Q 1.156 0.84
178_M 274_K 1.154 0.84
222_E 253_A 1.148 0.84
411_V 441_V 1.146 0.84
401_E 415_N 1.146 0.84
218_A 224_F 1.146 0.84
195_N 200_G 1.143 0.83
121_A 172_N 1.139 0.83
69_P 73_Q 1.138 0.83
404_N 411_V 1.135 0.83
143_L 167_I 1.127 0.82
130_N 134_D 1.126 0.82
340_N 361_S 1.124 0.82
118_I 167_I 1.122 0.82
44_M 241_V 1.122 0.82
170_P 173_L 1.122 0.82
162_I 270_S 1.119 0.82
334_D 369_R 1.114 0.81
358_P 361_S 1.105 0.80
57_V 137_T 1.1 0.80
357_M 363_L 1.091 0.79
434_I 463_Q 1.084 0.79
54_S 113_L 1.082 0.79
218_A 253_A 1.079 0.78
445_A 449_K 1.078 0.78
190_T 248_I 1.077 0.78
160_S 276_L 1.067 0.77
120_D 125_Y 1.066 0.77
41_L 205_S 1.064 0.77
319_V 332_A 1.061 0.77
117_V 176_I 1.061 0.77
294_M 318_Q 1.06 0.77
179_A 270_S 1.058 0.76
446_E 450_V 1.051 0.76
427_L 462_I 1.046 0.75
53_V 126_V 1.042 0.75
55_I 141_V 1.041 0.75
56_N 113_L 1.041 0.75
320_L 323_S 1.036 0.74
312_R 345_S 1.033 0.74
164_L 277_T 1.028 0.73
399_G 402_M 1.025 0.73
142_Q 148_K 1.024 0.73
191_V 243_L 1.023 0.73
285_Q 382_Q 1.017 0.72
117_V 222_E 1.014 0.72
274_K 278_S 1.006 0.71
190_T 207_I 1.005 0.71
162_I 268_I 1.004 0.71
126_V 165_I 1.002 0.71
444_I 447_L 1.002 0.71
152_K 309_D 1.002 0.71
299_N 302_L 1 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ky9A20.94511000.363Contact Map0.631
3pv2A40.91141000.398Contact Map0.807
4a8cA120.89451000.43Contact Map0.063
3stjA120.72571000.515Contact Map0.799
4flnA30.90081000.547Contact Map0.737
1lcyA10.65191000.587Contact Map0.733
3qo6A30.70041000.589Contact Map0.809
4ic6A30.71941000.591Contact Map0.75
1te0A20.66461000.607Contact Map0.701
3numA10.67091000.614Contact Map0.697
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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