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OPENSEQ.org

DEGS - Serine endoprotease DegS
UniProt: P0AEE3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11652
Length: 355 (312)
Sequences: 4047
Seq/Len: 12.97

DEGS
Paralog alert: 0.60 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: DEGP DEGQ DEGS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
207_N 211_E 6.087 1.00
52_R 150_H 4.857 1.00
306_S 334_V 4.426 1.00
335_V 344_L 4.172 1.00
145_A 239_Q 4.076 1.00
95_K 121_S 3.301 1.00
308_D 325_I 3.276 1.00
145_A 148_V 3.158 1.00
330_V 345_Q 2.98 1.00
142_P 211_E 2.917 1.00
116_A 130_L 2.867 1.00
141_I 212_L 2.845 1.00
332_P 343_T 2.802 1.00
334_V 341_Q 2.742 1.00
104_I 118_L 2.699 1.00
147_R 239_Q 2.632 1.00
57_A 140_T 2.601 1.00
129_V 249_I 2.591 1.00
332_P 345_Q 2.537 1.00
196_I 233_G 2.531 1.00
117_L 133_N 2.49 1.00
114_F 132_I 2.364 1.00
92_I 241_A 2.347 1.00
173_I 190_L 2.271 1.00
83_V 204_A 2.254 1.00
306_S 309_N 2.244 1.00
83_V 215_I 2.231 1.00
83_V 212_L 2.094 1.00
143_I 238_F 2.054 1.00
290_D 294_A 2.051 1.00
305_I 336_M 1.962 1.00
259_I 346_V 1.961 1.00
105_I 113_V 1.96 1.00
335_V 342_L 1.957 1.00
334_V 343_T 1.95 1.00
92_I 245_M 1.948 1.00
48_N 153_D 1.909 1.00
204_A 212_L 1.883 1.00
83_V 141_I 1.881 1.00
330_V 347_T 1.866 1.00
284_V 298_I 1.864 1.00
103_Q 115_E 1.848 1.00
127_L 215_I 1.835 1.00
64_R 103_Q 1.831 1.00
306_S 311_P 1.827 1.00
302_D 337_R 1.815 1.00
154_V 170_Q 1.803 1.00
298_I 335_V 1.774 1.00
298_I 344_L 1.761 1.00
298_I 333_V 1.753 1.00
326_R 329_S 1.719 1.00
143_I 242_T 1.716 1.00
262_G 286_E 1.715 1.00
246_D 250_R 1.706 1.00
51_V 168_I 1.7 1.00
90_Y 119_V 1.698 1.00
141_I 206_V 1.696 1.00
313_I 317_E 1.685 1.00
149_P 213_M 1.683 1.00
84_I 108_L 1.659 1.00
325_I 348_I 1.625 1.00
284_V 304_I 1.562 1.00
247_K 251_D 1.547 1.00
84_I 138_L 1.536 1.00
85_M 245_M 1.531 1.00
46_S 153_D 1.529 1.00
307_V 325_I 1.504 1.00
305_I 341_Q 1.501 1.00
48_N 150_H 1.489 1.00
325_I 329_S 1.488 1.00
117_L 131_K 1.486 1.00
54_A 206_V 1.484 1.00
251_D 255_I 1.479 1.00
215_I 241_A 1.471 1.00
305_I 334_V 1.464 1.00
295_N 349_Q 1.452 1.00
265_E 315_A 1.444 1.00
149_P 190_L 1.43 1.00
59_V 91_I 1.425 1.00
258_Y 292_P 1.416 1.00
90_Y 249_I 1.404 0.99
253_R 350_E 1.402 0.99
108_L 114_F 1.399 0.99
242_T 246_D 1.392 0.99
90_Y 131_K 1.388 0.99
146_R 239_Q 1.387 0.99
134_A 138_L 1.383 0.99
47_Y 154_V 1.376 0.99
310_K 321_Q 1.363 0.99
257_G 327_P 1.361 0.99
122_D 125_T 1.351 0.99
144_N 238_F 1.341 0.99
192_T 205_L 1.335 0.99
86_D 90_Y 1.325 0.99
54_A 141_I 1.299 0.99
154_V 208_S 1.294 0.99
108_L 132_I 1.286 0.99
57_A 141_I 1.281 0.99
263_G 315_A 1.281 0.99
280_Q 311_P 1.27 0.99
149_P 173_I 1.268 0.99
255_I 350_E 1.266 0.99
337_R 342_L 1.256 0.99
59_V 82_G 1.252 0.99
82_G 91_I 1.251 0.99
50_A 206_V 1.244 0.98
155_V 173_I 1.229 0.98
91_I 132_I 1.219 0.98
61_V 130_L 1.208 0.98
258_Y 352_P 1.206 0.98
288_S 291_G 1.204 0.98
325_I 331_I 1.2 0.98
280_Q 313_I 1.194 0.98
156_L 208_S 1.188 0.98
267_A 270_H 1.187 0.98
105_I 115_E 1.177 0.98
177_G 188_N 1.164 0.97
157_A 205_L 1.163 0.97
49_L 150_H 1.153 0.97
287_V 300_V 1.148 0.97
90_Y 129_V 1.142 0.97
89_G 131_K 1.142 0.97
289_P 294_A 1.14 0.97
331_I 348_I 1.139 0.97
157_A 216_N 1.131 0.97
144_N 149_P 1.129 0.97
107_A 113_V 1.111 0.96
96_H 201_S 1.1 0.96
108_L 112_R 1.096 0.96
63_N 104_I 1.095 0.96
95_K 99_N 1.093 0.96
314_S 317_E 1.089 0.96
96_H 126_D 1.088 0.96
219_S 229_P 1.082 0.96
176_T 190_L 1.077 0.95
120_G 248_L 1.076 0.95
114_F 134_A 1.076 0.95
50_A 156_L 1.07 0.95
219_S 230_E 1.069 0.95
122_D 256_R 1.042 0.94
308_D 332_P 1.041 0.94
162_Y 220_F 1.031 0.94
336_M 339_D 1.03 0.94
143_I 212_L 1.018 0.93
62_Y 107_A 1.016 0.93
336_M 341_Q 1.014 0.93
168_I 172_I 1.013 0.93
92_I 238_F 1.011 0.93
162_Y 230_E 1.008 0.93
222_K 230_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ky9A20.90141000.348Contact Map0.698
3pv2A40.91551000.355Contact Map0.9
3stjA120.90141000.368Contact Map0.865
4a8cA120.90141000.383Contact Map0.104
1te0A20.89581000.414Contact Map0.804
3qo6A30.89861000.423Contact Map0.905
1lcyA10.87321000.424Contact Map0.813
4ic6A30.92961000.431Contact Map0.815
3numA10.87891000.442Contact Map0.741
4flnA30.92681000.465Contact Map0.808

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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