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OPENSEQ.org

ISCR - HTH-type transcriptional regulator IscR
UniProt: P0AGK8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13397
Length: 162 (135)
Sequences: 3147
Seq/Len: 23.31

ISCR
Paralog alert: 0.58 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ISCR NSRR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
77_G 122_N 4.519 1.00
127_G 131_N 2.975 1.00
92_C 104_C 2.964 1.00
72_S 127_G 2.916 1.00
56_S 66_L 2.863 1.00
112_D 120_F 2.815 1.00
14_M 54_L 2.775 1.00
16_D 34_R 2.692 1.00
10_A 83_V 2.69 1.00
69_K 78_E 2.575 1.00
14_M 126_L 2.36 1.00
17_V 55_V 2.274 1.00
77_G 81_S 2.245 1.00
92_C 98_C 2.244 1.00
81_S 122_N 2.206 1.00
116_R 120_F 2.121 1.00
52_N 82_A 2.064 1.00
98_C 104_C 2.002 1.00
70_D 73_S 1.822 1.00
13_A 46_F 1.81 1.00
18_A 130_V 1.656 1.00
69_K 73_S 1.609 1.00
113_L 117_L 1.608 1.00
112_D 124_I 1.593 1.00
50_R 57_S 1.579 1.00
116_R 119_G 1.553 1.00
25_P 66_L 1.549 1.00
37_I 42_L 1.546 1.00
120_F 123_N 1.519 1.00
75_A 125_T 1.49 1.00
24_G 30_D 1.428 1.00
7_G 80_I 1.397 0.99
69_K 74_I 1.37 0.99
8_R 12_T 1.361 0.99
81_S 118_T 1.359 0.99
29_A 39_L 1.335 0.99
29_A 33_E 1.305 0.99
78_E 81_S 1.286 0.99
58_V 66_L 1.28 0.99
80_I 121_L 1.272 0.99
75_A 78_E 1.258 0.99
16_D 26_V 1.251 0.99
13_A 42_L 1.246 0.98
113_L 116_R 1.227 0.98
113_L 121_L 1.202 0.98
47_S 51_K 1.198 0.98
119_G 123_N 1.194 0.98
56_S 68_G 1.191 0.98
115_D 119_G 1.19 0.98
54_L 74_I 1.156 0.97
28_L 46_F 1.151 0.97
6_K 44_Q 1.134 0.97
67_L 71_A 1.072 0.95
46_F 55_V 1.072 0.95
16_D 35_Q 1.062 0.95
4_T 84_D 1.06 0.95
77_G 118_T 1.039 0.94
19_L 130_V 1.03 0.94
9_Y 37_I 1.029 0.94
41_Y 45_L 1.017 0.93
120_F 124_I 1.009 0.93
14_M 79_V 1.009 0.93
112_D 132_N 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hf1A211000.223Contact Map0.718
1xd7A10.86421000.369Contact Map0.705
4hf0A20.87041000.377Contact Map0.732
3k69A10.90741000.409Contact Map0.671
1ylfA30.84571000.414Contact Map0.729
3lwfA40.86421000.421Contact Map0.82
3t8rA10.864299.90.46Contact Map0.741
2y75A60.790199.90.482Contact Map0.877
2jscA20.64298.20.802Contact Map0.508
3rkxA10.882797.30.839Contact Map0.471

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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