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NSRR - HTH-type transcriptional repressor NsrR
UniProt: P0AF63 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11212
Length: 141 (132)
Sequences: 3312
Seq/Len: 25.09

NSRR
Paralog alert: 0.62 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ISCR NSRR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
77_G 120_D 4.37 1.00
91_C 102_C 2.98 1.00
125_A 129_E 2.915 1.00
72_S 125_A 2.911 1.00
110_K 118_E 2.855 1.00
56_T 66_R 2.745 1.00
16_Y 34_V 2.727 1.00
14_L 54_Y 2.704 1.00
10_G 83_L 2.678 1.00
69_K 78_D 2.566 1.00
14_L 124_L 2.297 1.00
77_G 81_R 2.235 1.00
17_M 55_V 2.194 1.00
114_S 118_E 2.193 1.00
81_R 120_D 2.127 1.00
52_A 82_E 2.068 1.00
96_C 102_C 1.961 1.00
70_P 73_A 1.889 1.00
91_C 96_C 1.857 1.00
13_A 46_I 1.84 1.00
69_K 73_A 1.695 1.00
25_M 66_R 1.617 1.00
18_A 128_V 1.578 1.00
111_A 115_F 1.553 1.00
110_K 122_Y 1.522 1.00
114_S 117_T 1.519 1.00
75_R 123_T 1.493 1.00
50_S 57_A 1.489 1.00
37_V 42_M 1.488 1.00
24_R 30_E 1.475 1.00
118_E 121_N 1.452 1.00
69_K 74_I 1.436 1.00
29_S 39_R 1.401 0.99
81_R 116_L 1.371 0.99
16_Y 26_T 1.323 0.99
7_T 80_V 1.311 0.99
8_D 12_R 1.286 0.99
29_S 33_D 1.257 0.99
111_A 114_S 1.255 0.99
78_D 81_R 1.242 0.98
113_Q 117_T 1.231 0.98
13_A 42_M 1.231 0.98
58_V 66_R 1.227 0.98
75_R 78_D 1.222 0.98
111_A 119_L 1.22 0.98
56_T 68_G 1.218 0.98
47_N 51_R 1.184 0.98
6_F 44_K 1.176 0.98
54_Y 74_I 1.175 0.98
80_V 119_L 1.17 0.97
67_L 71_A 1.142 0.97
117_T 121_N 1.113 0.96
28_I 46_I 1.105 0.96
110_K 130_E 1.095 0.96
27_S 30_E 1.084 0.96
14_L 79_V 1.079 0.95
46_I 55_V 1.07 0.95
112_V 116_L 1.059 0.95
16_Y 20_L 1.027 0.94
19_S 128_V 1 0.92
20_L 24_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hf1A20.99291000.164Contact Map0.721
4hf0A20.98581000.22Contact Map0.742
1xd7A10.96451000.225Contact Map0.7
3k69A10.99291000.236Contact Map0.679
1ylfA30.95741000.256Contact Map0.725
3lwfA40.94331000.26Contact Map0.821
3t8rA10.943399.90.304Contact Map0.737
2y75A60.900799.90.343Contact Map0.871
2jscA20.730598.40.737Contact Map0.473
3rkxA10.900797.40.793Contact Map0.499

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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