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OPENSEQ.org

UBIA - 4-hydroxybenzoate octaprenyltransferase
UniProt: P0AGK1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11370
Length: 290 (280)
Sequences: 2665
Seq/Len: 9.52

UBIA
Paralog alert: 0.59 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: CYOE UBIA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_R 93_E 3.791 1.00
69_Y 93_E 3.507 1.00
79_K 82_A 3.176 1.00
62_A 104_V 3.037 1.00
69_Y 97_R 2.543 1.00
12_A 90_A 2.539 1.00
74_F 200_I 2.501 1.00
115_N 118_T 2.44 1.00
92_T 95_E 2.367 1.00
118_T 159_A 2.294 1.00
116_T 120_L 2.264 1.00
242_S 282_G 2.247 1.00
65_V 103_L 2.166 1.00
15_R 90_A 2.101 1.00
230_G 239_Y 1.928 1.00
71_D 137_R 1.915 1.00
9_K 95_E 1.904 1.00
94_K 98_A 1.887 1.00
33_L 53_V 1.874 1.00
178_L 221_G 1.865 1.00
76_G 87_P 1.807 1.00
13_F 95_E 1.803 1.00
236_G 286_S 1.801 1.00
120_L 124_A 1.764 1.00
189_M 211_D 1.736 1.00
135_M 138_Y 1.725 1.00
91_V 96_A 1.703 1.00
128_L 149_A 1.611 1.00
131_V 145_V 1.595 1.00
17_M 99_L 1.591 1.00
70_A 134_F 1.587 1.00
118_T 156_M 1.575 1.00
59_M 107_S 1.564 1.00
112_L 116_T 1.555 1.00
142_P 202_S 1.553 1.00
221_G 225_L 1.53 1.00
272_N 276_G 1.53 1.00
252_Y 256_L 1.522 1.00
117_M 159_A 1.502 1.00
58_L 106_I 1.458 1.00
196_V 205_I 1.426 0.99
271_N 275_V 1.425 0.99
86_L 91_V 1.42 0.99
25_A 57_W 1.415 0.99
101_V 105_L 1.39 0.99
175_A 226_M 1.387 0.99
210_Y 214_I 1.386 0.99
148_A 173_F 1.378 0.99
86_L 96_A 1.377 0.99
127_A 131_V 1.376 0.99
165_V 170_W 1.368 0.99
165_V 169_C 1.363 0.99
91_V 99_L 1.362 0.99
77_H 198_I 1.356 0.99
71_D 74_F 1.354 0.99
193_D 196_V 1.35 0.99
243_I 247_G 1.334 0.99
155_P 173_F 1.315 0.99
65_V 99_L 1.303 0.99
98_A 102_V 1.294 0.99
167_L 170_W 1.292 0.99
272_N 275_V 1.282 0.99
105_L 109_L 1.265 0.99
143_Q 185_T 1.264 0.99
51_V 110_L 1.263 0.99
17_M 103_L 1.261 0.98
115_N 121_L 1.253 0.98
11_L 15_R 1.25 0.98
74_F 137_R 1.249 0.98
246_A 275_V 1.244 0.98
151_G 180_A 1.242 0.98
267_K 270_M 1.232 0.98
192_R 196_V 1.231 0.98
66_V 101_V 1.231 0.98
59_M 122_S 1.217 0.98
69_Y 96_A 1.208 0.98
55_G 111_V 1.198 0.98
230_G 240_Y 1.192 0.98
140_H 201_K 1.192 0.98
147_G 181_V 1.189 0.98
36_L 161_V 1.187 0.98
280_F 284_A 1.18 0.97
61_A 103_L 1.178 0.97
135_M 145_V 1.175 0.97
151_G 176_N 1.166 0.97
14_H 17_M 1.165 0.97
112_L 119_I 1.163 0.97
227_A 231_E 1.161 0.97
150_F 180_A 1.157 0.97
191_D 195_D 1.155 0.97
192_R 209_Q 1.154 0.97
261_E 264_A 1.153 0.97
251_V 255_K 1.146 0.97
17_M 61_A 1.145 0.97
248_A 252_Y 1.136 0.97
51_V 113_T 1.136 0.97
192_R 205_I 1.135 0.97
65_V 91_V 1.134 0.96
249_L 252_Y 1.132 0.96
36_L 52_F 1.131 0.96
109_L 113_T 1.13 0.96
264_A 268_A 1.122 0.96
143_Q 180_A 1.12 0.96
187_Y 191_D 1.1 0.96
65_V 100_F 1.099 0.96
19_T 57_W 1.097 0.96
166_P 169_C 1.094 0.95
151_G 177_I 1.092 0.95
38_V 158_F 1.09 0.95
97_R 101_V 1.084 0.95
72_R 76_G 1.083 0.95
50_A 54_A 1.081 0.95
203_T 207_F 1.081 0.95
144_V 181_V 1.074 0.95
91_V 95_E 1.073 0.95
14_H 19_T 1.071 0.95
139_T 203_T 1.069 0.95
150_F 183_Y 1.059 0.94
69_Y 72_R 1.054 0.94
247_G 251_V 1.053 0.94
117_M 121_L 1.052 0.94
116_T 119_I 1.046 0.94
45_Q 48_I 1.043 0.94
29_L 32_T 1.041 0.94
104_V 126_L 1.038 0.93
39_A 161_V 1.034 0.93
13_F 91_V 1.033 0.93
235_L 286_S 1.029 0.93
266_F 270_M 1.028 0.93
248_A 251_V 1.023 0.93
187_Y 195_D 1.023 0.93
271_N 274_Y 1.022 0.93
13_F 16_L 1.017 0.93
154_I 176_N 1.017 0.93
95_E 98_A 1.015 0.92
231_E 234_G 1.014 0.92
71_D 200_I 1.013 0.92
143_Q 184_D 1.011 0.92
51_V 114_L 1.006 0.92
125_A 152_W 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2xq2A10.86911.40.964Contact Map0.174
4ainA30.327610.90.964Contact Map0.164
4c7rA30.37245.30.969Contact Map0.278
2m20A20.19315.10.969Contact Map0.076
2wswA10.31723.70.971Contact Map0.165
3dh4A40.77933.50.972Contact Map0.093
1qleD10.124130.972Contact Map0.303
2wdqC30.4312.90.973Contact Map0.372
1m56D20.12412.70.973Contact Map0.607
1rklA10.10692.60.973Contact Map0.26

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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