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OPENSEQ.org

CYOE - Protoheme IX farnesyltransferase
UniProt: P0AEA5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10182
Length: 296 (284)
Sequences: 2680
Seq/Len: 9.44

CYOE
Paralog alert: 0.60 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: CYOE UBIA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
62_R 83_P 3.942 1.00
59_Y 83_P 3.543 1.00
69_E 72_K 3.102 1.00
52_S 94_G 3.029 1.00
59_Y 87_L 2.651 1.00
102_W 107_P 2.47 1.00
64_I 193_I 2.438 1.00
5_Q 80_L 2.418 1.00
106_N 109_A 2.405 1.00
55_V 93_L 2.312 1.00
109_A 152_C 2.286 1.00
177_S 180_I 2.281 1.00
82_S 85_V 2.207 1.00
107_P 111_W 2.193 1.00
23_I 43_L 2.064 1.00
8_Q 80_L 2.023 1.00
230_G 282_D 1.947 1.00
203_S 207_N 1.901 1.00
61_D 130_R 1.883 1.00
236_V 278_M 1.879 1.00
111_W 115_M 1.835 1.00
223_L 233_Y 1.824 1.00
81_I 86_S 1.809 1.00
84_A 88_V 1.794 1.00
128_M 131_H 1.788 1.00
66_R 77_V 1.779 1.00
60_I 126_L 1.765 1.00
6_Y 85_V 1.762 1.00
171_L 214_I 1.738 1.00
2_M 85_V 1.667 1.00
135_G 195_V 1.611 1.00
15_I 47_S 1.608 1.00
109_A 149_I 1.603 1.00
176_H 180_I 1.596 1.00
250_R 253_K 1.548 1.00
123_V 138_I 1.531 1.00
49_V 97_G 1.522 1.00
81_I 89_Y 1.493 1.00
205_A 209_I 1.482 1.00
108_L 152_C 1.469 1.00
144_A 173_Q 1.466 1.00
186_K 189_Q 1.455 1.00
61_D 64_I 1.432 1.00
189_Q 198_V 1.429 0.99
76_L 81_I 1.417 0.99
10_T 89_Y 1.407 0.99
67_K 191_A 1.394 0.99
158_F 163_A 1.394 0.99
120_Y 142_S 1.387 0.99
224_S 234_L 1.382 0.99
88_V 92_L 1.355 0.99
76_L 86_S 1.348 0.99
64_I 130_R 1.339 0.99
48_L 96_A 1.337 0.99
4_K 8_Q 1.337 0.99
141_L 166_L 1.332 0.99
148_V 166_L 1.33 0.99
94_G 117_F 1.326 0.99
136_T 178_Y 1.322 0.99
91_T 95_I 1.319 0.99
214_I 218_V 1.309 0.99
158_F 162_A 1.297 0.99
41_Y 100_L 1.286 0.99
56_F 91_T 1.277 0.99
19_L 43_L 1.274 0.99
185_F 189_Q 1.271 0.99
59_Y 86_S 1.263 0.98
257_D 260_W 1.258 0.98
55_V 90_A 1.258 0.98
184_R 188_Y 1.255 0.98
144_A 169_F 1.254 0.98
229_A 279_M 1.249 0.98
118_V 122_G 1.239 0.98
55_V 89_Y 1.237 0.98
106_N 112_L 1.235 0.98
10_T 93_L 1.231 0.98
95_I 99_M 1.223 0.98
51_A 93_L 1.221 0.98
45_G 101_L 1.211 0.98
168_I 219_A 1.208 0.98
159_D 162_A 1.2 0.98
27_L 276_S 1.186 0.97
213_I 248_A 1.184 0.97
229_A 282_D 1.183 0.97
55_V 81_I 1.179 0.97
35_D 38_L 1.178 0.97
263_K 266_G 1.167 0.97
98_F 102_W 1.163 0.97
237_A 278_M 1.162 0.97
239_A 243_W 1.156 0.97
62_R 66_R 1.152 0.97
22_V 42_T 1.15 0.97
119_V 141_L 1.148 0.97
133_V 194_P 1.148 0.97
128_M 138_I 1.143 0.97
118_V 123_V 1.14 0.97
26_F 154_V 1.135 0.96
13_G 17_G 1.129 0.96
107_P 110_C 1.124 0.96
7_L 12_P 1.124 0.96
37_P 41_Y 1.121 0.96
19_L 23_I 1.12 0.96
87_L 91_T 1.114 0.96
28_L 151_Y 1.105 0.96
49_V 113_G 1.101 0.96
81_I 85_V 1.1 0.96
26_F 42_T 1.098 0.95
269_I 273_T 1.096 0.95
204_V 208_H 1.087 0.95
196_L 200_K 1.084 0.95
147_P 169_F 1.08 0.95
243_W 246_G 1.08 0.95
59_Y 76_L 1.079 0.95
143_G 173_Q 1.079 0.95
10_T 51_A 1.072 0.95
221_L 225_L 1.07 0.95
61_D 193_I 1.064 0.94
240_V 275_L 1.061 0.94
164_I 226_G 1.061 0.94
260_W 264_L 1.059 0.94
69_E 186_K 1.059 0.94
242_V 246_G 1.05 0.94
7_L 10_T 1.048 0.94
41_Y 105_A 1.048 0.94
101_L 113_G 1.048 0.94
9_V 81_I 1.048 0.94
268_S 272_I 1.042 0.94
160_S 163_A 1.04 0.93
29_A 154_V 1.039 0.93
59_Y 62_R 1.038 0.93
136_T 173_Q 1.034 0.93
132_S 196_L 1.028 0.93
6_Y 9_V 1.018 0.92
12_P 17_G 1.017 0.92
260_W 263_K 1.014 0.92
163_A 167_A 1.013 0.92
85_V 88_V 1.007 0.92
113_G 149_I 1.005 0.92
137_L 174_M 1.003 0.92
176_H 179_A 1.002 0.92
102_W 110_C 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2xq2A10.834528.10.956Contact Map0.15
3aa0C10.07093.60.971Contact Map0.496
3dh4A40.73652.90.972Contact Map0.098
1fftA20.28722.80.972Contact Map
1fglB10.08452.60.973Contact Map
3aaeX50.1252.60.973Contact Map0.279
3ze3A60.34122.60.973Contact Map0.47
3qe7A10.26352.40.973Contact Map0.381
2i7tA10.18922.10.974Contact Map0.493
3aa6C10.07771.90.975Contact Map0.419

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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