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OPENSEQ.org
YHHJ - Inner membrane transport permease YhhJ
UniProt: P0AGH1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11767
Length: 374 (368)
Sequences: 3097
Seq/Len: 8.42
YHHJ
Paralog alert: 0.78 [within 20: 0.45] - ratio of genomes with paralogs
Cluster includes: YBHR YBHS YHHJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
53_A 95_Y 5.797 1.00
86_M 98_A 3.865 1.00
82_T 85_E 3.855 1.00
104_N 108_D 3.783 1.00
262_G 330_L 3.353 1.00
6_N 219_E 3.09 1.00
108_D 113_R 3.07 1.00
54_I 67_V 2.908 1.00
56_D 63_S 2.706 1.00
14_E 224_K 2.701 1.00
201_E 224_K 2.699 1.00
12_I 16_R 2.669 1.00
10_L 223_A 2.648 1.00
89_G 95_Y 2.637 1.00
7_I 11_G 2.633 1.00
263_V 327_F 2.591 1.00
345_W 349_L 2.583 1.00
11_G 226_W 2.582 1.00
99_I 119_V 2.544 1.00
60_S 63_S 2.425 1.00
101_I 105_F 2.4 1.00
58_D 106_Q 2.355 1.00
53_A 80_M 2.342 1.00
55_A 86_M 2.324 1.00
88_A 92_A 2.212 1.00
349_L 353_A 2.17 1.00
70_F 136_I 2.137 1.00
268_F 355_G 2.136 1.00
56_D 60_S 2.11 1.00
104_N 107_R 2.1 1.00
53_A 89_G 2.087 1.00
89_G 94_R 2.006 1.00
56_D 59_Q 1.971 1.00
63_S 106_Q 1.965 1.00
319_M 325_T 1.945 1.00
13_K 201_E 1.933 1.00
265_L 352_M 1.916 1.00
333_A 339_A 1.896 1.00
201_E 206_T 1.881 1.00
80_M 89_G 1.878 1.00
90_L 98_A 1.861 1.00
87_D 91_D 1.811 1.00
279_T 365_R 1.805 1.00
237_G 260_M 1.797 1.00
40_A 248_L 1.789 1.00
353_A 357_A 1.766 1.00
308_R 319_M 1.759 1.00
313_Q 317_D 1.738 1.00
8_F 12_I 1.7 1.00
49_L 76_L 1.672 1.00
96_T 122_D 1.66 1.00
273_I 294_V 1.633 1.00
329_S 347_Q 1.623 1.00
320_L 326_H 1.611 1.00
57_M 100_N 1.606 1.00
216_T 219_E 1.595 1.00
7_I 226_W 1.588 1.00
95_Y 98_A 1.582 1.00
58_D 104_N 1.554 1.00
229_G 264_A 1.531 1.00
57_M 83_A 1.512 1.00
60_S 106_Q 1.507 1.00
262_G 348_F 1.467 0.99
210_L 220_I 1.456 0.99
350_T 354_I 1.456 0.99
97_F 132_G 1.449 0.99
316_Q 320_L 1.447 0.99
66_I 140_I 1.445 0.99
276_F 361_I 1.424 0.99
16_R 19_L 1.413 0.99
62_L 109_V 1.403 0.99
85_E 89_G 1.398 0.99
52_I 99_I 1.389 0.99
62_L 106_Q 1.387 0.99
58_D 101_I 1.381 0.99
83_A 87_D 1.342 0.99
7_I 222_M 1.337 0.99
81_I 85_E 1.335 0.99
262_G 334_I 1.328 0.99
85_E 88_A 1.328 0.99
311_M 316_Q 1.294 0.98
272_S 355_G 1.292 0.98
218_F 222_M 1.292 0.98
41_T 247_V 1.283 0.98
340_G 343_I 1.279 0.98
269_A 355_G 1.278 0.98
306_T 310_S 1.274 0.98
218_F 363_L 1.272 0.98
100_N 120_N 1.268 0.98
259_F 331_A 1.262 0.98
333_A 337_R 1.257 0.98
13_K 224_K 1.252 0.98
51_P 96_T 1.248 0.98
346_P 350_T 1.247 0.98
6_N 9_N 1.245 0.98
8_F 11_G 1.243 0.98
7_I 219_E 1.229 0.98
258_L 334_I 1.228 0.98
223_A 227_S 1.222 0.97
320_L 325_T 1.213 0.97
225_I 268_F 1.213 0.97
53_A 98_A 1.212 0.97
83_A 100_N 1.191 0.97
236_S 263_V 1.186 0.97
348_F 352_M 1.181 0.97
339_A 343_I 1.176 0.97
11_G 230_L 1.176 0.97
360_T 364_L 1.162 0.96
56_D 106_Q 1.161 0.96
83_A 98_A 1.159 0.96
283_S 286_Q 1.156 0.96
281_A 286_Q 1.145 0.96
326_H 347_Q 1.135 0.96
274_G 278_G 1.128 0.95
106_Q 110_L 1.117 0.95
119_V 136_I 1.115 0.95
314_M 317_D 1.112 0.95
21_D 24_M 1.111 0.95
86_M 89_G 1.109 0.95
90_L 93_G 1.106 0.95
257_P 261_L 1.1 0.94
63_S 101_I 1.099 0.94
52_I 97_F 1.098 0.94
101_I 117_I 1.093 0.94
243_M 247_V 1.084 0.94
221_M 363_L 1.083 0.94
342_E 345_W 1.079 0.94
285_P 289_L 1.07 0.93
97_F 136_I 1.064 0.93
269_A 358_F 1.049 0.92
352_M 356_G 1.038 0.92
265_L 355_G 1.037 0.92
265_L 351_L 1.036 0.92
274_G 303_G 1.035 0.92
72_R 75_F 1.03 0.92
258_L 340_G 1.028 0.91
46_S 173_P 1.026 0.91
364_L 368_K 1.025 0.91
184_N 324_T 1.024 0.91
65_R 68_N 1.023 0.91
10_L 215_I 1.018 0.91
361_I 364_L 1.017 0.91
201_E 210_L 1.016 0.91
54_I 77_P 1.014 0.91
242_L 246_G 1.01 0.90
266_S 270_T 1.01 0.90
15_L 227_S 1.009 0.90
258_L 348_F 1.006 0.90
219_E 223_A 1.004 0.90
269_A 354_I 1.003 0.90
312_P 315_V 1.002 0.90
202_R 207_V 1.002 0.90
330_L 351_L 1.002 0.90
183_I 298_L 1.001 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cniA10.395799.80.7Contact Map0.644
2p0sA20.352998.10.873Contact Map0.587
2j48A10.278117.60.959Contact Map0.493
3i42A10.2995170.959Contact Map0.557
1p6qA10.307515.60.96Contact Map0.486
1xhfA20.302115.30.96Contact Map0.638
2plnA10.310215.30.96Contact Map0.587
1zgzA40.2995140.961Contact Map0.712
2qzjA60.339612.80.961Contact Map0.664
3h5iA10.339612.70.961Contact Map0.522
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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