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OPENSEQ.org
YBHS - Inner membrane transport permease YbhS
UniProt: P0AFQ2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13675
Length: 377 (370)
Sequences: 3057
Seq/Len: 8.26
YBHS
Paralog alert: 0.78 [within 20: 0.45] - ratio of genomes with paralogs
Cluster includes: YBHR YBHS YHHJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
57_G 100_I 5.855 1.00
87_N 90_E 3.891 1.00
109_D 113_Q 3.855 1.00
91_L 103_L 3.797 1.00
267_I 336_T 3.282 1.00
10_R 225_E 3.116 1.00
116_R 119_A 2.951 1.00
60_L 67_A 2.758 1.00
18_E 230_K 2.736 1.00
94_K 100_I 2.693 1.00
16_V 20_R 2.693 1.00
113_Q 119_A 2.677 1.00
58_I 71_T 2.673 1.00
15_C 232_I 2.582 1.00
11_V 15_C 2.577 1.00
268_S 333_F 2.571 1.00
207_E 230_K 2.564 1.00
104_V 125_V 2.547 1.00
14_L 229_C 2.535 1.00
243_L 265_F 2.527 1.00
351_V 355_L 2.496 1.00
106_I 110_F 2.335 1.00
62_Q 111_A 2.279 1.00
64_S 67_A 2.265 1.00
74_M 142_V 2.261 1.00
93_A 97_A 2.215 1.00
355_L 359_A 2.188 1.00
59_L 91_L 2.143 1.00
57_G 94_K 2.094 1.00
109_D 112_E 2.067 1.00
207_E 212_T 1.994 1.00
60_L 64_S 1.973 1.00
60_L 63_R 1.968 1.00
325_T 331_R 1.948 1.00
92_I 96_Q 1.919 1.00
17_K 207_E 1.898 1.00
242_M 268_S 1.888 1.00
339_S 345_N 1.87 1.00
95_M 103_L 1.857 1.00
94_K 99_K 1.854 1.00
67_A 111_A 1.85 1.00
273_L 361_A 1.85 1.00
319_A 323_A 1.732 1.00
359_A 363_M 1.732 1.00
61_E 105_V 1.716 1.00
314_I 325_T 1.706 1.00
270_L 358_I 1.691 1.00
284_T 371_K 1.675 1.00
44_G 253_L 1.673 1.00
247_L 251_F 1.635 1.00
53_K 81_D 1.634 1.00
101_R 128_D 1.628 1.00
326_Y 332_Y 1.624 1.00
57_G 85_S 1.612 1.00
12_R 16_V 1.581 1.00
62_Q 109_D 1.558 1.00
235_Y 269_S 1.532 1.00
102_G 138_V 1.53 1.00
66_A 114_M 1.497 1.00
222_T 225_E 1.493 1.00
335_S 353_N 1.483 1.00
64_S 111_A 1.479 0.99
56_V 104_V 1.472 0.99
239_M 243_L 1.463 0.99
62_Q 106_I 1.45 0.99
70_F 146_W 1.442 0.99
264_L 337_L 1.438 0.99
11_V 232_I 1.424 0.99
100_I 103_L 1.411 0.99
267_I 354_V 1.411 0.99
61_E 88_R 1.401 0.99
356_F 360_S 1.384 0.99
86_D 90_E 1.373 0.99
317_M 322_R 1.366 0.99
322_R 326_Y 1.366 0.99
294_Q 297_L 1.361 0.99
90_E 94_K 1.354 0.99
238_G 272_L 1.354 0.99
216_L 226_L 1.344 0.99
11_V 228_L 1.323 0.99
85_S 94_K 1.322 0.99
346_I 349_V 1.32 0.99
278_M 300_A 1.314 0.99
57_G 103_L 1.312 0.99
66_A 111_A 1.306 0.98
45_Y 252_I 1.304 0.98
55_R 101_R 1.288 0.98
274_S 361_A 1.287 0.98
224_T 228_L 1.279 0.98
20_R 23_V 1.269 0.98
88_R 92_I 1.266 0.98
262_L 266_F 1.258 0.98
231_L 273_L 1.245 0.98
332_Y 353_N 1.24 0.98
17_K 230_K 1.233 0.98
11_V 225_E 1.231 0.97
105_V 126_I 1.226 0.97
248_V 252_I 1.225 0.97
281_L 367_L 1.222 0.97
10_R 13_A 1.218 0.97
312_F 316_S 1.213 0.97
60_L 111_A 1.209 0.97
56_V 102_G 1.209 0.97
236_F 240_L 1.207 0.97
326_Y 331_R 1.197 0.97
358_I 362_V 1.193 0.97
267_I 340_L 1.189 0.97
90_E 93_A 1.186 0.97
352_V 356_F 1.184 0.97
12_R 15_C 1.181 0.97
125_V 142_V 1.18 0.97
270_L 357_L 1.177 0.96
55_R 83_T 1.174 0.96
15_C 236_F 1.172 0.96
339_S 343_A 1.164 0.96
102_G 142_V 1.158 0.96
69_D 72_H 1.15 0.96
277_G 361_A 1.147 0.96
72_H 75_T 1.144 0.96
366_G 370_L 1.143 0.96
286_T 291_N 1.131 0.95
354_V 358_I 1.126 0.95
25_D 28_S 1.118 0.95
320_V 323_A 1.109 0.95
88_R 103_L 1.106 0.94
229_C 233_P 1.105 0.94
271_F 275_T 1.101 0.94
279_G 283_S 1.092 0.94
84_I 99_K 1.088 0.94
67_A 106_I 1.087 0.94
73_T 152_Q 1.08 0.94
227_L 369_W 1.075 0.93
292_A 296_A 1.07 0.93
95_M 98_G 1.067 0.93
192_M 271_F 1.065 0.93
224_T 369_W 1.063 0.93
345_N 349_V 1.054 0.92
91_L 94_K 1.053 0.92
14_L 221_I 1.051 0.92
263_I 340_L 1.049 0.92
274_S 364_F 1.047 0.92
106_I 123_I 1.042 0.92
17_K 209_E 1.035 0.92
189_T 330_A 1.032 0.91
62_Q 67_A 1.032 0.91
288_N 291_N 1.03 0.91
111_A 115_E 1.029 0.91
348_V 351_V 1.028 0.91
7_S 11_V 1.026 0.91
318_P 321_I 1.02 0.91
110_F 149_W 1.017 0.91
274_S 360_S 1.011 0.90
95_M 100_I 1.008 0.90
19_T 236_F 1.007 0.90
18_E 207_E 1.001 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cniA10.395299.90.709Contact Map0.657
2p0sA20.352898.30.869Contact Map0.59
2plnA10.3103170.961Contact Map0.593
3cg0A40.331614.80.962Contact Map0.489
3i42A10.299712.90.963Contact Map0.555
2pl1A10.289112.80.963Contact Map0.586
3hdgA40.334212.60.963Contact Map0.622
3h5iA10.334212.50.963Contact Map0.535
2lpmA10.30512.10.963Contact Map0.511
2a9oA10.2918120.963Contact Map0.532
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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