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SSTT - Serine/threonine transporter SstT
UniProt: P0AGE4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12732
Length: 414 (394)
Sequences: 2905
Seq/Len: 7.37
SSTT
Paralog alert: 0.71 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DCTA GLTP SSTT YDJN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
142_D 146_K 3.94 1.00
279_E 285_R 3.147 1.00
102_F 225_C 2.824 1.00
136_M 154_V 2.707 1.00
82_R 403_E 2.631 1.00
271_I 292_I 2.613 1.00
32_L 197_F 2.574 1.00
28_L 197_F 2.532 1.00
220_V 224_G 2.498 1.00
91_G 237_L 2.45 1.00
23_L 27_V 2.399 1.00
31_L 35_I 2.367 1.00
159_L 180_A 2.325 1.00
104_F 327_A 2.311 1.00
111_H 319_G 2.306 1.00
63_L 67_M 2.302 1.00
323_D 326_T 2.293 1.00
223_V 383_C 2.249 1.00
168_E 171_K 2.247 1.00
44_G 48_T 2.219 1.00
67_M 174_V 2.184 1.00
60_I 65_L 2.183 1.00
21_Q 190_R 2.144 1.00
57_V 188_V 2.111 1.00
46_L 198_G 2.091 1.00
284_D 405_D 2.078 1.00
183_F 186_K 2.031 1.00
59_P 65_L 2.022 1.00
283_L 397_A 2.016 1.00
257_S 277_L 2.014 1.00
25_G 197_F 1.969 1.00
276_A 280_K 1.963 1.00
78_K 82_R 1.932 1.00
49_L 137_V 1.926 1.00
63_L 156_A 1.909 1.00
284_D 400_C 1.898 1.00
134_M 137_V 1.866 1.00
87_L 395_F 1.846 1.00
32_L 36_S 1.817 1.00
64_M 177_M 1.816 1.00
138_S 142_D 1.815 1.00
381_D 385_T 1.815 1.00
213_W 217_Q 1.811 1.00
167_N 170_T 1.808 1.00
278_C 393_V 1.799 1.00
17_S 20_K 1.774 1.00
163_L 180_A 1.766 1.00
258_G 390_S 1.736 1.00
107_P 316_N 1.73 1.00
141_I 144_L 1.726 1.00
225_C 305_I 1.725 1.00
25_G 29_G 1.707 1.00
140_P 155_W 1.703 1.00
226_M 383_C 1.68 1.00
102_F 228_L 1.675 1.00
103_S 312_L 1.643 1.00
283_L 400_C 1.622 1.00
169_T 172_N 1.618 1.00
239_W 243_R 1.614 1.00
148_N 151_G 1.61 1.00
141_I 145_L 1.602 1.00
284_D 287_T 1.597 1.00
219_L 378_V 1.585 1.00
31_L 34_W 1.579 1.00
173_L 176_D 1.575 1.00
321_P 325_P 1.57 1.00
101_V 105_A 1.57 1.00
165_H 183_F 1.568 1.00
139_N 143_A 1.56 1.00
226_M 387_L 1.554 1.00
274_N 393_V 1.53 1.00
131_G 135_S 1.529 1.00
82_R 402_A 1.514 0.99
314_A 371_A 1.498 0.99
18_L 22_I 1.498 0.99
187_L 191_F 1.497 0.99
106_F 224_G 1.462 0.99
291_S 396_T 1.453 0.99
159_L 177_M 1.444 0.99
97_L 328_L 1.444 0.99
20_K 24_V 1.441 0.99
238_V 394_L 1.435 0.99
306_T 384_E 1.432 0.99
253_C 281_L 1.416 0.99
228_L 232_V 1.406 0.99
216_A 220_V 1.377 0.99
318_L 371_A 1.375 0.99
183_F 187_L 1.366 0.99
55_K 138_S 1.365 0.99
81_I 85_L 1.364 0.99
270_N 274_N 1.35 0.98
103_S 309_V 1.349 0.98
56_A 155_W 1.349 0.98
70_I 157_I 1.349 0.98
48_T 52_G 1.347 0.98
303_A 348_S 1.347 0.98
175_N 179_N 1.345 0.98
100_V 327_A 1.344 0.98
274_N 292_I 1.334 0.98
102_F 221_V 1.325 0.98
95_A 99_A 1.321 0.98
181_V 185_V 1.318 0.98
314_A 361_I 1.312 0.98
97_L 101_V 1.311 0.98
108_S 111_H 1.309 0.98
254_L 393_V 1.306 0.98
44_G 202_S 1.304 0.98
278_C 292_I 1.3 0.98
249_L 254_L 1.299 0.98
276_A 279_E 1.298 0.98
301_A 338_A 1.294 0.98
274_N 389_S 1.283 0.98
245_N 248_P 1.279 0.98
186_K 276_A 1.272 0.98
173_L 180_A 1.27 0.98
324_L 328_L 1.27 0.98
52_G 138_S 1.268 0.97
268_A 343_G 1.248 0.97
297_T 300_M 1.24 0.97
242_I 401_Q 1.24 0.97
72_N 175_N 1.23 0.97
64_M 181_V 1.225 0.97
57_V 185_V 1.217 0.97
217_Q 316_N 1.216 0.97
27_V 31_L 1.213 0.96
162_A 184_M 1.212 0.96
60_I 63_L 1.212 0.96
254_L 390_S 1.205 0.96
333_V 358_M 1.205 0.96
337_C 355_A 1.202 0.96
66_V 153_L 1.197 0.96
106_F 221_V 1.196 0.96
247_F 252_L 1.189 0.96
162_A 187_L 1.187 0.96
78_K 403_E 1.18 0.96
311_T 330_L 1.178 0.96
135_S 154_V 1.178 0.96
214_G 217_Q 1.175 0.96
100_V 104_F 1.169 0.95
261_A 385_T 1.165 0.95
170_T 176_D 1.162 0.95
222_L 380_Q 1.161 0.95
89_L 93_F 1.156 0.95
321_P 326_T 1.155 0.95
343_G 346_G 1.152 0.95
202_S 206_T 1.146 0.95
324_L 327_A 1.141 0.95
230_A 387_L 1.136 0.94
213_W 216_A 1.133 0.94
166_G 176_D 1.117 0.94
172_N 175_N 1.116 0.94
275_M 288_Y 1.113 0.94
94_S 98_A 1.112 0.93
328_L 332_V 1.108 0.93
65_L 69_S 1.108 0.93
307_I 352_I 1.107 0.93
64_M 68_A 1.101 0.93
345_A 381_D 1.099 0.93
287_T 405_D 1.096 0.93
97_L 331_S 1.089 0.93
165_H 187_L 1.088 0.92
110_L 122_P 1.074 0.92
157_I 161_F 1.071 0.92
181_V 188_V 1.07 0.92
223_V 227_L 1.061 0.91
232_V 236_L 1.061 0.91
201_S 205_A 1.061 0.91
22_I 26_L 1.058 0.91
296_A 300_M 1.058 0.91
169_T 179_N 1.058 0.91
172_N 176_D 1.057 0.91
21_Q 25_G 1.054 0.91
16_G 21_Q 1.052 0.91
49_L 154_V 1.041 0.90
265_R 381_D 1.037 0.90
300_M 392_D 1.036 0.90
93_F 97_L 1.035 0.90
60_I 66_V 1.024 0.89
248_P 252_L 1.024 0.89
249_L 393_V 1.023 0.89
18_L 21_Q 1.021 0.89
62_V 65_L 1.02 0.89
258_G 386_A 1.019 0.89
185_V 262_F 1.018 0.89
253_C 257_S 1.017 0.89
222_L 309_V 1.017 0.89
166_G 170_T 1.016 0.89
343_G 347_G 1.016 0.89
283_L 288_Y 1.014 0.89
400_C 404_D 1.014 0.89
217_Q 220_V 1.007 0.88
50_F 191_F 1.007 0.88
178_S 182_T 1.006 0.88
257_S 270_N 1.006 0.88
287_T 400_C 1.004 0.88
235_P 251_L 1.001 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nwlA30.96141000.127Contact Map0.67
2wr1A30.13776.90.977Contact Map0.227
3hzqA10.1866.50.977Contact Map0.347
2ooaA20.07975.10.978Contact Map0.408
1dulA10.05562.60.981Contact Map0.539
2l0eA10.07491.90.982Contact Map0.194
2ls4A10.0581.80.983Contact Map0.139
3bo0B10.12321.70.983Contact Map0.334
3hd7B20.0991.60.983Contact Map0.715
2m8rA10.0991.60.983Contact Map0.511
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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