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OPENSEQ.org
GLTP - Proton glutamate symport protein
UniProt: P21345 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10405
Length: 437 (415)
Sequences: 2942
Seq/Len: 7.09
GLTP
Paralog alert: 0.73 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: DCTA GLTP SSTT YDJN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
153_A 157_K 3.894 1.00
146_L 165_F 3.165 1.00
292_E 298_V 3.153 1.00
83_K 412_E 3.066 1.00
183_E 187_T 2.902 1.00
180_T 183_E 2.902 1.00
104_N 340_E 2.893 1.00
102_L 240_A 2.842 1.00
284_L 305_V 2.678 1.00
47_I 147_V 2.652 1.00
91_I 252_V 2.576 1.00
18_L 212_F 2.541 1.00
13_L 17_V 2.486 1.00
184_P 191_S 2.48 1.00
22_L 212_F 2.472 1.00
21_L 25_Y 2.437 1.00
185_L 188_V 2.376 1.00
297_P 414_K 2.339 1.00
336_S 339_Q 2.332 1.00
61_I 167_S 2.331 1.00
61_I 65_V 2.284 1.00
198_K 201_H 2.273 1.00
107_Q 110_A 2.244 1.00
55_I 203_V 2.243 1.00
170_F 195_T 2.238 1.00
235_L 239_F 2.228 1.00
410_K 417_R 2.171 1.00
65_V 189_F 2.138 1.00
62_S 192_I 2.124 1.00
11_Q 205_R 2.098 1.00
44_A 213_A 2.09 1.00
141_G 145_S 2.072 1.00
87_Y 404_A 2.038 1.00
238_H 392_A 2.008 1.00
42_S 46_D 2 1.00
270_E 290_K 1.997 1.00
289_E 293_A 1.957 1.00
103_A 325_I 1.942 1.00
15_A 212_F 1.939 1.00
296_A 406_L 1.937 1.00
108_P 329_Q 1.892 1.00
297_P 409_A 1.853 1.00
7_S 10_W 1.844 1.00
386_D 393_R 1.836 1.00
151_I 166_F 1.827 1.00
101_T 105_V 1.805 1.00
234_V 385_V 1.792 1.00
228_W 232_K 1.79 1.00
327_I 378_G 1.788 1.00
106_F 236_L 1.774 1.00
82_A 86_I 1.763 1.00
390_D 394_T 1.755 1.00
79_R 412_E 1.754 1.00
179_A 182_R 1.751 1.00
185_L 191_S 1.737 1.00
102_L 243_F 1.731 1.00
271_L 399_V 1.727 1.00
149_T 153_A 1.721 1.00
174_L 195_T 1.718 1.00
79_R 83_K 1.693 1.00
22_L 26_L 1.686 1.00
240_A 318_L 1.685 1.00
83_K 411_W 1.647 1.00
62_S 196_M 1.64 1.00
102_L 236_L 1.635 1.00
185_L 195_T 1.632 1.00
159_E 162_P 1.631 1.00
103_A 322_I 1.59 1.00
331_Y 378_G 1.586 1.00
291_M 402_A 1.585 1.00
15_A 19_G 1.575 1.00
97_I 341_I 1.573 1.00
241_I 392_A 1.569 1.00
297_P 300_I 1.541 0.99
152_V 155_M 1.537 0.99
334_D 338_W 1.531 0.99
152_V 156_A 1.521 0.99
188_V 191_S 1.521 0.99
202_M 206_Y 1.514 0.99
231_A 235_L 1.51 0.99
296_A 409_A 1.508 0.99
70_G 190_R 1.495 0.99
97_I 101_T 1.491 0.99
106_F 239_F 1.485 0.99
177_L 182_R 1.467 0.99
241_I 396_L 1.459 0.99
170_F 192_I 1.449 0.99
21_L 24_S 1.441 0.99
173_G 202_M 1.438 0.99
243_F 247_V 1.435 0.99
53_K 149_T 1.434 0.99
287_I 402_A 1.424 0.99
319_Y 393_R 1.421 0.99
100_I 340_E 1.386 0.99
337_I 341_I 1.386 0.99
86_I 90_V 1.372 0.99
176_S 198_K 1.361 0.98
184_P 187_T 1.359 0.98
316_S 361_S 1.357 0.98
319_Y 386_D 1.355 0.98
147_V 165_F 1.355 0.98
266_I 294_Y 1.347 0.98
283_V 287_I 1.344 0.98
287_I 305_V 1.34 0.98
304_V 405_V 1.339 0.98
68_I 168_V 1.319 0.98
10_W 14_F 1.312 0.98
267_L 402_A 1.311 0.98
8_L 12_I 1.305 0.98
47_I 144_L 1.299 0.98
327_I 374_I 1.299 0.98
196_M 200_T 1.288 0.98
314_D 351_S 1.285 0.98
17_V 21_L 1.281 0.97
46_D 50_H 1.268 0.97
54_M 166_F 1.268 0.97
247_V 251_I 1.267 0.97
278_A 387_R 1.263 0.97
69_A 186_V 1.254 0.97
50_H 149_T 1.25 0.97
281_E 356_G 1.249 0.97
310_S 313_L 1.247 0.97
416_D 419_K 1.246 0.97
228_W 231_A 1.245 0.97
173_G 199_V 1.244 0.97
42_S 217_V 1.23 0.97
261_W 265_R 1.227 0.96
258_L 415_F 1.221 0.96
252_V 407_V 1.215 0.96
291_M 305_V 1.212 0.96
190_R 194_E 1.206 0.96
145_S 159_E 1.202 0.96
245_A 396_L 1.196 0.96
61_I 155_M 1.184 0.95
267_L 399_V 1.179 0.95
415_F 420_A 1.176 0.95
55_I 200_T 1.176 0.95
409_A 415_F 1.175 0.95
181_H 194_E 1.173 0.95
253_A 403_L 1.173 0.95
263_L 267_L 1.172 0.95
188_V 195_T 1.169 0.95
356_G 359_G 1.167 0.95
259_S 262_I 1.158 0.95
254_R 259_S 1.152 0.94
232_K 329_Q 1.151 0.94
253_A 258_L 1.148 0.94
287_I 398_V 1.142 0.94
94_V 98_L 1.133 0.94
201_H 289_E 1.133 0.94
274_A 394_T 1.127 0.94
350_T 368_T 1.121 0.93
113_D 332_G 1.118 0.93
97_I 344_V 1.115 0.93
263_L 402_A 1.112 0.93
217_V 221_N 1.111 0.93
150_N 154_S 1.106 0.93
270_E 283_V 1.106 0.93
229_P 232_K 1.096 0.92
182_R 191_S 1.096 0.92
288_I 301_T 1.094 0.92
409_A 413_H 1.094 0.92
356_G 360_V 1.089 0.92
271_L 395_A 1.084 0.92
84_T 304_V 1.084 0.92
262_I 265_R 1.082 0.92
64_L 164_I 1.081 0.92
362_F 383_A 1.078 0.92
196_M 203_V 1.075 0.91
334_D 339_Q 1.073 0.91
232_K 235_L 1.069 0.91
320_Q 365_L 1.069 0.91
90_V 94_V 1.062 0.91
337_I 340_E 1.061 0.91
237_V 322_I 1.061 0.91
6_F 11_Q 1.06 0.91
358_P 390_D 1.058 0.90
91_I 314_D 1.056 0.90
324_A 343_L 1.054 0.90
313_L 401_N 1.054 0.90
176_S 202_M 1.048 0.90
76_Q 414_K 1.042 0.90
198_K 202_M 1.042 0.90
266_I 290_K 1.04 0.89
266_I 270_E 1.038 0.89
309_Y 313_L 1.035 0.89
168_V 172_L 1.035 0.89
237_V 389_L 1.034 0.89
62_S 66_V 1.031 0.89
57_V 163_I 1.03 0.89
47_I 51_L 1.03 0.89
341_I 345_L 1.028 0.89
323_A 386_D 1.024 0.88
273_L 283_V 1.022 0.88
188_V 192_I 1.021 0.88
253_A 257_G 1.014 0.88
296_A 301_T 1.014 0.88
47_I 165_F 1.012 0.88
311_F 352_K 1.012 0.88
77_L 172_L 1.011 0.88
254_R 257_G 1.01 0.88
187_T 190_R 1.009 0.87
48_F 206_Y 1.005 0.87
174_L 185_L 1.002 0.87
346_T 371_S 1.002 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nwlA30.92681000.121Contact Map0.734
2oxlA20.14197.90.977Contact Map0.293
2jmkA10.12816.10.978Contact Map0.455
2ywxA10.31584.30.98Contact Map0.109
1o4vA10.36163.60.981Contact Map0.131
3hzqA10.17163.30.981Contact Map0.462
2ls4A10.05493.10.981Contact Map0.183
1p5sA10.16252.90.982Contact Map0.379
3orsA80.33412.90.982Contact Map0.226
3kuuA40.35012.80.982Contact Map0.168
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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