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TRKH - Trk system potassium uptake protein TrkH
UniProt: P0AFZ7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11021
Length: 483 (483)
Sequences: 2198
Seq/Len: 4.55
TRKH
Paralog alert: 0.41 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: TRKG TRKH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
345_G 351_G 5.874 1.00
100_D 455_K 4.05 1.00
411_S 461_N 4.027 1.00
243_A 309_F 3.957 1.00
200_L 242_I 3.509 1.00
197_A 211_I 3.21 1.00
99_T 456_W 3.178 1.00
346_C 356_V 3.158 1.00
226_H 232_Y 2.918 1.00
196_C 245_F 2.834 1.00
418_T 454_A 2.816 1.00
247_L 281_Q 2.656 1.00
414_A 457_I 2.538 1.00
415_I 454_A 2.536 1.00
213_H 224_S 2.483 1.00
412_M 426_F 2.398 1.00
325_S 328_R 2.367 1.00
115_T 119_G 2.333 1.00
431_A 447_F 2.319 1.00
239_N 307_Q 2.282 1.00
203_A 241_I 2.28 1.00
421_D 424_S 2.275 1.00
414_A 453_V 2.242 1.00
287_I 336_L 2.238 1.00
216_A 321_F 2.203 1.00
132_Q 212_G 2.187 1.00
250_G 277_F 2.169 1.00
135_Q 216_A 2.1 1.00
102_F 459_I 2.088 1.00
118_V 121_D 2.03 1.00
315_M 337_L 2.025 1.00
136_W 193_T 2.016 1.00
99_T 459_I 2.016 1.00
203_A 237_T 2.011 1.00
199_A 241_I 2.008 1.00
289_T 293_W 1.991 1.00
239_N 306_N 1.98 1.00
228_A 232_Y 1.953 1.00
362_L 401_F 1.943 1.00
361_L 389_L 1.891 1.00
46_A 83_V 1.881 1.00
239_N 323_T 1.876 1.00
224_S 227_D 1.865 1.00
97_T 100_D 1.85 1.00
11_G 50_G 1.844 1.00
411_S 457_I 1.814 1.00
311_Q 323_T 1.806 1.00
99_T 452_P 1.795 1.00
281_Q 309_F 1.793 1.00
218_I 249_S 1.754 1.00
205_M 238_I 1.748 1.00
408_F 430_V 1.743 1.00
288_C 333_L 1.718 0.99
237_T 241_I 1.715 0.99
312_V 315_M 1.703 0.99
243_A 313_V 1.688 0.99
96_L 122_S 1.688 0.99
22_I 43_F 1.687 0.99
285_V 309_F 1.686 0.99
418_T 453_V 1.684 0.99
192_L 248_I 1.676 0.99
342_F 408_F 1.673 0.99
247_L 313_V 1.667 0.99
281_Q 316_A 1.66 0.99
339_C 343_I 1.641 0.99
284_L 340_S 1.637 0.99
424_S 440_L 1.618 0.99
18_S 47_L 1.618 0.99
201_W 207_A 1.616 0.99
197_A 207_A 1.615 0.99
404_Y 433_L 1.612 0.99
99_T 455_K 1.606 0.99
408_F 433_L 1.606 0.99
334_P 440_L 1.604 0.99
199_A 237_T 1.592 0.99
338_L 430_V 1.584 0.99
114_A 447_F 1.564 0.99
27_V 129_F 1.555 0.99
212_G 225_T 1.554 0.99
230_I 242_I 1.549 0.99
318_T 436_L 1.547 0.99
106_F 459_I 1.541 0.99
240_T 244_I 1.527 0.98
284_L 312_V 1.525 0.98
226_H 233_F 1.517 0.98
127_I 131_R 1.514 0.98
288_C 337_L 1.51 0.98
196_C 200_L 1.507 0.98
217_T 321_F 1.503 0.98
213_H 225_T 1.486 0.98
25_G 43_F 1.484 0.98
250_G 317_T 1.482 0.98
354_L 359_I 1.476 0.98
81_G 106_F 1.47 0.98
96_L 117_L 1.455 0.98
107_S 223_F 1.453 0.98
367_N 371_K 1.444 0.97
200_L 238_I 1.434 0.97
183_K 187_L 1.434 0.97
120_L 227_D 1.425 0.97
88_F 134_L 1.421 0.97
428_S 443_V 1.42 0.97
74_V 463_L 1.419 0.97
330_P 333_L 1.417 0.97
104_E 119_G 1.409 0.97
415_I 429_V 1.398 0.97
209_D 226_H 1.397 0.97
298_Y 307_Q 1.382 0.96
246_L 314_S 1.379 0.96
293_W 304_T 1.377 0.96
96_L 123_L 1.377 0.96
104_E 116_T 1.373 0.96
246_L 319_A 1.369 0.96
87_P 90_F 1.368 0.96
102_F 456_W 1.367 0.96
128_L 132_Q 1.366 0.96
85_A 89_I 1.363 0.96
119_G 227_D 1.352 0.96
119_G 122_S 1.344 0.96
300_S 303_M 1.34 0.96
283_T 287_I 1.333 0.95
240_T 305_I 1.33 0.95
431_A 436_L 1.323 0.95
28_A 126_A 1.322 0.95
281_Q 313_V 1.316 0.95
108_G 223_F 1.316 0.95
291_V 333_L 1.313 0.95
343_I 356_V 1.31 0.95
181_T 349_S 1.302 0.95
412_M 429_V 1.302 0.95
347_A 356_V 1.284 0.94
326_I 337_L 1.279 0.94
276_M 360_L 1.278 0.94
224_S 229_S 1.278 0.94
196_C 214_S 1.274 0.94
454_A 458_L 1.268 0.94
49_I 83_V 1.266 0.94
347_A 357_I 1.265 0.93
197_A 214_S 1.264 0.93
217_T 245_F 1.264 0.93
100_D 116_T 1.261 0.93
236_P 239_N 1.257 0.93
289_T 308_A 1.256 0.93
439_G 443_V 1.25 0.93
236_P 306_N 1.246 0.93
127_I 130_Y 1.245 0.93
420_V 442_V 1.241 0.93
338_L 426_F 1.239 0.93
247_L 278_I 1.229 0.92
302_L 306_N 1.228 0.92
246_L 313_V 1.226 0.92
85_A 98_I 1.226 0.92
128_L 131_R 1.223 0.92
31_Y 125_H 1.217 0.92
280_V 356_V 1.205 0.91
192_L 256_H 1.204 0.91
194_V 198_L 1.198 0.91
231_G 325_S 1.191 0.90
271_D 275_R 1.19 0.90
361_L 394_L 1.19 0.90
200_L 217_T 1.189 0.90
64_L 68_E 1.188 0.90
285_V 308_A 1.181 0.90
318_T 352_G 1.179 0.90
285_V 305_I 1.179 0.90
307_Q 311_Q 1.179 0.90
18_S 43_F 1.178 0.90
418_T 451_N 1.174 0.90
239_N 243_A 1.173 0.90
326_I 440_L 1.173 0.90
115_T 120_L 1.166 0.89
203_A 238_I 1.158 0.89
199_A 203_A 1.157 0.89
234_D 303_M 1.156 0.89
391_E 395_E 1.152 0.88
408_F 412_M 1.147 0.88
289_T 304_T 1.139 0.88
205_M 209_D 1.139 0.88
240_T 309_F 1.136 0.88
244_I 248_I 1.134 0.87
81_G 84_G 1.131 0.87
22_I 26_L 1.127 0.87
240_T 306_N 1.126 0.87
243_A 285_V 1.119 0.86
365_Q 398_W 1.117 0.86
196_C 241_I 1.112 0.86
179_A 183_K 1.1 0.85
135_Q 193_T 1.099 0.85
469_V 473_L 1.099 0.85
131_R 134_L 1.095 0.85
326_I 329_W 1.089 0.84
217_T 242_I 1.088 0.84
28_A 36_G 1.072 0.83
311_Q 337_L 1.066 0.83
336_L 413_L 1.064 0.82
453_V 457_I 1.061 0.82
116_T 119_G 1.061 0.82
271_D 385_G 1.061 0.82
106_F 463_L 1.054 0.82
410_V 414_A 1.046 0.81
243_A 247_L 1.046 0.81
198_L 202_F 1.04 0.80
129_F 133_M 1.036 0.80
110_T 352_G 1.034 0.80
335_V 422_D 1.033 0.80
126_A 130_Y 1.032 0.80
193_T 214_S 1.024 0.79
98_I 102_F 1.022 0.79
285_V 289_T 1.02 0.79
303_M 307_Q 1.02 0.79
334_P 424_S 1.019 0.78
311_Q 314_S 1.016 0.78
196_C 242_I 1.016 0.78
33_D 125_H 1.009 0.78
231_G 322_T 1.008 0.77
415_I 458_L 1.008 0.77
76_F 142_I 1.006 0.77
27_V 31_Y 1.005 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pjzA211000.075Contact Map0.736
4j7cI40.88411000.351Contact Map0.704
3ukmA40.49994.80.953Contact Map0.489
4bw5A40.503194.50.954Contact Map0.555
4i9wA20.515588.90.96Contact Map0.498
1lnqA80.20779.70.965Contact Map0.248
3effK40.180176.90.966Contact Map0.738
2q67A20.23673.40.967Contact Map0.442
3vouA20.291971.30.967Contact Map0.355
2a9hA40.2712710.967Contact Map0.62
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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