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TRKG - Trk system potassium uptake protein TrkG
UniProt: P23849 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11020
Length: 485 (482)
Sequences: 2195
Seq/Len: 4.55
TRKG
Paralog alert: 0.41 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: TRKG TRKH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
347_G 353_C 5.854 1.00
246_G 311_F 4.045 1.00
103_D 457_K 4.017 1.00
413_F 463_A 3.998 1.00
203_Y 245_A 3.518 1.00
200_I 214_I 3.231 1.00
102_I 458_C 3.229 1.00
348_C 358_S 3.021 1.00
229_H 235_Y 2.891 1.00
199_C 248_F 2.804 1.00
420_M 456_A 2.768 1.00
416_V 459_L 2.603 1.00
417_L 456_A 2.589 1.00
327_D 330_S 2.468 1.00
216_H 227_S 2.443 1.00
414_I 428_F 2.441 1.00
423_D 426_T 2.342 1.00
242_E 309_H 2.29 1.00
433_A 449_F 2.269 1.00
219_S 323_L 2.264 1.00
206_A 244_V 2.248 1.00
118_T 122_D 2.207 1.00
135_S 215_C 2.156 1.00
253_A 280_F 2.148 1.00
416_V 455_I 2.133 1.00
138_N 219_S 2.121 1.00
102_I 461_C 2.099 1.00
105_L 461_C 2.09 1.00
202_C 244_V 2.053 1.00
317_M 339_L 2.027 1.00
121_D 124_S 2.022 1.00
242_E 308_I 2.008 1.00
139_F 196_G 1.994 1.00
290_V 338_F 1.981 1.00
206_A 240_L 1.98 1.00
231_E 235_Y 1.975 1.00
302_D 305_G 1.971 1.00
364_L 403_F 1.967 1.00
250_L 284_A 1.94 1.00
49_F 86_I 1.905 1.00
363_I 391_V 1.893 1.00
242_E 325_T 1.876 1.00
14_G 53_G 1.864 1.00
313_L 325_T 1.863 1.00
102_I 454_D 1.859 1.00
413_F 459_L 1.859 1.00
100_T 103_D 1.833 1.00
240_L 244_V 1.798 1.00
99_L 120_I 1.787 1.00
410_T 432_A 1.763 1.00
208_M 241_V 1.758 1.00
221_V 252_S 1.75 1.00
227_S 230_S 1.726 0.99
314_A 317_M 1.699 0.99
25_L 46_F 1.698 0.99
204_R 210_L 1.697 0.99
284_A 318_L 1.694 0.99
420_M 455_I 1.691 0.99
246_G 315_S 1.687 0.99
99_L 125_S 1.685 0.99
288_I 311_F 1.674 0.99
21_S 50_F 1.668 0.99
406_Y 435_I 1.663 0.99
344_F 410_T 1.652 0.99
426_T 442_F 1.638 0.99
250_L 315_S 1.636 0.99
340_L 432_A 1.632 0.99
410_T 435_I 1.626 0.99
200_I 210_L 1.614 0.99
336_I 442_F 1.609 0.99
341_L 345_F 1.592 0.99
102_I 457_K 1.581 0.99
320_D 438_M 1.574 0.99
215_C 228_T 1.566 0.99
287_V 314_A 1.564 0.99
202_C 240_L 1.556 0.99
30_V 132_Y 1.552 0.99
109_V 461_C 1.546 0.99
233_I 245_A 1.541 0.99
195_L 251_L 1.531 0.98
356_I 361_F 1.528 0.98
84_S 109_V 1.525 0.98
199_C 203_Y 1.522 0.98
220_T 323_L 1.515 0.98
430_T 445_T 1.513 0.98
117_A 449_F 1.505 0.98
229_H 236_F 1.477 0.98
216_H 228_T 1.469 0.98
243_L 247_S 1.464 0.98
287_V 342_S 1.463 0.98
253_A 319_T 1.456 0.98
110_S 226_F 1.452 0.98
28_M 46_F 1.444 0.97
203_Y 241_V 1.441 0.97
369_K 373_N 1.441 0.97
77_V 465_I 1.426 0.97
123_V 230_S 1.426 0.97
332_P 335_T 1.424 0.97
130_Y 134_R 1.413 0.97
249_S 316_S 1.396 0.97
284_A 311_F 1.394 0.97
122_D 230_S 1.389 0.97
417_L 431_V 1.384 0.97
122_D 125_S 1.379 0.96
131_L 135_S 1.372 0.96
212_D 229_H 1.372 0.96
107_E 119_V 1.367 0.96
99_L 126_L 1.367 0.96
301_Y 309_H 1.366 0.96
199_C 217_G 1.366 0.96
249_S 321_N 1.358 0.96
433_A 438_M 1.357 0.96
414_I 431_V 1.356 0.96
328_Y 339_L 1.348 0.96
345_F 358_S 1.345 0.96
291_T 335_T 1.34 0.96
105_L 458_C 1.333 0.95
31_A 129_A 1.322 0.95
184_T 351_S 1.319 0.95
111_G 226_F 1.319 0.95
107_E 122_D 1.318 0.95
52_I 86_I 1.31 0.95
249_S 315_S 1.309 0.95
186_R 190_I 1.282 0.94
349_I 359_L 1.281 0.94
243_L 307_F 1.279 0.94
456_A 460_M 1.276 0.94
349_I 358_S 1.272 0.94
220_T 248_F 1.265 0.93
291_T 339_L 1.259 0.93
304_H 308_I 1.258 0.93
88_A 101_F 1.256 0.93
271_L 275_I 1.253 0.93
286_G 290_V 1.252 0.93
281_L 362_L 1.25 0.93
422_Y 444_A 1.247 0.93
182_A 186_R 1.246 0.93
34_Y 128_R 1.245 0.93
227_S 232_S 1.239 0.93
234_G 327_D 1.238 0.93
250_L 281_L 1.237 0.92
200_I 217_G 1.235 0.92
239_Y 308_I 1.23 0.92
239_Y 242_E 1.23 0.92
237_N 305_G 1.222 0.92
441_G 445_T 1.219 0.92
203_Y 220_T 1.212 0.91
445_T 452_L 1.205 0.91
320_D 354_G 1.204 0.91
118_T 123_V 1.202 0.91
242_E 246_G 1.198 0.91
309_H 313_L 1.191 0.90
131_L 134_R 1.187 0.90
292_S 310_S 1.187 0.90
340_L 428_F 1.185 0.90
363_I 396_M 1.184 0.90
195_L 259_W 1.184 0.90
103_D 119_V 1.183 0.90
243_L 308_I 1.178 0.90
208_M 212_D 1.173 0.90
206_A 241_V 1.173 0.90
243_L 311_F 1.169 0.89
84_S 87_S 1.165 0.89
246_G 288_I 1.164 0.89
328_Y 442_F 1.163 0.89
138_N 196_G 1.16 0.89
88_A 92_W 1.159 0.89
283_I 358_S 1.159 0.89
420_M 453_N 1.157 0.89
292_S 296_W 1.155 0.89
288_I 310_S 1.154 0.89
130_Y 133_Y 1.154 0.89
294_Q 335_T 1.153 0.88
67_L 71_D 1.147 0.88
202_C 206_A 1.145 0.88
132_Y 136_Q 1.137 0.88
393_D 397_R 1.135 0.87
199_C 244_V 1.133 0.87
275_I 279_F 1.127 0.87
192_Y 196_G 1.124 0.87
21_S 46_F 1.121 0.87
410_T 414_I 1.115 0.86
134_R 137_L 1.113 0.86
279_F 362_L 1.102 0.85
367_Q 400_W 1.102 0.85
197_I 201_V 1.101 0.85
31_A 39_L 1.093 0.85
25_L 29_V 1.087 0.84
471_I 475_I 1.086 0.84
313_L 339_L 1.084 0.84
338_F 415_L 1.082 0.84
109_V 465_I 1.072 0.83
328_Y 331_W 1.069 0.83
91_L 137_L 1.068 0.83
220_T 245_A 1.067 0.83
274_D 387_G 1.066 0.83
412_F 416_V 1.06 0.82
336_I 426_T 1.055 0.82
458_C 461_C 1.052 0.81
80_W 87_S 1.049 0.81
303_L 307_F 1.048 0.81
196_G 200_I 1.043 0.81
258_L 274_D 1.041 0.80
30_V 34_Y 1.037 0.80
284_A 315_S 1.032 0.80
113_T 354_G 1.031 0.80
247_S 251_L 1.031 0.80
224_G 320_D 1.031 0.80
243_L 304_H 1.025 0.79
100_T 454_D 1.024 0.79
416_V 420_M 1.023 0.79
234_G 324_A 1.022 0.79
337_V 424_F 1.019 0.78
305_G 309_H 1.019 0.78
246_G 250_L 1.017 0.78
199_C 245_A 1.016 0.78
18_W 54_G 1.014 0.78
101_F 105_L 1.012 0.78
243_L 246_G 1.011 0.78
129_A 133_Y 1.011 0.78
371_E 397_R 1.009 0.78
288_I 307_F 1.009 0.78
455_I 459_L 1.008 0.77
99_L 119_V 1.007 0.77
36_E 128_R 1.007 0.77
119_V 122_D 1 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pjzA20.99381000.082Contact Map0.709
4j7cI40.88451000.348Contact Map0.689
3ukmA40.494893.70.955Contact Map0.489
4bw5A40.49992.70.957Contact Map0.553
4i9wA20.513490.30.959Contact Map0.512
1lnqA80.206279.30.965Contact Map0.292
3effK40.179476.90.966Contact Map0.739
2q67A20.23376.10.966Contact Map0.413
2ih3C10.224773.80.967Contact Map0.68
2a9hA40.270172.20.967Contact Map0.627
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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