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OPENSEQ.org
SANA - Protein SanA
UniProt: P0AFY2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12025
Length: 239 (220)
Sequences: 319
Seq/Len: 1.45
SANA
Paralog alert: 0.51 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: SANA YGJQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
66_Y 105_D 3.37 1.00
97_N 100_M 2.877 1.00
123_F 202_F 2.525 1.00
48_G 144_I 2.489 1.00
51_L 143_I 2.413 1.00
48_G 82_V 2.289 0.99
91_N 120_Y 2.287 0.99
49_V 141_F 2.27 0.99
34_Y 158_L 2.089 0.99
87_L 106_L 2.077 0.98
49_V 128_S 2.047 0.98
82_V 144_I 1.969 0.98
86_L 132_T 1.868 0.96
124_R 127_D 1.833 0.96
87_L 116_I 1.711 0.93
34_Y 154_L 1.68 0.92
62_I 70_I 1.601 0.90
157_A 164_A 1.534 0.87
123_F 204_G 1.518 0.86
74_I 135_V 1.517 0.86
84_Y 117_V 1.484 0.85
136_F 204_G 1.481 0.85
86_L 203_L 1.47 0.84
148_F 156_I 1.461 0.83
74_I 111_V 1.436 0.82
150_C 168_A 1.433 0.82
154_L 158_L 1.412 0.80
66_Y 172_P 1.397 0.79
38_E 41_D 1.396 0.79
45_R 142_I 1.395 0.79
154_L 164_A 1.382 0.78
141_F 162_I 1.36 0.77
124_R 192_D 1.357 0.77
35_I 79_S 1.356 0.77
92_A 202_F 1.331 0.75
92_A 123_F 1.33 0.75
74_I 78_N 1.312 0.73
53_T 63_N 1.288 0.71
71_Q 75_N 1.288 0.71
63_N 66_Y 1.279 0.70
127_D 148_F 1.274 0.70
86_L 90_D 1.239 0.67
129_I 157_A 1.234 0.66
200_P 203_L 1.231 0.66
121_A 136_F 1.225 0.66
67_R 71_Q 1.222 0.65
145_T 171_S 1.215 0.65
91_N 136_F 1.215 0.65
66_Y 150_C 1.212 0.64
77_Y 156_I 1.196 0.63
72_G 145_T 1.17 0.60
129_I 143_I 1.157 0.59
86_L 209_I 1.154 0.59
150_C 166_C 1.152 0.59
108_A 201_R 1.149 0.58
77_Y 80_G 1.148 0.58
77_Y 103_R 1.148 0.58
45_R 165_Q 1.142 0.58
53_T 105_D 1.142 0.58
123_F 203_L 1.142 0.58
71_Q 105_D 1.136 0.57
107_I 113_P 1.133 0.57
204_G 209_I 1.132 0.57
66_Y 101_T 1.13 0.56
70_I 109_A 1.119 0.55
77_Y 96_Y 1.118 0.55
81_K 148_F 1.115 0.55
116_I 201_R 1.112 0.55
50_V 189_A 1.108 0.54
103_R 113_P 1.104 0.54
100_M 120_Y 1.098 0.53
145_T 150_C 1.087 0.52
90_D 136_F 1.084 0.52
127_D 130_V 1.076 0.51
49_V 142_I 1.068 0.50
26_W 47_V 1.067 0.50
30_K 158_L 1.067 0.50
86_L 200_P 1.066 0.50
148_F 189_A 1.061 0.49
130_V 192_D 1.055 0.49
120_Y 136_F 1.052 0.48
123_F 136_F 1.047 0.48
115_D 142_I 1.043 0.48
91_N 202_F 1.04 0.47
145_T 169_V 1.04 0.47
142_I 165_Q 1.038 0.47
91_N 121_A 1.037 0.47
153_A 185_A 1.034 0.47
213_H 216_P 1.031 0.46
92_A 204_G 1.029 0.46
35_I 156_I 1.026 0.46
31_T 82_V 1.024 0.46
61_V 145_T 1.022 0.45
45_R 154_L 1.017 0.45
121_A 204_G 1.015 0.45
200_P 204_G 1.013 0.44
91_N 97_N 1.013 0.44
97_N 193_L 1.012 0.44
45_R 163_Q 1.011 0.44
150_C 172_P 1.01 0.44
157_A 186_R 1.005 0.44
55_K 101_T 1.004 0.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ca8A20.891299.90.754Contact Map0.345
2yp6A40.6485610.955Contact Map0.114
2hqsH40.426852.60.957Contact Map0.396
2kgwA10.468630.70.963Contact Map0.298
3ldtA10.6067280.963Contact Map0.344
1lbqA20.882827.50.964Contact Map0.292
1r1mA10.573225.40.964Contact Map0.356
4eo3A20.790825.10.964Contact Map0.042
2xmoA20.95423.90.965Contact Map0.208
4eh1A20.489522.20.965Contact Map0.472
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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