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OPENSEQ.org
OSMY - Osmotically-inducible protein Y
UniProt: P0AFH8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11391
Length: 201 (189)
Sequences: 388
Seq/Len: 2.05
OSMY
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: OSMY YRAP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
139_T 161_T 4.348 1.00
63_V 106_A 4.008 1.00
81_K 90_S 2.8 1.00
60_T 82_T 2.758 1.00
93_V 119_L 2.658 1.00
106_A 109_V 2.105 0.99
77_D 127_G 2.102 0.99
120_H 167_Q 2.035 0.99
120_H 165_V 1.937 0.99
51_G 55_D 1.873 0.98
59_I 82_T 1.787 0.97
77_D 132_Y 1.761 0.97
99_A 119_L 1.737 0.97
167_Q 195_K 1.668 0.96
157_V 172_V 1.655 0.96
159_V 168_L 1.632 0.95
183_S 186_K 1.62 0.95
152_V 180_R 1.582 0.94
145_K 188_V 1.577 0.94
182_E 196_N 1.547 0.93
77_D 92_F 1.527 0.92
182_E 186_K 1.49 0.91
157_V 181_A 1.487 0.91
57_S 60_T 1.417 0.88
46_S 53_F 1.414 0.88
127_G 132_Y 1.385 0.86
178_S 182_E 1.345 0.84
22_A 25_S 1.322 0.83
76_T 93_V 1.295 0.81
101_E 104_K 1.294 0.81
165_V 195_K 1.293 0.81
24_G 27_Y 1.276 0.80
103_V 107_K 1.272 0.79
26_A 29_E 1.256 0.78
83_D 100_E 1.251 0.78
115_V 193_S 1.251 0.78
63_V 109_V 1.248 0.77
51_G 109_V 1.237 0.77
175_Q 179_D 1.229 0.76
149_D 180_R 1.226 0.76
12_L 16_M 1.22 0.75
30_N 38_S 1.208 0.74
57_S 82_T 1.2 0.74
138_T 166_V 1.199 0.73
92_F 127_G 1.195 0.73
137_A 141_E 1.19 0.73
59_I 87_V 1.186 0.72
143_K 159_V 1.184 0.72
35_T 38_S 1.18 0.72
37_E 41_Q 1.176 0.71
46_S 194_V 1.168 0.71
78_I 181_A 1.167 0.71
172_V 178_S 1.162 0.70
100_E 142_I 1.16 0.70
89_L 106_A 1.152 0.69
8_I 11_T 1.144 0.68
70_H 73_I 1.141 0.68
59_I 112_V 1.126 0.67
96_Q 99_A 1.112 0.65
51_G 62_K 1.111 0.65
70_H 101_E 1.104 0.64
179_D 183_S 1.103 0.64
191_V 194_V 1.097 0.64
62_K 109_V 1.097 0.64
172_V 181_A 1.094 0.63
80_V 164_G 1.093 0.63
136_T 142_I 1.083 0.62
85_K 111_G 1.081 0.62
121_V 195_K 1.07 0.61
88_T 167_Q 1.066 0.60
83_D 169_S 1.064 0.60
149_D 184_I 1.052 0.59
80_V 106_A 1.043 0.58
76_T 98_Q 1.043 0.58
92_F 131_G 1.035 0.57
103_V 117_D 1.029 0.56
90_S 177_Q 1.028 0.56
78_I 102_A 1.026 0.56
179_D 196_N 1.012 0.54
152_V 157_V 1.011 0.54
75_S 102_A 1.01 0.54
178_S 196_N 1.007 0.54
142_I 185_A 1.006 0.54
185_A 194_V 1.006 0.54
13_L 16_M 1.005 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2kgsA10.60799.90.652Contact Map0.393
4alzA10.646899.70.719Contact Map0.34
2l26A10.7164980.859Contact Map0.376
2w7yA20.820917.40.954Contact Map0.001
4kysA20.810914.80.955Contact Map0.091
3zbiC140.238814.80.955Contact Map0.139
4fajA10.766213.90.956Contact Map0.04
3vxbA10.87069.30.959Contact Map0.087
4dx5A30.78118.90.959Contact Map0.5
3ne5A10.7917.40.961Contact Map0.482
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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