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DNAC - DNA replication protein DnaC
UniProt: P0AEF0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10237
Length: 245 (209)
Sequences: 1479
Seq/Len: 7.08
DNAC
Paralog alert: 0.44 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DNAC YDAV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
120_C 167_V 4.101 1.00
219_D 235_S 4.015 1.00
135_V 168_I 3.509 1.00
120_C 130_V 3.261 1.00
62_I 120_C 3.215 1.00
116_A 201_L 3.033 1.00
200_M 221_M 2.724 1.00
50_A 54_Q 2.363 1.00
79_E 83_N 2.319 1.00
116_A 199_G 2.245 1.00
128_K 164_D 2.199 1.00
132_I 201_L 2.179 1.00
166_L 187_I 2.155 1.00
110_T 231_F 2.138 1.00
191_R 198_T 2.051 1.00
52_K 56_T 2.029 1.00
71_F 118_A 2.018 1.00
114_H 118_A 1.987 1.00
122_E 125_L 1.914 1.00
116_A 167_V 1.866 1.00
104_F 229_V 1.792 1.00
188_V 198_T 1.758 1.00
57_F 62_I 1.738 1.00
129_S 164_D 1.651 1.00
97_G 128_K 1.649 1.00
100_A 227_L 1.59 1.00
69_C 114_H 1.535 0.99
168_I 184_I 1.488 0.99
135_V 171_I 1.469 0.99
108_P 210_T 1.458 0.99
105_S 202_T 1.435 0.99
62_I 117_A 1.413 0.99
96_D 123_L 1.379 0.99
57_F 124_L 1.377 0.99
122_E 126_R 1.368 0.99
103_I 202_T 1.364 0.98
44_L 48_N 1.361 0.98
104_F 115_L 1.355 0.98
170_E 174_Q 1.346 0.98
33_Q 36_Q 1.336 0.98
114_H 236_Y 1.316 0.98
72_E 122_E 1.287 0.98
33_Q 37_G 1.286 0.98
63_R 113_N 1.286 0.98
137_D 190_R 1.286 0.98
121_N 125_L 1.27 0.97
141_A 156_L 1.268 0.97
92_V 122_E 1.264 0.97
74_Y 114_H 1.261 0.97
164_D 196_R 1.258 0.97
88_A 119_I 1.253 0.97
158_N 162_N 1.239 0.97
46_R 50_A 1.239 0.97
101_S 197_P 1.237 0.97
156_L 159_D 1.232 0.97
47_E 51_M 1.227 0.96
92_V 123_L 1.223 0.96
208_E 211_K 1.217 0.96
233_W 237_R 1.212 0.96
234_D 239_R 1.199 0.96
50_A 53_M 1.196 0.96
105_S 228_W 1.193 0.96
110_T 233_W 1.192 0.96
172_G 203_N 1.188 0.96
139_M 180_E 1.185 0.95
171_I 200_M 1.185 0.95
107_K 110_T 1.147 0.94
173_V 185_N 1.127 0.94
73_N 114_H 1.12 0.93
90_Q 94_E 1.119 0.93
74_Y 115_L 1.113 0.93
170_E 201_L 1.094 0.92
131_L 163_V 1.092 0.92
130_V 167_V 1.086 0.92
102_F 199_G 1.085 0.92
36_Q 39_I 1.084 0.92
173_V 216_R 1.08 0.92
140_S 180_E 1.074 0.91
110_T 182_V 1.074 0.91
91_Y 197_P 1.068 0.91
87_K 227_L 1.066 0.91
205_N 208_E 1.051 0.90
71_F 119_I 1.038 0.89
139_M 184_I 1.027 0.89
129_S 163_V 1.021 0.88
37_G 40_R 1.016 0.88
84_A 229_V 1.016 0.88
160_L 166_L 1.008 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4m4wJ60.98781000.453Contact Map0.712
2qgzA10.98371000.461Contact Map0.559
2w58A20.76331000.518Contact Map0.678
3ec2A10.68161000.551Contact Map0.695
2vhjA30.955199.90.621Contact Map0.289
1l8qA10.722499.90.648Contact Map0.771
2z4sA10.959299.80.669Contact Map0.733
3bosA20.746999.80.674Contact Map0.705
1g5tA10.677699.70.723Contact Map0.578
4blqA60.914399.70.728Contact Map0.426
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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