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OPENSEQ.org
YTFL - UPF0053 inner membrane protein YtfL
UniProt: P0AE45 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12512
Length: 447 (419)
Sequences: 2877
Seq/Len: 6.87
YTFL
Paralog alert: 0.58 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: CORC YFJD YTFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
222_V 322_I 4.185 1.00
392_K 398_D 3.83 1.00
311_V 322_I 3.337 1.00
355_I 422_V 3.33 1.00
354_L 410_V 3.119 1.00
250_N 278_N 2.887 1.00
386_M 420_L 2.742 1.00
224_W 249_C 2.681 1.00
399_S 408_E 2.675 1.00
248_V 283_I 2.601 1.00
264_D 284_R 2.586 1.00
401_K 406_K 2.557 1.00
289_V 298_A 2.554 1.00
111_G 157_L 2.44 1.00
250_N 255_H 2.436 1.00
36_L 134_L 2.398 1.00
399_S 406_K 2.341 1.00
349_D 352_S 2.288 1.00
230_D 233_S 2.185 1.00
293_L 301_S 2.183 1.00
311_V 319_V 2.171 1.00
364_V 368_L 2.159 1.00
222_V 319_V 2.143 1.00
33_L 47_V 2.108 1.00
128_A 131_A 2.088 1.00
15_S 69_A 2.016 1.00
326_N 330_T 1.954 1.00
215_S 295_L 1.946 1.00
141_R 145_Y 1.941 1.00
229_E 233_S 1.908 1.00
359_T 382_I 1.896 1.00
254_D 318_L 1.872 1.00
348_R 352_S 1.85 1.00
224_W 253_I 1.832 1.00
382_I 420_L 1.829 1.00
359_T 364_V 1.818 1.00
152_W 156_G 1.808 1.00
276_A 279_S 1.805 1.00
244_S 261_D 1.799 1.00
184_V 201_I 1.792 1.00
160_I 164_I 1.786 1.00
200_L 204_V 1.783 1.00
212_V 298_A 1.769 1.00
406_K 423_T 1.76 1.00
354_L 419_Q 1.752 1.00
329_M 333_M 1.742 1.00
40_G 44_A 1.741 1.00
347_A 353_W 1.723 1.00
15_S 65_L 1.723 1.00
32_K 130_E 1.705 1.00
46_R 141_R 1.703 1.00
225_F 234_L 1.701 1.00
408_E 423_T 1.698 1.00
56_M 148_T 1.664 1.00
385_F 402_F 1.652 1.00
236_N 240_E 1.627 1.00
386_M 407_F 1.62 1.00
411_D 419_Q 1.62 1.00
17_F 139_P 1.613 1.00
46_R 138_N 1.606 1.00
41_N 134_L 1.602 1.00
225_F 248_V 1.59 1.00
46_R 137_I 1.586 1.00
259_Y 286_T 1.584 1.00
37_A 48_L 1.582 1.00
411_D 418_D 1.571 1.00
228_H 250_N 1.558 1.00
402_F 407_F 1.555 0.99
210_R 214_S 1.55 0.99
227_L 250_N 1.548 0.99
387_M 417_I 1.539 0.99
15_S 19_S 1.52 0.99
245_K 308_D 1.515 0.99
34_K 38_D 1.512 0.99
200_L 332_L 1.51 0.99
60_V 143_C 1.495 0.99
45_Q 49_N 1.472 0.99
65_L 69_A 1.47 0.99
364_V 382_I 1.466 0.99
295_L 328_V 1.465 0.99
21_S 136_I 1.46 0.99
220_E 318_L 1.46 0.99
386_M 409_V 1.46 0.99
245_K 326_N 1.457 0.99
298_A 323_I 1.453 0.99
225_F 277_L 1.448 0.99
407_F 420_L 1.446 0.99
6_L 10_C 1.443 0.99
135_R 139_P 1.441 0.99
62_Q 65_L 1.436 0.99
345_I 359_T 1.435 0.99
354_L 421_L 1.429 0.99
156_G 160_I 1.416 0.99
300_E 303_K 1.416 0.99
60_V 151_V 1.407 0.99
355_I 364_V 1.392 0.99
386_M 400_V 1.392 0.99
18_F 64_G 1.385 0.99
131_A 135_R 1.385 0.99
326_N 338_G 1.374 0.98
5_I 9_L 1.373 0.98
49_N 141_R 1.369 0.98
19_S 23_I 1.36 0.98
204_V 332_L 1.358 0.98
413_D 418_D 1.331 0.98
326_N 336_L 1.329 0.98
309_F 322_I 1.316 0.98
17_F 136_I 1.313 0.98
229_E 234_L 1.308 0.98
355_I 382_I 1.3 0.98
389_M 402_F 1.286 0.97
69_A 113_F 1.285 0.97
348_R 351_N 1.278 0.97
177_S 209_S 1.276 0.97
70_I 73_G 1.274 0.97
20_M 132_V 1.271 0.97
309_F 324_T 1.268 0.97
227_L 278_N 1.266 0.97
187_G 191_G 1.264 0.97
252_D 255_H 1.259 0.97
404_G 424_R 1.255 0.97
365_M 370_I 1.251 0.97
215_S 323_I 1.246 0.97
326_N 331_T 1.243 0.97
219_R 318_L 1.242 0.97
259_Y 309_F 1.241 0.97
226_D 229_E 1.238 0.96
227_L 257_I 1.236 0.96
410_V 421_L 1.235 0.96
361_I 365_M 1.232 0.96
136_I 139_P 1.231 0.96
223_I 243_H 1.229 0.96
347_A 350_E 1.223 0.96
260_V 282_Q 1.215 0.96
47_V 137_I 1.214 0.96
33_L 48_L 1.207 0.96
352_S 421_L 1.197 0.96
221_N 416_R 1.196 0.95
215_S 328_V 1.192 0.95
385_F 407_F 1.187 0.95
250_N 257_I 1.185 0.95
364_V 422_V 1.181 0.95
62_Q 66_N 1.181 0.95
23_I 26_A 1.181 0.95
207_L 328_V 1.177 0.95
326_N 339_Q 1.177 0.95
66_N 110_T 1.173 0.95
357_G 382_I 1.164 0.95
410_V 419_Q 1.162 0.94
120_T 161_I 1.153 0.94
365_M 373_F 1.153 0.94
43_N 134_L 1.15 0.94
348_R 421_L 1.15 0.94
65_L 113_F 1.15 0.94
37_A 40_G 1.149 0.94
43_N 47_V 1.147 0.94
118_D 122_K 1.146 0.94
408_E 421_L 1.143 0.94
65_L 119_L 1.123 0.93
47_V 133_A 1.123 0.93
238_V 246_F 1.122 0.93
223_I 246_F 1.122 0.93
315_E 384_G 1.121 0.93
43_N 138_N 1.118 0.93
257_I 283_I 1.111 0.93
76_G 109_V 1.106 0.92
7_V 10_C 1.102 0.92
74_I 106_F 1.098 0.92
41_N 44_A 1.093 0.92
66_N 113_F 1.092 0.92
124_I 167_L 1.092 0.92
241_H 246_F 1.088 0.92
346_V 354_L 1.086 0.91
50_M 57_F 1.086 0.91
70_I 110_T 1.084 0.91
223_I 237_K 1.077 0.91
293_L 298_A 1.074 0.91
34_K 48_L 1.073 0.91
314_N 320_V 1.071 0.91
8_I 109_V 1.068 0.91
345_I 355_I 1.068 0.91
10_C 14_V 1.068 0.91
15_S 66_N 1.067 0.90
308_D 329_M 1.066 0.90
352_S 423_T 1.06 0.90
22_E 122_K 1.052 0.90
219_R 254_D 1.049 0.89
15_S 68_V 1.049 0.89
70_I 106_F 1.047 0.89
12_I 117_A 1.043 0.89
138_N 142_F 1.041 0.89
226_D 251_E 1.04 0.89
58_F 119_L 1.038 0.89
302_F 320_V 1.037 0.89
291_D 320_V 1.036 0.89
386_M 390_L 1.032 0.88
176_T 180_I 1.031 0.88
159_N 163_R 1.031 0.88
290_P 293_L 1.03 0.88
251_E 255_H 1.028 0.88
383_G 387_M 1.026 0.88
387_M 393_I 1.024 0.88
62_Q 69_A 1.019 0.88
73_G 106_F 1.01 0.87
383_G 416_R 1.006 0.87
330_T 339_Q 1.006 0.87
330_T 338_G 1.005 0.87
256_I 311_V 1.003 0.86
180_I 187_G 1.003 0.86
76_G 80_F 1.001 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hg0A10.64431000.526Contact Map0.722
3lhhA10.38481000.78Contact Map0.808
3oi8A20.34999.90.794Contact Map0.825
3ocoA20.3499.90.795Contact Map0.816
3ocmA20.38799.90.801Contact Map0.807
2v8qE10.579499.90.803Contact Map0.5
3kxrA10.429599.90.805Contact Map0.592
3lv9A10.331199.90.807Contact Map0.785
3dedA60.239499.90.82Contact Map0.764
3t4nC10.579499.90.824Contact Map0.494
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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