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OPENSEQ.org
ISPB - Octaprenyl-diphosphate synthase
UniProt: P0AD57 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10017
Length: 323 (319)
Sequences: 4430
Seq/Len: 13.89
ISPB
Paralog alert: 0.76 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ISPA ISPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
296_I 316_H 3.668 1.00
202_Y 294_K 3.234 1.00
56_A 66_H 3.039 1.00
189_T 192_E 3.028 1.00
287_R 290_E 2.901 1.00
180_Q 197_Q 2.668 1.00
296_I 312_I 2.651 1.00
202_Y 291_E 2.622 1.00
91_D 101_A 2.53 1.00
222_Q 322_D 2.501 1.00
159_T 162_N 2.439 1.00
176_E 197_Q 2.395 1.00
273_E 277_A 2.293 1.00
254_M 270_P 2.259 1.00
180_Q 193_E 2.233 1.00
134_V 180_Q 2.218 1.00
213_L 284_T 2.188 1.00
293_D 297_A 2.165 1.00
168_Y 201_R 2.149 1.00
104_G 107_A 2.129 1.00
219_D 222_Q 2.129 1.00
300_Q 312_I 2.121 1.00
134_V 184_I 2.064 1.00
279_G 282_E 2.054 1.00
290_E 294_K 2.03 1.00
282_E 286_Q 1.983 1.00
242_H 280_S 1.972 1.00
176_E 201_R 1.922 1.00
218_A 223_L 1.918 1.00
226_N 229_D 1.908 1.00
198_D 298_A 1.904 1.00
246_H 283_W 1.883 1.00
297_A 300_Q 1.881 1.00
242_H 283_W 1.877 1.00
179_A 200_G 1.876 1.00
92_M 97_A 1.857 1.00
194_K 198_D 1.805 1.00
289_E 293_D 1.791 1.00
131_V 181_C 1.765 1.00
308_R 312_I 1.754 1.00
87_V 146_E 1.731 1.00
198_D 202_Y 1.678 1.00
210_I 288_A 1.651 1.00
251_Q 277_A 1.638 1.00
304_D 309_E 1.63 1.00
286_Q 290_E 1.629 1.00
82_L 99_A 1.6 1.00
55_A 196_L 1.598 1.00
209_L 284_T 1.57 1.00
183_G 196_L 1.564 1.00
146_E 149_Q 1.555 1.00
296_I 315_A 1.533 1.00
205_T 291_E 1.529 1.00
287_R 291_E 1.515 1.00
248_T 251_Q 1.509 1.00
292_A 296_I 1.506 1.00
20_A 71_A 1.471 1.00
217_N 285_R 1.45 1.00
118_R 121_Q 1.441 1.00
130_K 190_P 1.434 1.00
202_Y 298_A 1.428 1.00
13_D 57_R 1.419 1.00
195_G 301_V 1.418 1.00
20_A 23_E 1.418 1.00
253_Q 257_T 1.414 1.00
165_R 169_S 1.404 0.99
130_K 193_E 1.397 0.99
275_M 280_S 1.395 0.99
55_A 179_A 1.392 0.99
174_L 178_A 1.378 0.99
55_A 59_V 1.37 0.99
80_T 142_I 1.366 0.99
83_H 112_G 1.366 0.99
286_Q 289_E 1.364 0.99
304_D 308_R 1.357 0.99
214_L 223_L 1.354 0.99
316_H 320_Q 1.347 0.99
195_G 298_A 1.34 0.99
59_V 182_S 1.334 0.99
90_S 229_D 1.332 0.99
182_S 186_A 1.332 0.99
68_T 125_S 1.331 0.99
58_A 302_L 1.33 0.99
19_A 23_E 1.323 0.99
291_E 294_K 1.32 0.99
199_Y 315_A 1.316 0.99
130_K 133_E 1.311 0.99
59_V 186_A 1.311 0.99
292_A 319_V 1.306 0.99
282_E 285_R 1.306 0.99
69_I 181_C 1.3 0.99
270_P 273_E 1.295 0.99
176_E 180_Q 1.284 0.99
160_E 242_H 1.275 0.99
216_Y 239_P 1.27 0.99
160_E 287_R 1.268 0.99
83_H 113_D 1.263 0.99
43_G 46_R 1.259 0.99
213_L 281_L 1.258 0.99
283_W 286_Q 1.255 0.99
229_D 233_E 1.244 0.98
243_A 275_M 1.239 0.98
86_V 105_N 1.218 0.98
242_H 246_H 1.216 0.98
121_Q 137_E 1.204 0.98
87_V 110_L 1.199 0.98
273_E 276_N 1.198 0.98
22_L 37_Y 1.182 0.98
16_G 19_A 1.176 0.98
255_I 271_V 1.172 0.98
183_G 188_C 1.168 0.97
312_I 316_H 1.16 0.97
188_C 192_E 1.155 0.97
163_Y 167_I 1.154 0.97
51_I 179_A 1.15 0.97
199_Y 298_A 1.141 0.97
251_Q 278_C 1.135 0.97
52_A 73_I 1.13 0.97
266_H 269_E 1.128 0.97
31_L 104_G 1.127 0.97
125_S 133_E 1.123 0.97
152_N 166_V 1.116 0.96
177_A 181_C 1.115 0.96
243_A 278_C 1.114 0.96
213_L 285_R 1.111 0.96
53_V 70_A 1.111 0.96
272_L 276_N 1.106 0.96
309_E 313_G 1.103 0.96
54_L 57_R 1.102 0.96
15_A 19_A 1.1 0.96
213_L 288_A 1.099 0.96
167_I 205_T 1.093 0.96
298_A 301_V 1.092 0.96
134_V 177_A 1.091 0.96
289_E 320_Q 1.088 0.96
37_Y 41_S 1.084 0.96
264_G 267_L 1.075 0.95
100_N 105_N 1.073 0.95
168_Y 205_T 1.069 0.95
218_A 222_Q 1.069 0.95
46_R 49_P 1.064 0.95
292_A 315_A 1.062 0.95
309_E 312_I 1.055 0.95
276_N 281_L 1.055 0.95
9_L 310_A 1.05 0.94
149_Q 235_K 1.049 0.94
163_Y 241_L 1.048 0.94
56_A 61_Y 1.047 0.94
206_A 295_A 1.042 0.94
59_V 192_E 1.042 0.94
199_Y 299_L 1.042 0.94
20_A 68_T 1.04 0.94
203_L 318_A 1.039 0.94
252_A 256_R 1.038 0.94
75_F 118_R 1.038 0.94
130_K 184_I 1.035 0.94
155_D 162_N 1.033 0.94
107_A 147_V 1.029 0.94
198_D 294_K 1.023 0.93
288_A 319_V 1.018 0.93
214_L 218_A 1.017 0.93
124_T 132_L 1.014 0.93
18_N 46_R 1.008 0.93
269_E 273_E 1.004 0.93
158_I 162_N 1.002 0.92
138_A 177_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4jxyA111000.039Contact Map0.735
3oyrA211000.041Contact Map0.765
4lobA10.99381000.051Contact Map0.689
3mzvA211000.052Contact Map0.717
3aqbB20.99691000.057Contact Map0.732
3rmgA20.99691000.063Contact Map0.753
1wy0A111000.064Contact Map0.755
4dhdA10.99071000.072Contact Map0.735
3lmdA10.99071000.074Contact Map0.673
3pkoA20.98451000.082Contact Map0.724
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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