| UniProt: | P22939 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10508 | ||
| Length: | 299 (297) | ||
| Sequences: | 4073 | ||
| Seq/Len: | 13.71 |
| ISPA
Paralog alert: 0.78 [within 20: 0.01] - ratio of genomes with paralogs Cluster includes: ISPA ISPB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 271_R | 292_D | 4.092 | 1.00 | |
| 88_A | 111_I | 3.427 | 1.00 | |
| 201_G | 204_A | 3.292 | 1.00 | |
| 214_S | 269_D | 3.209 | 1.00 | |
| 93_D | 103_V | 2.985 | 1.00 | |
| 56_G | 66_L | 2.904 | 1.00 | |
| 262_K | 265_D | 2.877 | 1.00 | |
| 191_R | 209_D | 2.831 | 1.00 | |
| 214_S | 266_L | 2.669 | 1.00 | |
| 234_T | 298_N | 2.602 | 1.00 | |
| 170_P | 173_A | 2.579 | 1.00 | |
| 271_R | 288_E | 2.52 | 1.00 | |
| 187_R | 209_D | 2.468 | 1.00 | |
| 106_G | 109_N | 2.294 | 1.00 | |
| 191_R | 205_L | 2.268 | 1.00 | |
| 231_D | 234_T | 2.251 | 1.00 | |
| 179_R | 213_E | 2.248 | 1.00 | |
| 94_L | 99_P | 2.148 | 1.00 | |
| 238_R | 241_A | 2.128 | 1.00 | |
| 265_D | 269_D | 2.112 | 1.00 | |
| 275_K | 288_E | 2.07 | 1.00 | |
| 144_E | 195_L | 2.06 | 1.00 | |
| 144_E | 191_R | 2.054 | 1.00 | |
| 268_D | 272_Q | 2.027 | 1.00 | |
| 187_R | 213_E | 1.989 | 1.00 | |
| 225_I | 259_A | 1.987 | 1.00 | |
| 272_Q | 275_K | 1.927 | 1.00 | |
| 258_Q | 261_K | 1.858 | 1.00 | |
| 210_K | 273_S | 1.819 | 1.00 | |
| 264_R | 268_D | 1.781 | 1.00 | |
| 83_H | 114_G | 1.776 | 1.00 | |
| 194_A | 208_L | 1.765 | 1.00 | |
| 222_Q | 263_A | 1.764 | 1.00 | |
| 210_K | 214_S | 1.74 | 1.00 | |
| 254_L | 258_Q | 1.735 | 1.00 | |
| 43_G | 46_R | 1.729 | 1.00 | |
| 55_T | 208_L | 1.718 | 1.00 | |
| 89_M | 158_Q | 1.688 | 1.00 | |
| 284_T | 288_E | 1.683 | 1.00 | |
| 279_E | 285_S | 1.677 | 1.00 | |
| 141_M | 192_L | 1.668 | 1.00 | |
| 190_V | 212_A | 1.641 | 1.00 | |
| 207_V | 276_Q | 1.616 | 1.00 | |
| 221_V | 259_A | 1.573 | 1.00 | |
| 241_A | 245_L | 1.561 | 1.00 | |
| 55_T | 59_F | 1.549 | 1.00 | |
| 120_L | 123_S | 1.545 | 1.00 | |
| 140_S | 143_S | 1.542 | 1.00 | |
| 68_A | 127_D | 1.539 | 1.00 | |
| 206_P | 210_K | 1.538 | 1.00 | |
| 207_V | 273_S | 1.537 | 1.00 | |
| 229_V | 260_R | 1.534 | 1.00 | |
| 261_K | 265_D | 1.528 | 1.00 | |
| 200_K | 204_A | 1.527 | 1.00 | |
| 17_A | 71_A | 1.519 | 1.00 | |
| 82_I | 101_C | 1.51 | 1.00 | |
| 217_L | 266_L | 1.505 | 1.00 | |
| 17_A | 68_A | 1.503 | 1.00 | |
| 158_Q | 161_D | 1.5 | 1.00 | |
| 171_L | 254_L | 1.493 | 1.00 | |
| 58_M | 277_L | 1.481 | 1.00 | |
| 267_I | 271_R | 1.478 | 1.00 | |
| 55_T | 190_V | 1.468 | 1.00 | |
| 266_L | 269_D | 1.464 | 1.00 | |
| 140_S | 202_R | 1.459 | 1.00 | |
| 176_R | 180_H | 1.457 | 1.00 | |
| 140_S | 205_L | 1.453 | 1.00 | |
| 211_Y | 291_A | 1.444 | 1.00 | |
| 109_N | 159_A | 1.421 | 1.00 | |
| 271_R | 291_A | 1.417 | 1.00 | |
| 92_D | 241_A | 1.413 | 1.00 | |
| 39_G | 101_C | 1.404 | 0.99 | |
| 292_D | 296_Q | 1.387 | 0.99 | |
| 214_S | 273_S | 1.387 | 0.99 | |
| 89_M | 112_L | 1.381 | 0.99 | |
| 17_A | 20_R | 1.38 | 0.99 | |
| 80_S | 154_M | 1.38 | 0.99 | |
| 59_F | 197_A | 1.377 | 0.99 | |
| 31_P | 106_G | 1.362 | 0.99 | |
| 188_A | 192_L | 1.361 | 0.99 | |
| 262_K | 266_L | 1.355 | 0.99 | |
| 230_G | 235_L | 1.354 | 0.99 | |
| 267_I | 295_I | 1.352 | 0.99 | |
| 16_Q | 20_R | 1.345 | 0.99 | |
| 51_L | 190_V | 1.338 | 0.99 | |
| 123_S | 147_S | 1.335 | 0.99 | |
| 15_N | 46_R | 1.319 | 0.99 | |
| 83_H | 115_D | 1.283 | 0.99 | |
| 59_F | 204_A | 1.279 | 0.99 | |
| 187_R | 191_R | 1.278 | 0.99 | |
| 19_S | 37_Q | 1.276 | 0.99 | |
| 59_F | 193_G | 1.274 | 0.99 | |
| 215_I | 294_I | 1.27 | 0.99 | |
| 226_L | 235_L | 1.256 | 0.99 | |
| 160_L | 176_R | 1.255 | 0.99 | |
| 185_L | 189_A | 1.249 | 0.99 | |
| 263_A | 295_I | 1.229 | 0.98 | |
| 257_E | 261_K | 1.223 | 0.98 | |
| 171_L | 262_K | 1.222 | 0.98 | |
| 102_H | 107_E | 1.221 | 0.98 | |
| 261_K | 264_R | 1.22 | 0.98 | |
| 56_G | 61_V | 1.218 | 0.98 | |
| 53_Y | 70_A | 1.21 | 0.98 | |
| 193_G | 197_A | 1.199 | 0.98 | |
| 167_K | 173_A | 1.198 | 0.98 | |
| 69_P | 192_L | 1.191 | 0.98 | |
| 37_Q | 41_L | 1.181 | 0.98 | |
| 228_V | 251_P | 1.173 | 0.98 | |
| 210_K | 269_D | 1.169 | 0.97 | |
| 75_C | 120_L | 1.16 | 0.97 | |
| 46_R | 49_P | 1.16 | 0.97 | |
| 285_S | 289_A | 1.159 | 0.97 | |
| 232_T | 238_R | 1.145 | 0.97 | |
| 202_R | 206_P | 1.132 | 0.97 | |
| 174_L | 178_H | 1.131 | 0.97 | |
| 232_T | 239_Q | 1.127 | 0.97 | |
| 226_L | 230_G | 1.115 | 0.96 | |
| 225_I | 263_A | 1.106 | 0.96 | |
| 273_S | 276_Q | 1.103 | 0.96 | |
| 52_V | 73_V | 1.102 | 0.96 | |
| 225_I | 256_L | 1.099 | 0.96 | |
| 207_V | 211_Y | 1.099 | 0.96 | |
| 225_I | 260_R | 1.096 | 0.96 | |
| 288_E | 292_D | 1.096 | 0.96 | |
| 264_R | 296_Q | 1.094 | 0.96 | |
| 267_I | 291_A | 1.093 | 0.96 | |
| 134_S | 137_D | 1.091 | 0.96 | |
| 54_A | 57_H | 1.079 | 0.95 | |
| 51_L | 215_I | 1.072 | 0.95 | |
| 164_A | 169_V | 1.07 | 0.95 | |
| 35_T | 101_C | 1.058 | 0.95 | |
| 165_E | 248_S | 1.055 | 0.95 | |
| 144_E | 188_A | 1.043 | 0.94 | |
| 230_G | 234_T | 1.04 | 0.94 | |
| 197_A | 200_K | 1.036 | 0.94 | |
| 17_A | 21_F | 1.036 | 0.94 | |
| 39_G | 78_A | 1.025 | 0.93 | |
| 61_V | 66_L | 1.024 | 0.93 | |
| 235_L | 239_Q | 1.02 | 0.93 | |
| 187_R | 212_A | 1.02 | 0.93 | |
| 211_Y | 273_S | 1.017 | 0.93 | |
| 237_K | 242_D | 1.015 | 0.93 | |
| 12_K | 15_N | 1.005 | 0.93 | |
| 13_Q | 16_Q | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1rqjA | 2 | 1 | 100 | 0.058 | Contact Map | 0.758 |
| 4kkmA | 2 | 0.9833 | 100 | 0.058 | Contact Map | 0.809 |
| 3lsnA | 1 | 0.9866 | 100 | 0.064 | Contact Map | 0.749 |
| 3ts7A | 2 | 0.9866 | 100 | 0.067 | Contact Map | 0.777 |
| 4f62A | 2 | 0.9799 | 100 | 0.068 | Contact Map | 0.787 |
| 3pdeA | 4 | 0.9799 | 100 | 0.068 | Contact Map | 0.718 |
| 2h8oA | 1 | 0.9833 | 100 | 0.071 | Contact Map | 0.741 |
| 1rtrA | 2 | 0.9766 | 100 | 0.074 | Contact Map | 0.807 |
| 3ucaA | 2 | 0.9766 | 100 | 0.078 | Contact Map | 0.781 |
| 4llsA | 2 | 0.9632 | 100 | 0.081 | Contact Map | 0.772 |
Sequence Conservation (Image Generated using WebLogo v3)