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OPENSEQ.org

DBHA - DNA-binding protein HU-alpha
UniProt: P0ACF0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10466
Length: 90 (90)
Sequences: 2945
Seq/Len: 32.72

DBHA
Paralog alert: 0.56 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DBHA DBHB IHFA IHFB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
53_N 78_A 3.611 1.00
59_T 68_E 3.056 1.00
57_E 70_K 2.805 1.00
22_K 26_E 2.796 1.00
54_H 75_N 2.708 1.00
35_S 40_D 2.562 1.00
61_R 66_G 2.494 1.00
60_G 71_I 2.492 1.00
83_K 87_D 2.409 1.00
8_D 18_K 2.395 1.00
59_T 70_K 2.212 1.00
20_Q 23_A 2.192 1.00
10_I 25_L 2.17 1.00
52_V 75_N 2.094 1.00
55_R 76_V 1.91 1.00
61_R 68_E 1.756 1.00
28_T 32_I 1.723 1.00
36_L 85_L 1.591 1.00
51_K 80_V 1.543 1.00
41_A 51_K 1.511 1.00
19_T 23_A 1.501 1.00
17_S 20_Q 1.481 1.00
41_A 49_T 1.458 1.00
9_V 13_K 1.449 1.00
36_L 52_V 1.437 1.00
45_V 82_G 1.396 0.99
54_H 73_A 1.386 0.99
21_A 24_A 1.358 0.99
33_T 85_L 1.289 0.99
32_I 42_V 1.26 0.99
57_E 73_A 1.247 0.99
64_Q 67_K 1.224 0.98
48_G 79_F 1.219 0.98
13_K 34_E 1.212 0.98
16_L 21_A 1.129 0.97
9_V 31_A 1.118 0.96
10_I 28_T 1.108 0.96
9_V 12_E 1.08 0.95
30_A 33_T 1.076 0.95
37_K 88_A 1.076 0.95
8_D 12_E 1.071 0.95
47_F 50_F 1.029 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2o97B1199.90.084Contact Map0.639
1mulA1199.90.088Contact Map0.803
1b8zA2199.90.088Contact Map0.834
2iieA1199.90.089Contact Map0.786
1exeA2199.90.093Contact Map0.655
1p71A2199.90.093Contact Map0.842
3rhiA4199.90.095Contact Map0.941
3c4iA2199.90.095Contact Map0.877
1owfB1199.90.097Contact Map0.689
1owfA1199.90.1Contact Map0.701

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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