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OPENSEQ.org
PHSG - Glycogen phosphorylase
UniProt: P0AC86 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10380
Length: 815 (808)
Sequences: 1149
Seq/Len: 1.42
PHSG
Paralog alert: 0.42 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: PHSG PHSM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
543_A 584_V 4.803 1.00
531_I 539_V 4.045 1.00
316_A 432_H 3.933 1.00
433_K 462_T 3.889 1.00
387_E 391_Y 3.869 1.00
513_N 785_M 3.852 1.00
565_V 585_N 3.791 1.00
291_S 295_Q 3.766 1.00
487_E 515_A 3.747 1.00
504_Q 790_N 3.707 1.00
552_I 589_G 3.641 1.00
517_H 781_T 3.619 1.00
573_K 617_Q 3.55 1.00
302_Y 339_H 3.544 1.00
213_G 292_S 3.511 1.00
562_V 608_V 3.452 1.00
717_D 761_R 3.336 1.00
499_L 502_E 3.221 1.00
691_F 773_L 3.209 1.00
684_H 793_Y 3.164 1.00
779_E 783_K 3.083 1.00
513_N 778_E 3.03 1.00
714_Y 725_T 3.019 1.00
567_T 760_Y 2.996 1.00
532_A 538_V 2.919 1.00
464_V 806_H 2.812 1.00
521_L 542_K 2.794 1.00
409_R 452_D 2.737 1.00
464_V 799_T 2.69 1.00
348_E 352_Q 2.67 1.00
309_D 345_D 2.623 1.00
516_V 784_A 2.58 1.00
574_A 722_Q 2.573 1.00
361_L 444_L 2.482 1.00
480_S 526_R 2.469 1.00
468_V 665_L 2.466 1.00
188_Y 215_A 2.458 1.00
572_I 618_I 2.422 1.00
644_L 671_I 2.413 1.00
516_V 788_I 2.412 1.00
674_L 696_T 2.404 1.00
721_H 725_T 2.35 0.99
133_F 799_T 2.334 0.99
570_N 726_Q 2.329 0.99
25_L 36_A 2.282 0.99
298_L 334_L 2.228 0.99
443_N 447_Q 2.222 0.99
501_N 790_N 2.204 0.99
297_I 317_I 2.199 0.99
108_N 111_E 2.173 0.99
508_D 782_A 2.169 0.99
294_I 334_L 2.152 0.99
406_L 410_A 2.138 0.99
762_S 765_D 2.124 0.99
562_V 565_V 2.105 0.99
308_Y 341_F 2.099 0.98
665_L 791_M 2.071 0.98
164_S 603_H 2.068 0.98
298_L 311_L 2.059 0.98
664_A 791_M 2.043 0.98
486_D 494_R 2.041 0.98
488_H 506_H 2.026 0.98
57_W 230_T 2.025 0.98
488_H 512_V 2 0.98
531_I 586_I 1.988 0.98
24_K 28_T 1.987 0.98
776_L 779_E 1.979 0.98
362_M 653_T 1.978 0.98
501_N 504_Q 1.961 0.97
549_I 638_I 1.959 0.97
406_L 455_K 1.95 0.97
682_L 687_A 1.939 0.97
492_N 499_L 1.938 0.97
355_S 432_H 1.925 0.97
711_R 715_E 1.919 0.97
149_I 266_S 1.916 0.97
454_A 459_G 1.891 0.97
310_N 313_D 1.874 0.96
137_L 142_L 1.855 0.96
714_Y 757_L 1.832 0.96
443_N 446_V 1.831 0.96
674_L 682_L 1.829 0.96
773_L 783_K 1.825 0.96
451_A 455_K 1.808 0.95
516_V 785_M 1.807 0.95
540_N 623_K 1.807 0.95
343_W 347_F 1.802 0.95
406_L 409_R 1.8 0.95
374_L 385_I 1.786 0.95
311_L 353_V 1.782 0.95
521_L 525_K 1.772 0.95
312_A 352_Q 1.769 0.94
682_L 690_I 1.766 0.94
496_D 499_L 1.757 0.94
142_L 810_I 1.748 0.94
482_S 493_W 1.747 0.94
761_R 765_D 1.73 0.94
714_Y 748_I 1.727 0.93
714_Y 721_H 1.712 0.93
342_S 345_D 1.708 0.93
644_L 770_V 1.702 0.93
486_D 493_W 1.694 0.93
801_K 805_D 1.677 0.92
585_N 622_L 1.676 0.92
31_K 40_E 1.674 0.92
720_L 760_Y 1.672 0.92
702_E 706_Q 1.666 0.92
489_L 502_E 1.662 0.92
332_M 343_W 1.659 0.92
480_S 522_E 1.648 0.91
195_R 207_E 1.637 0.91
280_E 376_K 1.637 0.91
627_I 634_L 1.636 0.91
301_H 310_N 1.632 0.91
507_C 513_N 1.629 0.91
562_V 604_L 1.629 0.91
630_Y 639_I 1.627 0.91
389_N 393_L 1.623 0.90
748_I 757_L 1.622 0.90
326_L 374_L 1.616 0.90
517_H 777_Q 1.613 0.90
525_K 529_E 1.61 0.90
773_L 779_E 1.609 0.90
485_L 489_L 1.609 0.90
186_T 215_A 1.608 0.90
328_I 354_F 1.603 0.90
765_D 769_K 1.596 0.89
535_L 628_P 1.593 0.89
540_N 620_D 1.586 0.89
523_N 526_R 1.585 0.89
669_L 691_F 1.584 0.89
539_V 584_V 1.581 0.89
137_L 144_G 1.577 0.89
804_A 810_I 1.57 0.88
301_H 308_Y 1.57 0.88
332_M 347_F 1.57 0.88
480_S 519_A 1.566 0.88
72_V 810_I 1.564 0.88
433_K 464_V 1.562 0.88
301_H 312_A 1.559 0.88
403_D 406_L 1.552 0.88
600_H 742_D 1.55 0.87
480_S 523_N 1.545 0.87
572_I 578_A 1.543 0.87
549_I 663_F 1.538 0.87
587_F 624_V 1.534 0.87
798_R 802_E 1.532 0.87
583_R 767_Q 1.529 0.87
635_A 639_I 1.528 0.86
150_R 180_E 1.527 0.86
81_I 131_A 1.523 0.86
334_L 339_H 1.521 0.86
696_T 699_E 1.517 0.86
470_P 497_L 1.514 0.86
643_D 781_T 1.508 0.85
368_T 420_R 1.505 0.85
484_V 512_V 1.478 0.84
579_K 775_E 1.474 0.84
434_V 460_R 1.474 0.84
544_L 644_L 1.466 0.83
403_D 409_R 1.462 0.83
571_R 768_D 1.456 0.83
796_S 800_I 1.453 0.82
597_M 743_L 1.45 0.82
464_V 802_E 1.447 0.82
24_K 51_D 1.446 0.82
70_R 316_A 1.439 0.82
326_L 329_P 1.438 0.82
510_P 778_E 1.437 0.81
133_F 800_I 1.429 0.81
177_N 218_Q 1.428 0.81
327_S 354_F 1.425 0.81
489_L 499_L 1.424 0.81
147_Y 296_D 1.421 0.80
295_Q 334_L 1.412 0.80
387_E 390_D 1.409 0.80
583_R 771_D 1.407 0.80
488_H 515_A 1.399 0.79
681_M 685_V 1.395 0.79
802_E 806_H 1.394 0.79
526_R 637_L 1.389 0.78
547_V 642_A 1.388 0.78
75_L 293_T 1.386 0.78
700_V 755_Q 1.384 0.78
575_D 578_A 1.382 0.78
336_I 342_S 1.376 0.77
439_E 443_N 1.373 0.77
564_H 568_R 1.371 0.77
36_A 40_E 1.37 0.77
485_L 512_V 1.365 0.77
685_V 690_I 1.361 0.76
347_F 388_I 1.359 0.76
13_S 16_A 1.35 0.76
566_I 727_I 1.346 0.75
382_L 421_V 1.345 0.75
316_A 355_S 1.344 0.75
502_E 505_Q 1.34 0.75
308_Y 311_L 1.339 0.75
669_L 783_K 1.326 0.74
343_W 387_E 1.323 0.73
709_K 712_E 1.316 0.73
389_N 411_S 1.316 0.73
674_L 692_I 1.315 0.73
311_L 315_I 1.314 0.73
197_Q 206_I 1.308 0.72
136_S 796_S 1.308 0.72
587_F 605_I 1.307 0.72
799_T 802_E 1.294 0.71
88_A 221_P 1.291 0.71
84_T 119_P 1.29 0.71
537_V 625_V 1.29 0.71
529_E 533_Q 1.288 0.71
728_G 744_V 1.284 0.70
548_Q 561_N 1.282 0.70
767_Q 770_V 1.273 0.69
137_L 810_I 1.27 0.69
454_A 461_F 1.269 0.69
760_Y 764_V 1.265 0.69
603_H 607_D 1.265 0.69
81_I 84_T 1.264 0.69
209_E 284_R 1.259 0.68
83_R 118_D 1.259 0.68
347_F 430_V 1.259 0.68
307_T 310_N 1.258 0.68
149_I 289_L 1.255 0.68
192_F 211_I 1.254 0.68
374_L 382_L 1.253 0.68
247_F 255_A 1.247 0.67
689_N 783_K 1.246 0.67
530_Y 534_Q 1.241 0.66
73_Y 315_I 1.241 0.66
405_D 408_G 1.238 0.66
549_I 639_I 1.235 0.66
189_K 210_E 1.227 0.65
428_V 434_V 1.219 0.64
579_K 621_K 1.213 0.64
177_N 180_E 1.213 0.64
500_L 503_L 1.2 0.63
325_V 427_A 1.199 0.63
539_V 586_I 1.199 0.63
70_R 432_H 1.199 0.63
390_D 394_K 1.195 0.62
141_G 225_T 1.195 0.62
781_T 785_M 1.194 0.62
712_E 715_E 1.191 0.62
77_M 450_F 1.188 0.61
462_T 806_H 1.187 0.61
567_T 719_E 1.186 0.61
528_A 541_P 1.183 0.61
375_G 382_L 1.183 0.61
192_F 284_R 1.182 0.61
512_V 785_M 1.181 0.61
332_M 350_C 1.179 0.61
570_N 722_Q 1.179 0.61
482_S 486_D 1.176 0.60
393_L 411_S 1.175 0.60
457_F 460_R 1.173 0.60
214_V 237_Q 1.164 0.59
375_G 386_F 1.163 0.59
484_V 519_A 1.16 0.59
119_P 636_Q 1.159 0.59
286_E 325_V 1.159 0.59
462_T 799_T 1.158 0.59
289_L 326_L 1.152 0.58
254_A 257_E 1.15 0.58
70_R 312_A 1.15 0.58
25_L 40_E 1.149 0.58
150_R 216_Y 1.146 0.57
682_L 692_I 1.144 0.57
442_S 462_T 1.141 0.57
167_E 599_K 1.14 0.57
196_I 383_Q 1.14 0.57
507_C 786_L 1.138 0.57
799_T 806_H 1.136 0.56
301_H 341_F 1.133 0.56
630_Y 635_A 1.133 0.56
514_H 518_Q 1.132 0.56
37_N 519_A 1.132 0.56
191_R 207_E 1.128 0.56
153_Y 170_D 1.127 0.55
301_H 311_L 1.127 0.55
769_K 772_E 1.126 0.55
674_L 687_A 1.124 0.55
432_H 809_H 1.121 0.55
38_K 111_E 1.121 0.55
734_P 737_P 1.119 0.55
318_H 355_S 1.119 0.55
363_S 589_G 1.118 0.55
22_A 105_M 1.116 0.54
567_T 571_R 1.115 0.54
741_R 745_D 1.114 0.54
485_L 503_L 1.112 0.54
247_F 250_G 1.111 0.54
484_V 488_H 1.11 0.54
196_I 203_T 1.11 0.54
382_L 386_F 1.107 0.53
473_W 630_Y 1.106 0.53
486_D 491_R 1.102 0.53
530_Y 637_L 1.1 0.53
77_M 286_E 1.1 0.53
351_C 460_R 1.097 0.52
777_Q 781_T 1.096 0.52
316_A 809_H 1.096 0.52
618_I 623_K 1.095 0.52
647_Q 668_A 1.095 0.52
507_C 785_M 1.094 0.52
188_Y 299_S 1.092 0.52
386_F 411_S 1.09 0.52
99_Q 103_E 1.086 0.51
28_T 47_F 1.085 0.51
411_S 415_E 1.084 0.51
644_L 754_Y 1.084 0.51
259_K 263_E 1.083 0.51
205_W 381_H 1.082 0.51
310_N 341_F 1.081 0.51
72_V 144_G 1.079 0.51
442_S 464_V 1.079 0.51
571_R 575_D 1.078 0.50
142_L 804_A 1.077 0.50
286_E 326_L 1.076 0.50
397_Q 407_L 1.076 0.50
695_N 758_A 1.075 0.50
274_S 594_A 1.073 0.50
99_Q 110_E 1.071 0.50
670_T 787_N 1.071 0.50
565_V 622_L 1.07 0.50
518_Q 522_E 1.068 0.49
68_E 314_K 1.067 0.49
150_R 173_L 1.064 0.49
608_V 612_I 1.06 0.49
329_P 430_V 1.059 0.49
568_R 771_D 1.058 0.48
562_V 566_I 1.056 0.48
610_K 614_N 1.055 0.48
17_L 98_V 1.054 0.48
505_Q 513_N 1.052 0.48
393_L 415_E 1.048 0.47
510_P 513_N 1.048 0.47
566_I 732_F 1.043 0.47
397_Q 404_T 1.043 0.47
473_W 633_S 1.041 0.47
719_E 761_R 1.037 0.46
141_G 227_A 1.036 0.46
663_F 796_S 1.033 0.46
60_S 64_Q 1.032 0.46
252_Y 268_V 1.031 0.46
77_M 289_L 1.028 0.45
498_S 801_K 1.025 0.45
627_I 638_I 1.024 0.45
70_R 73_Y 1.02 0.45
14_V 18_K 1.02 0.45
704_R 753_H 1.019 0.44
70_R 809_H 1.019 0.44
83_R 169_P 1.016 0.44
250_G 255_A 1.015 0.44
371_V 386_F 1.014 0.44
14_V 100_G 1.013 0.44
351_C 395_T 1.009 0.43
413_I 421_V 1.007 0.43
386_F 389_N 1.007 0.43
440_L 565_V 1.006 0.43
514_H 778_E 1.005 0.43
21_I 45_T 1.002 0.43
131_A 231_L 1.001 0.43
68_E 305_H 1.001 0.43
482_S 485_L 1 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ygpA20.99511000.282Contact Map0.692
2gj4A10.99631000.329Contact Map0.761
1l5wA20.97421000.334Contact Map0.699
2c4mA40.96441000.359Contact Map0.757
3vueA10.629499.60.958Contact Map0.444
4hlnA10.6736990.969Contact Map0.429
3nb0A40.716698.20.976Contact Map0.298
2qzsA10.550996.20.983Contact Map0.393
1rzuA20.527694.50.985Contact Map0.455
3froA30.4957670.989Contact Map0.416
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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