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OPENSEQ.org
PHSM - Maltodextrin phosphorylase
UniProt: P00490 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10560
Length: 797 (783)
Sequences: 1143
Seq/Len: 1.46
PHSM
Paralog alert: 0.42 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: PHSG PHSM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
527_A 568_V 4.737 1.00
515_V 523_I 4.292 1.00
471_K 499_Q 4.153 1.00
374_E 378_R 4.034 1.00
497_R 770_I 3.974 1.00
303_V 416_F 3.954 1.00
549_I 569_F 3.846 1.00
417_A 446_H 3.756 1.00
501_R 766_T 3.71 1.00
488_E 775_R 3.705 1.00
289_H 326_H 3.633 1.00
557_R 601_L 3.616 1.00
701_D 746_A 3.539 1.00
200_G 279_C 3.446 1.00
483_Q 486_N 3.434 1.00
278_A 282_A 3.388 1.00
536_L 573_A 3.364 1.00
546_L 592_V 3.363 1.00
516_K 522_E 3.294 1.00
497_R 763_E 3.29 1.00
764_A 768_A 3.25 1.00
675_F 758_L 3.192 1.00
335_A 339_K 3.176 1.00
668_K 778_M 3.046 1.00
505_Q 526_Q 3.039 1.00
551_A 745_F 2.954 1.00
296_H 332_D 2.925 1.00
698_R 709_K 2.855 1.00
558_E 706_A 2.751 1.00
448_V 791_R 2.746 1.00
396_K 436_E 2.7 1.00
464_A 510_R 2.621 1.00
98_N 101_D 2.572 1.00
452_I 649_L 2.529 1.00
500_Y 769_A 2.463 1.00
705_D 709_K 2.436 1.00
476_E 483_Q 2.401 1.00
658_L 680_T 2.394 1.00
448_V 784_S 2.392 1.00
492_D 767_R 2.383 1.00
556_I 602_V 2.381 1.00
761_D 764_A 2.367 1.00
348_L 428_L 2.348 0.99
628_I 655_V 2.332 0.99
500_Y 773_T 2.293 0.99
505_Q 509_V 2.286 0.99
554_K 710_E 2.267 0.99
285_L 321_V 2.243 0.99
747_A 750_E 2.209 0.99
686_A 690_K 2.197 0.99
297_E 300_D 2.189 0.99
295_L 328_M 2.17 0.99
464_A 506_A 2.161 0.99
178_V 202_A 2.16 0.99
281_V 321_V 2.156 0.99
427_D 431_K 2.132 0.99
393_V 397_L 2.104 0.99
472_S 490_F 2.092 0.99
123_F 784_S 2.078 0.98
285_L 298_L 2.073 0.98
485_I 775_R 2.07 0.98
485_I 488_E 2.069 0.98
139_L 253_T 2.029 0.98
284_I 304_I 2.028 0.98
695_V 699_K 2.015 0.98
19_W 23_G 1.989 0.98
758_L 768_A 1.987 0.98
299_A 339_K 1.971 0.98
52_F 217_P 1.965 0.98
515_V 570_L 1.964 0.98
472_S 496_F 1.948 0.97
494_A 763_E 1.942 0.97
546_L 549_I 1.942 0.97
786_R 790_A 1.937 0.97
666_A 671_E 1.93 0.97
470_D 478_A 1.923 0.97
361_V 372_I 1.918 0.97
486_N 489_K 1.905 0.97
127_M 132_Q 1.899 0.97
473_L 486_N 1.884 0.97
154_K 587_F 1.879 0.97
435_P 439_Q 1.87 0.96
393_V 439_Q 1.867 0.96
390_D 396_K 1.85 0.96
329_S 332_D 1.849 0.96
501_R 762_Q 1.843 0.96
480_D 483_Q 1.84 0.96
746_A 750_E 1.837 0.96
628_I 755_V 1.831 0.96
658_L 666_A 1.817 0.96
648_A 776_C 1.806 0.95
342_A 416_F 1.805 0.95
750_E 754_Q 1.78 0.95
427_D 430_V 1.774 0.95
524_N 607_K 1.774 0.95
533_I 622_L 1.757 0.94
666_A 674_I 1.756 0.94
438_H 443_N 1.734 0.94
349_M 637_K 1.731 0.94
185_K 194_P 1.729 0.94
423_A 427_D 1.72 0.94
267_K 363_G 1.717 0.94
393_V 396_K 1.713 0.93
513_E 517_V 1.713 0.93
470_D 477_W 1.713 0.93
491_A 497_R 1.711 0.93
330_W 334_W 1.711 0.93
569_F 606_L 1.683 0.93
563_D 760_R 1.68 0.93
698_R 705_D 1.679 0.93
524_N 604_D 1.671 0.92
466_A 477_W 1.669 0.92
132_Q 795_A 1.667 0.92
649_L 776_C 1.666 0.92
313_I 361_V 1.66 0.92
509_V 513_E 1.659 0.92
584_N 726_Q 1.656 0.92
464_A 507_N 1.65 0.92
698_R 742_M 1.649 0.92
698_R 733_K 1.647 0.92
653_L 675_F 1.645 0.92
319_L 330_W 1.641 0.91
758_L 764_A 1.632 0.91
473_L 483_Q 1.625 0.91
733_K 742_M 1.624 0.91
464_A 503_I 1.62 0.91
787_D 791_R 1.618 0.91
519_T 612_P 1.609 0.90
754_Q 757_V 1.598 0.90
472_S 499_Q 1.595 0.90
26_S 34_Q 1.586 0.89
176_L 202_A 1.583 0.89
288_H 297_E 1.582 0.89
611_L 618_A 1.582 0.89
500_Y 770_I 1.58 0.89
298_L 340_T 1.578 0.89
418_V 444_K 1.576 0.89
288_H 299_A 1.575 0.89
187_T 193_E 1.565 0.89
680_T 683_Q 1.559 0.88
693_D 696_K 1.559 0.88
374_E 377_T 1.546 0.88
521_I 609_V 1.541 0.88
376_N 380_K 1.535 0.87
555_E 753_K 1.528 0.87
704_L 745_F 1.525 0.87
523_I 568_V 1.513 0.86
140_N 170_F 1.511 0.86
789_Q 795_A 1.506 0.86
752_Q 755_V 1.497 0.85
126_S 781_S 1.496 0.85
62_V 795_A 1.494 0.85
294_K 297_E 1.492 0.85
127_M 134_A 1.489 0.85
288_H 295_L 1.488 0.85
315_I 341_F 1.486 0.85
507_N 510_R 1.481 0.85
319_L 334_W 1.479 0.85
614_Y 623_I 1.46 0.83
390_D 393_V 1.452 0.83
559_N 562_A 1.445 0.83
653_L 768_A 1.442 0.82
550_L 711_L 1.442 0.82
528_I 628_I 1.441 0.82
468_L 496_F 1.439 0.82
510_R 621_K 1.434 0.82
417_A 448_V 1.431 0.82
581_L 727_M 1.429 0.82
781_S 785_I 1.415 0.81
282_A 321_V 1.412 0.81
745_F 749_V 1.41 0.80
567_R 756_D 1.406 0.80
514_F 518_R 1.405 0.80
321_V 326_H 1.404 0.80
783_R 787_D 1.404 0.80
725_D 729_H 1.391 0.79
548_H 552_L 1.391 0.79
673_N 768_A 1.387 0.79
313_I 316_P 1.387 0.79
766_T 770_I 1.385 0.79
454_P 481_L 1.383 0.79
571_F 608_V 1.382 0.79
684_V 740_L 1.377 0.78
619_A 623_I 1.373 0.78
571_F 589_I 1.369 0.78
314_A 341_F 1.368 0.78
71_I 121_A 1.368 0.78
712_E 728_L 1.367 0.78
531_I 626_A 1.366 0.77
469_L 473_L 1.365 0.77
533_I 647_L 1.362 0.77
546_L 588_A 1.358 0.77
392_K 395_A 1.357 0.77
19_W 45_E 1.355 0.77
123_F 785_I 1.351 0.76
567_R 752_Q 1.349 0.76
355_R 404_Q 1.349 0.76
323_I 329_S 1.337 0.75
587_F 591_K 1.336 0.75
362_K 373_N 1.329 0.75
71_I 74_L 1.325 0.74
369_M 405_V 1.313 0.73
295_L 298_L 1.311 0.73
669_V 674_I 1.308 0.73
470_D 475_K 1.307 0.73
137_Y 283_D 1.304 0.73
563_D 605_K 1.304 0.73
658_L 676_I 1.302 0.73
512_A 525_P 1.296 0.72
506_A 509_V 1.294 0.72
167_Y 205_L 1.289 0.71
448_V 787_D 1.287 0.71
89_Q 93_K 1.284 0.71
491_A 771_L 1.279 0.71
498_Q 502_E 1.272 0.70
303_V 342_A 1.265 0.69
361_V 369_M 1.26 0.69
416_F 794_Q 1.26 0.69
602_V 607_K 1.258 0.69
627_D 766_T 1.256 0.69
489_K 497_R 1.25 0.68
334_W 375_I 1.248 0.68
65_I 280_S 1.238 0.67
762_Q 766_T 1.238 0.67
665_I 669_V 1.236 0.67
369_M 373_N 1.229 0.66
377_T 381_T 1.229 0.66
63_N 302_E 1.229 0.66
469_L 496_F 1.228 0.66
502_E 506_A 1.227 0.66
696_K 699_K 1.227 0.66
60_R 303_V 1.217 0.65
362_K 369_M 1.217 0.65
157_E 583_K 1.212 0.65
532_Q 545_N 1.211 0.65
554_K 706_A 1.208 0.64
330_W 374_E 1.204 0.64
32_P 101_D 1.202 0.64
334_W 414_G 1.199 0.63
186_V 370_Q 1.198 0.63
376_N 398_A 1.195 0.63
426_S 446_H 1.193 0.63
400_V 405_V 1.19 0.63
468_L 472_S 1.188 0.62
441_W 444_K 1.187 0.62
182_I 271_M 1.185 0.62
139_L 276_Q 1.184 0.62
784_S 787_D 1.184 0.62
20_Q 34_Q 1.183 0.62
196_F 271_M 1.183 0.62
522_E 604_D 1.182 0.62
412_V 418_V 1.178 0.61
592_V 596_I 1.177 0.61
179_Q 197_T 1.173 0.61
484_L 487_L 1.168 0.60
312_T 411_C 1.168 0.60
466_A 470_D 1.164 0.60
58_N 292_G 1.161 0.60
555_E 559_N 1.161 0.60
78_N 208_V 1.159 0.59
556_I 562_A 1.157 0.59
495_K 498_Q 1.156 0.59
750_E 753_K 1.149 0.59
751_A 754_Q 1.148 0.58
380_K 398_A 1.148 0.58
384_E 394_W 1.147 0.58
533_I 623_I 1.146 0.58
784_S 791_R 1.142 0.58
712_E 733_K 1.142 0.58
551_A 703_V 1.142 0.58
703_V 746_A 1.139 0.58
338_S 382_L 1.136 0.57
74_L 109_P 1.136 0.57
319_L 337_T 1.13 0.57
373_N 398_A 1.129 0.56
438_H 445_F 1.128 0.56
60_R 416_F 1.125 0.56
31_T 503_I 1.125 0.56
491_A 770_I 1.123 0.56
666_A 676_I 1.123 0.56
482_D 786_R 1.122 0.56
446_H 791_R 1.121 0.56
73_R 108_D 1.12 0.56
496_F 770_I 1.117 0.55
127_M 795_A 1.116 0.55
167_Y 170_F 1.115 0.55
757_V 760_R 1.115 0.55
298_L 302_E 1.115 0.55
178_V 286_R 1.11 0.55
328_M 336_I 1.11 0.55
658_L 671_E 1.108 0.54
58_N 301_Y 1.108 0.54
131_G 212_N 1.107 0.54
16_S 94_A 1.106 0.54
675_F 755_V 1.104 0.54
140_N 203_W 1.104 0.54
89_Q 100_T 1.103 0.54
384_E 391_E 1.1 0.54
669_V 772_N 1.094 0.53
373_N 376_N 1.094 0.53
551_A 555_E 1.093 0.53
60_R 299_A 1.091 0.53
550_L 716_Y 1.091 0.53
726_Q 729_H 1.091 0.53
234_F 242_A 1.089 0.52
185_K 193_E 1.086 0.52
729_H 734_Q 1.083 0.52
67_M 434_F 1.082 0.52
143_Y 160_D 1.081 0.52
182_I 198_I 1.08 0.52
718_D 721_K 1.08 0.52
86_Q 89_Q 1.077 0.51
201_Q 224_T 1.073 0.51
305_Q 342_A 1.073 0.51
591_K 594_D 1.072 0.51
514_F 621_K 1.071 0.51
446_H 784_S 1.07 0.50
469_L 487_L 1.064 0.50
62_V 134_A 1.062 0.50
468_L 503_I 1.062 0.50
300_D 339_K 1.061 0.50
524_N 603_G 1.058 0.49
722_H 725_D 1.058 0.49
426_S 448_V 1.044 0.48
679_H 687_I 1.044 0.48
132_Q 789_Q 1.043 0.48
273_Q 313_I 1.038 0.47
654_T 772_N 1.037 0.47
288_H 298_L 1.036 0.47
631_Q 652_A 1.034 0.47
186_V 190_G 1.034 0.47
238_D 241_R 1.033 0.47
319_L 371_I 1.033 0.47
273_Q 312_T 1.033 0.47
380_K 383_V 1.032 0.47
614_Y 619_A 1.031 0.46
140_N 163_H 1.031 0.46
767_R 771_L 1.03 0.46
679_H 743_A 1.029 0.46
288_H 328_M 1.027 0.46
192_W 368_H 1.023 0.46
241_R 244_Q 1.022 0.46
289_H 295_L 1.018 0.45
32_P 105_E 1.017 0.45
505_Q 525_P 1.014 0.45
524_N 568_V 1.014 0.45
688_L 738_P 1.014 0.45
497_R 766_T 1.013 0.45
234_F 237_G 1.013 0.45
457_W 614_Y 1.013 0.45
498_Q 763_E 1.009 0.44
246_G 250_E 1.008 0.44
524_N 527_A 1.008 0.44
580_Y 727_M 1.005 0.44
297_E 328_M 1.005 0.44
131_G 214_V 1.002 0.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ygpA20.99251000.281Contact Map0.707
1l5wA20.99621000.322Contact Map0.713
2gj4A10.9951000.329Contact Map0.779
2c4mA40.97621000.355Contact Map0.78
3vueA10.626199.60.955Contact Map0.462
4hlnA10.6763990.967Contact Map0.474
3nb0A40.72998.50.973Contact Map0.318
2qzsA10.543396.90.981Contact Map0.423
1rzuA20.543395.70.983Contact Map0.489
3froA30.508271.40.989Contact Map0.445
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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