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OPENSEQ.org
DUSB - tRNA-dihydrouridine synthase B
UniProt: P0ABT5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11311
Length: 321 (319)
Sequences: 3062
Seq/Len: 9.60
DUSB
Paralog alert: 0.58 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: DUSA DUSB DUSC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
190_K 219_D 4.657 1.00
31_E 261_A 4.385 1.00
87_V 133_D 3.168 1.00
205_D 208_K 3.116 1.00
204_T 208_K 3.062 1.00
129_V 164_Q 2.926 1.00
211_A 215_Y 2.825 1.00
79_M 96_I 2.795 1.00
125_L 163_I 2.587 1.00
126_T 130_N 2.535 1.00
65_G 92_Q 2.484 1.00
210_R 214_D 2.373 1.00
159_E 194_S 2.358 1.00
25_F 29_C 2.231 1.00
305_D 308_E 2.229 1.00
210_R 240_Y 2.206 1.00
199_A 212_V 2.18 1.00
116_Q 144_W 2.154 1.00
188_A 191_Q 2.132 1.00
187_R 191_Q 2.078 1.00
264_R 310_L 2.044 1.00
184_D 215_Y 2.043 1.00
262_H 286_Y 2.018 1.00
203_I 212_V 2.003 1.00
204_T 226_A 1.995 1.00
83_A 132_V 1.985 1.00
208_K 211_A 1.966 1.00
193_V 197_V 1.941 1.00
259_L 283_V 1.923 1.00
98_M 121_V 1.91 1.00
81_D 84_R 1.906 1.00
77_K 81_D 1.886 1.00
142_T 185_S 1.87 1.00
117_Y 120_V 1.801 1.00
207_L 211_A 1.788 1.00
159_E 195_I 1.785 1.00
239_H 247_L 1.772 1.00
79_M 128_V 1.772 1.00
109_L 117_Y 1.756 1.00
75_D 78_E 1.748 1.00
182_E 185_S 1.732 1.00
175_C 182_E 1.727 1.00
151_C 189_V 1.721 1.00
123_S 126_T 1.704 1.00
73_G 79_M 1.697 1.00
36_L 68_T 1.692 1.00
122_K 161_C 1.688 1.00
140_I 168_I 1.642 1.00
260_C 310_L 1.642 1.00
68_T 93_I 1.635 1.00
260_C 314_E 1.634 1.00
96_I 128_V 1.609 1.00
211_A 214_D 1.598 1.00
122_K 126_T 1.595 1.00
121_V 154_I 1.591 1.00
119_D 157_L 1.589 1.00
308_E 311_E 1.586 1.00
186_I 199_A 1.581 1.00
2_R 7_Q 1.581 1.00
251_P 254_E 1.573 1.00
239_H 243_T 1.572 1.00
298_R 302_A 1.562 1.00
132_V 136_V 1.548 1.00
165_A 198_I 1.534 1.00
119_D 123_S 1.527 1.00
199_A 203_I 1.527 1.00
307_S 311_E 1.525 1.00
304_E 308_E 1.51 1.00
264_R 268_D 1.504 1.00
153_E 156_Q 1.497 1.00
187_R 215_Y 1.489 1.00
13_I 198_I 1.478 1.00
199_A 218_A 1.452 1.00
185_S 188_A 1.452 1.00
35_G 238_Q 1.448 1.00
125_L 161_C 1.44 1.00
76_P 80_A 1.43 1.00
187_R 212_V 1.423 0.99
120_V 123_S 1.408 0.99
198_I 222_M 1.403 0.99
239_H 245_E 1.396 0.99
207_L 246_L 1.392 0.99
311_E 315_A 1.377 0.99
122_K 157_L 1.377 0.99
303_I 312_A 1.375 0.99
69_V 86_N 1.364 0.99
112_S 173_R 1.363 0.99
155_A 193_V 1.362 0.99
156_Q 159_E 1.347 0.99
86_N 94_I 1.34 0.99
181_A 202_D 1.321 0.99
10_N 35_G 1.318 0.99
126_T 161_C 1.307 0.99
168_I 189_V 1.301 0.99
156_Q 160_D 1.291 0.99
152_E 192_K 1.288 0.99
299_T 315_A 1.287 0.99
36_L 93_I 1.287 0.99
45_N 78_E 1.287 0.99
156_Q 192_K 1.285 0.99
138_L 163_I 1.285 0.99
12_L 237_I 1.285 0.99
84_R 131_A 1.282 0.99
87_V 132_V 1.274 0.99
266_L 274_K 1.273 0.99
223_I 237_I 1.27 0.99
310_L 314_E 1.269 0.99
170_G 186_I 1.263 0.99
190_K 197_V 1.258 0.98
159_E 193_V 1.253 0.98
303_I 308_E 1.243 0.98
122_K 160_D 1.231 0.98
209_A 221_L 1.226 0.98
230_R 236_E 1.226 0.98
115_L 140_I 1.204 0.98
235_R 254_E 1.201 0.98
198_I 220_A 1.2 0.98
138_L 158_A 1.199 0.98
115_L 154_I 1.192 0.98
145_A 148_H 1.187 0.98
253_A 257_R 1.16 0.97
137_T 165_A 1.142 0.97
146_P 175_C 1.139 0.97
243_T 247_L 1.138 0.97
51_S 54_S 1.133 0.97
84_R 88_E 1.13 0.96
85_I 88_E 1.128 0.96
260_C 264_R 1.127 0.96
76_P 120_V 1.125 0.96
261_A 265_E 1.125 0.96
295_Q 298_R 1.119 0.96
212_V 218_A 1.114 0.96
24_P 269_F 1.107 0.96
12_L 221_L 1.101 0.96
202_D 225_R 1.1 0.96
38_V 68_T 1.099 0.96
129_V 163_I 1.094 0.96
154_I 158_A 1.092 0.95
188_A 192_K 1.092 0.95
168_I 197_V 1.084 0.95
238_Q 242_D 1.074 0.95
240_Y 243_T 1.072 0.95
156_Q 193_V 1.071 0.95
125_L 158_A 1.071 0.95
213_L 218_A 1.07 0.95
265_E 268_D 1.068 0.95
157_L 161_C 1.063 0.95
152_E 188_A 1.055 0.94
151_C 185_S 1.052 0.94
99_G 200_N 1.048 0.94
259_L 279_A 1.047 0.94
12_L 223_I 1.042 0.94
87_V 134_V 1.04 0.94
13_I 36_L 1.039 0.94
155_A 189_V 1.038 0.94
118_P 153_E 1.038 0.94
115_L 121_V 1.032 0.93
129_V 136_V 1.03 0.93
77_K 127_E 1.023 0.93
80_A 131_A 1.021 0.93
295_Q 299_T 1.018 0.93
183_Y 212_V 1.012 0.92
206_P 240_Y 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vhnA10.96261000.339Contact Map0.73
3b0pA20.95331000.362Contact Map0.758
3w9zA10.9471000.371Contact Map0.701
4bfaA20.96881000.375Contact Map0.729
1gteA40.97511000.604Contact Map0.675
3l5aA10.89411000.618Contact Map0.662
3tjlA10.88791000.621Contact Map0.535
3sgzA30.80061000.623Contact Map0.578
3k30A20.96261000.625Contact Map0.573
4jicA30.8381000.626Contact Map0.658
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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